PMID- 26079721
OWN - NLM
STAT- MEDLINE
DCOM- 20161104
LR  - 20161230
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 133
IP  - 4
DP  - 2016 Apr
TI  - Impact of Helicobacter pylori on multiple sclerosis-related clinically isolated
      syndrome.
PG  - 268-75
LID - 10.1111/ane.12453 [doi]
AB  - OBJECTIVES: There are no data regarding the relationship between Helicobacter
      pylori infection (Hp-I) and clinically isolated syndrome (CIS) suggestive of
      multiple sclerosis. The purpose of this pilot study was to investigate the
      association between active Hp-I, confirmed by histology, and CIS and to evaluate 
      the impact of Hp eradication on the CIS clinical course. MATERIAL AND METHODS: We
      conducted a study on 48 patients with CIS and 20 matched controls. At baseline,
      apart from histology, serum anti-Hp-specific IgG titer, inflammatory mediators,
      and HLA-A, HLA-B, HLA-DR genetic polymorphisms were estimated. Hp-positive
      patients received standard triple eradication regimen, and all patients were
      followed up for 2 years. RESULTS: The prevalence of Hp-I was significantly higher
      in patients with CIS (43/48, 89.6%) than in control (10/20, 50%) (P < 0.001, OR: 
      8.6, 95% CI: 2.4-30.8). When compared with controls, patients with CIS also
      showed significantly higher serum anti-Hp IgG titer and HLA-A26, HLA-A30, and
      HLA-B57 frequencies. Hp-positive patients also showed higher serum concentrations
      of inflammatory cytokines and homocysteine. At 2-year clinical endpoint, in the
      subgroup of CIS patients with successful Hp eradication, the number of patients
      who presented with a second episode was significantly lower accompanied by
      significant improvement in mean Expanded Disability Status Scale score.
      CONCLUSIONS: Hp-I seems more frequent in a Greek CIS cohort and its eradication
      might delay CIS progression, suggesting a possible link between Hp-I and CIS.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Deretzi, G
AU  - Deretzi G
AD  - Multiple Sclerosis Unit, Department of Neurology, "Papageorgiou" Hospital,
      Thessaloniki, Greece.
FAU - Gavalas, E
AU  - Gavalas E
AD  - Department of Medicine, Second Medical Clinic, Aristotle University of
      Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
FAU - Boziki, M
AU  - Boziki M
AD  - 2nd Department of Neurology, AHEPA University Hospital, Aristotle University of
      Thessaloniki, Thessaloniki, Greece.
FAU - Tsiptsios, D
AU  - Tsiptsios D
AD  - Multiple Sclerosis Unit, Department of Neurology, "Papageorgiou" Hospital,
      Thessaloniki, Greece.
FAU - Polyzos, S A
AU  - Polyzos SA
AD  - Department of Medicine, Second Medical Clinic, Aristotle University of
      Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
FAU - Venizelos, I
AU  - Venizelos I
AD  - Department of Medicine, Second Medical Clinic, Aristotle University of
      Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
FAU - Zavos, C
AU  - Zavos C
AD  - Department of Medicine, Second Medical Clinic, Aristotle University of
      Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
FAU - Koutlas, E
AU  - Koutlas E
AD  - Multiple Sclerosis Unit, Department of Neurology, "Papageorgiou" Hospital,
      Thessaloniki, Greece.
FAU - Tsiptsios, I
AU  - Tsiptsios I
AD  - Multiple Sclerosis Unit, Department of Neurology, "Papageorgiou" Hospital,
      Thessaloniki, Greece.
FAU - Katsinelos, P
AU  - Katsinelos P
AD  - Department of Medicine, Second Medical Clinic, Aristotle University of
      Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
FAU - Kountouras, J
AU  - Kountouras J
AD  - Department of Medicine, Second Medical Clinic, Aristotle University of
      Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20150616
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*26 antigen)
RN  - 0 (HLA-A*30 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Demyelinating Diseases/blood/*epidemiology
MH  - Female
MH  - Greece
MH  - HLA-A Antigens/blood
MH  - HLA-B Antigens/blood
MH  - Helicobacter Infections/blood/*epidemiology
MH  - Helicobacter pylori/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
OTO - NOTNLM
OT  - HLA alleles
OT  - Helicobacter pylori
OT  - clinically isolated syndrome
OT  - histological analysis
OT  - multiple sclerosis
OT  - proinflammatory cytokines
EDAT- 2015/06/17 06:00
MHDA- 2016/11/05 06:00
CRDT- 2015/06/17 06:00
PHST- 2015/05/26 00:00 [accepted]
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2016/11/05 06:00 [medline]
AID - 10.1111/ane.12453 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2016 Apr;133(4):268-75. doi: 10.1111/ane.12453. Epub 2015 Jun 
      16.