PMID- 26066649
OWN - NLM
STAT- MEDLINE
DCOM- 20160413
LR  - 20171116
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 6
DP  - 2015
TI  - The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone
      Geometry and Fracture Risk: The Rotterdam Study.
PG  - e0129116
LID - 10.1371/journal.pone.0129116 [doi]
AB  - The association between metabolic syndrome (MS) and bone health remains unclear. 
      We aimed to study the association between MS and hip bone geometry (HBG), femoral
      neck bone mineral density (FN-BMD), and the risk of osteoporosis and incident
      fractures. Data of 2040 women and 1510 men participants in the third visit
      (1997-1999) of the Rotterdam Study (RSI-3), a prospective population based
      cohort, were available (mean follow-up 6.7 years). MS was defined according to
      the recent harmonized definition. HBG parameters were measured at the third round
      visit whereas FN-BMD was assessed at the third round and 5 years later. Incident 
      fractures were identified from medical registry data. After correcting for age,
      body mass index (BMI), lifestyle factors and medication use, individuals with MS 
      had lower bone width (beta = -0.054, P = 0.003), lower cortical buckling ratio
      (beta = -0.81, P = 0.003) and lower odds of having osteoporosis (odds ratio
      =0.56, P = 0.007) in women but not in men. Similarly, MS was associated with
      higher FN-BMD only in women (beta = 0.028, P=0.001). In the analyses of MS
      components, the glucose component (unrelated to diabetes status) was positively
      associated with FN-BMD in both genders (beta = 0.016, P = 0.01 for women and beta
      = 0.022, P = 0.004 for men). In men, waist circumference was inversely associated
      with FN-BMD (beta = -0.03, P = 0.004). No association was observed with fracture 
      risk in either sex. In conclusion, women with MS had higher FN-BMD independent of
      BMI. The glucose component of MS was associated with high FN-BMD in both genders,
      highlighting the need to preserve glycemic control to prevent skeletal
      complications.
FAU - Muka, Taulant
AU  - Muka T
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
FAU - Trajanoska, Katerina
AU  - Trajanoska K
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the
      Netherlands.
FAU - Kiefte-de Jong, Jessica C
AU  - Kiefte-de Jong JC
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
FAU - Oei, Ling
AU  - Oei L
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the
      Netherlands; Netherlands Consortium for Healthy Ageing, Netherlands Genomics
      Inititiative, The Hague, the Netherlands; Department of Internal Medicine,
      IJsselland Hospital, Capelle aan den Ijssel, the Netherlands.
FAU - Uitterlinden, Andre G
AU  - Uitterlinden AG
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the
      Netherlands; Netherlands Consortium for Healthy Ageing, Netherlands Genomics
      Inititiative, The Hague, the Netherlands.
FAU - Hofman, Albert
AU  - Hofman A
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Netherlands Consortium for Healthy Ageing, Netherlands Genomics Inititiative, The
      Hague, the Netherlands.
FAU - Dehghan, Abbas
AU  - Dehghan A
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Netherlands Consortium for Healthy Ageing, Netherlands Genomics Inititiative, The
      Hague, the Netherlands.
FAU - Zillikens, M Carola
AU  - Zillikens MC
AD  - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the
      Netherlands; Netherlands Consortium for Healthy Ageing, Netherlands Genomics
      Inititiative, The Hague, the Netherlands.
FAU - Franco, Oscar H
AU  - Franco OH
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Netherlands Consortium for Healthy Ageing, Netherlands Genomics Inititiative, The
      Hague, the Netherlands.
FAU - Rivadeneira, Fernando
AU  - Rivadeneira F
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;
      Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the
      Netherlands; Netherlands Consortium for Healthy Ageing, Netherlands Genomics
      Inititiative, The Hague, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150612
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bone Density
MH  - Female
MH  - Hip Fractures/*epidemiology
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Osteoporosis/*epidemiology
MH  - Pelvic Bones/*anatomy & histology/metabolism
PMC - PMC4466576
EDAT- 2015/06/13 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/06/13 06:00
PHST- 2014/12/10 00:00 [received]
PHST- 2015/05/05 00:00 [accepted]
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - 10.1371/journal.pone.0129116 [doi]
AID - PONE-D-14-55413 [pii]
PST - epublish
SO  - PLoS One. 2015 Jun 12;10(6):e0129116. doi: 10.1371/journal.pone.0129116.
      eCollection 2015.