PMID- 26030300
OWN - NLM
STAT- MEDLINE
DCOM- 20160304
LR  - 20150610
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 6
DP  - 2015
TI  - Comparison of the prescribing pattern of bisphosphonate and raloxifene in Korean 
      women with osteoporosis: from a national health insurance claims database.
PG  - e0127970
LID - 10.1371/journal.pone.0127970 [doi]
AB  - This study aimed to evaluate the differences of prescribing pattern between
      bisphosphonate and raloxifene users among Korean women with osteoporosis,
      focusing on the underlying conditions, concurrent medications, nature of
      healthcare utilization, and regional disparity. We used the Health Insurance
      Review and Assessment Service National Patients Sample database of the year 2010.
      Study subjects were defined as female osteoporosis patients aged over 50 years
      with both the diagnosis of osteoporosis and prescriptions of bisphosphonate or
      raloxifene. The frequency and the proportion of bisphosphonate and raloxifene
      were compared using chi-square test and the trend of the proportion using the
      Cochran-Armitage test. Medications were quantified as defined daily doses per
      1,000 patients per day. The prescription pattern was visualized by using the
      Quantum Geographic Information Systems program. Of the 1,367,367 people who
      utilized medical services in 2010, the final number of study subjects was
      26,881--26,032 (96.8%) bisphosphonate and 849 (3.2%) raloxifene recipients.
      Raloxifene users were younger than bisphosphonate users and were more frequently 
      patients with a lipid disorder (16.0% vs. 22.1%, p-value < 0.0001), rheumatic
      disease (4.0% vs. 6.1%, p-value = 0.0024), hot flash (1.8% vs. 6.1%, p <0.0001), 
      and coronary artery disease (1.2% vs. 2.8%, p< 0.0001). The proportion of
      raloxifene users was higher in tertiary care institutions (21.6% vs. 44.7%,
      p-value < 0.0001). A regional distribution showed that raloxifene use was higher 
      in the Seoul metropolitan area. These differences in demographic and clinical
      profiles of each recipient may influence prescription decisions.
FAU - Kim, Jungmee
AU  - Kim J
AD  - Department of Preventive Medicine, Seoul National University, College of
      Medicine, Daehangno, Jongno-gu, Seoul, Korea.
FAU - Shin, Ju-Young
AU  - Shin JY
AD  - Korea Institute of Drug Safety and Risk Management, Boryung building,
      Changgyeonggung-ro, Jongno-gu, Seoul, Korea.
FAU - Lee, Joongyub
AU  - Lee J
AD  - Medical Research Collaborating Center, Seoul National University Hospital and
      Seoul National University College of Medicine, Seoul, Korea.
FAU - Song, Hong-Ji
AU  - Song HJ
AD  - Department of Family Medicine, College of Medicine, Hallym University, Chuncheon,
      Korea.
FAU - Choi, Nam-Kyong
AU  - Choi NK
AD  - Medical Research Collaborating Center, Seoul National University Hospital and
      Seoul National University College of Medicine, Seoul, Korea.
FAU - Park, Byung-Joo
AU  - Park BJ
AD  - Department of Preventive Medicine, Seoul National University, College of
      Medicine, Daehangno, Jongno-gu, Seoul, Korea; Korea Institute of Drug Safety and 
      Risk Management, Boryung building, Changgyeonggung-ro, Jongno-gu, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150601
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Diphosphonates)
RN  - 4F86W47BR6 (Raloxifene Hydrochloride)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Density Conservation Agents/*therapeutic use
MH  - Databases, Factual
MH  - Diphosphonates/*therapeutic use
MH  - Drug Administration Schedule
MH  - Drug Prescriptions/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Insurance, Health
MH  - Middle Aged
MH  - Osteoporosis/*drug therapy
MH  - Osteoporosis, Postmenopausal/drug therapy
MH  - Raloxifene Hydrochloride/*therapeutic use
MH  - Seoul
PMC - PMC4451256
EDAT- 2015/06/02 06:00
MHDA- 2016/03/05 06:00
CRDT- 2015/06/02 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2015/04/21 00:00 [accepted]
PHST- 2015/06/02 06:00 [entrez]
PHST- 2015/06/02 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
AID - 10.1371/journal.pone.0127970 [doi]
AID - PONE-D-14-43868 [pii]
PST - epublish
SO  - PLoS One. 2015 Jun 1;10(6):e0127970. doi: 10.1371/journal.pone.0127970.
      eCollection 2015.