PMID- 26011912
OWN - NLM
STAT- MEDLINE
DCOM- 20160126
LR  - 20150527
IS  - 1753-4887 (Electronic)
IS  - 0029-6643 (Linking)
VI  - 73
IP  - 6
DP  - 2015 Jun
TI  - Obesity and the gastrointestinal microbiota: a review of associations and
      mechanisms.
PG  - 376-85
LID - 10.1093/nutrit/nuv004 [doi]
AB  - The two-way obesity model that considers only the interplay between humans and
      their environment has been revised to include the gastrointestinal microbiota.
      Notable perturbations in the bacterial communities in obese individuals have been
      uncovered. Research is helping to distinguish between the obesogenic mechanisms
      attributable to diet and those that may be associated with the microbiota.
      Examples include studies in which transplant of the microbiota from murine models
      of weight loss (gastric bypass) into germ-free mice resulted in significant
      weight loss. Several mechanisms have been identified that suggest the microbiota 
      may play a role in obesity development and propagation. There is some evidence
      from animal and human studies that the microbiota in the obese harvests energy
      more effectively and may manipulate host gene function leading to increased
      adiposity, aggravation of inflammatory mechanisms, metabolic endotoxemia, and
      metabolic dysfunction. Research findings highlight the potential of the
      microbiota to influence body weight and they allude to its potential therapeutic 
      use in tackling the costly global epidemic of obesity.
CI  - (c) The Author(s) 2015. Published by Oxford University Press on behalf of the
      International Life Sciences Institute. All rights reserved. For Permissions,
      please e-mail: journals.permissions@oup.com.
FAU - Graham, Catherine
AU  - Graham C
AD  - C. Graham, A. Mullen, and K. Whelan are with the Diabetes and Nutritional
      Sciences Division, Faculty of Life Sciences & Medicine, King's College London,
      London, SE1 9NN, UK.
FAU - Mullen, Anne
AU  - Mullen A
AD  - C. Graham, A. Mullen, and K. Whelan are with the Diabetes and Nutritional
      Sciences Division, Faculty of Life Sciences & Medicine, King's College London,
      London, SE1 9NN, UK.
FAU - Whelan, Kevin
AU  - Whelan K
AD  - C. Graham, A. Mullen, and K. Whelan are with the Diabetes and Nutritional
      Sciences Division, Faculty of Life Sciences & Medicine, King's College London,
      London, SE1 9NN, UK. kevin.whelan@kcl.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150406
PL  - United States
TA  - Nutr Rev
JT  - Nutrition reviews
JID - 0376405
SB  - IM
MH  - Adiposity
MH  - Animals
MH  - *Body Weight
MH  - Diet
MH  - *Gastrointestinal Microbiome
MH  - Gastrointestinal Tract/*microbiology
MH  - Humans
MH  - Inflammation/complications
MH  - Obesity/etiology/metabolism/*microbiology
OTO - NOTNLM
OT  - Bacteroidetes
OT  - diet
OT  - inflammation
OT  - metabolic syndrome
OT  - microbiota
OT  - obesity
EDAT- 2015/05/27 06:00
MHDA- 2016/01/27 06:00
CRDT- 2015/05/27 06:00
PHST- 2015/05/27 06:00 [entrez]
PHST- 2015/05/27 06:00 [pubmed]
PHST- 2016/01/27 06:00 [medline]
AID - nuv004 [pii]
AID - 10.1093/nutrit/nuv004 [doi]
PST - ppublish
SO  - Nutr Rev. 2015 Jun;73(6):376-85. doi: 10.1093/nutrit/nuv004. Epub 2015 Apr 6.