PMID- 26009804
OWN - NLM
STAT- MEDLINE
DCOM- 20160829
LR  - 20160118
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 133
IP  - 3
DP  - 2016 Mar
TI  - Benign multiple sclerosis: physical and cognitive impairment follow distinct
      evolutions.
PG  - 183-91
LID - 10.1111/ane.12442 [doi]
AB  - BACKGROUND: Benign multiple sclerosis (BMS) definitions rely on physical
      disability level but do not account sufficiently for cognitive impairment which, 
      however, is not rare. OBJECTIVE: To study the evolution of physical disability
      and cognitive performance of a group of patients with BMS followed at an
      University Hospital Multiple Sclerosis Center. METHODS: A consecutive sample of
      24 BMS cases (diagnosis according to 2005 McDonald's criteria,
      relapsing-remitting course, disease duration >/= 10 years, and expanded
      disability status scale [EDSS] score </= 2.0) and 13 sex- and age-matched non-BMS
      patients differing from BMS cases for having EDSS score 2.5-5.5 were included.
      Main outcome measures were as follows: (i) baseline and 5-year follow-up
      cognitive impairment defined as failure of at least two tests of the administered
      neuropsychological battery; (ii) EDSS score worsening defined as confirmed
      increase >/= 1 point (or 0.5 point if baseline EDSS score = 5.5). RESULTS: At
      inclusion, BMS subjects were 41 +/- 8 years old and had median EDSS score 1.5
      (range 0-2), while non-BMS patients were 46 +/- 8 years old and had median EDSS
      score 3.0 (2.5-5.5). At baseline 16% of patients in both groups were cognitively 
      impaired. After 5 years, EDSS score worsened in 8% of BMS and 46% of non-BMS
      patients (P = 0.008), while the proportion of cognitively impaired subjects
      increased to 25% in both groups. CONCLUSIONS: Patients with BMS had better
      physical disability outcome at 5 years compared to non-BMS cases. However,
      cognitive impairment frequency and decline over time appeared similar.
      Neuropsychological assessment is essential in patients with BMS given the
      distinct pathways followed by disease progression in cognitive and physical
      domains.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Gajofatto, A
AU  - Gajofatto A
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona,
      Italy.
AD  - UOC Neurologia dU, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
FAU - Turatti, M
AU  - Turatti M
AD  - UO Neurologia, Casa di Cura Privata Pederzoli, Peschiera del Garda, Italy.
FAU - Bianchi, M R
AU  - Bianchi MR
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona,
      Italy.
AD  - UOC Neurologia dU, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
FAU - Forlivesi, S
AU  - Forlivesi S
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona,
      Italy.
AD  - UOC Neurologia dU, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
FAU - Gobbin, F
AU  - Gobbin F
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona,
      Italy.
AD  - UOC Neurologia dU, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
FAU - Azzara, A
AU  - Azzara A
AD  - Istituto Auxologico Italiano, Milano, Italy.
FAU - Monaco, S
AU  - Monaco S
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona,
      Italy.
AD  - UOC Neurologia dU, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
FAU - Benedetti, M D
AU  - Benedetti MD
AD  - UOC Neurologia dU, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150526
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
SB  - IM
MH  - Adult
MH  - Cognition Disorders/*etiology/*psychology
MH  - Disability Evaluation
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*physiopathology/*psychology
MH  - Neuropsychological Tests
MH  - Treatment Outcome
OTO - NOTNLM
OT  - benign course
OT  - cognitive impairment
OT  - multiple sclerosis
OT  - physical disability
EDAT- 2015/05/27 06:00
MHDA- 2016/08/30 06:00
CRDT- 2015/05/27 06:00
PHST- 2015/05/04 00:00 [accepted]
PHST- 2015/05/27 06:00 [entrez]
PHST- 2015/05/27 06:00 [pubmed]
PHST- 2016/08/30 06:00 [medline]
AID - 10.1111/ane.12442 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2016 Mar;133(3):183-91. doi: 10.1111/ane.12442. Epub 2015 May 
      26.