PMID- 25996939
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 5
DP  - 2015
TI  - Right ventricular sex differences in patients with idiopathic pulmonary arterial 
      hypertension characterised by magnetic resonance imaging: pair-matched case
      controlled study.
PG  - e0127415
LID - 10.1371/journal.pone.0127415 [doi]
AB  - PURPOSE: Sex differences exist in both the prevalence and survival of patients
      with idiopathic pulmonary arterial hypertension (IPAH). Men are less frequently
      affected by the condition but have worse outcome as compared to females. We
      sought to characterise the sex related differences in right ventricular
      remodelling in age matched male and female patients with IPAH using cardiac
      magnetic resonance imaging (MRI). METHODS: A case controlled pair-matched study
      was conducted with patients matched by age and sex. Steady state free precession 
      (SSFP) MRI of the heart was performed at 1.5T. Cardiac volume, function and mass 
      measurements were corrected for age, sex and BSA according to reference data.
      RESULTS: 40 age and sex matched patients with IPAH were identified. The mean age 
      was 57 (SD 17) in both male and female cohorts. Men had proportionally lower
      right ventricular (RV) ejection fraction, RV stroke volume and LV stroke volume
      than females, p=0.028, p=0.007 and p=0.013, respectively. However, there was no
      significant difference in RV mass or haemodynamic indices of mPAP and PVR between
      males and females. CONCLUSION: Male patients with IPAH have proportionally worse 
      RV function despite similar afterload. We hypothesise that adaptive remodelling
      of the RV in response to increased afterload in IPAH is more effective in
      females.
FAU - Swift, Andrew J
AU  - Swift AJ
AD  - Department of Cardiovascular Science, University of Sheffield, Sheffield, United 
      Kingdom; INSIGNEO, Institute for In Silico Medicine, University of Sheffield,
      Sheffield, United Kingdom.
FAU - Capener, Dave
AU  - Capener D
AD  - Department of Cardiovascular Science, University of Sheffield, Sheffield, United 
      Kingdom.
FAU - Hammerton, Charlotte
AU  - Hammerton C
AD  - Department of Cardiovascular Science, University of Sheffield, Sheffield, United 
      Kingdom.
FAU - Thomas, Steven M
AU  - Thomas SM
AD  - Radiology Department, Sheffield Teaching Hospitals NHS Foundation Trust,
      Sheffield, United Kingdom.
FAU - Elliot, Charlie
AU  - Elliot C
AD  - Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield 
      Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
FAU - Condliffe, Robin
AU  - Condliffe R
AD  - Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield 
      Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
FAU - Wild, Jim M
AU  - Wild JM
AD  - Department of Cardiovascular Science, University of Sheffield, Sheffield, United 
      Kingdom; INSIGNEO, Institute for In Silico Medicine, University of Sheffield,
      Sheffield, United Kingdom.
FAU - Kiely, David G
AU  - Kiely DG
AD  - INSIGNEO, Institute for In Silico Medicine, University of Sheffield, Sheffield,
      United Kingdom; Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire
      Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United
      Kingdom.
LA  - eng
GR  - MR/M008894/1/Medical Research Council/United Kingdom
GR  - NIHR-RP-R3-12-027/Department of Health/United Kingdom
GR  - SP/14/6/31350/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150521
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Familial Primary Pulmonary
      Hypertension/diagnosis/mortality/*pathology/*physiopathology
MH  - Female
MH  - Heart Ventricles/*pathology/*physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Sex Factors
MH  - Stroke Volume
PMC - PMC4440634
EDAT- 2015/05/23 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/05/22 06:00
PHST- 2014/10/20 00:00 [received]
PHST- 2015/04/14 00:00 [accepted]
PHST- 2015/05/22 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - 10.1371/journal.pone.0127415 [doi]
AID - PONE-D-14-46509 [pii]
PST - epublish
SO  - PLoS One. 2015 May 21;10(5):e0127415. doi: 10.1371/journal.pone.0127415.
      eCollection 2015.