PMID- 25874962
DCOM- 20160126
LR  - 20170220
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 4
DP  - 2015
TI  - The use of alendronate is associated with a decreased incidence of type 2
      diabetes mellitus--a population-based cohort study in Taiwan.
PG  - e0123279
LID - 10.1371/journal.pone.0123279 [doi]
AB  - PURPOSE: Bone remodeling has been linked to glucose metabolism in animal studies,
      but the results of human trials were inconclusive. Bisphosphonates may play a
      role in glucose metabolism through their impacts on bone remodeling enzymes. In
      this study, we aimed to examine the influence of alendronate usage on the
      incidence of type 2 diabetes mellitus (DM) among osteoporotic patients. METHODS: 
      A retrospective cohort study was designed to include osteoporotic patients
      without DM from a population-based cohort containing 1,000,000 subjects. Patients
      treated with alendronate (exposed group, N=1,011) were compared with those who
      received no treatment (age and gender matched non-exposed group, N=3,033). Newly 
      diagnosed DM was identified from medical records by International Classification 
      of Diseases, Ninth Revision, Clinical Modification (ICD-9CM) code. The incidence 
      of DM in both groups was calculated for comparison. RESULTS: The non-exposed
      group had a significantly higher incidence of DM (Odds ratio 1.21, 95% confidence
      interval 1.03~1.41) when compared with the exposed group. In subgroup analysis,
      the DM risk reduction in exposed group was only significant among those younger
      than 65 years and those without hypertension or dyslipidemia. Patients who were
      prescribed alendronate more than or equal to 3 times had demonstrated a
      significant reduction in DM risk. CONCLUSIONS: Our study showed alendronate might
      yield a protective effect for incident DM. This effect became insignificant in
      patients with older age, dyslipidemia or hypertension. The underlying mechanism
      needs further exploration with prospective data for confirmation of the observed 
FAU - Chan, Ding-Cheng
AU  - Chan DC
AD  - Department of Gerontology and Geriatrics, National Taiwan University Hospital,
      Taipei, Taiwan; Department of Internal Medicine, National Taiwan University
      Hospital, Taipei, Taiwan; Superintendent Office, National Taiwan University
      Hospital JinShan Branch, New Taipei City, Taiwan.
FAU - Yang, Rong-Sen
AU  - Yang RS
AD  - Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Ho, Chung-Han
AU  - Ho CH
AD  - Institute of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Tsai, Yau-Sheng
AU  - Tsai YS
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung
      University, Tainan, Taiwan.
FAU - Wang, Jhi-Joung
AU  - Wang JJ
AD  - Institute of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Tsai, Kang-Ting
AU  - Tsai KT
AD  - Department of Geriatrics, Chi Mei Medical Center, Tainan, Taiwan; Department of
      Family Medicine, Chi Mei Medical Center, Tainan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20150413
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - X1J18R4W8P (Alendronate)
SB  - IM
MH  - Alendronate/*therapeutic use
MH  - Body Mass Index
MH  - Bone Remodeling/drug effects
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/*prevention & control
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/*complications/drug therapy
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Taiwan/epidemiology
PMC - PMC4395231
EDAT- 2015/04/16 06:00
MHDA- 2016/01/27 06:00
CRDT- 2015/04/16 06:00
PHST- 2014/10/28 00:00 [received]
PHST- 2015/02/18 00:00 [accepted]
PHST- 2015/04/16 06:00 [entrez]
PHST- 2015/04/16 06:00 [pubmed]
PHST- 2016/01/27 06:00 [medline]
AID - 10.1371/journal.pone.0123279 [doi]
AID - PONE-D-14-48484 [pii]
PST - epublish
SO  - PLoS One. 2015 Apr 13;10(4):e0123279. doi: 10.1371/journal.pone.0123279.
      eCollection 2015.