PMID- 25228162
DCOM- 20171026
LR  - 20171026
IS  - 1423-0399 (Electronic)
IS  - 0042-1138 (Linking)
VI  - 98
IP  - 3
DP  - 2017
TI  - Salvage Pelvic Lymph Node Dissection after Radical Prostatectomy for Biochemical 
      and Lymph Node Recurrence.
PG  - 367-369
LID - 10.1159/000356990 [doi]
AB  - Prostate cancer is the most common male malignancy. Radiation therapy and radical
      prostatectomy are the main curative treatment options for organ confined disease.
      Despite the good long-term oncologic outcomes, roughly 40% of patients undergoing
      surgery develop biochemical recurrence, manifested as a rising prostate-specific 
      antigen (PSA). Those patients are at higher risk of developing a local or distant
      recurrence. The diagnosis of a nodal recurrence is challenging. This report is
      about a 66-year-old male, who had a radical prostatectomy in 2006.
      Postoperatively, the PSA was never undetectable. Radiotherapy was delivered in
      2007, but the PSA rose again. Anti-androgen therapy was started, but he developed
      painful mastodynia. A (11C) choline PET-CT showed an enlarged suspicious lymph
      node at the left common iliac and a salvage pelvic lymphadenectomy was performed.
      Postoperatively, the PSA remained undetectable for the last 5 years. The use of
      lesion - targeted therapy for oligometastatic disease is a new concept in
      urology, aiming at reducing the tumor burden. Therefore, even though this
      surgical approach might not be associated with a durable response over time, the 
      tumor load is decreased and further cancer progression might be delayed, allowing
      to postpone the delivery of hormone therapy.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Peeters, Charlotte
AU  - Peeters C
AD  - Department of Urology, UZ Gasthuisberg, Leuven, Belgium.
FAU - Ponette, Diederik
AU  - Ponette D
FAU - van Poppel, Hendrik
AU  - van Poppel H
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140906
PL  - Switzerland
TA  - Urol Int
JT  - Urologia internationalis
JID - 0417373
RN  - EC (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Lymph Node Excision
MH  - Lymph Nodes/diagnostic imaging/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Neoplasm Recurrence, Local/pathology
MH  - Positron Emission Tomography Computed Tomography
MH  - Prostate-Specific Antigen/blood
MH  - Prostatectomy/*methods
MH  - Prostatic Neoplasms/blood/*surgery
MH  - Salvage Therapy
MH  - Urologic Surgical Procedures
EDAT- 2014/09/18 06:00
MHDA- 2017/10/27 06:00
CRDT- 2014/09/18 06:00
PHST- 2013/07/22 00:00 [received]
PHST- 2013/10/28 00:00 [accepted]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2014/09/18 06:00 [entrez]
AID - 000356990 [pii]
AID - 10.1159/000356990 [doi]
PST - ppublish
SO  - Urol Int. 2017;98(3):367-369. doi: 10.1159/000356990. Epub 2014 Sep 6.