PMID- 20682983
DCOM- 20100830
LR  - 20130520
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 30
IP  - 7
DP  - 2010 Jul
TI  - MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and
PG  - 2561-6
AB  - UNLABELLED: Smoking and alcohol abuse cause squamous cell carcinoma of the head
      and neck (SCCHN) through smoke-induced mutations, which are counteracted by
      O(6)-methylguanine-DNA methyltransferase (MGMT). This study aimed at elucidating 
      the role of MGMT in SCCHN and its precursor lesions (SIN). MGMT was also
      determined in the normal mucosa (NM) and blood lymphocytes (PBLCs). RESULTS: a)
      MGMT was lower in NM than in PBLCs. b) Smoking reduced MGMT in NM but had no
      effect in PBLCs. c) MGMT activity increased in the sequence NM<SIN II and
      III<CIS. d) There was no correlation between MGMT and prognostic parameters or
      clinical course in SCCHN. The data suggest that MGMT becomes down-regulated due
      to smoking in non-cancerous pharyngeal mucosa. The low MGMT activity in early
      dysplastic mucosal lesions may increase the risk for tumour development. Since
      some advanced carcinomas showed low MGMT activity, chemotherapy with
      O(6)-alkylating agents might be an alternative option.
FAU - Jacob, Roland
AU  - Jacob R
AD  - Bundeswehrzentralkrankenhaus Koblenz, Abt V HNO 56072 Koblenz, Germany.
FAU - Shafiei, Navid
AU  - Shafiei N
FAU - Nagel, Georg
AU  - Nagel G
FAU - Welkoborsky, Hans Jurgen
AU  - Welkoborsky HJ
FAU - Mann, Wolf
AU  - Mann W
FAU - Kaina, Bernd
AU  - Kaina B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.1.1.- (DNA Modification Methylases)
RN  - EC (MGMT protein, human)
RN  - EC 6.5.1.- (DNA Repair Enzymes)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aneuploidy
MH  - Carcinoma, Squamous Cell/blood/*enzymology/genetics/pathology
MH  - Case-Control Studies
MH  - Cell Growth Processes
MH  - DNA Modification Methylases/*metabolism
MH  - DNA Repair Enzymes/*metabolism
MH  - Female
MH  - Head and Neck Neoplasms/blood/*enzymology/genetics/pathology
MH  - Humans
MH  - Lymphocytes/enzymology
MH  - Male
MH  - Middle Aged
MH  - Mucous Membrane/enzymology
MH  - Sex Factors
MH  - Tumor Suppressor Proteins/*metabolism
EDAT- 2010/08/05 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 30/7/2561 [pii]
PST - ppublish
SO  - Anticancer Res. 2010 Jul;30(7):2561-6.