PMID- 31026211
OWN - NLM
STAT- In-Data-Review
LR  - 20190605
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 37
IP  - 17
DP  - 2019 Jun 10
TI  - Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals
      Follow-Up Study.
PG  - 1499-1511
LID - 10.1200/JCO.18.02462 [doi]
AB  - PURPOSE: It is unknown whether alcohol intake is associated with the risk of
      lethal (metastatic or fatal) prostate cancer. We examine (1) whether alcohol
      intake among men at risk of prostate cancer is associated with diagnosis of
      lethal prostate cancer and (2) whether intake among men with nonmetastatic
      prostate cancer is associated with metastasis or death. METHODS: This prospective
      cohort study uses the Health Professionals Follow-Up Study (1986 to 2012). Our
      analysis of alcohol intake among men at risk of prostate cancer included 47,568
      cancer-free men. Our analysis of alcohol intake among men with prostate cancer
      was restricted to 5,182 men diagnosed with nonmetastatic prostate cancer during
      follow-up. We examine the association of total alcohol, red and white wine, beer,
      and liquor with lethal prostate cancer and death. Multivariate Cox proportional
      hazards regression estimated hazard ratios (HRs) and 95% CIs. RESULTS: Alcohol
      drinkers had a lower risk of lethal prostate cancer (any v none: HR, 0.84 [95%
      CI, 0.71 to 0.99]) without a dose-response relationship. Total alcohol intake
      among patients with prostate cancer was not associated with progression to lethal
      prostate cancer (any v none: HR, 0.99 [95% CI, 0.57 to 1.72]), whereas moderate
      red wine intake was associated with a lower risk (any v none: HR, 0.50 [95% CI,
      0.29 to 0.86]; P trend = .05). Compared with none, 15 to 30 g/d of total alcohol 
      after prostate cancer diagnosis was associated with a lower risk of death (HR,
      0.71 [95% CI, 0.50 to 1.00]), as was red wine (any v none: HR, 0.74 [95% CI, 0.57
      to 0.97]; P trend = .007). CONCLUSION: Cancer-free men who consumed alcohol had a
      slightly lower risk of lethal prostate cancer compared with abstainers. Among men
      with prostate cancer, red wine was associated with a lower risk of progression to
      lethal disease. These observed associations merit additional study but provide
      assurance that moderate alcohol consumption is safe for patients with prostate
      cancer.
FAU - Downer, Mary K
AU  - Downer MK
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Kenfield, Stacey A
AU  - Kenfield SA
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
AD  - 3 University of California, San Francisco, San Francisco, CA.
FAU - Stampfer, Meir J
AU  - Stampfer MJ
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Wilson, Kathryn M
AU  - Wilson KM
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Dickerman, Barbra A
AU  - Dickerman BA
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
FAU - Giovannucci, Edward L
AU  - Giovannucci EL
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Rimm, Eric B
AU  - Rimm EB
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Wang, Molin
AU  - Wang M
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
FAU - Mucci, Lorelei A
AU  - Mucci LA
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Willett, Walter C
AU  - Willett WC
AD  - 1 Harvard T.H. Chan School of Public Health, Boston, MA.
AD  - 2 Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
FAU - Chan, June M
AU  - Chan JM
AD  - 3 University of California, San Francisco, San Francisco, CA.
FAU - Van Blarigan, Erin L
AU  - Van Blarigan EL
AD  - 3 University of California, San Francisco, San Francisco, CA.
LA  - eng
PT  - Journal Article
DEP - 20190426
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
EDAT- 2019/04/27 06:00
MHDA- 2019/04/27 06:00
CRDT- 2019/04/27 06:00
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/04/27 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - 10.1200/JCO.18.02462 [doi]
PST - ppublish
SO  - J Clin Oncol. 2019 Jun 10;37(17):1499-1511. doi: 10.1200/JCO.18.02462. Epub 2019 
      Apr 26.