PMID- 28916660
OWN - NLM
STAT- MEDLINE
DCOM- 20171127
LR  - 20171128
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 358
DP  - 2017 Sep 15
TI  - People at high risk of diabetes should undergo intensive lifestyle change, says
      NICE.
PG  - j4301
LID - 10.1136/bmj.j4301 [doi]
FAU - Gulland, Anne
AU  - Gulland A
AD  - London.
LA  - eng
PT  - News
DEP - 20170915
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - AIM
SB  - IM
MH  - Diabetes Mellitus, Type 2/blood/economics/epidemiology/*prevention & control
MH  - Humans
MH  - *Life Style
MH  - State Medicine
MH  - United Kingdom
EDAT- 2017/09/17 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/09/17 06:00
PHST- 2017/09/17 06:00 [entrez]
PHST- 2017/09/17 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PST - epublish
SO  - BMJ. 2017 Sep 15;358:j4301.

id: 28916642 Error occurred: The following PMID is not available: 28916642

PMID- 28929513
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180802
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 34
IP  - 12
DP  - 2017 Dec
TI  - Association between HbA1c and peripheral neuropathy in a 10-year follow-up study 
      of people with normal glucose tolerance, impaired glucose tolerance and Type 2
      diabetes.
PG  - 1756-1764
LID - 10.1111/dme.13514 [doi]
AB  - AIMS: To explore the association between HbA1c and sural nerve function in a
      group of people with normal glucose tolerance, impaired glucose tolerance or Type
      2 diabetes. METHODS: We conducted a 10-year follow-up study in 87 out of an
      original 119 participants. At study commencement (2004), 64 men and 55 women
      (mean age 61.1 years) with normal glucose tolerance (n=39), impaired glucose
      tolerance (n=29), or Type 2 diabetes (n=51) were enrolled. At the 2014 follow-up 
      (men, n=46, women, n=41; mean age 71.1 years), 36, nine and 42 participants in
      the normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes
      categories, respectively, were re-tested. Biometric data and blood samples were
      collected, with an electrophysiological examination performed on both occasions. 
      RESULTS: At follow-up, we measured the amplitude of the sural nerve in 74 of the 
      87 participants. The mean amplitude had decreased from 10.9 muV (2004) to 7.0 muV
      (2014; P<0.001). A 1% increase in HbA1c was associated with a ~1% average
      decrease in the amplitude of the sural nerve, irrespective of group
      classification. Crude and adjusted estimates ranged from -0.84 (95% CI -1.32,
      -0.37) to -1.25 (95% CI -2.31, -0.18). Although the mean conduction velocity of
      those measured at both occasions (n=73) decreased from 47.6 m/s to 45.8 m/s
      (P=0.009), any association with HbA1c level was weak. Results were robust with
      regard to potential confounders and missing data. CONCLUSIONS: Our data suggest
      an association between sural nerve amplitude and HbA1c at all levels of HbA1c .
      Decreased amplitude was more pronounced than was diminished conduction velocity, 
      supporting the notion that axonal degeneration is an earlier and more prominent
      effect of hyperglycaemia than demyelination.
CI  - (c) 2017 Diabetes UK.
FAU - Peterson, M
AU  - Peterson M
AUID- ORCID: 0000-0001-9523-3971
AD  - Department of Public Health and Caring Sciences, Section of Family Medicine and
      Preventive Medicine, Uppsala University, Uppsala.
FAU - Pingel, R
AU  - Pingel R
AD  - Department of Public Health and Caring Sciences, Section of Family Medicine and
      Preventive Medicine, Uppsala University, Uppsala.
FAU - Lagali, N
AU  - Lagali N
AD  - Department of Clinical and Experimental Medicine, Section of Ophthalmology,
      Linkoping University, Linkoping.
FAU - Dahlin, L B
AU  - Dahlin LB
AD  - Department of Translational Medicine, Hand Surgery Lund University, Malmo.
AD  - Department of Hand Surgery, Skane University Hospital, Malmo.
FAU - Rolandsson, O
AU  - Rolandsson O
AD  - Department of Public Health and Clinical Medicine, Section of Family Medicine,
      Umea University, Umea, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171018
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology
MH  - Diabetic Neuropathies/blood/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/blood/*epidemiology
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin A/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sweden/epidemiology
EDAT- 2017/09/21 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/09/21 06:00
PHST- 2017/09/15 00:00 [accepted]
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/09/21 06:00 [entrez]
AID - 10.1111/dme.13514 [doi]
PST - ppublish
SO  - Diabet Med. 2017 Dec;34(12):1756-1764. doi: 10.1111/dme.13514. Epub 2017 Oct 18.

PMID- 28921715
OWN - NLM
STAT- MEDLINE
DCOM- 20180621
LR  - 20180621
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 34
IP  - 10
DP  - 2017 Oct
TI  - A crisis in diabetes research funding.
PG  - 1331
LID - 10.1111/dme.13457 [doi]
FAU - Holt, R I G
AU  - Holt RIG
AD  - University of Southampton.
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
SB  - IM
CON - Diabet Med. 2017 Oct;34(10 ):1354-1360. PMID: 28636762
MH  - *Biomedical Research
MH  - *Diabetes Mellitus
MH  - Humans
EDAT- 2017/09/19 06:00
MHDA- 2018/06/22 06:00
CRDT- 2017/09/19 06:00
PHST- 2017/09/19 06:00 [entrez]
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2018/06/22 06:00 [medline]
AID - 10.1111/dme.13457 [doi]
PST - ppublish
SO  - Diabet Med. 2017 Oct;34(10):1331. doi: 10.1111/dme.13457.

PMID- 28921676
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180802
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 34
IP  - 12
DP  - 2017 Dec
TI  - Perioperative passport: empowering people with diabetes along their surgical
      journey.
PG  - 1737-1741
LID - 10.1111/dme.13513 [doi]
AB  - AIM: To determine whether a handheld 'perioperative passport' could improve the
      experience of perioperative care for people with diabetes and overcome some of
      the communication issues commonly identified in inpatient extracts. METHODS:
      Individuals with diabetes undergoing elective surgery requiring at least an
      overnight stay were identified via a customized information technology system.
      Those allocated to the passport group were given the perioperative passport
      before their hospital admission. A 26-item questionnaire was completed after
      surgery by 50 participants in the passport group (mean age 69 years) and by 35
      participants with diabetes who followed the usual surgical pathway (mean age 70
      years). In addition, the former group had a structured interview about their
      experience of the passport. RESULTS: The prevalence of those who reported having 
      received prior information about their expected diabetes care was 35% in the
      control group vs 92% in the passport group (P<0.001). The passport group found
      the information given significantly more helpful (P<0.001), including the advice 
      on medication adjustment (P=0.008). Furthermore, those with the passport were
      more involved in planning their diabetes care (P <0.001), less anxious whilst in 
      hospital (P<0.044) and better prepared to manage their diabetes on discharge
      (P</=0.001). The mean length of hospital stay was shorter in the passport group, 
      although the difference did not reach significance (4.4 vs 6.5 days; P<0.058).
      Content analysis indicated that the passport was well liked and innovative.
      CONCLUSION: Our data indicate that the perioperative passport is effective in
      both informing and involving people in their diabetes care throughout the
      perioperative period.
CI  - (c) 2017 Diabetes UK.
FAU - Page, E
AU  - Page E
AUID- ORCID: 0000-0002-6998-7064
AD  - Diabetes Centre, Ipswich Hospital NHS Trust, Ipswich, UK.
FAU - Akiboye, F
AU  - Akiboye F
AD  - Diabetes Centre, Ipswich Hospital NHS Trust, Ipswich, UK.
FAU - Jackson, S
AU  - Jackson S
AD  - Department of Psychology, University of the West of England, Bristol, UK.
FAU - Kerry, C
AU  - Kerry C
AD  - Diabetes Centre, Ipswich Hospital NHS Trust, Ipswich, UK.
FAU - Round, R
AU  - Round R
AD  - Diabetes Centre, Ipswich Hospital NHS Trust, Ipswich, UK.
FAU - Rayman, G
AU  - Rayman G
AD  - Diabetes Centre, Ipswich Hospital NHS Trust, Ipswich, UK.
CN  - DICE team*
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171020
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Communication
MH  - Critical Pathways/*organization & administration/standards
MH  - Diabetes Mellitus/*therapy
MH  - Elective Surgical Procedures/methods/psychology/standards
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Records/*standards
MH  - Middle Aged
MH  - Patient Care Planning/organization & administration/standards
MH  - Patient Participation/*methods
MH  - Perioperative Care/methods/*standards
MH  - Physician-Patient Relations
MH  - Quality of Life
MH  - Surveys and Questionnaires
EDAT- 2017/09/19 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/09/19 06:00
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/09/19 06:00 [entrez]
AID - 10.1111/dme.13513 [doi]
PST - ppublish
SO  - Diabet Med. 2017 Dec;34(12):1737-1741. doi: 10.1111/dme.13513. Epub 2017 Oct 20.

PMID- 28931553
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20180109
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 66
IP  - 10
DP  - 2017 Oct
TI  - Sirtuin 6 Builds a Wall Against Inflammation, Trumping Diabetes.
PG  - 2535-2537
LID - 10.2337/dbi17-0025 [doi]
FAU - Giblin, William
AU  - Giblin W
AD  - Department of Pathology, University of Michigan, Ann Arbor, MI.
FAU - Lombard, David B
AU  - Lombard DB
AD  - Department of Pathology, University of Michigan, Ann Arbor, MI
      davidlom@umich.edu.
AD  - Institute of Gerontology, University of Michigan, Ann Arbor, MI.
LA  - eng
GR  - R01 GM101171/GM/NIGMS NIH HHS/United States
GR  - R01 HL114858/HL/NHLBI NIH HHS/United States
GR  - R21 AG053561/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Comment
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - EC 3.5.1.- (Sirtuins)
SB  - AIM
SB  - IM
CON - Diabetes. 2017 Oct;66(10 ):2659-2668. PMID: 28607107
MH  - Humans
MH  - *Inflammation
MH  - Sirtuin 1
MH  - *Sirtuins
PMC - PMC5606319
EDAT- 2017/09/22 06:00
MHDA- 2018/01/10 06:00
CRDT- 2017/09/22 06:00
PMCR- 2018/10/01 00:00
PHST- 2018/10/01 00:00 [pmc-release]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
AID - 66/10/2535 [pii]
AID - 10.2337/dbi17-0025 [doi]
PST - ppublish
SO  - Diabetes. 2017 Oct;66(10):2535-2537. doi: 10.2337/dbi17-0025.

PMID- 28931552
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20180108
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 66
IP  - 10
DP  - 2017 Oct
TI  - In This Issue of Diabetes.
PG  - 2533-2534
LID - 10.2337/db17-ti10 [doi]
LA  - eng
PT  - Editorial
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 66/10/2533 [pii]
AID - 10.2337/db17-ti10 [doi]
PST - ppublish
SO  - Diabetes. 2017 Oct;66(10):2533-2534. doi: 10.2337/db17-ti10.

PMID- 28931519
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20180512
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 67
IP  - 1
DP  - 2018 Jan
TI  - beta-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer
      Embryonic Stem Cells.
PG  - 26-35
LID - 10.2337/db17-0120 [doi]
AB  - beta-Cells derived from stem cells hold great promise for cell replacement
      therapy for diabetes. Here we examine the ability of nuclear transfer embryonic
      stem cells (NT-ESs) derived from a patient with type 1 diabetes to differentiate 
      into beta-cells and provide a source of autologous islets for cell replacement.
      NT-ESs differentiate in vitro with an average efficiency of 55% into
      C-peptide-positive cells, expressing markers of mature beta-cells, including MAFA
      and NKX6.1. Upon transplantation in immunodeficient mice, grafted cells form
      vascularized islet-like structures containing MAFA/C-peptide-positive cells.
      These beta-cells adapt insulin secretion to ambient metabolite status and show
      normal insulin processing. Importantly, NT-ES-beta-cells maintain normal blood
      glucose levels after ablation of the mouse endogenous beta-cells. Cystic
      structures, but no teratomas, were observed in NT-ES-beta-cell grafts. Isogenic
      induced pluripotent stem cell lines showed greater variability in beta-cell
      differentiation. Even though different methods of somatic cell reprogramming
      result in stem cell lines that are molecularly indistinguishable, full
      differentiation competence is more common in ES cell lines than in induced
      pluripotent stem cell lines. These results demonstrate the suitability of
      NT-ES-beta-cells for cell replacement for type 1 diabetes and provide proof of
      principle for therapeutic cloning combined with cell therapy.
CI  - (c) 2017 by the American Diabetes Association.
FAU - Sui, Lina
AU  - Sui L
AD  - Naomi Berrie Diabetes Center and Department of Pediatrics, College of Physicians 
      and Surgeons, Columbia University Medical Center, New York, NY.
FAU - Danzl, Nichole
AU  - Danzl N
AD  - Columbia Center for Translational Immunology, Department of Medicine, College of 
      Physicians and Surgeons, Columbia University Medical Center, New York, NY.
FAU - Campbell, Sean R
AU  - Campbell SR
AD  - Columbia Center for Translational Immunology, Department of Medicine, College of 
      Physicians and Surgeons, Columbia University Medical Center, New York, NY.
FAU - Viola, Ryan
AU  - Viola R
AD  - Naomi Berrie Diabetes Center and Department of Pediatrics, College of Physicians 
      and Surgeons, Columbia University Medical Center, New York, NY.
FAU - Williams, Damian
AU  - Williams D
AD  - Columbia Stem Cell Core Facility, Columbia University Medical Center, New York,
      NY.
FAU - Xing, Yuan
AU  - Xing Y
AD  - Department of Surgery/Division of Transplantation, University of Illinois at
      Chicago, Chicago, IL.
FAU - Wang, Yong
AU  - Wang Y
AD  - Department of Surgery/Division of Transplantation, University of Illinois at
      Chicago, Chicago, IL.
FAU - Phillips, Neil
AU  - Phillips N
AD  - Division of Diabetes, Endocrinology and Metabolism, Department of Medicine,
      Vanderbilt University Medical Center, Nashville, TN.
FAU - Poffenberger, Greg
AU  - Poffenberger G
AD  - Division of Diabetes, Endocrinology and Metabolism, Department of Medicine,
      Vanderbilt University Medical Center, Nashville, TN.
FAU - Johannesson, Bjarki
AU  - Johannesson B
AD  - New York Stem Cell Foundation Research Institute, New York, NY.
FAU - Oberholzer, Jose
AU  - Oberholzer J
AD  - Department of Surgery/Division of Transplantation, University of Illinois at
      Chicago, Chicago, IL.
FAU - Powers, Alvin C
AU  - Powers AC
AD  - Division of Diabetes, Endocrinology and Metabolism, Department of Medicine,
      Vanderbilt University Medical Center, Nashville, TN.
AD  - VA Tennessee Valley Healthcare System, Nashville, TN.
FAU - Leibel, Rudolph L
AU  - Leibel RL
AD  - Naomi Berrie Diabetes Center and Department of Pediatrics, College of Physicians 
      and Surgeons, Columbia University Medical Center, New York, NY.
FAU - Chen, Xiaojuan
AU  - Chen X
AD  - Columbia Center for Translational Immunology, Department of Medicine, College of 
      Physicians and Surgeons, Columbia University Medical Center, New York, NY.
AD  - Department of Surgery, College of Physicians and Surgeons, Columbia University
      Medical Center, New York, NY.
FAU - Sykes, Megan
AU  - Sykes M
AD  - Columbia Center for Translational Immunology, Department of Medicine, College of 
      Physicians and Surgeons, Columbia University Medical Center, New York, NY.
AD  - Department of Surgery, College of Physicians and Surgeons, Columbia University
      Medical Center, New York, NY.
AD  - Department of Microbiology & Immunology, College of Physicians and Surgeons,
      Columbia University Medical Center, New York, NY.
FAU - Egli, Dieter
AU  - Egli D
AUID- ORCID: 0000-0002-5876-2409
AD  - Naomi Berrie Diabetes Center and Department of Pediatrics, College of Physicians 
      and Surgeons, Columbia University Medical Center, New York, NY
      de2220@cumc.columbia.edu.
AD  - New York Stem Cell Foundation Research Institute, New York, NY.
LA  - eng
GR  - S10 RR027050/RR/NCRR NIH HHS/United States
GR  - UC4 DK104207/DK/NIDDK NIH HHS/United States
GR  - P60 DK020593/DK/NIDDK NIH HHS/United States
GR  - UC4 DK104211/DK/NIDDK NIH HHS/United States
GR  - R01 DK103585/DK/NIDDK NIH HHS/United States
GR  - U01 DK072473/DK/NIDDK NIH HHS/United States
GR  - U01 DK089572/DK/NIDDK NIH HHS/United States
GR  - P30 DK020593/DK/NIDDK NIH HHS/United States
GR  - S10 OD020056/OD/NIH HHS/United States
GR  - R01 DK091526/DK/NIDDK NIH HHS/United States
GR  - P30 DK026687/DK/NIDDK NIH HHS/United States
GR  - R24 DK106755/DK/NIDDK NIH HHS/United States
GR  - T32 DK007563/DK/NIDDK NIH HHS/United States
GR  - P30 DK063608/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170920
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insulin)
RN  - 0 (Maf Transcription Factors, Large)
RN  - IY9XDZ35W2 (Glucose)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cell Differentiation/physiology
MH  - Cell Line
MH  - Diabetes Mellitus, Type 1/blood/immunology/*metabolism/*therapy
MH  - Embryonic Stem Cells/*cytology/physiology
MH  - Female
MH  - Flow Cytometry
MH  - Glucose/pharmacology
MH  - Homeodomain Proteins/metabolism
MH  - Humans
MH  - Immunocompromised Host
MH  - Immunohistochemistry
MH  - Insulin/metabolism
MH  - Insulin-Secreting Cells/*cytology/physiology
MH  - Maf Transcription Factors, Large/metabolism
MH  - Male
MH  - Mice
PMC - PMC5741143
EDAT- 2017/09/22 06:00
MHDA- 2018/01/13 06:00
CRDT- 2017/09/22 06:00
PMCR- 2019/01/01 00:00
PHST- 2017/01/28 00:00 [received]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2019/01/01 00:00 [pmc-release]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2017/09/22 06:00 [entrez]
AID - db17-0120 [pii]
AID - 10.2337/db17-0120 [doi]
PST - ppublish
SO  - Diabetes. 2018 Jan;67(1):26-35. doi: 10.2337/db17-0120. Epub 2017 Sep 20.

PMID- 28931713
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive
      Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care
      2017;40:723-725.
PG  - e156
LID - 10.2337/dci17-0030 [doi]
FAU - Jackson, Jessica
AU  - Jackson J
AD  - Department of Pathology, Immunology and Laboratory Medicine, University of
      Florida, Gainesville, FL.
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology,
      University of Florida, Gainesville, FL.
FAU - Posgai, Amanda
AU  - Posgai A
AD  - Department of Pathology, Immunology and Laboratory Medicine, University of
      Florida, Gainesville, FL.
FAU - Campbell-Thompson, Martha
AU  - Campbell-Thompson M
AD  - Department of Pathology, Immunology and Laboratory Medicine, University of
      Florida, Gainesville, FL.
FAU - Kusmartseva, Irina
AU  - Kusmartseva I
AUID- ORCID: 0000-0003-2614-0813
AD  - Department of Pathology, Immunology and Laboratory Medicine, University of
      Florida, Gainesville, FL inkusmartseva@ufl.edu.
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
CON - Diabetes Care. 2017 Oct;40(10 ):e155. PMID: 28931712
CON - Diabetes Care. 2017 May;40(5):723-725. PMID: 28428323
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/e156 [pii]
AID - 10.2337/dci17-0030 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):e156. doi: 10.2337/dci17-0030.

PMID- 28931712
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor
      With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725.
PG  - e155
LID - 10.2337/dc17-1044 [doi]
FAU - Marchand, Lucien
AU  - Marchand L
AD  - Department of Endocrinology and Diabetes, Hospices Civils de Lyon, Lyon-Sud
      Hospital, Pierre-Benite, France lucien.marchand@chu-lyon.fr.
FAU - Garnier, Lorna
AU  - Garnier L
AUID- ORCID: 0000-0001-9101-5002
AD  - Department of Immunology, Hospices Civils de Lyon, Lyon-Sud Hospital,
      Pierre-Benite, France.
FAU - Fabien, Nicole
AU  - Fabien N
AD  - Department of Immunology, Hospices Civils de Lyon, Lyon-Sud Hospital,
      Pierre-Benite, France.
FAU - Thivolet, Charles
AU  - Thivolet C
AD  - Department of Endocrinology and Diabetes, Hospices Civils de Lyon, Lyon-Sud
      Hospital, Pierre-Benite, France.
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
CON - Diabetes Care. 2017 May;40(5):723-725. PMID: 28428323
CIN - Diabetes Care. 2017 Oct;40(10 ):e156. PMID: 28931713
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/e155 [pii]
AID - 10.2337/dc17-1044 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):e155. doi: 10.2337/dc17-1044.

PMID- 28931711
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Response to Comment on Bloomgarden et al. Is HbA1c <7% a Marker of Poor
      Performance in Individuals >65 Years Old? Diabetes Care 2017;40:526-528.
PG  - e154
LID - 10.2337/dci17-0027 [doi]
FAU - Bloomgarden, Zachary T
AU  - Bloomgarden ZT
AD  - Icahn School of Medicine at Mount Sinai, New York, NY zbloom@gmail.com.
FAU - Einhorn, Daniel
AU  - Einhorn D
AUID- ORCID: 0000-0003-3863-9267
AD  - University of California, San Diego, San Diego, CA.
AD  - Scripps Whittier Diabetes Institute, La Jolla, CA.
FAU - Handelsman, Yehuda
AU  - Handelsman Y
AD  - Metabolic Institute of America, Tarzana, CA.
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
CON - Diabetes Care. 2017 Oct;40(10 ):e152-e153. PMID: 28931710
CON - Diabetes Care. 2017 Apr;40(4):526-528. PMID: 28325800
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/e154 [pii]
AID - 10.2337/dci17-0027 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):e154. doi: 10.2337/dci17-0027.

PMID- 28931710
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Comment on Bloomgarden et al. Is HbA1c <7% a Marker of Poor Performance in
      Individuals >65 Years Old? Diabetes Care 2017;40:526-528.
PG  - e152-e153
LID - 10.2337/dc17-0893 [doi]
FAU - Pogach, Leonard M
AU  - Pogach LM
AD  - Office of Specialty Care Services, Department of Veterans Affairs, Washington,
      DC.
FAU - Aron, David C
AU  - Aron DC
AUID- ORCID: 0000-0002-2837-0797
AD  - Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, 
      OH david.aron@va.gov.
AD  - Case Western Reserve University School of Medicine, Cleveland, OH.
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
CON - Diabetes Care. 2017 Apr;40(4):526-528. PMID: 28325800
CIN - Diabetes Care. 2017 Oct;40(10 ):e154. PMID: 28931711
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/e152 [pii]
AID - 10.2337/dc17-0893 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):e152-e153. doi: 10.2337/dc17-0893.

PMID- 28931709
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Response to Comment on Lewis et al. Management of Hemoglobin Variants Detected
      Incidentally in HbA1c Testing: A Common Problem Currently Lacking a Standard
      Approach. Diabetes Care 2017;40:e8-e9.
PG  - e150-e151
LID - 10.2337/dci17-0020 [doi]
FAU - Lewis, Michael R
AU  - Lewis MR
AD  - Department of Pathology and Laboratory Medicine, University of Vermont,
      Burlington, VT michael.lewis@uvmhealth.org.
FAU - Sheehan, Patricia R
AU  - Sheehan PR
AUID- ORCID: 0000-0003-1798-0319
AD  - Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Tufts
      Medical Center, Boston, MA.
FAU - Staten, Myrlene A
AU  - Staten MA
AD  - Kelly Government Solutions for National Institute of Diabetes and Digestive and
      Kidney Diseases, Bethesda, MD.
FAU - Phillips, Lawrence S
AU  - Phillips LS
AD  - Atlanta VA Medical Center, Decatur, GA, and Division of Endocrinology, Metabolism
      and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta,
      GA.
FAU - Pittas, Anastassios G
AU  - Pittas AG
AD  - Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Tufts
      Medical Center, Boston, MA.
LA  - eng
GR  - U01 DK098245/DK/NIDDK NIH HHS/United States
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, N.I.H., Extramural
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
CON - Diabetes Care. 2017 Oct;40(10 ):e149. PMID: 28931708
CON - Diabetes Care. 2017 Feb;40(2):e8-e9. PMID: 27899488
PMC - PMC5606307
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PMCR- 2018/10/01 00:00
PHST- 2018/10/01 00:00 [pmc-release]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/e150 [pii]
AID - 10.2337/dci17-0020 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):e150-e151. doi: 10.2337/dci17-0020.

PMID- 28931708
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Comment on Lewis et al. Management of Hemoglobin Variants Detected Incidentally
      in HbA1c Testing: A Common Problem Currently Lacking a Standard Approach.
      Diabetes Care 2017;40:e8-e9.
PG  - e149
LID - 10.2337/dc17-0731 [doi]
FAU - Little, Randie R
AU  - Little RR
AUID- ORCID: 0000-0001-6450-8012
AD  - University of Missouri School of Medicine, Columbia, MO
      littler@health.missouri.edu.
FAU - Rohlfing, Curt L
AU  - Rohlfing CL
AD  - University of Missouri School of Medicine, Columbia, MO.
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
CON - Diabetes Care. 2017 Feb;40(2):e8-e9. PMID: 27899488
CIN - Diabetes Care. 2017 Oct;40(10 ):e150-e151. PMID: 28931709
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/e149 [pii]
AID - 10.2337/dc17-0731 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):e149. doi: 10.2337/dc17-0731.

PMID- 28931706
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20180426
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Diabetes Research and Care Through the Ages.
PG  - 1302-1313
LID - 10.2337/dci17-0042 [doi]
AB  - As has been well established, the Diabetes Care journal's most visible signature 
      event is the Diabetes Care Symposium held each year during the American Diabetes 
      Association's Scientific Sessions. Held this past year on 10 June 2017 in San
      Diego, California, at the 77th Scientific Sessions, this event has become one of 
      the most attended sessions during the Scientific Sessions. Each year, in order to
      continue to have the symposium generate interest, we revise the format and
      content of this event. For this past year, our 6th annual symposium, I felt it
      was time to provide a comprehensive overview of our efforts in diabetes care to
      determine, first and foremost, how we arrived at our current state of management.
      I also felt the narrative needed to include the current status of management,
      especially with a focus toward cardiovascular disease, and finally, we wanted to 
      ask what the future holds. Toward this goal, I asked four of the most noted
      experts in the world to provide their opinion on this topic. The symposium
      started with a very thoughtful presentation by Dr. Jay Skyler entitled "A Look
      Back as to How We Got Here." That was followed by two lectures on current
      concepts by Dr. Bernard Zinman entitled "Current Treatment Paradigms Today-How
      Well Are We Doing?" and by Dr. Matthew Riddle entitled "Evolving Concepts and
      Future Directions for Cardiovascular Outcomes Trials." The final lecture for the 
      symposium was delivered by Dr. Ele Ferrannini and was entitled "What Does the
      Future Hold?" As always, a well-attended and well-received symposium is now the
      norm for our signature event and our efforts were rewarded by the enthusiasm of
      the attendees. This narrative summarizes the lectures held at the
      symposium.-William T. CefaluChief Scientific, Medical & Mission Officer, American
      Diabetes Association.
CI  - (c) 2017 by the American Diabetes Association.
FAU - Zinman, Bernard
AU  - Zinman B
AD  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of
      Toronto, Toronto, Ontario, Canada.
FAU - Skyler, Jay S
AU  - Skyler JS
AD  - Diabetes Research Institute, University of Miami, Miami, FL.
FAU - Riddle, Matthew C
AU  - Riddle MC
AD  - Division of Endocrinology, Diabetes & Clinical Nutrition, Oregon Health & Science
      University, Portland, OR riddlem@ohsu.edu.
FAU - Ferrannini, Ele
AU  - Ferrannini E
AUID- ORCID: 0000-0002-1384-1584
AD  - CNR Institute of Clinical Physiology, and the Department of Clinical and
      Experimental Medicine, University of Pisa, Pisa, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - California
MH  - Congresses as Topic
MH  - Diabetes Mellitus/*diet therapy/*drug therapy
MH  - Diet
MH  - *Disease Management
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypoglycemic Agents/blood/therapeutic use
MH  - Insulin/blood/therapeutic use
MH  - *Research Design
MH  - Societies, Medical
EDAT- 2017/09/22 06:00
MHDA- 2018/03/21 06:00
CRDT- 2017/09/22 06:00
PHST- 2017/07/26 00:00 [received]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
AID - 40/10/1302 [pii]
AID - 10.2337/dci17-0042 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):1302-1313. doi: 10.2337/dci17-0042.

PMID- 28931705
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20180607
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - From Programs to Policy and Back Again: The Push and Pull of Realizing Type 2
      Diabetes Prevention on a National Scale.
PG  - 1298-1301
LID - 10.2337/dci17-0012 [doi]
FAU - Ackermann, Ronald T
AU  - Ackermann RT
AUID- ORCID: 0000-0002-4006-0070
AD  - Department of Medicine and Center for Community Health, Institute for Public
      Health and Medicine, Northwestern University Feinberg School of Medicine,
      Chicago, IL r.ackermann@northwestern.edu.
LA  - eng
GR  - U54 TR001018/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Comment
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
CON - Diabetes Care. 2017 Oct;40(10 ):1289-1297. PMID: 28798086
CON - Diabetes Care. 2017 Oct;40(10 ):1331-1341. PMID: 28500215
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
EDAT- 2017/09/22 06:00
MHDA- 2018/04/28 06:00
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
AID - 40/10/1298 [pii]
AID - 10.2337/dci17-0012 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):1298-1301. doi: 10.2337/dci17-0012.

PMID- 28931704
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20180426
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - In This Issue of Diabetes Care.
PG  - 1287-1288
LID - 10.2337/dc17-ti10 [doi]
LA  - eng
PT  - Editorial
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
AID - 40/10/1287 [pii]
AID - 10.2337/dc17-ti10 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Oct;40(10):1287-1288. doi: 10.2337/dc17-ti10.

PMID- 28931542
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20180705
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 41
IP  - 3
DP  - 2018 Mar
TI  - Cumulative Kidney Complication Risk by 50 Years of Type 1 Diabetes: The Effects
      of Sex, Age, and Calendar Year at Onset.
PG  - 426-433
LID - 10.2337/dc17-1118 [doi]
AB  - OBJECTIVE: A common belief is that only a minority of patients with type 1
      diabetes (T1D) develop advanced kidney disease and that incidence is higher among
      men and lower in those diagnosed at a younger age. However, because few patients 
      with T1D survived to older ages until recently, long-term risks have been
      unclear. RESEARCH DESIGN AND METHODS: We examined the 50-year cumulative kidney
      complication risk in a childhood-onset T1D cohort diagnosed during 1950-80 (n =
      932; mean baseline age 29 years, duration 19 years). Participants comprised 144
      who died prior to baseline, 130 followed with periodic surveys, and 658 followed 
      with biennial surveys and a maximum of nine examinations for 25 years. Micro- and
      macroalbuminuria were defined as an albumin excretion rate of 20-199 and >/=200
      mug/min, respectively, and end-stage renal disease (ESRD) was defined as dialysis
      or kidney transplantation. Cumulative incidence was estimated at 10-year
      intervals between 20 and 50 years(,) duration and compared by calendar year of
      diabetes onset. RESULTS: By 50 years(,) T1D duration, ESRD affected 60% of the
      cohort; macroalbuminuria, 72%; and microalbuminuria, 88%. Little evidence existed
      for declines in cumulative incidence in recent cohorts, except for ESRD
      (microalbuminuria 3% increase, macroalbuminuria no change; ESRD 45% decrease by
      40 years of T1D duration). Onset before age 6 years was associated with the
      lowest risk; incidence generally did not differ by sex. CONCLUSIONS: Some degree 
      of kidney disease in T1D is virtually universal at long durations and not
      declining, which has major implications for formulating health care and research 
      strategies. ESRD has declined, but continues to affect >25% of the population by 
      40 years(,) duration.
CI  - (c) 2017 by the American Diabetes Association.
FAU - Costacou, Tina
AU  - Costacou T
AUID- ORCID: 0000-0001-9303-3810
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
      costacout@edc.pitt.edu.
FAU - Orchard, Trevor J
AU  - Orchard TJ
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
LA  - eng
GR  - R01 DK034818/DK/NIDDK NIH HHS/United States
GR  - R37 DK034818/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170920
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
CIN - Diabetes Care. 2018 Mar;41(3):389-390. PMID: 29463664
MH  - Adult
MH  - Age Distribution
MH  - Age of Onset
MH  - Albuminuria/etiology/mortality/urine
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*complications/mortality/urine
MH  - Diabetic Nephropathies/etiology/mortality/urine
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kidney Failure, Chronic/*etiology/mortality/urine
MH  - Logistic Models
MH  - Male
MH  - Sex Distribution
MH  - Survival Analysis
MH  - Young Adult
PMC - PMC5829956
EDAT- 2017/09/22 06:00
MHDA- 2018/07/06 06:00
CRDT- 2017/09/22 06:00
PMCR- 2019/03/01 00:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/08/30 00:00 [accepted]
PHST- 2019/03/01 00:00 [pmc-release]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PHST- 2017/09/22 06:00 [entrez]
AID - dc17-1118 [pii]
AID - 10.2337/dc17-1118 [doi]
PST - ppublish
SO  - Diabetes Care. 2018 Mar;41(3):426-433. doi: 10.2337/dc17-1118. Epub 2017 Sep 20.

PMID- 28928117
OWN - NLM
STAT- MEDLINE
DCOM- 20180405
LR  - 20180426
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 12
DP  - 2017 Dec
TI  - Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The
      Atherosclerosis Risk in Communities (ARIC) Study.
PG  - 1661-1667
LID - 10.2337/dc17-0819 [doi]
AB  - OBJECTIVE: Severe hypoglycemia is a rare but important complication of type 2
      diabetes. Few studies have examined the epidemiology of hypoglycemia in a
      community-based population. RESEARCH DESIGN AND METHODS: We included 1,206
      Atherosclerosis Risk in Communities (ARIC) Study participants with diagnosed
      diabetes (baseline: 1996-1998). Severe hypoglycemic events were identified
      through 2013 by ICD-9 codes from claims for hospitalizations, emergency
      department visits, and ambulance use. We used Cox regression to evaluate risk
      factors for severe hypoglycemia. RESULTS: The mean age of participants was 64
      years, 32% were black, and 54% were female. During a median follow-up period of
      15.2 years, there were 185 severe hypoglycemic events. Important risk factors
      after multivariable adjustment were as follows: age (per 5 years: hazard ratio
      [HR] 1.24; 95% CI 1.07-1.43), black race (HR 1.39; 95% CI 1.02-1.88), diabetes
      medications (any insulin use vs. no medications: HR 3.00; 95% CI 1.71-5.28; oral 
      medications only vs. no medications: HR 2.20; 95% CI 1.28-3.76), glycemic control
      (moderate vs. good: HR 1.78; 95% CI 1.11-2.83; poor vs. good: HR 2.62; 95% CI
      1.67-4.10), macroalbuminuria (HR 1.95; 95% CI 1.23-3.07), and poor cognitive
      function (Digit Symbol Substitution Test z score: HR 1.57; 95% CI 1.33-1.84). In 
      an analysis of nontraditional risk factors, low 1,5-anhydroglucitol, difficulty
      with activities of daily living, Medicaid insurance, and antidepressant use were 
      positively associated with severe hypoglycemia after multivariate adjustment.
      CONCLUSIONS: Poor glycemic control, glycemic variability as captured by
      1,5-anhydroglucitol, kidney damage, and measures of cognitive and functional
      impairments were strongly associated with increased risk of severe hypoglycemia. 
      These factors should be considered in hypoglycemia risk assessments when
      individualizing diabetes care for older adults.
CI  - (c) 2017 by the American Diabetes Association.
FAU - Lee, Alexandra K
AU  - Lee AK
AD  - Department of Epidemiology and Welch Center for Prevention, Epidemiology, and
      Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore,
      MD.
FAU - Lee, Clare J
AU  - Lee CJ
AUID- ORCID: 0000-0002-0824-0207
AD  - Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University 
      School of Medicine, Baltimore, MD.
FAU - Huang, Elbert S
AU  - Huang ES
AD  - Section of Internal Medicine, The University of Chicago Medicine, Chicago, IL.
FAU - Sharrett, A Richey
AU  - Sharrett AR
AD  - Department of Epidemiology and Welch Center for Prevention, Epidemiology, and
      Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore,
      MD.
FAU - Coresh, Josef
AU  - Coresh J
AD  - Department of Epidemiology and Welch Center for Prevention, Epidemiology, and
      Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore,
      MD.
FAU - Selvin, Elizabeth
AU  - Selvin E
AUID- ORCID: 0000-0001-6923-7151
AD  - Department of Epidemiology and Welch Center for Prevention, Epidemiology, and
      Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
      eselvin@jhu.edu.
LA  - eng
GR  - HHSN268201100012C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100009I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100010C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100008C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100005G/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100008I/HL/NHLBI NIH HHS/United States
GR  - R01 DK089174/DK/NIDDK NIH HHS/United States
GR  - HHSN268201100007C/HL/NHLBI NIH HHS/United States
GR  - R01 HS018542/HS/AHRQ HHS/United States
GR  - HHSN268201100011I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100011C/HL/NHLBI NIH HHS/United States
GR  - T32 HL007024/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100006C/HL/NHLBI NIH HHS/United States
GR  - K23 DK107921/DK/NIDDK NIH HHS/United States
GR  - HHSN268201100005I/HL/NHLBI NIH HHS/United States
GR  - K24 DK106414/DK/NIDDK NIH HHS/United States
GR  - K24 DK105340/DK/NIDDK NIH HHS/United States
GR  - HHSN268201100009C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100005C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100007I/HL/NHLBI NIH HHS/United States
GR  - P30 DK092949/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Research Support, N.I.H., Extramural
DEP - 20170919
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Antidepressive Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Antidepressive Agents/administration & dosage/adverse effects
MH  - Atherosclerosis/blood/*ethnology
MH  - Blood Glucose/metabolism
MH  - Cognition
MH  - Diabetes Mellitus, Type 2/blood/complications/*ethnology
MH  - Ethnic Groups
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypoglycemia/blood/*ethnology
MH  - Hypoglycemic Agents/administration & dosage/adverse effects
MH  - Incidence
MH  - Insulin/administration & dosage/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC5711330
EDAT- 2017/09/21 06:00
MHDA- 2018/04/06 06:00
CRDT- 2017/09/21 06:00
PMCR- 2018/12/01 00:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/08/27 00:00 [accepted]
PHST- 2018/12/01 00:00 [pmc-release]
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2018/04/06 06:00 [medline]
PHST- 2017/09/21 06:00 [entrez]
AID - dc17-0819 [pii]
AID - 10.2337/dc17-0819 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Dec;40(12):1661-1667. doi: 10.2337/dc17-0819. Epub 2017 Sep
      19.

PMID- 28916531
OWN - NLM
STAT- MEDLINE
DCOM- 20180405
LR  - 20180426
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 11
DP  - 2017 Nov
TI  - Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease 
      on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).
PG  - 1514-1521
LID - 10.2337/dc17-1185 [doi]
AB  - OBJECTIVE: To examine the associations of prediabetes, diabetes, and diabetes
      severity (as assessed by HbA1c and diabetes duration) with brain volumes and
      vascular pathology on brain MRI and to assess whether the associations of
      diabetes with brain volumes are mediated by brain vascular pathology. RESEARCH
      DESIGN AND METHODS: Cross-sectional study of 1,713 participants in the
      Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) (mean age 75 
      years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T
      brain MRI scans in 2011-2013. Participants were categorized by diabetes-HbA1c
      status as without diabetes (<5.7% [reference]), with prediabetes (5.7 to <6.5%), 
      and with diabetes ([defined as prior diagnosis or HbA1c >/=6.5%] <7.0% vs.
      >/=7.0%), with further stratification by diabetes duration (<10 vs. >/=10 years).
      RESULTS: In adjusted analyses, compared with participants without diabetes and
      HbA1c <5.7%, participants with prediabetes and those with diabetes and HbA1c
      <7.0% did not have significantly different brain volumes or vascular pathology
      (all P > 0.05), but those with diabetes and HbA1c >/=7.0% had smaller total brain
      volume (beta -0.20 SDs, 95% CI -0.31, -0.09), smaller regional brain volumes
      (including frontal, temporal, occipital, and parietal lobes; deep gray matter;
      Alzheimer disease signature region; and hippocampus [all P < 0.05]), and
      increased burden of white matter hyperintensities (WMH) (P = 0.016). Among
      participants with diabetes, those with HbA1c >/=7.0% had smaller total and
      regional brain volumes and an increased burden of WMH (all P < 0.05) compared
      with those with HbA1c <7.0%. Similarly, participants with longer duration of
      diabetes (>/=10 years) had smaller brain volumes and higher burden of lacunes
      (all P < 0.05) than those with a diabetes duration <10 years. We found no
      evidence for mediation by WMH in associations of diabetes with smaller brain
      volumes by structural equation models (all P > 0.05). CONCLUSIONS: More-severe
      diabetes (defined by higher HbA1c and longer disease duration) but not
      prediabetes or less-severe diabetes was associated with smaller brain volumes and
      an increased burden of brain vascular pathology. No evidence was found that
      associations of diabetes with smaller brain volumes are mediated by brain
      vascular pathology, suggesting that other mechanisms may be responsible for these
      associations.
CI  - (c) 2017 by the American Diabetes Association.
FAU - Schneider, Andrea L C
AU  - Schneider ALC
AUID- ORCID: 0000-0003-0026-5052
AD  - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public
      Health, Baltimore, MD achris13@jhmi.edu.
AD  - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, 
      MD.
FAU - Selvin, Elizabeth
AU  - Selvin E
AUID- ORCID: 0000-0001-6923-7151
AD  - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public
      Health, Baltimore, MD.
FAU - Sharrett, A Richey
AU  - Sharrett AR
AD  - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public
      Health, Baltimore, MD.
FAU - Griswold, Michael
AU  - Griswold M
AD  - Center of Biostatistics and Bioinformatics, University of Mississippi Medical
      Center, Jackson, MS.
FAU - Coresh, Josef
AU  - Coresh J
AD  - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public
      Health, Baltimore, MD.
FAU - Jack, Clifford R Jr
AU  - Jack CR Jr
AD  - Department of Radiology, Mayo Clinic, Rochester, MN.
FAU - Knopman, David
AU  - Knopman D
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Mosley, Thomas
AU  - Mosley T
AD  - Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
FAU - Gottesman, Rebecca F
AU  - Gottesman RF
AD  - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public
      Health, Baltimore, MD.
AD  - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, 
      MD.
LA  - eng
GR  - U01 HL096812/HL/NHLBI NIH HHS/United States
GR  - U01 HL096917/HL/NHLBI NIH HHS/United States
GR  - R01 DK089174/DK/NIDDK NIH HHS/United States
GR  - U01 HL096902/HL/NHLBI NIH HHS/United States
GR  - R25 NS065729/NS/NINDS NIH HHS/United States
GR  - K24 DK106414/DK/NIDDK NIH HHS/United States
GR  - U01 HL096814/HL/NHLBI NIH HHS/United States
GR  - U01 HL096899/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170915
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Atherosclerosis/*diagnostic imaging
MH  - Biomarkers/blood
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Cerebrovascular Disorders/*diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/*diagnostic imaging
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin A/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neurocognitive Disorders/*diagnostic imaging
MH  - Organ Size
MH  - Prediabetic State/*diagnostic imaging
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC5652590
EDAT- 2017/09/17 06:00
MHDA- 2018/04/06 06:00
CRDT- 2017/09/17 06:00
PMCR- 2018/11/01 00:00
PHST- 2017/06/14 00:00 [received]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2018/11/01 00:00 [pmc-release]
PHST- 2017/09/17 06:00 [pubmed]
PHST- 2018/04/06 06:00 [medline]
PHST- 2017/09/17 06:00 [entrez]
AID - dc17-1185 [pii]
AID - 10.2337/dc17-1185 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Nov;40(11):1514-1521. doi: 10.2337/dc17-1185. Epub 2017 Sep
      15.