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Items: 1 to 20 of 49

1.

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ.

Biochem Pharmacol. 2018 Jan;147:141-152. doi: 10.1016/j.bcp.2017.11.007. Epub 2017 Nov 15.

2.

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase.

Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ.

J Med Chem. 2017 Jun 22;60(12):5015-5028. doi: 10.1021/acs.jmedchem.7b00389. Epub 2017 Jun 12.

PMID:
28548833
3.

Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential.

Langsjoen RM, Auguste AJ, Rossi SL, Roundy CM, Penate HN, Kastis M, Schnizlein MK, Le KC, Haller SL, Chen R, Watowich SJ, Weaver SC.

Antiviral Res. 2017 Jul;143:246-251. doi: 10.1016/j.antiviral.2017.04.014. Epub 2017 Apr 28.

PMID:
28461071
4.

Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity.

Neelakantan H, Vance V, Wang HL, McHardy SF, Watowich SJ.

Biochemistry. 2017 Feb 14;56(6):824-832. doi: 10.1021/acs.biochem.6b01215. Epub 2017 Jan 30.

PMID:
28121423
5.

Drug search for leishmaniasis: a virtual screening approach by grid computing.

Ochoa R, Watowich SJ, Flórez A, Mesa CV, Robledo SM, Muskus C.

J Comput Aided Mol Des. 2016 Jul;30(7):541-52. doi: 10.1007/s10822-016-9921-4. Epub 2016 Jul 20.

PMID:
27438595
6.

Identification of a novel inhibitor of dengue virus protease through use of a virtual screening drug discovery Web portal.

Viswanathan U, Tomlinson SM, Fonner JM, Mock SA, Watowich SJ.

J Chem Inf Model. 2014 Oct 27;54(10):2816-25. doi: 10.1021/ci500531r. Epub 2014 Oct 10.

PMID:
25263519
7.

Intrinsic flexibility of West Nile virus protease in solution characterized using small-angle X-ray scattering.

Garces AP, Watowich SJ.

Biochemistry. 2013 Oct 1;52(39):6856-65. doi: 10.1021/bi400782w. Epub 2013 Sep 20.

PMID:
24015950
8.

An assembly model of rift valley Fever virus.

Rusu M, Bonneau R, Holbrook MR, Watowich SJ, Birmanns S, Wriggers W, Freiberg AN.

Front Microbiol. 2012 Jul 19;3:254. doi: 10.3389/fmicb.2012.00254. eCollection 2012.

9.

Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors.

Tomlinson SM, Watowich SJ.

Antiviral Res. 2012 Feb;93(2):245-52. doi: 10.1016/j.antiviral.2011.12.003. Epub 2011 Dec 13.

10.

Using free energy of binding calculations to improve the accuracy of virtual screening predictions.

Malmstrom RD, Watowich SJ.

J Chem Inf Model. 2011 Jul 25;51(7):1648-55. doi: 10.1021/ci200126v. Epub 2011 Jul 11.

11.

Anthracene-based inhibitors of dengue virus NS2B-NS3 protease.

Tomlinson SM, Watowich SJ.

Antiviral Res. 2011 Feb;89(2):127-35. doi: 10.1016/j.antiviral.2010.12.006. Epub 2010 Dec 23.

12.

Structural basis for substrate specificity of alphavirus nsP2 proteases.

Russo AT, Malmstrom RD, White MA, Watowich SJ.

J Mol Graph Model. 2010 Aug 24;29(1):46-53. doi: 10.1016/j.jmgm.2010.04.005. Epub 2010 Apr 24.

13.

Hark back: passive immunotherapy for influenza and other serious infections.

Luke TC, Casadevall A, Watowich SJ, Hoffman SL, Beigel JH, Burgess TH.

Crit Care Med. 2010 Apr;38(4 Suppl):e66-73. doi: 10.1097/CCM.0b013e3181d44c1e. Review.

PMID:
20154602
14.

A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB.

Sherman MB, Freiberg AN, Razmus D, Yazuka S, Koht C, Hilser VJ, Lemon SM, Brocard AS, Zimmerman D, Chiu W, Watowich SJ, Weaver SC.

Appl Biosaf. 2010;15(3):130-136.

15.

New approaches to structure-based discovery of dengue protease inhibitors.

Tomlinson SM, Malmstrom RD, Watowich SJ.

Infect Disord Drug Targets. 2009 Jun;9(3):327-43. Review.

PMID:
19519486
16.

Structure-based discovery of dengue virus protease inhibitors.

Tomlinson SM, Malmstrom RD, Russo A, Mueller N, Pang YP, Watowich SJ.

Antiviral Res. 2009 Jun;82(3):110-4. doi: 10.1016/j.antiviral.2009.02.190. Epub 2009 Feb 21. Review.

17.

Chapter 20 Effects of hepatitis C core protein on mitochondrial electron transport and production of reactive oxygen species.

Campbell RV, Yang Y, Wang T, Rachamallu A, Li Y, Watowich SJ, Weinman SA.

Methods Enzymol. 2009;456:363-80. doi: 10.1016/S0076-6879(08)04420-0.

18.

Single-particle cryo-electron microscopy of Rift Valley fever virus.

Sherman MB, Freiberg AN, Holbrook MR, Watowich SJ.

Virology. 2009 Apr 25;387(1):11-5. doi: 10.1016/j.virol.2009.02.038. Epub 2009 Mar 21.

19.

Substrate inhibition kinetic model for West Nile virus NS2B-NS3 protease.

Tomlinson SM, Watowich SJ.

Biochemistry. 2008 Nov 11;47(45):11763-70. doi: 10.1021/bi801034f. Epub 2008 Oct 15.

20.

Three-dimensional organization of Rift Valley fever virus revealed by cryoelectron tomography.

Freiberg AN, Sherman MB, Morais MC, Holbrook MR, Watowich SJ.

J Virol. 2008 Nov;82(21):10341-8. doi: 10.1128/JVI.01191-08. Epub 2008 Aug 20.

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