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Molecular dynamics simulations on human fibulin-4 mutants D203A and E126K reveal conformational changes in EGF domains potentially responsible for enhanced protease lability and impaired extracellular matrix assembly.

Sasaki T, von der Mark K, Lanig H.

Biochim Biophys Acta Proteins Proteom. 2019 Sep;1867(9):748-756. doi: 10.1016/j.bbapap.2019.05.007. Epub 2019 May 22.


A degradation fragment of type X collagen is a real-time marker for bone growth velocity.

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaan4669. doi: 10.1126/scitranslmed.aan4669.


SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes.

Wang L, Huang J, Moore DC, Zuo C, Wu Q, Xie L, von der Mark K, Yuan X, Chen D, Warman ML, Ehrlich MG, Yang W.

Sci Rep. 2017 Oct 5;7(1):12699. doi: 10.1038/s41598-017-12767-9.


A Dual Role of Upper Zone of Growth Plate and Cartilage Matrix-Associated Protein in Human and Mouse Osteoarthritic Cartilage: Inhibition of Aggrecanases and Promotion of Bone Turnover.

Stock M, Menges S, Eitzinger N, Geßlein M, Botschner R, Wormser L, Distler A, Schlötzer-Schrehardt U, Dietel K, Distler J, Beyer C, Gelse K, Engelke K, Koenders MI, van den Berg W, von der Mark K, Schett G.

Arthritis Rheumatol. 2017 Jun;69(6):1233-1245. doi: 10.1002/art.40042. Epub 2017 Apr 24.


β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.

Houben A, Kostanova-Poliakova D, Weissenböck M, Graf J, Teufel S, von der Mark K, Hartmann C.

Development. 2016 Oct 15;143(20):3826-3838. Epub 2016 Sep 12.


Protein interactions with layers of TiO2 nanotube and nanopore arrays: Morphology and surface charge influence.

Kulkarni M, Mazare A, Park J, Gongadze E, Killian MS, Kralj S, von der Mark K, Iglič A, Schmuki P.

Acta Biomater. 2016 Nov;45:357-366. doi: 10.1016/j.actbio.2016.08.050. Epub 2016 Aug 28.


Electric Field-Induced Osteogenic Differentiation on TiO2 Nanotubular Layer.

Park J, Mazare A, Schneider H, von der Mark K, Fischer MJ, Schmuki P.

Tissue Eng Part C Methods. 2016 Aug;22(8):809-21. doi: 10.1089/ten.TEC.2016.0182.


Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

Sasaki T, Hanisch FG, Deutzmann R, Sakai LY, Sakuma T, Miyamoto T, Yamamoto T, Hannappel E, Chu ML, Lanig H, von der Mark K.

Matrix Biol. 2016 Dec;56:132-149. doi: 10.1016/j.matbio.2016.06.003. Epub 2016 Jun 23.


Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking.

Sasaki T, Stoop R, Sakai T, Hess A, Deutzmann R, Schlötzer-Schrehardt U, Chu ML, von der Mark K.

Matrix Biol. 2016 Mar;50:53-66. doi: 10.1016/j.matbio.2015.12.002. Epub 2015 Dec 9.


Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth.

Jing Y, Zhou X, Han X, Jing J, von der Mark K, Wang J, de Crombrugghe B, Hinton RJ, Feng JQ.

J Dent Res. 2015 Dec;94(12):1668-75. doi: 10.1177/0022034515598135. Epub 2015 Sep 4.


Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage.

Park J, Gebhardt M, Golovchenko S, Perez-Branguli F, Hattori T, Hartmann C, Zhou X, deCrombrugghe B, Stock M, Schneider H, von der Mark K.

Biol Open. 2015 Apr 16;4(5):608-21. doi: 10.1242/bio.201411031.


Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice.

Zhou X, von der Mark K, Henry S, Norton W, Adams H, de Crombrugghe B.

PLoS Genet. 2014 Dec 4;10(12):e1004820. doi: 10.1371/journal.pgen.1004820. eCollection 2014 Dec.


Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation.

Golovchenko S, Hattori T, Hartmann C, Gebhardt M, Gebhard S, Hess A, Pausch F, Schlund B, von der Mark K.

Bone. 2013 Jul;55(1):102-12. doi: 10.1016/j.bone.2013.03.019. Epub 2013 Apr 6.


Ucma is not necessary for normal development of the mouse skeleton.

Eitzinger N, Surmann-Schmitt C, Bösl M, Schett G, Engelke K, Hess A, von der Mark K, Stock M.

Bone. 2012 Mar;50(3):670-80. doi: 10.1016/j.bone.2011.11.017. Epub 2011 Dec 2.


Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO2 nanotubes.

Park J, Bauer S, Pittrof A, Killian MS, Schmuki P, von der Mark K.

Small. 2012 Jan 9;8(1):98-107. doi: 10.1002/smll.201100790. Epub 2011 Nov 18.


The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity.

Surmann-Schmitt C, Sasaki T, Hattori T, Eitzinger N, Schett G, von der Mark K, Stock M.

J Cell Physiol. 2012 May;227(5):2207-16. doi: 10.1002/jcp.22957.


Covalent functionalization of TiO2 nanotube arrays with EGF and BMP-2 for modified behavior towards mesenchymal stem cells.

Bauer S, Park J, Pittrof A, Song YY, von der Mark K, Schmuki P.

Integr Biol (Camb). 2011 Sep;3(9):927-36. doi: 10.1039/c0ib00155d. Epub 2011 Aug 10.


Thrombospondin-1 prevents excessive ossification in cartilage repair tissue induced by osteogenic protein-1.

Gelse K, Klinger P, Koch M, Surmann-Schmitt C, von der Mark K, Swoboda B, Hennig FF, Gusinde J.

Tissue Eng Part A. 2011 Aug;17(15-16):2101-12. doi: 10.1089/ten.TEA.2010.0691. Epub 2011 Jun 1.


Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue.

Klinger P, Surmann-Schmitt C, Brem M, Swoboda B, Distler JH, Carl HD, von der Mark K, Hennig FF, Gelse K.

Arthritis Rheum. 2011 Sep;63(9):2721-31. doi: 10.1002/art.30335.


Gene expression analysis of ischaemia and reperfusion in human microsurgical free muscle tissue transfer.

Dragu A, Schnürer S, Surmann-Schmitt C, von der Mark K, Stürzl M, Unglaub F, Wolf MB, Leffler M, Beier JP, Kneser U, Horch RE.

J Cell Mol Med. 2011 Apr;15(4):983-93. doi: 10.1111/j.1582-4934.2010.01061.x.


Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status.

Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, Ehlen H, Vogel S, Zaucke F, von der Mark K, Bateman JF, Brachvogel B.

J Bone Miner Res. 2010 Jun;25(6):1267-81. doi: 10.1002/jbmr.30.


SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification.

Hattori T, Müller C, Gebhard S, Bauer E, Pausch F, Schlund B, Bösl MR, Hess A, Surmann-Schmitt C, von der Mark H, de Crombrugghe B, von der Mark K.

Development. 2010 Mar;137(6):901-11. doi: 10.1242/dev.045203.


Size selective behavior of mesenchymal stem cells on ZrO(2) and TiO(2) nanotube arrays.

Bauer S, Park J, Faltenbacher J, Berger S, von der Mark K, Schmuki P.

Integr Biol (Camb). 2009 Sep;1(8-9):525-32. doi: 10.1039/b908196h. Epub 2009 Jun 19.


Cell interactions with the extracellular matrix.

Bruckner-Tuderman L, von der Mark K, Pihlajaniemi T, Unsicker K.

Cell Tissue Res. 2010 Jan;339(1):1-5. doi: 10.1007/s00441-009-0891-x. No abstract available.


Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix.

von der Mark K, Park J, Bauer S, Schmuki P.

Cell Tissue Res. 2010 Jan;339(1):131-53. doi: 10.1007/s00441-009-0896-5. Epub 2009 Nov 7. Review.


Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.

Surmann-Schmitt C, Widmann N, Dietz U, Saeger B, Eitzinger N, Nakamura Y, Rattel M, Latham R, Hartmann C, von der Mark H, Schett G, von der Mark K, Stock M.

J Cell Sci. 2009 Oct 15;122(Pt 20):3627-37. doi: 10.1242/jcs.048926. Epub 2009 Sep 15.


Stable subclones of the chondrogenic murine cell line MC615 mimic distinct stages of chondrocyte differentiation.

Surmann-Schmitt C, Widmann N, Mallein-Gerin F, von der Mark K, Stock M.

J Cell Biochem. 2009 Oct 15;108(3):589-99. doi: 10.1002/jcb.22290.


Narrow window in nanoscale dependent activation of endothelial cell growth and differentiation on TiO2 nanotube surfaces.

Park J, Bauer S, Schmuki P, von der Mark K.

Nano Lett. 2009 Sep;9(9):3157-64. doi: 10.1021/nl9013502.


Another look at "Stem cell fate dictated solely by altered nanotube dimension".

von der Mark K, Bauer S, Park J, Schmuki P.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):E60; author reply E61. doi: 10.1073/pnas.0903663106. Epub 2009 Jun 8. No abstract available.


TiO2 nanotube surfaces: 15 nm--an optimal length scale of surface topography for cell adhesion and differentiation.

Park J, Bauer S, Schlegel KA, Neukam FW, von der Mark K, Schmuki P.

Small. 2009 Mar;5(6):666-71. doi: 10.1002/smll.200801476. No abstract available.


Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter.

Gebhard S, Hattori T, Bauer E, Schlund B, Bösl MR, de Crombrugghe B, von der Mark K.

Matrix Biol. 2008 Oct;27(8):693-9. doi: 10.1016/j.matbio.2008.07.001. Epub 2008 Jul 12.


Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes.

Bauer S, Park J, von der Mark K, Schmuki P.

Acta Biomater. 2008 Sep;4(5):1576-82. doi: 10.1016/j.actbio.2008.04.004. Epub 2008 Apr 25.


Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis.

Gelse K, Mühle C, Franke O, Park J, Jehle M, Durst K, Göken M, Hennig F, von der Mark K, Schneider H.

Arthritis Rheum. 2008 Feb;58(2):475-88. doi: 10.1002/art.23124.


Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis.

Surmann-Schmitt C, Dietz U, Kireva T, Adam N, Park J, Tagariello A, Onnerfjord P, Heinegård D, Schlötzer-Schrehardt U, Deutzmann R, von der Mark K, Stock M.

J Biol Chem. 2008 Mar 14;283(11):7082-93. Epub 2007 Dec 21.


Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms.

von der Mark H, Pöschl E, Lanig H, Sasaki T, Deutzman R, von der Mark K.

J Mol Biol. 2007 Aug 31;371(5):1188-203. Epub 2007 Jun 2.


Isolated Anxa5+/Sca-1+ perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo.

Brachvogel B, Pausch F, Farlie P, Gaipl U, Etich J, Zhou Z, Cameron T, von der Mark K, Bateman JF, Pöschl E.

Exp Cell Res. 2007 Jul 15;313(12):2730-43. Epub 2007 May 8.


Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5.

Gaipl US, Munoz LE, Rödel F, Pausch F, Frey B, Brachvogel B, von der Mark K, Pöschl E.

Autoimmunity. 2007 Jun;40(4):254-9. Review.


Nanosize and vitality: TiO2 nanotube diameter directs cell fate.

Park J, Bauer S, von der Mark K, Schmuki P.

Nano Lett. 2007 Jun;7(6):1686-91. Epub 2007 May 16.


Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation.

Samson T, Will C, Knoblauch A, Sharek L, von der Mark K, Burridge K, Wixler V.

J Biol Chem. 2007 May 25;282(21):15730-42. Epub 2007 Apr 2.


The role of annexin A5 in the modulation of the immune response against dying and dead cells.

Munoz LE, Frey B, Pausch F, Baum W, Mueller RB, Brachvogel B, Poschl E, Rödel F, von der Mark K, Herrmann M, Gaipl US.

Curr Med Chem. 2007;14(3):271-7. Review.


Nanotube diameter directs stem cell fate.

Park J, Bauer S, Schmuki P, Schlegel K, Neukam F, von der Mark K.

J Stem Cells Regen Med. 2007 May 16;2(1):168. eCollection 2007. No abstract available.


Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration.

Koga H, Muneta T, Ju YJ, Nagase T, Nimura A, Mochizuki T, Ichinose S, von der Mark K, Sekiya I.

Stem Cells. 2007 Mar;25(3):689-96. Epub 2006 Nov 30.


BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter.

Gebhard S, Hattori T, Bauer E, Bösl MR, Schlund B, Pöschl E, Adam N, de Crombrugghe B, von der Mark K.

Histochem Cell Biol. 2007 Feb;127(2):183-94. Epub 2006 Oct 19.


Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.

Schmidl M, Adam N, Surmann-Schmitt C, Hattori T, Stock M, Dietz U, de Crombrugghe B, Pöschl E, von der Mark K.

J Biol Chem. 2006 Oct 20;281(42):31790-800. Epub 2006 Aug 10.


Abnormal expression of Col X, PTHrP, TGF-beta, bFGF, and VEGF in cartilage with Kashin-Beck disease.

Guo X, Zuo H, Cao CX, Zhang Y, Geng D, Zhang ZT, Zhang YG, von der Mark K, von der Mark H.

J Bone Miner Metab. 2006;24(4):319-28.


Differential gene expression in pseudoexfoliation syndrome.

Zenkel M, Pöschl E, von der Mark K, Hofmann-Rummelt C, Naumann GO, Kruse FE, Schlötzer-Schrehardt U.

Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3742-52.


A simplified laminin nomenclature.

Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD.

Matrix Biol. 2005 Aug;24(5):326-32. Review.


Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages.

Brachvogel B, Moch H, Pausch F, Schlötzer-Schrehardt U, Hofmann C, Hallmann R, von der Mark K, Winkler T, Pöschl E.

Development. 2005 Jun;132(11):2657-68. Epub 2005 Apr 27.


A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.

Gebhard S, Pöschl E, Riemer S, Bauer E, Hattori T, Eberspaecher H, Zhang Z, Lefebvre V, de Crombrugghe B, von der Mark K.

Matrix Biol. 2004 Aug;23(5):309-22.


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