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Items: 49


Hidden patterns of codon usage bias across kingdoms.

Deng Y, de Lima Hedayioglu F, Kalfon J, Chu D, von der Haar T.

J R Soc Interface. 2020 Feb;17(163):20190819. doi: 10.1098/rsif.2019.0819. Epub 2020 Feb 19.


Quantitative Analyses of the Yeast Oxidative Protein Folding Pathway In Vitro and In Vivo.

Beal DM, Bastow EL, Staniforth GL, von der Haar T, Freedman RB, Tuite MF.

Antioxid Redox Signal. 2019 Aug 1;31(4):261-274. doi: 10.1089/ars.2018.7615. Epub 2019 Apr 25.


Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan.

Xie J, de Souza Alves V, von der Haar T, O'Keefe L, Lenchine RV, Jensen KB, Liu R, Coldwell MJ, Wang X, Proud CG.

Curr Biol. 2019 Mar 4;29(5):737-749.e5. doi: 10.1016/j.cub.2019.01.029. Epub 2019 Feb 14.


Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2.

Khan MF, Spurgeon S, von der Haar T.

J Theor Biol. 2018 May 14;445:92-102. doi: 10.1016/j.jtbi.2018.02.020. Epub 2018 Feb 21.


RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.

Bastide A, Peretti D, Knight JR, Grosso S, Spriggs RV, Pichon X, Sbarrato T, Roobol A, Roobol J, Vito D, Bushell M, von der Haar T, Smales CM, Mallucci GR, Willis AE.

Curr Biol. 2017 Mar 6;27(5):638-650. doi: 10.1016/j.cub.2017.01.047. Epub 2017 Feb 23.


Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS.

Saintas E, Abrahams L, Ahmad GT, Ajakaiye AM, AlHumaidi AS, Ashmore-Harris C, Clark I, Dura UK, Fixmer CN, Ike-Morris C, Mato Prado M, Mccullough D, Mishra S, Schöler KM, Timur H, Williamson MD, Alatsatianos M, Bahsoun B, Blackburn E, Hogwood CE, Lithgow PE, Rowe M, Yiangou L, Rothweiler F, Cinatl J Jr, Zehner R, Baines AJ, Garrett MD, Gourlay CW, Griffin DK, Gullick WJ, Hargreaves E, Howard MJ, Lloyd DR, Rossman JS, Smales CM, Tsaousis AD, von der Haar T, Wass MN, Michaelis M.

PLoS One. 2017 Feb 13;12(2):e0172140. doi: 10.1371/journal.pone.0172140. eCollection 2017.


The control of translational accuracy is a determinant of healthy ageing in yeast.

von der Haar T, Leadsham JE, Sauvadet A, Tarrant D, Adam IS, Saromi K, Laun P, Rinnerthaler M, Breitenbach-Koller H, Breitenbach M, Tuite MF, Gourlay CW.

Open Biol. 2017 Jan;7(1). pii: 160291. doi: 10.1098/rsob.160291.


Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism.

Tarrant DJ, Stirpe M, Rowe M, Howard MJ, von der Haar T, Gourlay CW.

J Cell Sci. 2016 Dec 15;129(24):4455-4465. Epub 2016 Nov 2.


Hijacked then lost in translation: the plight of the recombinant host cell in membrane protein structural biology projects.

Bill RM, von der Haar T.

Curr Opin Struct Biol. 2015 Jun;32:147-55. doi: 10.1016/ Epub 2015 Jun 1. Review.


Translation initiation factor eIF3 promotes programmed stop codon readthrough.

Beznosková P, Wagner S, Jansen ME, von der Haar T, Valášek LS.

Nucleic Acids Res. 2015 May 26;43(10):5099-111. doi: 10.1093/nar/gkv421. Epub 2015 Apr 29.


New insights into stop codon recognition by eRF1.

Blanchet S, Rowe M, Von der Haar T, Fabret C, Demais S, Howard MJ, Namy O.

Nucleic Acids Res. 2015 Mar 31;43(6):3298-308. doi: 10.1093/nar/gkv154. Epub 2015 Mar 3.


Synonymous codons, ribosome speed, and eukaryotic gene expression regulation.

Tarrant D, von der Haar T.

Cell Mol Life Sci. 2014 Nov;71(21):4195-206. doi: 10.1007/s00018-014-1684-2. Epub 2014 Jul 20. Review.


Charting the dynamics of translation.

Chu D, Thompson J, von der Haar T.

Biosystems. 2014 May;119:1-9. doi: 10.1016/j.biosystems.2014.02.005. Epub 2014 Mar 12.


The translational machinery is an optimized molecular network that affects cellular homoeostasis and disease.

Kazana E, von der Haar T.

Biochem Soc Trans. 2014 Feb;42(1):173-6. doi: 10.1042/BST20130131. Review.


Control and regulation of mRNA translation.

Mead EJ, Masterton RJ, von der Haar T, Tuite MF, Smales CM.

Biochem Soc Trans. 2014 Feb;42(1):151-4. doi: 10.1042/BST20130259.


Translation elongation can control translation initiation on eukaryotic mRNAs.

Chu D, Kazana E, Bellanger N, Singh T, Tuite MF, von der Haar T.

EMBO J. 2014 Jan 7;33(1):21-34. doi: 10.1002/embj.201385651. Epub 2013 Dec 19.


Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells.

Beznosková P, Cuchalová L, Wagner S, Shoemaker CJ, Gunišová S, von der Haar T, Valášek LS.

PLoS Genet. 2013 Nov;9(11):e1003962. doi: 10.1371/journal.pgen.1003962. Epub 2013 Nov 21.


Specialized yeast ribosomes: a customized tool for selective mRNA translation.

Bauer JW, Brandl C, Haubenreisser O, Wimmer B, Weber M, Karl T, Klausegger A, Breitenbach M, Hintner H, von der Haar T, Tuite MF, Breitenbach-Koller L.

PLoS One. 2013 Jul 8;8(7):e67609. doi: 10.1371/journal.pone.0067609. Print 2013.


The influence of training status, age, and muscle fiber type on cycling efficiency and endurance performance.

Hopker JG, Coleman DA, Gregson HC, Jobson SA, Von der Haar T, Wiles J, Passfield L.

J Appl Physiol (1985). 2013 Sep 1;115(5):723-9. doi: 10.1152/japplphysiol.00361.2013. Epub 2013 Jun 27.


Experimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell lines.

Mead EJ, Chiverton LM, Spurgeon SK, Martin EB, Montague GA, Smales CM, von der Haar T.

PLoS One. 2012;7(10):e47422. doi: 10.1371/journal.pone.0047422. Epub 2012 Oct 10.


The architecture of eukaryotic translation.

Chu D, von der Haar T.

Nucleic Acids Res. 2012 Nov 1;40(20):10098-106. doi: 10.1093/nar/gks825. Epub 2012 Sep 10.


Probing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusions.

Jossé L, Marchante R, Zenthon J, von der Haar T, Tuite MF.

Prion. 2012 Jul 1;6(3):201-10. doi: 10.4161/pri.19214. Epub 2012 Jul 1. Review.


Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview.

von der Haar T.

Comput Struct Biotechnol J. 2012 Feb 20;1:e201204002. doi: 10.5936/csbj.201204002. eCollection 2012. Review.


A novel and versatile computational tool to model translation.

Chu D, Zabet N, von der Haar T.

Bioinformatics. 2012 Jan 15;28(2):292-3. doi: 10.1093/bioinformatics/btr650. Epub 2011 Nov 22.


The role of tRNA and ribosome competition in coupling the expression of different mRNAs in Saccharomyces cerevisiae.

Chu D, Barnes DJ, von der Haar T.

Nucleic Acids Res. 2011 Aug;39(15):6705-14. doi: 10.1093/nar/gkr300. Epub 2011 May 9.


Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast.

Merritt GH, Naemi WR, Mugnier P, Webb HM, Tuite MF, von der Haar T.

Nucleic Acids Res. 2010 Sep;38(16):5479-92. doi: 10.1093/nar/gkq338. Epub 2010 May 5.


One for all? A viral protein supplants the mRNA cap-binding complex.

von der Haar T.

EMBO J. 2009 Jan 7;28(1):6-7. doi: 10.1038/emboj.2008.251. Review. No abstract available.


Identification of the limitations on recombinant gene expression in CHO cell lines with varying luciferase production rates.

Mead EJ, Chiverton LM, Smales CM, von der Haar T.

Biotechnol Bioeng. 2009 Apr 15;102(6):1593-602. doi: 10.1002/bit.22201.


A quantitative estimation of the global translational activity in logarithmically growing yeast cells.

von der Haar T.

BMC Syst Biol. 2008 Oct 16;2:87. doi: 10.1186/1752-0509-2-87.


tRNA and protein methylase complexes mediate zymocin toxicity in yeast.

Studte P, Zink S, Jablonowski D, Bär C, von der Haar T, Tuite MF, Schaffrath R.

Mol Microbiol. 2008 Sep;69(5):1266-77. doi: 10.1111/j.1365-2958.2008.06358.x. Epub 2008 Jul 24.


Biophysical studies of the translation initiation pathway with immobilized mRNA analogs.

McCarthy JE, Marsden S, von der Haar T.

Methods Enzymol. 2007;430:247-64.


Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivo.

von der Haar T, Jossé L, Wright P, Zenthon J, Tuite MF.

Neurodegener Dis. 2007;4(2-3):136-47.


Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex.

Gilbert RJ, Gordiyenko Y, von der Haar T, Sonnen AF, Hofmann G, Nardelli M, Stuart DI, McCarthy JE.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5788-93. Epub 2007 Mar 26.


Regulated translational bypass of stop codons in yeast.

von der Haar T, Tuite MF.

Trends Microbiol. 2007 Feb;15(2):78-86. Epub 2006 Dec 21. Review.


Folding transitions during assembly of the eukaryotic mRNA cap-binding complex.

von der Haar T, Oku Y, Ptushkina M, Moerke N, Wagner G, Gross JD, McCarthy JE.

J Mol Biol. 2006 Mar 3;356(4):982-92. Epub 2005 Dec 27.


The mRNA cap-binding protein eIF4E in post-transcriptional gene expression.

von der Haar T, Gross JD, Wagner G, McCarthy JE.

Nat Struct Mol Biol. 2004 Jun;11(6):503-11. Review.


Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.

Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G.

Cell. 2003 Dec 12;115(6):739-50.


The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.

He H, von der Haar T, Singh CR, Ii M, Li B, Hinnebusch AG, McCarthy JE, Asano K.

Mol Cell Biol. 2003 Aug;23(15):5431-45.


Translation initiation and surface plasmon resonance: new technology applied to old questions.

von der Haar T, Hughes JM, Manjarul Karim M, Ptushkina M, McCarthy JE.

Biochem Soc Trans. 2002 Apr;30(2):155-62. Review.


A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties.

Ptushkina M, Berthelot K, von der Haar T, Geffers L, Warwicker J, McCarthy JE.

Nucleic Acids Res. 2001 Nov 15;29(22):4561-9.


Stabilization of eukaryotic initiation factor 4E binding to the mRNA 5'-Cap by domains of eIF4G.

von Der Haar T, Ball PD, McCarthy JE.

J Biol Chem. 2000 Sep 29;275(39):30551-5.


Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.

Ptushkina M, von der Haar T, Karim MM, Hughes JM, McCarthy JE.

EMBO J. 1999 Jul 15;18(14):4068-75.


Translational repression by human 4E-BP1 in yeast specifically requires human eIF4E as target.

Hughes JM, Ptushkina M, Karim MM, Koloteva N, von der Haar T, McCarthy JE.

J Biol Chem. 1999 Feb 5;274(6):3261-4.


Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20.

Ptushkina M, von der Haar T, Vasilescu S, Frank R, Birkenhäger R, McCarthy JE.

EMBO J. 1998 Aug 17;17(16):4798-808.


Toward an understanding of the fluorescence intensity changes observed on fluorescein 5'-Isothiocyanate-Na(+),K (+)-ATPase.

Grell E, Lewitzki E, Ruf H, Brand K, Schneider FW, von der Haar T, Zachariasse KA.

J Fluoresc. 1994 Sep;4(3):251-4. doi: 10.1007/BF01878459.


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