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Items: 1 to 50 of 205

1.

Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey.

Ishaq A, Schröder J, Edwards N, von Zglinicki T, Saretzki G.

J Nutr Health Aging. 2018;22(4):555-561. doi: 10.1007/s12603-017-0968-2.

2.

The epigenetic clock and telomere length are independently associated with chronological age and mortality.

Marioni RE, Harris SE, Shah S, McRae AF, von Zglinicki T, Martin-Ruiz C, Wray NR, Visscher PM, Deary IJ.

Int J Epidemiol. 2018 Feb 1;47(1):356. doi: 10.1093/ije/dyx233. No abstract available.

3.

The senescent bystander effect is caused by ROS-activated NF-κB signalling.

Nelson G, Kucheryavenko O, Wordsworth J, von Zglinicki T.

Mech Ageing Dev. 2018 Mar;170:30-36. doi: 10.1016/j.mad.2017.08.005. Epub 2017 Aug 25.

4.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

5.

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.

Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI.

J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31.

6.

Grip strength and inflammatory biomarker profiles in very old adults.

Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Aihie Sayer A.

Age Ageing. 2017 Nov 1;46(6):976-982. doi: 10.1093/ageing/afx088.

7.

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

Fielder E, von Zglinicki T, Jurk D.

J Alzheimers Dis. 2017;60(s1):S107-S131. doi: 10.3233/JAD-161221. Review.

PMID:
28436392
8.

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

Hägg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, van der Lee SJ, Broer L, Deelen J, Marioni RE, Wong A, Lundquist A, Zhu G, Hansell NK, Sillanpää E, Fedko IO, Amin NA, Beekman M, de Craen AJM, Degerman S, Harris SE, Kan KJ, Martin-Ruiz CM, Montgomery GW; NeuroCHARGE Cognitive Working Group, Adolfsson AN, Reynolds CA, Samani NJ, Suchiman HED, Viljanen A, von Zglinicki T, Wright MJ, Hottenga JJ, Boomsma DI, Rantanen T, Kaprio JA, Nyholt DR, Martin NG, Nyberg L, Adolfsson R, Kuh D, Starr JM, Deary IJ, Slagboom PE, van Duijn CM, Codd V, Pedersen NL.

Transl Psychiatry. 2017 Apr 18;7(4):e1100. doi: 10.1038/tp.2017.73.

9.

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

Korolchuk VI, Miwa S, Carroll B, von Zglinicki T.

EBioMedicine. 2017 Jul;21:7-13. doi: 10.1016/j.ebiom.2017.03.020. Epub 2017 Mar 14. Review.

10.

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Langie SA, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RW, van Schooten FJ, Reik W, von Zglinicki T, Mathers JC.

Genes (Basel). 2017 Feb 17;8(2). pii: E75. doi: 10.3390/genes8020075.

11.

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria.

Miwa S, Czapiewski R, Wan T, Bell A, Hill KN, von Zglinicki T, Saretzki G.

Aging (Albany NY). 2016 Oct 22;8(10):2551-2567. doi: 10.18632/aging.101089.

12.

Frailty in mouse ageing: A conceptual approach.

von Zglinicki T, Varela Nieto I, Brites D, Karagianni N, Ortolano S, Georgopoulos S, Cardoso AL, Novella S, Lepperdinger G, Trendelenburg AU, van Os R.

Mech Ageing Dev. 2016 Dec;160:34-40. doi: 10.1016/j.mad.2016.07.004. Epub 2016 Jul 18. Review.

13.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

14.

Accelerated Aging in Bone Marrow Transplant Survivors.

Skinner R, von Zglinicki T.

JAMA Oncol. 2016 Oct 1;2(10):1267-1268. doi: 10.1001/jamaoncol.2016.0877. No abstract available.

PMID:
27254135
15.

The epigenetic clock and telomere length are independently associated with chronological age and mortality.

Marioni RE, Harris SE, Shah S, McRae AF, von Zglinicki T, Martin-Ruiz C, Wray NR, Visscher PM, Deary IJ.

Int J Epidemiol. 2016 Apr 13. pii: dyw041. [Epub ahead of print]

16.

Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921.

Harris SE, Marioni RE, Martin-Ruiz C, Pattie A, Gow AJ, Cox SR, Corley J, von Zglinicki T, Starr JM, Deary IJ.

Mech Ageing Dev. 2016 Mar;154:43-8. doi: 10.1016/j.mad.2016.02.004. Epub 2016 Feb 10.

17.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.

18.

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):3-15. Epub 2016 Jan 24.

19.

CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study.

Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T.

Aging Cell. 2016 Apr;15(2):389-92. doi: 10.1111/acel.12430. Epub 2015 Dec 22.

20.

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians.

Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T.

EBioMedicine. 2015 Jul 29;2(10):1549-58. doi: 10.1016/j.ebiom.2015.07.029. eCollection 2015 Oct.

21.

Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays.

Miwa S, Treumann A, Bell A, Vistoli G, Nelson G, Hay S, von Zglinicki T.

Free Radic Biol Med. 2016 Jan;90:173-83. doi: 10.1016/j.freeradbiomed.2015.11.011. Epub 2015 Nov 11.

22.

Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van Der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1686-7. doi: 10.1093/ije/dyv169. Epub 2015 Sep 24. No abstract available.

PMID:
26403813
23.

Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van Der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1739-41. doi: 10.1093/ije/dyv170. Epub 2015 Sep 24. No abstract available.

PMID:
26403811
24.

Reproducibility of Telomere Length Assessment--An International Collaborative Study.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1749-54. doi: 10.1093/ije/dyv171. Epub 2015 Sep 24. No abstract available.

PMID:
26403809
25.

Age-related frailty and its association with biological markers of ageing.

Mitnitski A, Collerton J, Martin-Ruiz C, Jagger C, von Zglinicki T, Rockwood K, Kirkwood TB.

BMC Med. 2015 Jul 13;13:161. doi: 10.1186/s12916-015-0400-x.

26.

Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts.

Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW.

Biogerontology. 2015 Aug;16(4):423-34. doi: 10.1007/s10522-015-9560-5. Epub 2015 Feb 21.

27.

Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients.

Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I.

Circ Res. 2015 Jan 2;116(1):87-98. doi: 10.1161/CIRCRESAHA.116.304393. Epub 2014 Nov 10.

28.

Reproducibility of telomere length assessment: an international collaborative study.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1673-83. doi: 10.1093/ije/dyu191. Epub 2014 Sep 19.

29.

Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions.

Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TB, von Zglinicki T, Shanley DP.

PLoS Comput Biol. 2014 Aug 28;10(8):e1003728. doi: 10.1371/journal.pcbi.1003728. eCollection 2014 Aug.

30.

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.

Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I.

Atherosclerosis. 2014 Oct;236(2):312-20. doi: 10.1016/j.atherosclerosis.2014.07.020. Epub 2014 Aug 4.

PMID:
25127175
31.

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.

Granic A, Hill TR, Kirkwood TB, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, Mathers JC, Jagger C.

Eur J Neurol. 2015 Jan;22(1):106-15, e6-7. doi: 10.1111/ene.12539. Epub 2014 Aug 13.

32.

Telomere length predicts cardiovascular disease.

Spyridopoulos I, von Zglinicki T.

BMJ. 2014 Jul 8;349:g4373. doi: 10.1136/bmj.g4373. No abstract available.

PMID:
25005709
33.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.

34.

Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.

Masi S, D'Aiuto F, Martin-Ruiz C, Kahn T, Wong A, Ghosh AK, Whincup P, Kuh D, Hughes A, von Zglinicki T, Hardy R, Deanfield JE; NSHD scientific and data collection teams.

Eur Heart J. 2014 Dec 7;35(46):3296-303. doi: 10.1093/eurheartj/ehu226. Epub 2014 Jun 22.

35.

25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study.

Granic A, Aspray T, Hill T, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Mathers JC, Jagger C.

J Intern Med. 2015 Apr;277(4):456-67. doi: 10.1111/joim.12273. Epub 2014 Jun 20.

36.

Inflammation, telomere length, and grip strength: a 10-year longitudinal study.

Baylis D, Ntani G, Edwards MH, Syddall HE, Bartlett DB, Dennison EM, Martin-Ruiz C, von Zglinicki T, Kuh D, Lord JM, Aihie Sayer A, Cooper C.

Calcif Tissue Int. 2014 Jul;95(1):54-63. doi: 10.1007/s00223-014-9862-7. Epub 2014 May 25.

37.

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.

Miwa S, Jow H, Baty K, Johnson A, Czapiewski R, Saretzki G, Treumann A, von Zglinicki T.

Nat Commun. 2014 May 12;5:3837. doi: 10.1038/ncomms4837.

38.

Biomarkers of healthy ageing: expectations and validation.

Martin-Ruiz C, von Zglinicki T.

Proc Nutr Soc. 2014 Aug;73(3):422-9. doi: 10.1017/S0029665114000147. Epub 2014 May 9.

PMID:
24810550
39.

Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study.

Collerton J, Gautrey HE, van Otterdijk SD, Davies K, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Jagger C, Mathers JC, Strathdee G.

Biogerontology. 2014 Aug;15(4):317-28. doi: 10.1007/s10522-014-9500-9. Epub 2014 Apr 26.

PMID:
24770842
40.

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old.

Wiley L, Ashok D, Martin-Ruiz C, Talbot DC, Collerton J, Kingston A, Davies K, Chinnery PF, Catt M, Jagger C, Kirkwood TB, von Zglinicki T.

PLoS One. 2014 Mar 10;9(3):e91005. doi: 10.1371/journal.pone.0091005. eCollection 2014.

41.

Gender and telomere length: systematic review and meta-analysis.

Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W, Cooper C, Christensen K, De Meyer T, Deary I, Der G, Diez Roux A, Fitzpatrick A, Hajat A, Halaschek-Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li C, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Paolisso G, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, von Zglinicki T, Ben-Shlomo Y; Halcyon study team.

Exp Gerontol. 2014 Mar;51:15-27. doi: 10.1016/j.exger.2013.12.004. Epub 2013 Dec 21. Review.

42.

Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study.

Anderson KN, Catt M, Collerton J, Davies K, von Zglinicki T, Kirkwood TB, Jagger C.

Age Ageing. 2014 Jan;43(1):57-63. doi: 10.1093/ageing/aft153. Epub 2013 Oct 11.

PMID:
24123786
43.

Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay.

Gorniak JP, Cameron KM, Waldron KJ, von Zglinicki T, Mathers JC, Langie SA.

Mutagenesis. 2013 Nov;28(6):673-81. doi: 10.1093/mutage/get047. Epub 2013 Oct 4.

PMID:
24097409
44.

Shared Ageing Research Models (ShARM): a new facility to support ageing research.

Duran AL, Potter P, Wells S, Kirkwood T, von Zglinicki T, McArdle A, Scudamore C, Meng QJ, de Haan G, Corcoran A, Bellantuono I.

Biogerontology. 2013 Dec;14(6):789-94. doi: 10.1007/s10522-013-9457-0. Epub 2013 Oct 2.

45.

Cell sorting of young and senescent cells.

Hewitt G, von Zglinicki T, Passos JF.

Methods Mol Biol. 2013;1048:31-47. doi: 10.1007/978-1-62703-556-9_4.

PMID:
23929096
46.

Telomere length and physical performance at older ages: an individual participant meta-analysis.

Gardner MP, Martin-Ruiz C, Cooper R, Hardy R, Sayer AA, Cooper C, Deary IJ, Gallacher J, Harris SE, Shiels PG, Starr JM, Kuh D, von Zglinicki T, Ben-Shlomo Y; Halcyon study team.

PLoS One. 2013 Jul 26;8(7):e69526. doi: 10.1371/journal.pone.0069526. Print 2013.

47.

SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis.

Valentijn AJ, Palial K, Al-Lamee H, Tempest N, Drury J, Von Zglinicki T, Saretzki G, Murray P, Gargett CE, Hapangama DK.

Hum Reprod. 2013 Oct;28(10):2695-708. doi: 10.1093/humrep/det285. Epub 2013 Jul 11.

PMID:
23847113
48.

Biliary epithelial senescence and plasticity in acute cellular rejection.

Brain JG, Robertson H, Thompson E, Humphreys EH, Gardner A, Booth TA, Jones DE, Afford SC, von Zglinicki T, Burt AD, Kirby JA.

Am J Transplant. 2013 Jul;13(7):1688-702. doi: 10.1111/ajt.12271. Epub 2013 Jun 10.

49.

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

Collerton J, Ashok D, Martin-Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood TB, Chinnery PF.

Neurobiol Aging. 2013 Dec;34(12):2889.e1-4. doi: 10.1016/j.neurobiolaging.2013.04.001. Epub 2013 Apr 30.

50.

Measuring reactive oxygen species in senescent cells.

Passos JF, Miwa S, von Zglinicki T.

Methods Mol Biol. 2013;965:253-63. doi: 10.1007/978-1-62703-239-1_17.

PMID:
23296664

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