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Items: 1 to 50 of 149

1.

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.

Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L.

Science. 2018 Jun 29;360(6396). pii: eaat4422. doi: 10.1126/science.aat4422. Epub 2018 May 31.

PMID:
29853555
2.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

PMID:
29754753
3.

Catalytic activation of β-arrestin by GPCRs.

Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M.

Nature. 2018 May;557(7705):381-386. doi: 10.1038/s41586-018-0079-1. Epub 2018 May 2.

PMID:
29720660
4.

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.

Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ.

Cell Rep. 2018 Mar 6;22(10):2593-2600. doi: 10.1016/j.celrep.2018.02.031.

5.

Subcellular Organization of GPCR Signaling.

Eichel K, von Zastrow M.

Trends Pharmacol Sci. 2018 Feb;39(2):200-208. doi: 10.1016/j.tips.2017.11.009. Epub 2018 Jan 28. Review.

PMID:
29478570
6.

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.

Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C.

Nat Genet. 2018 Feb;50(2):180-185. doi: 10.1038/s41588-017-0020-9. Epub 2018 Jan 8.

7.

Time-gated detection of protein-protein interactions with transcriptional readout.

Kim MW, Wang W, Sanchez MI, Coukos R, von Zastrow M, Ting AY.

Elife. 2017 Nov 30;6. pii: e30233. doi: 10.7554/eLife.30233.

8.

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS.

Sci Signal. 2017 Jun 20;10(484). pii: eaal3395. doi: 10.1126/scisignal.aal3395.

9.

Functional selectivity of GPCR-directed drug action through location bias.

Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M.

Nat Chem Biol. 2017 Jul;13(7):799-806. doi: 10.1038/nchembio.2389. Epub 2017 May 29.

10.

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ.

Cell. 2017 Apr 6;169(2):350-360.e12. doi: 10.1016/j.cell.2017.03.022.

11.

G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.

Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M.

Mol Pharmacol. 2017 Feb;91(2):145-156. doi: 10.1124/mol.116.106369. Epub 2016 Nov 22.

12.

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.

Varandas KC, Irannejad R, von Zastrow M.

Curr Biol. 2016 Dec 5;26(23):3129-3142. doi: 10.1016/j.cub.2016.09.052. Epub 2016 Nov 10.

13.

Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling.

Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M.

Mol Pharmacol. 2017 Jan;91(1):65-73. Epub 2016 Nov 7.

14.

GIV/Girdin activates Gαi and inhibits Gαs via the same motif.

Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12.

15.

Molecular Pharmacology of δ-Opioid Receptors.

Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G.

Pharmacol Rev. 2016 Jul;68(3):631-700. doi: 10.1124/pr.114.008979. Review.

16.

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL.

J Biol Chem. 2016 Jul 8;291(28):14510-25. doi: 10.1074/jbc.M116.716589. Epub 2016 May 11.

17.

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation.

Eichel K, Jullié D, von Zastrow M.

Nat Cell Biol. 2016 Mar;18(3):303-10. doi: 10.1038/ncb3307. Epub 2016 Feb 1.

18.
19.

Effects of endocytosis on receptor-mediated signaling.

Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M.

Curr Opin Cell Biol. 2015 Aug;35:137-43. doi: 10.1016/j.ceb.2015.05.005. Epub 2015 Jun 6. Review.

20.

The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization.

Koliwer J, Park M, Bauch C, von Zastrow M, Kreienkamp HJ.

J Biol Chem. 2015 Mar 6;290(10):6120-9. doi: 10.1074/jbc.M114.605725. Epub 2015 Jan 22.

21.

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.

Tsvetanova NG, Irannejad R, von Zastrow M.

J Biol Chem. 2015 Mar 13;290(11):6689-96. doi: 10.1074/jbc.R114.617951. Epub 2015 Jan 20. Review.

22.

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis.

Tsvetanova NG, von Zastrow M.

Nat Chem Biol. 2014 Dec;10(12):1061-5. doi: 10.1038/nchembio.1665. Epub 2014 Nov 2.

23.

Endocytosis, signaling, and beyond.

Di Fiore PP, von Zastrow M.

Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a016865. doi: 10.1101/cshperspect.a016865. Review.

24.

Retromer mediates a discrete route of local membrane delivery to dendrites.

Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M.

Neuron. 2014 Apr 2;82(1):55-62. doi: 10.1016/j.neuron.2014.02.018.

25.

GPCR signaling along the endocytic pathway.

Irannejad R, von Zastrow M.

Curr Opin Cell Biol. 2014 Apr;27:109-16. doi: 10.1016/j.ceb.2013.10.003. Epub 2013 Dec 28. Review.

26.

Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors.

Benovic JL, von Zastrow M.

Curr Opin Cell Biol. 2014 Apr;27:v-vi. doi: 10.1016/j.ceb.2014.01.009. Epub 2014 Feb 12. No abstract available.

PMID:
24529749
27.

Investigating signaling consequences of GPCR trafficking in the endocytic pathway.

Irannejad R, Kotowski SJ, von Zastrow M.

Methods Enzymol. 2014;535:403-18. doi: 10.1016/B978-0-12-397925-4.00023-7.

28.

GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.

Marley A, Choy RW, von Zastrow M.

PLoS One. 2013 Aug 2;8(8):e70857. doi: 10.1371/journal.pone.0070857. Print 2013.

29.

Conformational biosensors reveal GPCR signalling from endosomes.

Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M.

Nature. 2013 Mar 28;495(7442):534-8. doi: 10.1038/nature12000. Epub 2013 Mar 20.

30.

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ.

Pharmacol Rev. 2013 Jan 15;65(1):223-54. doi: 10.1124/pr.112.005942. Print 2013 Jan. Review.

31.

Differentiation of opioid drug effects by hierarchical multi-site phosphorylation.

Just S, Illing S, Trester-Zedlitz M, Lau EK, Kotowski SJ, Miess E, Mann A, Doll C, Trinidad JC, Burlingame AL, von Zastrow M, Schulz S.

Mol Pharmacol. 2013 Mar;83(3):633-9. doi: 10.1124/mol.112.082875. Epub 2012 Dec 13.

32.

A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia.

Marley A, von Zastrow M.

PLoS One. 2012;7(10):e46647. doi: 10.1371/journal.pone.0046647. Epub 2012 Oct 3.

33.

Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.

von Zastrow M, Williams JT.

Neuron. 2012 Oct 4;76(1):22-32. doi: 10.1016/j.neuron.2012.09.022. Review.

34.

Regulation of endocytic clathrin dynamics by cargo ubiquitination.

Henry AG, Hislop JN, Grove J, Thorn K, Marsh M, von Zastrow M.

Dev Cell. 2012 Sep 11;23(3):519-32. doi: 10.1016/j.devcel.2012.08.003. Epub 2012 Aug 30.

35.

A chemical screen identifies class a g-protein coupled receptors as regulators of cilia.

Avasthi P, Marley A, Lin H, Gregori-Puigjane E, Shoichet BK, von Zastrow M, Marshall WF.

ACS Chem Biol. 2012 May 18;7(5):911-9. doi: 10.1021/cb200349v. Epub 2012 Mar 8.

36.

Ubiquitination in the first cytoplasmic loop of μ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation.

Hislop JN, Henry AG, von Zastrow M.

J Biol Chem. 2011 Nov 18;286(46):40193-204. doi: 10.1074/jbc.M111.288555. Epub 2011 Sep 27.

37.

Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity.

Romero G, von Zastrow M, Friedman PA.

Adv Pharmacol. 2011;62:279-314. doi: 10.1016/B978-0-12-385952-5.00003-8. Review.

38.

Investigating G protein-coupled receptor endocytosis and trafficking by TIR-FM.

Yudowski GA, von Zastrow M.

Methods Mol Biol. 2011;756:325-32. doi: 10.1007/978-1-61779-160-4_19.

39.

Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection.

Lau EK, Trester-Zedlitz M, Trinidad JC, Kotowski SJ, Krutchinsky AN, Burlingame AL, von Zastrow M.

Sci Signal. 2011 Aug 9;4(185):ra52. doi: 10.1126/scisignal.2001748.

40.

Endocytosis promotes rapid dopaminergic signaling.

Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M.

Neuron. 2011 Jul 28;71(2):278-90. doi: 10.1016/j.neuron.2011.05.036.

41.

Analysis of GPCR localization and trafficking.

Hislop JN, von Zastrow M.

Methods Mol Biol. 2011;746:425-40. doi: 10.1007/978-1-61779-126-0_25.

42.

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.

Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan NJ, von Zastrow M.

Nat Cell Biol. 2011 Jun;13(6):715-21. doi: 10.1038/ncb2252. Epub 2011 May 22.

43.

Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.

Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT.

J Neurosci. 2011 Mar 23;31(12):4434-43. doi: 10.1523/JNEUROSCI.4874-10.2011.

44.

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M.

Cell. 2010 Nov 24;143(5):761-73. doi: 10.1016/j.cell.2010.10.003.

45.

The role of ubiquitination in lysosomal trafficking of δ-opioid receptors.

Henry AG, White IJ, Marsh M, von Zastrow M, Hislop JN.

Traffic. 2011 Feb;12(2):170-84. doi: 10.1111/j.1600-0854.2010.01145.x. Epub 2010 Dec 22.

46.

{Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism.

Tzingounis AV, von Zastrow M, Yudowski GA.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21028-33. doi: 10.1073/pnas.1004169107. Epub 2010 Nov 15.

47.

Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors.

Hislop JN, von Zastrow M.

Traffic. 2011 Feb;12(2):137-48. doi: 10.1111/j.1600-0854.2010.01121.x. Epub 2010 Oct 15. Review.

48.

Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion.

Yu YJ, Dhavan R, Chevalier MW, Yudowski GA, von Zastrow M.

J Neurosci. 2010 Sep 1;30(35):11703-14. doi: 10.1523/JNEUROSCI.6282-09.2010.

49.

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.

Lauffer BE, Melero C, Temkin P, Lei C, Hong W, Kortemme T, von Zastrow M.

J Cell Biol. 2010 Aug 23;190(4):565-74. doi: 10.1083/jcb.201004060.

50.

DISC1 regulates primary cilia that display specific dopamine receptors.

Marley A, von Zastrow M.

PLoS One. 2010 May 28;5(5):e10902. doi: 10.1371/journal.pone.0010902.

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