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Items: 24

1.

In Vivo Stable-Isotope Labeling and Mass-Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats.

Dator R, von Weymarn LB, Villalta PW, Hooyman CJ, Maertens LA, Upadhyaya P, Murphy SE, Balbo S.

Anal Chem. 2018 Oct 16;90(20):11863-11872. doi: 10.1021/acs.analchem.8b01881. Epub 2018 Oct 4.

PMID:
30086646
2.

Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers.

Murphy SE, von Weymarn LB, Parenteau M, Stepanov I, Tiirikainen M, LeMarchand L, Park SL.

Chem Res Toxicol. 2018 Mar 19;31(3):168-175. doi: 10.1021/acs.chemrestox.7b00264. Epub 2018 Feb 28.

3.

Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.

Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ.

Pharmacogenomics J. 2018 Jan;18(1):136-143. doi: 10.1038/tpj.2016.92. Epub 2017 Mar 14.

4.

Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry.

von Weymarn LB, Thomson NM, Donny EC, Hatsukami DK, Murphy SE.

Chem Res Toxicol. 2016 Mar 21;29(3):390-7. doi: 10.1021/acs.chemrestox.5b00521. Epub 2016 Feb 12.

5.

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.

Narayanapillai SC, von Weymarn LB, Carmella SG, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy SE, Xing C.

Drug Metab Dispos. 2016 Mar;44(3):422-7. doi: 10.1124/dmd.115.068387. Epub 2016 Jan 7.

6.

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.

Bloom AJ, von Weymarn LB, Martinez M, Bierut LJ, Goate A, Murphy SE.

Pharmacogenet Genomics. 2013 Dec;23(12):706-16. doi: 10.1097/FPC.0000000000000011.

7.

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

Bloom AJ, Murphy SE, Martinez M, von Weymarn LB, Bierut LJ, Goate A.

Pharmacogenet Genomics. 2013 Feb;23(2):62-8. doi: 10.1097/FPC.0b013e32835c3b48.

8.

CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ion.

von Weymarn LB, Retzlaff C, Murphy SE.

J Pharmacol Exp Ther. 2012 Nov;343(2):307-15. doi: 10.1124/jpet.112.195255. Epub 2012 Aug 6.

9.

Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol.

Kramlinger VM, von Weymarn LB, Murphy SE.

Chem Biol Interact. 2012 May 30;197(2-3):87-92. doi: 10.1016/j.cbi.2012.03.009. Epub 2012 Apr 1.

10.

Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

Murphy SE, von Weymarn LB, Schutten MM, Kassie F, Modiano JF.

Cancer Prev Res (Phila). 2011 Nov;4(11):1752-60. doi: 10.1158/1940-6207.CAPR-11-0366. Epub 2011 Oct 25.

11.

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE.

Pharmacogenet Genomics. 2011 Jul;21(7):403-16. doi: 10.1097/FPC.0b013e328346e8c0.

12.

UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.

Berg JZ, von Weymarn LB, Thompson EA, Wickham KM, Weisensel NA, Hatsukami DK, Murphy SE.

Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1423-31. doi: 10.1158/1055-9965.EPI-09-0959. Epub 2010 May 25.

13.

Effects of eleven isothiocyanates on P450 2A6- and 2A13-catalyzed coumarin 7-hydroxylation.

von Weymarn LB, Chun JA, Knudsen GA, Hollenberg PF.

Chem Res Toxicol. 2007 Sep;20(9):1252-9. Epub 2007 Aug 3.

PMID:
17672516
14.

Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry.

Murphy SE, Villalta P, Ho SW, von Weymarn LB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 15;857(1):1-8. Epub 2007 Jun 29.

15.

Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.

von Weymarn LB, Chun JA, Hollenberg PF.

Carcinogenesis. 2006 Apr;27(4):782-90. Epub 2005 Dec 19.

PMID:
16364922
16.
17.

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism.

von Weymarn LB, Brown KM, Murphy SE.

J Pharmacol Exp Ther. 2006 Jan;316(1):295-303. Epub 2005 Sep 27.

PMID:
16188955
18.

Effects of 8-methoxypsoralen on cytochrome P450 2A13.

von Weymarn LB, Zhang QY, Ding X, Hollenberg PF.

Carcinogenesis. 2005 Mar;26(3):621-9. Epub 2004 Dec 3.

PMID:
15579482
19.
20.
21.

CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6.

von Weymarn LB, Murphy SE.

Xenobiotica. 2003 Jan;33(1):73-81.

PMID:
12519695
22.

Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3.

von Weymarn LB, Murphy SE.

Chem Res Toxicol. 2001 Oct;14(10):1386-92.

PMID:
11599930
23.

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