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SerpinB2 Regulates Immune Response in Kidney Injury and Aging.

Sen P, Helmke A, Liao CM, Sörensen-Zender I, Rong S, Bräsen JH, Melk A, Haller H, von Vietinghoff S, Schmitt R.

J Am Soc Nephrol. 2020 Mar 24. pii: ASN.2019101085. doi: 10.1681/ASN.2019101085. [Epub ahead of print]


Kidney injury enhances renal G-CSF expression and modulates granulopoiesis and human neutrophil CD177 in vivo.

Volkmann J, Schmitz J, Nordlohne J, Dong L, Helmke A, Sen P, Immenschuh S, Bernhardt WM, Gwinner W, Bräsen JH, Schmitt R, Haller H, von Vietinghoff S.

Clin Exp Immunol. 2020 Jan;199(1):97-108. doi: 10.1111/cei.13372. Epub 2019 Sep 30.


Inflammation in atherosclerosis: A key role for cytokines.

von Vietinghoff S, Koltsova EK.

Cytokine. 2019 Oct;122:154819. doi: 10.1016/j.cyto.2019.154819. Epub 2019 Aug 22. No abstract available.


[Acute on chronic renal failure in a 62-year-old man with ANCA-associated vasculitis].

Schroeder C, Schenk H, Khalifa A, Braesen JH, von Vietinghoff S.

Internist (Berl). 2019 Oct;60(10):1106-1110. doi: 10.1007/s00108-019-0657-9. German.


Chemokine CXCL13 as a New Systemic Biomarker for B-Cell Involvement in Acute T Cell-Mediated Kidney Allograft Rejection.

Schiffer L, Wiehler F, Bräsen JH, Gwinner W, Greite R, Kreimann K, Thorenz A, Derlin K, Teng B, Rong S, von Vietinghoff S, Haller H, Mengel M, Pape L, Lerch C, Schiffer M, Gueler F.

Int J Mol Sci. 2019 May 24;20(10). pii: E2552. doi: 10.3390/ijms20102552.


Erratum: Azathioprine hypersensitivity syndrome in anti-myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.

Greite R, Deutsch K, Bräsen JH, von Vietinghoff S.

Clin Kidney J. 2018 Oct 15;12(2):311. doi: 10.1093/ckj/sfy092. eCollection 2019 Apr.


CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis.

Helmke A, Nordlohne J, Balzer MS, Dong L, Rong S, Hiss M, Shushakova N, Haller H, von Vietinghoff S.

Kidney Int. 2019 Jun;95(6):1405-1417. doi: 10.1016/j.kint.2018.12.030. Epub 2019 Mar 5.


Azathioprine hypersensitivity syndrome in anti-myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.

Greite R, Deutsch K, Bräsen JH, von Vietinghoff S.

Clin Kidney J. 2019 Feb;12(1):89-91. doi: 10.1093/ckj/sfy038. Epub 2018 May 23. Erratum in: Clin Kidney J. 2018 Oct 15;12(2):311.


Renal transplant recipients receiving loop diuretic therapy have increased urinary tract infection rate and altered medullary macrophage polarization marker expression.

Casper J, Schmitz J, Bräsen JH, Khalifa A, Schmidt BMW, Einecke G, Haller H, von Vietinghoff S.

Kidney Int. 2018 Nov;94(5):993-1001. doi: 10.1016/j.kint.2018.06.029. Epub 2018 Sep 28.


Endothelial-to-mesenchymal transition shapes the atherosclerotic plaque and modulates macrophage function.

Helmke A, Casper J, Nordlohne J, David S, Haller H, Zeisberg EM, von Vietinghoff S.

FASEB J. 2019 Feb;33(2):2278-2289. doi: 10.1096/fj.201801238R. Epub 2018 Sep 27.


Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha.

Balzer MS, Helmke A, Ackermann M, Casper J, Dong L, Hiss M, Kiyan Y, Rong S, Timrott K, von Vietinghoff S, Wang L, Haller H, Shushakova N.

Nephrol Dial Transplant. 2019 Jun 1;34(6):947-960. doi: 10.1093/ndt/gfy282.


Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A.

Nordlohne J, Helmke A, Ge S, Rong S, Chen R, Waisman A, Haller H, von Vietinghoff S.

JACC Basic Transl Sci. 2018 Jan 10;3(1):54-66. doi: 10.1016/j.jacbts.2017.08.005. eCollection 2018 Feb.


Interleukin 17A in atherosclerosis - Regulation and pathophysiologic effector function.

Nordlohne J, von Vietinghoff S.

Cytokine. 2019 Oct;122:154089. doi: 10.1016/j.cyto.2017.06.016. Epub 2017 Jun 26.


Macrophage density in early surveillance biopsies predicts future renal transplant function.

Bräsen JH, Khalifa A, Schmitz J, Dai W, Einecke G, Schwarz A, Hallensleben M, Schmidt BMW, Kreipe HH, Haller H, von Vietinghoff S.

Kidney Int. 2017 Aug;92(2):479-489. doi: 10.1016/j.kint.2017.01.029. Epub 2017 Mar 27.


[Pulmonary Manifestations of Vasculitis].

von Vietinghoff S.

Pneumologie. 2016 Nov;70(11):747-757. Epub 2016 Nov 9. Review. German.


Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization.

Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S.

Sci Rep. 2016 Nov 3;6:36598. doi: 10.1038/srep36598.


Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice.

Hueper K, Gutberlet M, Bräsen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F.

PLoS One. 2016 Sep 15;11(9):e0162705. doi: 10.1371/journal.pone.0162705. eCollection 2016.


A kidney-shaped polycystic mass on the back of a hemodialysis patient.

Volkmann J, Nordlohne J, Schmitt R, von Vietinghoff S.

Clin Case Rep. 2016 Jul 6;4(8):840-1. doi: 10.1002/ccr3.627. eCollection 2016 Aug.


Protein kinase C α inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate.

Wang L, Balzer MS, Rong S, Menne J, von Vietinghoff S, Dong L, Gueler F, Jang MS, Xu G, Timrott K, Tkachuk S, Hiss M, Haller H, Shushakova N.

Kidney Int. 2016 Jun;89(6):1253-67. doi: 10.1016/j.kint.2016.01.025. Epub 2016 Mar 25.


Extracellular vesicles as mediators of vascular inflammation in kidney disease.

Helmke A, von Vietinghoff S.

World J Nephrol. 2016 Mar 6;5(2):125-38. doi: 10.5527/wjn.v5.i2.125. Review.


T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment.

Dong L, Nordlohne J, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S.

J Am Soc Nephrol. 2016 Jun;27(6):1753-64. doi: 10.1681/ASN.2015050540. Epub 2015 Oct 8.


Pathogenetic role of glomerular CXCL13 expression in lupus nephritis.

Worthmann K, Gueler F, von Vietinghoff S, Davalos-Mißlitz A, Wiehler F, Davidson A, Witte T, Haller H, Schiffer M, Falk CS, Schiffer L.

Clin Exp Immunol. 2014 Oct;178(1):20-7. doi: 10.1111/cei.12380.


Interleukin 17 receptor A modulates monocyte subsets and macrophage generation in vivo.

Ge S, Hertel B, Susnik N, Rong S, Dittrich AM, Schmitt R, Haller H, von Vietinghoff S.

PLoS One. 2014 Jan 15;9(1):e85461. doi: 10.1371/journal.pone.0085461. eCollection 2014.


Ablation of proximal tubular suppressor of cytokine signaling 3 enhances tubular cell cycling and modifies macrophage phenotype during acute kidney injury.

Susnik N, Sörensen-Zender I, Rong S, von Vietinghoff S, Lu X, Rubera I, Tauc M, Falk CS, Alexander WS, Melk A, Haller H, Schmitt R.

Kidney Int. 2014 Jun;85(6):1357-68. doi: 10.1038/ki.2013.525. Epub 2014 Jan 8.


Invariant natural killer T cells are depleted in renal impairment and recover after kidney transplantation.

Peukert K, Wingender G, Patecki M, Wagner S, Schmitt R, Ge S, Schwarz A, Kronenberg M, Haller H, von Vietinghoff S.

Nephrol Dial Transplant. 2014 May;29(5):1020-8. doi: 10.1093/ndt/gft495. Epub 2013 Dec 18.


Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by interleukin-17A.

Ge S, Hertel B, Koltsova EK, Sörensen-Zender I, Kielstein JT, Ley K, Haller H, von Vietinghoff S.

Circ Res. 2013 Sep 27;113(8):965-74. doi: 10.1161/CIRCRESAHA.113.301934. Epub 2013 Aug 1.


Surface receptor CD177/NB1 does not confer a recruitment advantage to neutrophilic granulocytes during human peritonitis.

Wang L, Ge S, Agustian A, Hiss M, Haller H, von Vietinghoff S.

Eur J Haematol. 2013 May;90(5):436-7. doi: 10.1111/ejh.12095. Epub 2013 Mar 22. No abstract available.


Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice.

Koltsova EK, Kim G, Lloyd KM, Saris CJ, von Vietinghoff S, Kronenberg M, Ley K.

Circ Res. 2012 Oct 26;111(10):1274-85. doi: 10.1161/CIRCRESAHA.112.277525. Epub 2012 Aug 27.


Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis.

Koltsova EK, Garcia Z, Chodaczek G, Landau M, McArdle S, Scott SR, von Vietinghoff S, Galkina E, Miller YI, Acton ST, Ley K.

J Clin Invest. 2012 Sep;122(9):3114-26. doi: 10.1172/JCI61758. Epub 2012 Aug 13.


Protein kinase C-θ is required for murine neutrophil recruitment and adhesion strengthening under flow.

Bertram A, Zhang H, von Vietinghoff S, de Pablo C, Haller H, Shushakova N, Ley K.

J Immunol. 2012 Apr 15;188(8):4043-51. doi: 10.4049/jimmunol.1101651. Epub 2012 Mar 7.


Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans.

Wingender G, Hiss M, Engel I, Peukert K, Ley K, Haller H, Kronenberg M, von Vietinghoff S.

J Immunol. 2012 Apr 1;188(7):3000-8. doi: 10.4049/jimmunol.1101273. Epub 2012 Mar 2.


Microparticle generation and leucocyte death in Shiga toxin-mediated HUS.

Ge S, Hertel B, Emden SH, Beneke J, Menne J, Haller H, von Vietinghoff S.

Nephrol Dial Transplant. 2012 Jul;27(7):2768-75. doi: 10.1093/ndt/gfr748. Epub 2012 Jan 10.


Bβ(15-42) attenuates the effect of ischemia-reperfusion injury in renal transplantation.

Sörensen I, Rong S, Susnik N, Gueler F, Shushakova N, Albrecht M, Dittrich AM, von Vietinghoff S, Becker JU, Melk A, Bohlmann A, Reingruber S, Petzelbauer P, Haller H, Schmitt R.

J Am Soc Nephrol. 2011 Oct;22(10):1887-96. doi: 10.1681/ASN.2011010031. Epub 2011 Aug 12.


Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation.

von Vietinghoff S, Koltsova EK, Mestas J, Diehl CJ, Witztum JL, Ley K.

J Am Coll Cardiol. 2011 May 24;57(21):2194-204. doi: 10.1016/j.jacc.2010.12.030.


Interleukin 17 in vascular inflammation.

von Vietinghoff S, Ley K.

Cytokine Growth Factor Rev. 2010 Dec;21(6):463-9. doi: 10.1016/j.cytogfr.2010.10.003. Epub 2010 Nov 12. Review.


Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice.

von Vietinghoff S, Asagiri M, Azar D, Hoffmann A, Ley K.

J Immunol. 2010 Jul 1;185(1):670-8. doi: 10.4049/jimmunol.1000339. Epub 2010 Jun 2.


Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production.

von Vietinghoff S, Ouyang H, Ley K.

Kidney Int. 2010 Jul;78(1):79-88. doi: 10.1038/ki.2010.84. Epub 2010 Apr 7.


T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo.

Smith E, von Vietinghoff S, Stark MA, Zarbock A, Sanders JM, Duley A, Rivera-Nieves J, Bender TP, Ley K.

J Immunol. 2009 Nov 1;183(9):5685-93. doi: 10.4049/jimmunol.0900887.


Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).

Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K.

J Immunol. 2009 Oct 1;183(7):4715-22. doi: 10.4049/jimmunol.0802592. Epub 2009 Sep 14.


IL-17A controls IL-17F production and maintains blood neutrophil counts in mice.

von Vietinghoff S, Ley K.

J Immunol. 2009 Jul 15;183(2):865-73. doi: 10.4049/jimmunol.0804080. Epub 2009 Jun 19. Erratum in: J Immunol. 2009 Sep 15;183(6):4136.


Homeostatic regulation of blood neutrophil counts.

von Vietinghoff S, Ley K.

J Immunol. 2008 Oct 15;181(8):5183-8. Review.


Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.

von Vietinghoff S, Eulenberg C, Wellner M, Luft FC, Kettritz R.

Clin Exp Immunol. 2008 Jun;152(3):508-16. doi: 10.1111/j.1365-2249.2008.03663.x.


Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.

Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, Herzig S.

PLoS One. 2007 Mar 14;2(3):e292.


NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.

von Vietinghoff S, Tunnemann G, Eulenberg C, Wellner M, Cristina Cardoso M, Luft FC, Kettritz R.

Blood. 2007 May 15;109(10):4487-93. Epub 2007 Jan 23.


Major histocompatibility complex HLA region largely explains the genetic variance exercised on neutrophil membrane proteinase 3 expression.

von Vietinghoff S, Busjahn A, Schönemann C, Massenkeil G, Otto B, Luft FC, Kettritz R.

J Am Soc Nephrol. 2006 Nov;17(11):3185-91. Epub 2006 Sep 27.


Crescentic glomerulonephritis and malignancy--guilty or guilt by association?

von Vietinghoff S, Schneider W, Luft FC, Kettritz R.

Nephrol Dial Transplant. 2006 Nov;21(11):3324-6. Epub 2006 Aug 5. Review. No abstract available.


Apoptosis, proliferation and inflammatory infiltration in ANCA-positive glomerulonephritis.

Kettritz R, Wilke S, von Vietinghoff S, Luft F, Schneider W.

Clin Nephrol. 2006 May;65(5):309-16.


Membrane proteinase 3 and Wegener's granulomatosis.

von Vietinghoff S, Schreiber A, Otto B, Choi M, Göbel U, Kettritz R.

Clin Nephrol. 2005 Dec;64(6):453-9. Review.


A 77 year-old haemodialysis patient with unexpected alkalosis.

von Vietinghoff S, Luft FC, Kettritz R.

Nephrol Dial Transplant. 2005 Nov;20(11):2569-70. Epub 2005 Aug 9. No abstract available.


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