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Items: 29


Molecular Profiling of Ulcerative Colitis Subjects from the TURANDOT Trial Reveals Novel Pharmacodynamic/Efficacy Biomarkers.

Zhou H, Xi L, Ziemek D, O'Neil S, Lee J, Stewart Z, Zhan Y, Zhao S, Zhang Y, Page K, Huang A, Maciejewski M, Zhang B, Gorelick KJ, Fitz L, Pradhan V, Cataldi F, Vincent M, Von Schack D, Hung K, Hassan-Zahraee M.

J Crohns Colitis. 2019 May 27;13(6):702-713. doi: 10.1093/ecco-jcc/jjy217.


De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin.

Martinetz S, Meinung CP, Jurek B, von Schack D, van den Burg EH, Slattery DA, Neumann ID.

Biol Psychiatry. 2019 May 15;85(10):802-811. doi: 10.1016/j.biopsych.2019.01.010. Epub 2019 Jan 22.


Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial.

Davenport EE, Amariuta T, Gutierrez-Arcelus M, Slowikowski K, Westra HJ, Luo Y, Shen C, Rao DA, Zhang Y, Pearson S, von Schack D, Beebe JS, Bing N, John S, Vincent MS, Zhang B, Raychaudhuri S.

Genome Biol. 2018 Oct 19;19(1):168. doi: 10.1186/s13059-018-1560-8.


Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis.

Ouahed J, Gordon W, Canavan JB, Zhou H, Du S, von Schack D, Phillips K, Wang L, Dunn WA 3rd, Field M, Friel S, Griffith A, Evans S, Tollefson S, Carrellas M, Cao B, Merker A, Bousvaros A, Shouval DS; BCH IBD Center; BWH Crohn’s and Colitis Center, Hung K, Lepsy C, Afzelius L, Korzenik JR, Snapper SB.

Inflamm Bowel Dis. 2018 Nov 29;24(12):2565-2578. doi: 10.1093/ibd/izy242.


Evaluation of two main RNA-seq approaches for gene quantification in clinical RNA sequencing: polyA+ selection versus rRNA depletion.

Zhao S, Zhang Y, Gamini R, Zhang B, von Schack D.

Sci Rep. 2018 Mar 19;8(1):4781. doi: 10.1038/s41598-018-23226-4.


Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn's Disease.

Hassan-Zahraee M, Banerjee A, Cheng JB, Zhang W, Ahmad A, Page K, von Schack D, Zhang B, Martin SW, Nayak S, Reddy P, Xi L, Neubert H, Fernandez Ocana M, Gorelick K, Clare R, Vincent M, Cataldi F, Hung K.

J Crohns Colitis. 2018 Jan 5;12(1):77-86. doi: 10.1093/ecco-jcc/jjx121.


QuickMIRSeq: a pipeline for quick and accurate quantification of both known miRNAs and isomiRs by jointly processing multiple samples from microRNA sequencing.

Zhao S, Gordon W, Du S, Zhang C, He W, Xi L, Mathur S, Agostino M, Paradis T, von Schack D, Vincent M, Zhang B.

BMC Bioinformatics. 2017 Mar 20;18(1):180. doi: 10.1186/s12859-017-1601-4.


Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study.

Krueger J, Clark JD, Suárez-Fariñas M, Fuentes-Duculan J, Cueto I, Wang CQ, Tan H, Wolk R, Rottinghaus ST, Whitley MZ, Valdez H, von Schack D, O'Neil SP, Reddy PS, Tatulych S; A3921147 Study Investigators.

J Allergy Clin Immunol. 2016 Apr;137(4):1079-1090. doi: 10.1016/j.jaci.2015.12.1318.


QuickRNASeq lifts large-scale RNA-seq data analyses to the next level of automation and interactive visualization.

Zhao S, Xi L, Quan J, Xi H, Zhang Y, von Schack D, Vincent M, Zhang B.

BMC Genomics. 2016 Jan 8;17:39. doi: 10.1186/s12864-015-2356-9.


Comparison of stranded and non-stranded RNA-seq transcriptome profiling and investigation of gene overlap.

Zhao S, Zhang Y, Gordon W, Quan J, Xi H, Du S, von Schack D, Zhang B.

BMC Genomics. 2015 Sep 3;16:675. doi: 10.1186/s12864-015-1876-7.


Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM.

J Immunol. 2015 Jul 1;195(1):145-55. doi: 10.4049/jimmunol.1402381. Epub 2015 May 20.


Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.

Benson MJ, Rodriguez V, von Schack D, Keegan S, Cook TA, Edmonds J, Benoit S, Seth N, Du S, Messing D, Nickerson-Nutter CL, Dunussi-Joannopoulos K, Rankin AL, Ruzek M, Schnute ME, Douhan J 3rd.

J Immunol. 2014 Jul 1;193(1):185-97. doi: 10.4049/jimmunol.1302570. Epub 2014 Jun 4.


Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6.

Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton KM, Tyminski E, Paradis T, Zhang Y, Jones JE, von Schack D, Brown CT, Milos PM, Coyle AJ, Tremblay F, Martinez RV.

PLoS One. 2014 Mar 21;9(3):e92608. doi: 10.1371/journal.pone.0092608. eCollection 2014.


The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function.

Sütterlin P, Williams EJ, Chambers D, Saraf K, von Schack D, Reisenberg M, Doherty P, Williams G.

Mol Cell Neurosci. 2013 Jan;52:20-30. doi: 10.1016/j.mcn.2012.10.006. Epub 2012 Oct 17.


Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.

Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA.

J Exp Med. 2012 Sep 24;209(10):1713-22, S1-19. Epub 2012 Sep 10.


Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus.

Monopoli MP, Raghnaill MN, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH, von Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ.

Proteomics. 2011 Nov;11(21):4189-201. doi: 10.1002/pmic.201100072. Epub 2011 Oct 17.


Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain.

von Schack D, Agostino MJ, Murray BS, Li Y, Reddy PS, Chen J, Choe SE, Strassle BW, Li C, Bates B, Zhang L, Hu H, Kotnis S, Bingham B, Liu W, Whiteside GT, Samad TA, Kennedy JD, Ajit SK.

PLoS One. 2011 Mar 14;6(3):e17670. doi: 10.1371/journal.pone.0017670.


Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat.

Murphy KJ, Ter Horst JP, Cassidy AW, DeSouza IE, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, O'Connor WT, Ring RH, von Schack D, Regan CM.

J Neurochem. 2010 May;113(3):601-14. doi: 10.1111/j.1471-4159.2010.06617.x. Epub 2010 Jan 24.


Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2.

Atkinson PJ, Dellovade T, Albers D, Von Schack D, Saraf K, Needle E, Reinhart PH, Hirst WD.

J Neurochem. 2009 Mar;108(6):1539-49. doi: 10.1111/j.1471-4159.2009.05900.x. Epub 2009 Jan 22.


Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8. Epub 2007 Dec 27.


Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia.

Shamloo M, Soriano L, von Schack D, Rickhag M, Chin DJ, Gonzalez-Zulueta M, Gido G, Urfer R, Wieloch T, Nikolich K.

Eur J Neurosci. 2006 Nov;24(10):2705-20.


Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue.

Rickhag M, Wieloch T, Gidö G, Elmér E, Krogh M, Murray J, Lohr S, Bitter H, Chin DJ, von Schack D, Shamloo M, Nikolich K.

J Neurochem. 2006 Jan;96(1):14-29. Epub 2005 Nov 21.


Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S, Patthy L, Gonzalez-Zulueta M, Nikolich K, Urfer R.

J Biol Chem. 2004 Feb 13;279(7):5565-72. Epub 2003 Nov 10. Erratum in: J Biol Chem. 2004 May 28;279(22):23845.


A role for receptor tyrosine phosphatase zeta in glioma cell migration.

Müller S, Kunkel P, Lamszus K, Ulbricht U, Lorente GA, Nelson AM, von Schack D, Chin DJ, Lohr SC, Westphal M, Melcher T.

Oncogene. 2003 Oct 2;22(43):6661-8.


Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system.

von Schack D, Casademunt E, Schweigreiter R, Meyer M, Bibel M, Dechant G.

Nat Neurosci. 2001 Oct;4(10):977-8. No abstract available.


Roles of neurotrophin-3 during early development of the peripheral nervous system.

Ockel M, von Schack D, Schröpel A, Dechant G, Lewin GR, Barde YA.

Philos Trans R Soc Lond B Biol Sci. 1996 Mar 29;351(1338):383-7.


The histidine tail of recombinant DNA binding proteins may influence the quality of interaction with DNA.

Büning H, Gärtner U, von Schack D, Baeuerle PA, Zorbas H.

Anal Biochem. 1996 Feb 15;234(2):227-30. No abstract available.


Early expression of the nerve growth factor receptor ctrkA in chick sympathetic and sensory ganglia.

Schröpel A, von Schack D, Dechant G, Barde YA.

Mol Cell Neurosci. 1995 Dec;6(6):544-66.


Epithelial-mesenchymal conversion of dermatome progenitors requires neural tube-derived signals: characterization of the role of Neurotrophin-3.

Brill G, Kahane N, Carmeli C, von Schack D, Barde YA, Kalcheim C.

Development. 1995 Aug;121(8):2583-94.

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