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Items: 26

1.

The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer models.

Wengner AM, Siemeister G, Lücking U, Lefranc J, Wortmann L, Lienau P, Bader B, Bömer U, Moosmayer D, Eberspächer U, Golfier S, Schatz CA, Baumgart SJ, Haendler B, Lejeune P, Schlicker A, von Nussbaum F, Brands M, Ziegelbauer K, Mumberg D.

Mol Cancer Ther. 2019 Oct 3. pii: molcanther.0019.2019. doi: 10.1158/1535-7163.MCT-19-0019. [Epub ahead of print]

PMID:
31582533
2.

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25.

3.

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.

Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, Moosmayer D, Eberspaecher U, Weiske J, Lechner C, Prechtl S, Suelzle D, Siegel F, Prinz F, Lesche R, Nicke B, Nowak-Reppel K, Himmel H, Mumberg D, von Nussbaum F, Nising CF, Bauser M, Haegebarth A.

J Med Chem. 2019 Jan 24;62(2):928-940. doi: 10.1021/acs.jmedchem.8b01606. Epub 2019 Jan 9.

PMID:
30563338
4.

Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo.

Siemeister G, Mengel A, Fernández-Montalván AE, Bone W, Schröder J, Zitzmann-Kolbe S, Briem H, Prechtl S, Holton SJ, Mönning U, von Ahsen O, Johanssen S, Cleve A, Pütter V, Hitchcock M, von Nussbaum F, Brands M, Ziegelbauer K, Mumberg D.

Clin Cancer Res. 2019 Feb 15;25(4):1404-1414. doi: 10.1158/1078-0432.CCR-18-0628. Epub 2018 Nov 14.

PMID:
30429199
5.

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.

Lücking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, Briem H, Terebesi I, Meyer K, Prelle K, Denner K, Bömer U, Schäfer M, Eis K, Valencia R, Ince S, von Nussbaum F, Mumberg D, Ziegelbauer K, Klebl B, Choidas A, Nussbaumer P, Baumann M, Schultz-Fademrecht C, Rühter G, Eickhoff J, Brands M.

ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16.

6.

BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity.

Santag S, Siegel F, Wengner AM, Lange C, Bömer U, Eis K, Pühler F, Lienau P, Bergemann L, Michels M, von Nussbaum F, Mumberg D, Petersen K.

Cancer Lett. 2017 Apr 1;390:21-29. doi: 10.1016/j.canlet.2016.12.029. Epub 2016 Dec 31.

7.

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.

Politz O, Siegel F, Bärfacker L, Bömer U, Hägebarth A, Scott WJ, Michels M, Ince S, Neuhaus R, Meyer K, Fernández-Montalván AE, Liu N, von Nussbaum F, Mumberg D, Ziegelbauer K.

Int J Cancer. 2017 Jan 15;140(2):449-459. doi: 10.1002/ijc.30457. Epub 2016 Oct 20.

8.

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.

Baron AP, von Schubert C, Cubizolles F, Siemeister G, Hitchcock M, Mengel A, Schröder J, Fernández-Montalván A, von Nussbaum F, Mumberg D, Nigg EA.

Elife. 2016 Feb 17;5. pii: e12187. doi: 10.7554/eLife.12187.

9.

Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity.

Wengner AM, Siemeister G, Koppitz M, Schulze V, Kosemund D, Klar U, Stoeckigt D, Neuhaus R, Lienau P, Bader B, Prechtl S, Raschke M, Frisk AL, von Ahsen O, Michels M, Kreft B, von Nussbaum F, Brands M, Mumberg D, Ziegelbauer K.

Mol Cancer Ther. 2016 Apr;15(4):583-92. doi: 10.1158/1535-7163.MCT-15-0500. Epub 2016 Feb 1.

10.

BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients.

Sugawara T, Lejeune P, Köhr S, Neuhaus R, Faus H, Gelato KA, Busemann M, Cleve A, Lücking U, von Nussbaum F, Brands M, Mumberg D, Jung K, Stephan C, Haendler B.

Oncotarget. 2016 Feb 2;7(5):6015-28. doi: 10.18632/oncotarget.6864.

11.

Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.

von Nussbaum F, Li VM.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81. doi: 10.1016/j.bmcl.2015.08.049. Epub 2015 Aug 20. Review.

12.

Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.

von Nussbaum F, Li VM, Meibom D, Anlauf S, Bechem M, Delbeck M, Gerisch M, Harrenga A, Karthaus D, Lang D, Lustig K, Mittendorf J, Schäfer M, Schäfer S, Schamberger J.

ChemMedChem. 2016 Jan 19;11(2):199-206. doi: 10.1002/cmdc.201500269. Epub 2015 Sep 3.

PMID:
26333652
13.

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.

von Nussbaum F, Li VM, Allerheiligen S, Anlauf S, Bärfacker L, Bechem M, Delbeck M, Fitzgerald MF, Gerisch M, Gielen-Haertwig H, Haning H, Karthaus D, Lang D, Lustig K, Meibom D, Mittendorf J, Rosentreter U, Schäfer M, Schäfer S, Schamberger J, Telan LA, Tersteegen A.

ChemMedChem. 2015 Jul;10(7):1163-73. doi: 10.1002/cmdc.201500131. Epub 2015 Jun 17.

14.

Multiple attack on bacteria by the new antibiotic teixobactin.

von Nussbaum F, Süssmuth RD.

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6684-6. doi: 10.1002/anie.201501440. Epub 2015 May 12. No abstract available.

PMID:
25968231
15.

Aspergillomarasmine A, an inhibitor of bacterial metallo-β-lactamases conferring blaNDM and blaVIM resistance.

von Nussbaum F, Schiffer G.

Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11696-8. doi: 10.1002/anie.201407921. Epub 2014 Sep 24.

PMID:
25256630
16.

Lost in transcription--inhibition of RNA polymerase.

Haebich D, von Nussbaum F.

Angew Chem Int Ed Engl. 2009;48(19):3397-400. doi: 10.1002/anie.200900338.

PMID:
19294713
17.

"Superbugs bunny" outsmarts our immune defense.

Haebich D, von Nussbaum F.

ChemMedChem. 2008 Aug;3(8):1173-7. doi: 10.1002/cmdc.200800171. No abstract available.

PMID:
18671218
18.

Total synthesis and initial structure-activity relationships of longicatenamycin A.

von Nussbaum F, Anlauf S, Freiberg C, Benet-Buchholz J, Schamberger J, Henkel T, Schiffer G, Häbich D.

ChemMedChem. 2008 Apr;3(4):619-26. doi: 10.1002/cmdc.200700297.

PMID:
18246567
19.

Structure and total synthesis of lysobactin (katanosin B).

von Nussbaum F, Anlauf S, Benet-Buchholz J, Häbich D, Köbberling J, Musza L, Telser J, Rübsamen-Waigmann H, Brunner NA.

Angew Chem Int Ed Engl. 2007;46(12):2039-42. No abstract available.

PMID:
17211904
20.

Platensimycin, a new antibiotic and "superbug challenger" from nature.

Häbich D, von Nussbaum F.

ChemMedChem. 2006 Sep;1(9):951-4. Review. No abstract available.

PMID:
16952137
21.

Antibacterial natural products in medicinal chemistry--exodus or revival?

von Nussbaum F, Brands M, Hinzen B, Weigand S, Häbich D.

Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5072-129. Review.

PMID:
16881035
22.

Stephacidin B-A new stage of complexity within prenylated indole alkaloids from fungi.

von Nussbaum F.

Angew Chem Int Ed Engl. 2003 Jul 14;42(27):3068-71. Review. No abstract available.

PMID:
12866092
24.

Detection of a 2,3-Aminomutase in the Mushroom Cortinarius violaceus This contribution was supported by the Deutsche Forschungsgemeinschaft (SFB 369).

Spiteller P, Rüth M, von Nussbaum F, Steglich W.

Angew Chem Int Ed Engl. 2000 Aug 4;39(15):2754-2756. No abstract available.

PMID:
10934416
25.

Synthesis of 1-(2-aminophenyl)isoquinolines and the biological activity of their cis-dichloro platinum(II) complexes.

von Nussbaum F, Miller B, Wild S, Hilger CS, Schumann S, Zorbas H, Beck W, Steglich W.

J Med Chem. 1999 Sep 9;42(18):3478-85.

PMID:
10479280
26.

An Iron(III)-Catechol Complex as a Mushroom Pigment.

von Nussbaum F, Spiteller P, Rüth M, Steglich W, Wanner G, Gamblin B, Stievano L, Wagner FE.

Angew Chem Int Ed Engl. 1998 Dec 17;37(23):3292-3295. doi: 10.1002/(SICI)1521-3773(19981217)37:23<3292::AID-ANIE3292>3.0.CO;2-N.

PMID:
29711421

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