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Items: 1 to 50 of 65

1.

Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial.

Suttorp M, Schulze P, Glauche I, Göhring G, von Neuhoff N, Metzler M, Sedlacek P, de Bont ESJM, Balduzzi A, Lausen B, Aleinikova O, Sufliarska S, Henze G, Strauss G, Eggert A, Kremens B, Groll AH, Berthold F, Klein C, Groß-Wieltsch U, Sykora KW, Borkhardt A, Kulozik AE, Schrappe M, Nowasz C, Krumbholz M, Tauer JT, Claviez A, Harbott J, Kreipe HH, Schlegelberger B, Thiede C.

Leukemia. 2018 Jun 20. doi: 10.1038/s41375-018-0179-9. [Epub ahead of print]

PMID:
29925908
2.

Two cancer-predisposing variants in one family: Incidental finding of a fumarate hydrogenase (FH) germline variant in a family with Li-Fraumeni syndrome.

Pahl L, Beier R, von Neuhoff N, Auber B, Höfs M, Prott EC, Schlegelberger B, Reinhardt D, Steinemann D.

Pediatr Blood Cancer. 2018 Jun 12:e27254. doi: 10.1002/pbc.27254. [Epub ahead of print] No abstract available.

PMID:
29893455
3.

Single-cell whole exome and targeted sequencing in NPM1/FLT3 positive pediatric acute myeloid leukemia.

Walter C, Pozzorini C, Reinhardt K, Geffers R, Xu Z, Reinhardt D, von Neuhoff N, Hanenberg H.

Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26848. Epub 2017 Nov 1.

PMID:
29090521
4.

Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy.

Yang M, Pan Z, Huang K, Büsche G, Feuerhake F, Chaturvedi A, Nie D, Heuser M, Thol F, von Neuhoff N, Ganser A, Li Z.

Oncotarget. 2017 May 19;8(43):73871-73883. doi: 10.18632/oncotarget.18027. eCollection 2017 Sep 26.

5.

Diagnosis of monogenic liver diseases in childhood by next-generation sequencing.

Stalke A, Skawran B, Auber B, Illig T, Schlegelberger B, Junge N, Goldschmidt I, Leiskau C, von Neuhoff N, Baumann U, Pfister ED.

Clin Genet. 2018 Mar;93(3):665-670. doi: 10.1111/cge.13120. Epub 2017 Dec 12.

PMID:
28776642
6.

Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.

Rasche M, von Neuhoff C, Dworzak M, Bourquin JP, Bradtke J, Göhring G, Escherich G, Fleischhack G, Graf N, Gruhn B, Haas OA, Klingebiel T, Kremens B, Lehrnbecher T, von Stackelberg A, Tchinda J, Zemanova Z, Thiede C, von Neuhoff N, Zimmermann M, Creutzig U, Reinhardt D.

Leukemia. 2017 Dec;31(12):2807-2814. doi: 10.1038/leu.2017.121. Epub 2017 Apr 25.

7.

First experience of the AML-Berlin-Frankfurt-Münster group in pediatric patients with standard-risk acute promyelocytic leukemia treated with arsenic trioxide and all-trans retinoid acid.

Creutzig U, Dworzak MN, Bochennek K, Faber J, Flotho C, Graf N, Kontny U, Rossig C, Schmid I, von Stackelberg A, Mueller JE, von Neuhoff C, Reinhardt D, von Neuhoff N.

Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26461. Epub 2017 Jan 23.

PMID:
28111878
8.

Leukemogenic potency of the novel FLT3-N676K mutant.

Huang K, Yang M, Pan Z, Heidel FH, Scherr M, Eder M, Fischer T, Büsche G, Welte K, von Neuhoff N, Ganser A, Li Z.

Ann Hematol. 2016 Apr;95(5):783-91. doi: 10.1007/s00277-016-2616-z. Epub 2016 Feb 19.

PMID:
26891877
9.

Expression of the ETS transcription factor GABPα is positively correlated to the BCR-ABL1/ABL1 ratio in CML patients and affects imatinib sensitivity in vitro.

Manukjan G, Ripperger T, Santer L, von Neuhoff N, Ganser A, Schambach A, Schlegelberger B, Steinemann D.

Exp Hematol. 2015 Oct;43(10):880-90. doi: 10.1016/j.exphem.2015.05.011. Epub 2015 Jun 11.

PMID:
26072332
10.

Bortezomib Treatment can Overcome Glucocorticoid Resistance in Childhood B-cell Precursor Acute Lymphoblastic Leukemia Cell Lines.

Junk S, Cario G, Wittner N, Stanulla M, Scherer R, Schlegelberger B, Schrappe M, von Neuhoff N, Lauten M.

Klin Padiatr. 2015 May;227(3):123-30. doi: 10.1055/s-0034-1398628. Epub 2015 May 18.

PMID:
25985447
11.

Comprehensive MALDI-TOF biotyping of the non-redundant Harvard Pseudomonas aeruginosa PA14 transposon insertion mutant library.

Oumeraci T, Jensen V, Talbot SR, Hofmann W, Kostrzewa M, Schlegelberger B, von Neuhoff N, Häussler S.

PLoS One. 2015 Feb 9;10(2):e0117144. doi: 10.1371/journal.pone.0117144. eCollection 2015.

12.

In vivo mRNA profiling of uropathogenic Escherichia coli from diverse phylogroups reveals common and group-specific gene expression profiles.

Bielecki P, Muthukumarasamy U, Eckweiler D, Bielecka A, Pohl S, Schanz A, Niemeyer U, Oumeraci T, von Neuhoff N, Ghigo JM, Häussler S.

MBio. 2014 Aug 5;5(4):e01075-14. doi: 10.1128/mBio.01075-14.

13.

t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients.

Sandahl JD, Coenen EA, Forestier E, Harbott J, Johansson B, Kerndrup G, Adachi S, Auvrignon A, Beverloo HB, Cayuela JM, Chilton L, Fornerod M, de Haas V, Harrison CJ, Inaba H, Kaspers GJ, Liang DC, Locatelli F, Masetti R, Perot C, Raimondi SC, Reinhardt K, Tomizawa D, von Neuhoff N, Zecca M, Zwaan CM, van den Heuvel-Eibrink MM, Hasle H.

Haematologica. 2014 May;99(5):865-72. doi: 10.3324/haematol.2013.098517. Epub 2014 Jan 17.

14.

Monitoring CSF proteome alterations in amyotrophic lateral sclerosis: obstacles and perspectives in translating a novel marker panel to the clinic.

von Neuhoff N, Oumeraci T, Wolf T, Kollewe K, Bewerunge P, Neumann B, Brors B, Bufler J, Wurster U, Schlegelberger B, Dengler R, Zapatka M, Petri S.

PLoS One. 2012;7(9):e44401. doi: 10.1371/journal.pone.0044401. Epub 2012 Sep 6.

15.

Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency.

Koczulla AR, Jonigk D, Wolf T, Herr C, Noeske S, Klepetko W, Vogelmeier C, von Neuhoff N, Rische J, Wrenger S, Golpon H, Voswinckel R, Luisetti M, Ferrarotti I, Welte T, Janciauskiene S.

Orphanet J Rare Dis. 2012 May 23;7:29. doi: 10.1186/1750-1172-7-29.

16.

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations.

Thol F, Kölking B, Damm F, Reinhardt K, Klusmann JH, Reinhardt D, von Neuhoff N, Brugman MH, Schlegelberger B, Suerbaum S, Krauter J, Ganser A, Heuser M.

Genes Chromosomes Cancer. 2012 Jul;51(7):689-95. doi: 10.1002/gcc.21955. Epub 2012 Mar 27.

PMID:
22454318
17.

Clinical efficacy of immunochemotherapy with fludarabine, epirubicin and rituximab in the treatment for chronic lymphocytic leukaemia and prolymphocytic leukaemia.

Chow KU, Kim SZ, von Neuhoff N, Schlegelberger B, Stilgenbauer S, Wunderle L, Cordes HJ, Bergmann L.

Eur J Haematol. 2011 Nov;87(5):426-33. doi: 10.1111/j.1600-0609.2011.01680.x. Epub 2011 Aug 23.

PMID:
21749447
18.

Proteomic bronchiolitis obliterans syndrome risk monitoring in lung transplant recipients.

Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N.

Transplantation. 2011 Aug 27;92(4):477-85. doi: 10.1097/TP.0b013e318224c109.

PMID:
21716170
19.

The homeobox gene HLXB9 is upregulated in a morphological subset of poorly differentiated hepatocellular carcinoma.

Wilkens L, Jaggi R, Hammer C, Inderbitzin D, Giger O, von Neuhoff N.

Virchows Arch. 2011 Jun;458(6):697-708. doi: 10.1007/s00428-011-1070-5. Epub 2011 Apr 12.

20.

Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology.

Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, von Neuhoff N.

Lung Cancer. 2011 Apr;72(1):136-8. doi: 10.1016/j.lungcan.2011.01.015. Epub 2011 Feb 18.

PMID:
21334092
21.

Genetically modified donor leukocyte transfusion and graft-versus-leukemia effect after allogeneic stem cell transplantation.

Borchers S, Provasi E, Silvani A, Radrizzani M, Benati C, Dammann E, Krons A, Kontsendorn J, Schmidtke J, Kuehnau W, von Neuhoff N, Stadler M, Ciceri F, Bonini C, Ganser A, Hertenstein B, Weissinger EM.

Hum Gene Ther. 2011 Jul;22(7):829-41. doi: 10.1089/hum.2010.162. Epub 2011 Mar 30.

22.

Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse.

Ehlers S, Herbst C, Zimmermann M, Scharn N, Germeshausen M, von Neuhoff N, Zwaan CM, Reinhardt K, Hollink IH, Klusmann JH, Lehrnbecher T, Roettgers S, Stary J, Dworzak M, Welte K, Creutzig U, Reinhardt D.

J Clin Oncol. 2010 May 20;28(15):2591-7. doi: 10.1200/JCO.2009.25.9010. Epub 2010 Apr 20.

PMID:
20406937
23.

Impact of the type of the BCR-ABL fusion transcript on the molecular response in pediatric patients with chronic myeloid leukemia.

Suttorp M, Thiede C, Tauer JT, Range U, Schlegelberger B, von Neuhoff N.

Haematologica. 2010 May;95(5):852-3. doi: 10.3324/haematol.2009.019224. Epub 2010 Feb 9. No abstract available.

24.

JAK2(V617F) allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis.

Hussein K, Bock O, Theophile K, von Neuhoff N, Buhr T, Schlué J, Büsche G, Kreipe H.

Exp Hematol. 2009 Oct;37(10):1186-1193.e7. doi: 10.1016/j.exphem.2009.07.005. Epub 2009 Jul 17.

PMID:
19616600
25.

Bronchial epithelial cells as a new source for differential transcriptome analysis after lung transplantation.

Skawran B, Dierich M, Steinemann D, Hohlfeld J, Haverich A, Schlegelberger B, Welte T, von Neuhoff N.

Eur J Cardiothorac Surg. 2009 Oct;36(4):715-21. doi: 10.1016/j.ejcts.2009.04.031. Epub 2009 Jun 13.

PMID:
19525122
26.

Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies.

Hussein K, von Neuhoff N, Büsche G, Buhr T, Kreipe H, Bock O.

Ann Hematol. 2009 Nov;88(11):1059-67. doi: 10.1007/s00277-009-0727-5. Epub 2009 Mar 17.

PMID:
19290526
27.

Kinetics of the in vivo expression of glucocorticoid receptor splice variants during prednisone treatment in childhood acute lymphoblastic leukaemia.

Lauten M, Fernandez-Munoz I, Gerdes K, von Neuhoff N, Welte K, Schlegelberger B, Schrappe M, Beger C.

Pediatr Blood Cancer. 2009 Apr;52(4):459-63. doi: 10.1002/pbc.21867.

PMID:
19061214
28.

High-affinity neurotrophin receptors and ligands promote leukemogenesis.

Li Z, Beutel G, Rhein M, Meyer J, Koenecke C, Neumann T, Yang M, Krauter J, von Neuhoff N, Heuser M, Diedrich H, Göhring G, Wilkens L, Schlegelberger B, Ganser A, Baum C.

Blood. 2009 Feb 26;113(9):2028-37. doi: 10.1182/blood-2008-05-155200. Epub 2008 Dec 4.

29.

Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene.

El-Harith el-HA, Roesl C, Ballmaier M, Germeshausen M, Frye-Boukhriss H, von Neuhoff N, Becker C, Nürnberg G, Nürnberg P, Ahmed MA, Hübener J, Schmidtke J, Welte K, Stuhrmann M.

Br J Haematol. 2009 Jan;144(2):185-94. doi: 10.1111/j.1365-2141.2008.07430.x. Epub 2008 Nov 19.

PMID:
19036112
30.

The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97.

Bertram C, von Neuhoff N, Skawran B, Steinemann D, Schlegelberger B, Hass R.

BMC Cell Biol. 2008 Feb 15;9:12. doi: 10.1186/1471-2121-9-12.

31.

Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia.

Buesche G, Ganser A, Schlegelberger B, von Neuhoff N, Gadzicki D, Hecker H, Bock O, Frye B, Kreipe H.

Leukemia. 2007 Dec;21(12):2420-7. Epub 2007 Sep 6.

PMID:
17805334
32.

Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas.

Ripperger T, von Neuhoff N, Kamphues K, Emura M, Lehmann U, Tauscher M, Schraders M, Groenen P, Skawran B, Rudolph C, Callet-Bauchu E, van Krieken JH, Schlegelberger B, Steinemann D.

Haematologica. 2007 Apr;92(4):460-8.

33.

High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics.

Heuser M, Beutel G, Krauter J, Döhner K, von Neuhoff N, Schlegelberger B, Ganser A.

Blood. 2006 Dec 1;108(12):3898-905. Epub 2006 Aug 15.

34.

Amyotrophic lateral sclerosis: new developments in diagnostic markers.

Dengler R, von Neuhoff N, Bufler J, Krampfl K, Peschel T, Grosskreutz J.

Neurodegener Dis. 2005;2(3-4):177-84. Review.

PMID:
16909023
35.

Quantitative microsatellite analysis to delineate the commonly deleted region 1p22.3 in mantle cell lymphomas.

Balakrishnan A, von Neuhoff N, Rudolph C, Kamphues K, Schraders M, Groenen P, van Krieken JH, Callet-Bauchu E, Schlegelberger B, Steinemann D.

Genes Chromosomes Cancer. 2006 Oct;45(10):883-92.

PMID:
16830336
36.

Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response.

Köllner I, Sodeik B, Schreek S, Heyn H, von Neuhoff N, Germeshausen M, Zeidler C, Krüger M, Schlegelberger B, Welte K, Beger C.

Blood. 2006 Jul 15;108(2):493-500. Epub 2006 Mar 21.

37.

Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance.

Lauten M, Schrauder A, Kardinal C, Harbott J, Welte K, Schlegelberger B, Schrappe M, von Neuhoff N.

Leukemia. 2006 May;20(5):820-6.

PMID:
16541142
38.

Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia.

Heuser M, Wingen LU, Steinemann D, Cario G, von Neuhoff N, Tauscher M, Bullinger L, Krauter J, Heil G, Döhner H, Schlegelberger B, Ganser A.

Haematologica. 2005 Nov;90(11):1484-92.

39.

Protein detection in dried blood by surface-enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS).

Dammann CE, Meyer M, Dammann O, von Neuhoff N.

Biol Neonate. 2006;89(2):126-32. Epub 2005 Oct 5.

PMID:
16210847
40.

Expression of the p75 neurotrophin receptor in acute leukaemia.

Beutel G, Meyer J, Ma L, Yin S, Eder M, von Neuhoff N, Wilkens L, Wei J, Hertenstein B, Heil G, Schlegelberger B, Ganser A, Li Z, Baum C.

Br J Haematol. 2005 Oct;131(1):67-70.

PMID:
16173964
41.

Cytogenetic characterization of a BCR-ABL transduced mouse cell line.

Rudolph C, Hegazy AN, von Neuhoff N, Steinemann D, Schröck E, Stripecke R, Klein C, Schlegelberger B.

Cancer Genet Cytogenet. 2005 Aug;161(1):51-6.

PMID:
16080957
42.

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

Kustikova O, Fehse B, Modlich U, Yang M, Düllmann J, Kamino K, von Neuhoff N, Schlegelberger B, Li Z, Baum C.

Science. 2005 May 20;308(5725):1171-4.

43.

BCR-ABL gene amplification and overexpression in a patient with chronic myeloid leukemia treated with imatinib.

Gadzicki D, von Neuhoff N, Steinemann D, Just M, Büsche G, Kreipe H, Wilkens L, Schlegelberger B.

Cancer Genet Cytogenet. 2005 Jun;159(2):164-7.

PMID:
15899391
44.

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

Modlich U, Kustikova OS, Schmidt M, Rudolph C, Meyer J, Li Z, Kamino K, von Neuhoff N, Schlegelberger B, Kuehlcke K, Bunting KD, Schmidt S, Deichmann A, von Kalle C, Fehse B, Baum C.

Blood. 2005 Jun 1;105(11):4235-46. Epub 2005 Feb 15.

45.

Mass spectrometry-based methods for biomarker detection and analysis.

von Neuhoff N, Pich A.

Drug Discov Today Technol. 2005 Winter;2(4):361-7. doi: 10.1016/j.ddtec.2005.11.011.

PMID:
24982013
46.

Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519.

Rudolph C, Steinemann D, Von Neuhoff N, Gadzicki D, Ripperger T, Drexler HG, Mrasek K, Liehr T, Claussen U, Emura M, Schrock E, Schlegelberger B.

Cancer Genet Cytogenet. 2004 Sep;153(2):144-50.

PMID:
15350304
47.

Tumor cells escape suicide gene therapy by genetic and epigenetic instability.

Frank O, Rudolph C, Heberlein C, von Neuhoff N, Schröck E, Schambach A, Schlegelberger B, Fehse B, Ostertag W, Stocking C, Baum C.

Blood. 2004 Dec 1;104(12):3543-9. Epub 2004 Aug 12.

48.

Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR.

Ritgen M, Stilgenbauer S, von Neuhoff N, Humpe A, Brüggemann M, Pott C, Raff T, Kröber A, Bunjes D, Schlenk R, Schmitz N, Döhner H, Kneba M, Dreger P.

Blood. 2004 Oct 15;104(8):2600-2. Epub 2004 Jun 17.

49.

Effects of BisGMA on glutathione metabolism and apoptosis in human gingival fibroblasts in vitro.

Engelmann J, Janke V, Volk J, Leyhausen G, von Neuhoff N, Schlegelberger B, Geurtsen W.

Biomaterials. 2004 Aug;25(19):4573-80.

PMID:
15120502
50.

TEGDMA causes apoptosis in primary human gingival fibroblasts.

Janke V, von Neuhoff N, Schlegelberger B, Leyhausen G, Geurtsen W.

J Dent Res. 2003 Oct;82(10):814-8.

PMID:
14514762

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