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Items: 22


Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons.

Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R.

Immunity. 2019 Aug 27. pii: S1074-7613(19)30323-1. doi: 10.1016/j.immuni.2019.07.007. [Epub ahead of print]


The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond.

Ting HA, von Moltke J.

J Immunol. 2019 Mar 1;202(5):1321-1329. doi: 10.4049/jimmunol.1801069. Review.


CIRCling the wagons to protect intestinal stem cells.

Soveg F, von Moltke J, Savan R.

Nat Immunol. 2019 Feb;20(2):114-116. doi: 10.1038/s41590-018-0302-0. No abstract available.


The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.

Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA.

Sci Immunol. 2018 Oct 5;3(28). pii: eaat9453. doi: 10.1126/sciimmunol.aat9453.


Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.

Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18.


Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J.

Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016.


A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM.

Cell. 2018 Jul 12;174(2):271-284.e14. doi: 10.1016/j.cell.2018.05.014. Epub 2018 Jun 7.


Interpreting heterogeneity in intestinal tuft cell structure and function.

Banerjee A, McKinley ET, von Moltke J, Coffey RJ, Lau KS.

J Clin Invest. 2018 May 1;128(5):1711-1719. doi: 10.1172/JCI120330. Epub 2018 May 1. Review.


NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease.

Nichols RD, von Moltke J, Vance RE.

Nat Commun. 2017 Dec 20;8(1):2209. doi: 10.1038/s41467-017-02266-w.


MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM.

J Exp Med. 2017 Dec 4;214(12):3627-3643. doi: 10.1084/jem.20170545. Epub 2017 Nov 9.


Sentinels of the Type 2 Immune Response.

von Moltke J, Pepper M.

Trends Immunol. 2018 Feb;39(2):99-111. doi: 10.1016/ Epub 2017 Nov 6. Review.


NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE.

Immunity. 2017 Apr 18;46(4):649-659. doi: 10.1016/j.immuni.2017.03.016. Epub 2017 Apr 11.


Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.

von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM.

J Exp Med. 2017 Jan;214(1):27-37. doi: 10.1084/jem.20161274. Epub 2016 Dec 23.


Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.

von Moltke J, Ji M, Liang HE, Locksley RM.

Nature. 2016 Jan 14;529(7585):221-5. doi: 10.1038/nature16161. Epub 2015 Dec 14.


I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.

von Moltke J, Locksley RM.

Curr Opin Immunol. 2014 Dec;31:58-65. doi: 10.1016/j.coi.2014.09.009. Epub 2014 Oct 13. Review.


Type 2 innate lymphoid cells control eosinophil homeostasis.

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM.

Nature. 2013 Oct 10;502(7470):245-8. doi: 10.1038/nature12526. Epub 2013 Sep 15.


Recognition of bacteria by inflammasomes.

von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE.

Annu Rev Immunol. 2013;31:73-106. doi: 10.1146/annurev-immunol-032712-095944. Epub 2012 Nov 26. Review.


Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.


Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.

Broz P, von Moltke J, Jones JW, Vance RE, Monack DM.

Cell Host Microbe. 2010 Dec 16;8(6):471-83. doi: 10.1016/j.chom.2010.11.007.


The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.

Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.


Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.

Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE.

Nat Immunol. 2008 Oct;9(10):1171-8. doi: 10.1038/ni.1646. Epub 2008 Aug 24.


Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency.

Quinzii CM, López LC, Von-Moltke J, Naini A, Krishna S, Schuelke M, Salviati L, Navas P, DiMauro S, Hirano M.

FASEB J. 2008 Jun;22(6):1874-85. doi: 10.1096/fj.07-100149. Epub 2008 Jan 29.

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