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Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity.

Enkirch T, Sauber S, Anderson DE, Gan ES, Kenanov D, Maurer-Stroh S, von Messling V.

Front Immunol. 2019 Jun 5;10:1097. doi: 10.3389/fimmu.2019.01097. eCollection 2019.


Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.

Anderson DE, Pfeffermann K, Kim SY, Sawatsky B, Pearson J, Kovtun M, Corcoran DL, Krebs Y, Sigmundsson K, Jamison SF, Yeo ZZJ, Rennick LJ, Wang LF, Talbot PJ, Duprex WP, Garcia-Blanco MA, von Messling V.

MBio. 2019 May 14;10(3). pii: e00826-19. doi: 10.1128/mBio.00826-19.


Generation of therapeutic antisera for emerging viral infections.

Schmidt R, Beltzig LC, Sawatsky B, Dolnik O, Dietzel E, Krähling V, Volz A, Sutter G, Becker S, von Messling V.

NPJ Vaccines. 2018 Oct 5;3:42. doi: 10.1038/s41541-018-0082-4. eCollection 2018.


Neuraminidase-Inhibiting Antibody Titers Correlate with Protection from Heterologous Influenza Virus Strains of the Same Neuraminidase Subtype.

Walz L, Kays SK, Zimmer G, von Messling V.

J Virol. 2018 Aug 16;92(17). pii: e01006-18. doi: 10.1128/JVI.01006-18. Print 2018 Sep 1.


Canine Distemper Virus Spread and Transmission to Naive Ferrets: Selective Pressure on Signaling Lymphocyte Activation Molecule-Dependent Entry.

Sawatsky B, Cattaneo R, von Messling V.

J Virol. 2018 Jul 17;92(15). pii: e00669-18. doi: 10.1128/JVI.00669-18. Print 2018 Aug 1.


Morbillivirus Pathogenesis and Virus-Host Interactions.

Pfeffermann K, Dörr M, Zirkel F, von Messling V.

Adv Virus Res. 2018;100:75-98. doi: 10.1016/bs.aivir.2017.12.003. Epub 2018 Feb 1. Review.


The Unstructured Paramyxovirus Nucleocapsid Protein Tail Domain Modulates Viral Pathogenesis through Regulation of Transcriptase Activity.

Thakkar VD, Cox RM, Sawatsky B, da Fontoura Budaszewski R, Sourimant J, Wabbel K, Makhsous N, Greninger AL, von Messling V, Plemper RK.

J Virol. 2018 Mar 28;92(8). pii: e02064-17. doi: 10.1128/JVI.02064-17. Print 2018 Apr 15.


Zika virus infection elicits auto-antibodies to C1q.

Koma T, Veljkovic V, Anderson DE, Wang LF, Rossi SL, Shan C, Shi PY, Beasley DW, Bukreyeva N, Smith JN, Hallam S, Huang C, von Messling V, Paessler S.

Sci Rep. 2018 Jan 30;8(1):1882. doi: 10.1038/s41598-018-20185-8.


Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection.

McAuley AJ, Sawatsky B, Ksiazek T, Torres M, Korva M, Lotrič-Furlan S, Avšič-Županc T, von Messling V, Holbrook MR, Freiberg AN, Beasley DWC, Bente DA.

NPJ Vaccines. 2017 Mar 13;2:5. doi: 10.1038/s41541-017-0009-5. eCollection 2017.


Nectin-4 Interactions Govern Measles Virus Virulence in a New Model of Pathogenesis, the Squirrel Monkey (Saimiri sciureus).

Delpeut S, Sawatsky B, Wong XX, Frenzke M, Cattaneo R, von Messling V.

J Virol. 2017 May 12;91(11). pii: e02490-16. doi: 10.1128/JVI.02490-16. Print 2017 Jun 1.


Inactivated Recombinant Rabies Viruses Displaying Canine Distemper Virus Glycoproteins Induce Protective Immunity against Both Pathogens.

da Fontoura Budaszewski R, Hudacek A, Sawatsky B, Krämer B, Yin X, Schnell MJ, von Messling V.

J Virol. 2017 Mar 29;91(8). pii: e02077-16. doi: 10.1128/JVI.02077-16. Print 2017 Apr 15.


Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.

da Fontoura Budaszewski R, von Messling V.

Viruses. 2016 Oct 11;8(10). pii: E274. Review.


Squalene-containing licensed adjuvants enhance strain-specific antibody responses against the influenza hemagglutinin and induce subtype-specific antibodies against the neuraminidase.

Schmidt R, Holznagel E, Neumann B, Alex N, Sawatsky B, Enkirch T, Pfeffermann K, Kruip C, von Messling V, Wagner R.

Vaccine. 2016 Oct 17;34(44):5329-5335. doi: 10.1016/j.vaccine.2016.08.082. Epub 2016 Sep 8.


Morbillivirus and henipavirus attachment protein cytoplasmic domains differently affect protein expression, fusion support and particle assembly.

Sawatsky B, Bente DA, Czub M, von Messling V.

J Gen Virol. 2016 May;97(5):1066-76. doi: 10.1099/jgv.0.000415. Epub 2016 Jan 26.


[Regulatory aspects of the development, licensing, and availability of immunological veterinary medicinal products].

JungbMck C, Werner E, Von Messling V.

Berl Munch Tierarztl Wochenschr. 2015 Nov-Dec;128(11-12):473-7. German.


Nipah Virus Matrix Protein Influences Fusogenicity and Is Essential for Particle Infectivity and Stability.

Dietzel E, Kolesnikova L, Sawatsky B, Heiner A, Weis M, Kobinger GP, Becker S, von Messling V, Maisner A.

J Virol. 2015 Dec 16;90(5):2514-22. doi: 10.1128/JVI.02920-15.


High definition viral vaccine strain identity and stability testing using full-genome population data--The next generation of vaccine quality control.

Höper D, Freuling CM, Müller T, Hanke D, von Messling V, Duchow K, Beer M, Mettenleiter TC.

Vaccine. 2015 Oct 26;33(43):5829-5837. doi: 10.1016/j.vaccine.2015.08.091. Epub 2015 Sep 19.


Novel Furin Inhibitors with Potent Anti-infectious Activity.

Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T.

ChemMedChem. 2015 Jul;10(7):1218-31. doi: 10.1002/cmdc.201500103. Epub 2015 May 14.


Ferret models of viral pathogenesis.

Enkirch T, von Messling V.

Virology. 2015 May;479-480:259-70. doi: 10.1016/j.virol.2015.03.017. Epub 2015 Mar 26. Review.


An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK.

Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517.


Morbillivirus control of the interferon response: relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets.

Svitek N, Gerhauser I, Goncalves C, Grabski E, Döring M, Kalinke U, Anderson DE, Cattaneo R, von Messling V.

J Virol. 2014 Mar;88(5):2941-50. doi: 10.1128/JVI.03076-13. Epub 2013 Dec 26.


Enhanced neutralizing antibody titers and Th1 polarization from a novel Escherichia coli derived pandemic influenza vaccine.

Skibinski DA, Hanson BJ, Lin Y, von Messling V, Jegerlehner A, Tee JB, Chye de H, Wong SK, Ng AA, Lee HY, Au B, Lee BT, Santoso L, Poidinger M, Fairhurst AM, Matter A, Bachmann MF, Saudan P, Connolly JE.

PLoS One. 2013 Oct 18;8(10):e76571. doi: 10.1371/journal.pone.0076571. eCollection 2013.


Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells.

Pothlichet J, Meunier I, Davis BK, Ting JP, Skamene E, von Messling V, Vidal SM.

PLoS Pathog. 2013;9(4):e1003256. doi: 10.1371/journal.ppat.1003256. Epub 2013 Apr 11.


Nectin-4-dependent measles virus spread to the cynomolgus monkey tracheal epithelium: role of infected immune cells infiltrating the lamina propria.

Frenzke M, Sawatsky B, Wong XX, Delpeut S, Mateo M, Cattaneo R, von Messling V.

J Virol. 2013 Mar;87(5):2526-34. doi: 10.1128/JVI.03037-12. Epub 2012 Dec 19.


Antagonistic pleiotropy and fitness trade-offs reveal specialist and generalist traits in strains of canine distemper virus.

Nikolin VM, Osterrieder K, von Messling V, Hofer H, Anderson D, Dubovi E, Brunner E, East ML.

PLoS One. 2012;7(12):e50955. doi: 10.1371/journal.pone.0050955. Epub 2012 Dec 11.


Virology. A henipavirus vaccine in sight.

von Messling V, Cattaneo R.

Science. 2012 Aug 10;337(6095):651-2. doi: 10.1126/science.1227810. No abstract available.


Membrane fusion-mediated autophagy induction enhances morbillivirus cell-to-cell spread.

Delpeut S, Rudd PA, Labonté P, von Messling V.

J Virol. 2012 Aug;86(16):8527-35. doi: 10.1128/JVI.00807-12. Epub 2012 May 30.


How respiratory viruses overcome mucosal defenses and exploit the unique environment of the respiratory tract.

von Messling VA, Griffin DE.

Curr Opin Virol. 2012 Jun;2(3):221-4. doi: 10.1016/j.coviro.2012.04.002. Epub 2012 May 1. No abstract available.


Recombinant canine distemper virus strain Snyder Hill expressing green or red fluorescent proteins causes meningoencephalitis in the ferret.

Ludlow M, Nguyen DT, Silin D, Lyubomska O, de Vries RD, von Messling V, McQuaid S, De Swart RL, Duprex WP.

J Virol. 2012 Jul;86(14):7508-19. doi: 10.1128/JVI.06725-11. Epub 2012 May 2.


Elements in the canine distemper virus M 3' UTR contribute to control of replication efficiency and virulence.

Anderson DE, Castan A, Bisaillon M, von Messling V.

PLoS One. 2012;7(2):e31561. doi: 10.1371/journal.pone.0031561. Epub 2012 Feb 13.


PB1-F2 modulates early host responses but does not affect the pathogenesis of H1N1 seasonal influenza virus.

Meunier I, von Messling V.

J Virol. 2012 Apr;86(8):4271-8. doi: 10.1128/JVI.07243-11. Epub 2012 Feb 8.


Canine distemper virus epithelial cell infection is required for clinical disease but not for immunosuppression.

Sawatsky B, Wong XX, Hinkelmann S, Cattaneo R, von Messling V.

J Virol. 2012 Apr;86(7):3658-66. doi: 10.1128/JVI.06414-11. Epub 2012 Jan 25.


Productive replication and evolution of HIV-1 in ferret cells.

Fadel HJ, Saenz DT, Guevara R, von Messling V, Peretz M, Poeschla EM.

J Virol. 2012 Feb;86(4):2312-22. doi: 10.1128/JVI.06035-11. Epub 2011 Dec 14.


Local innate immune responses and influenza virus transmission and virulence in ferrets.

Maines TR, Belser JA, Gustin KM, van Hoeven N, Zeng H, Svitek N, von Messling V, Katz JM, Tumpey TM.

J Infect Dis. 2012 Feb 1;205(3):474-85. doi: 10.1093/infdis/jir768. Epub 2011 Dec 9.


A novel ribozyme-based prophylaxis inhibits influenza A virus replication and protects from severe disease.

Motard J, Rouxel R, Paun A, von Messling V, Bisaillon M, Perreault JP.

PLoS One. 2011;6(11):e27327. doi: 10.1371/journal.pone.0027327. Epub 2011 Nov 14.


Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets.

Meunier I, Embury-Hyatt C, Stebner S, Gray M, Bastien N, Li Y, Plummer F, Kobinger GP, von Messling V.

Virology. 2012 Jan 5;422(1):125-31. doi: 10.1016/j.virol.2011.10.018. Epub 2011 Nov 8.


Adherens junction protein nectin-4 is the epithelial receptor for measles virus.

Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB Jr, Cichutek K, von Messling V, Lopez M, Cattaneo R.

Nature. 2011 Nov 2;480(7378):530-3. doi: 10.1038/nature10639.


Envelope-chimeric entry-targeted measles virus escapes neutralization and achieves oncolysis.

Miest TS, Yaiw KC, Frenzke M, Lampe J, Hudacek AW, Springfeld C, von Messling V, Ungerechts G, Cattaneo R.

Mol Ther. 2011 Oct;19(10):1813-20. doi: 10.1038/mt.2011.92. Epub 2011 May 24.


Canine distemper virus matrix protein influences particle infectivity, particle composition, and envelope distribution in polarized epithelial cells and modulates virulence.

Dietzel E, Anderson DE, Castan A, von Messling V, Maisner A.

J Virol. 2011 Jul;85(14):7162-8. doi: 10.1128/JVI.00051-11. Epub 2011 May 4.


NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferrets.

Meunier I, von Messling V.

J Gen Virol. 2011 Jul;92(Pt 7):1635-44. doi: 10.1099/vir.0.032193-0. Epub 2011 Mar 16.


Endogenously expressed matrix protein M1 and nucleoprotein of influenza A are efficiently presented by class I and class II major histocompatibility complexes.

Doucet JD, Forget MA, Grange C, Rouxel RN, Arbour N, von Messling V, Lapointe R.

J Gen Virol. 2011 May;92(Pt 5):1162-71. doi: 10.1099/vir.0.029777-0. Epub 2011 Feb 9.


Cellular immune response in the presence of protective antibody levels correlates with protection against 1918 influenza in ferrets.

Pillet S, Kobasa D, Meunier I, Gray M, Laddy D, Weiner DB, von Messling V, Kobinger GP.

Vaccine. 2011 Sep 9;29(39):6793-801. doi: 10.1016/j.vaccine.2010.12.059. Epub 2011 Jan 4.


Viral infectivity and intracellular distribution of matrix (M) protein of canine distemper virus are affected by actin filaments.

Klauschies F, Gützkow T, Hinkelmann S, von Messling V, Vaske B, Herrler G, Haas L.

Arch Virol. 2010 Sep;155(9):1503-8. doi: 10.1007/s00705-010-0737-6. Epub 2010 Jul 13.


Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus.

Kobinger GP, Meunier I, Patel A, Pillet S, Gren J, Stebner S, Leung A, Neufeld JL, Kobasa D, von Messling V.

J Infect Dis. 2010 Apr 1;201(7):1000-6. doi: 10.1086/651171.


Canine distemper viruses expressing a hemagglutinin without N-glycans lose virulence but retain immunosuppression.

Sawatsky B, von Messling V.

J Virol. 2010 Mar;84(6):2753-61. doi: 10.1128/JVI.01813-09. Epub 2009 Dec 30.


Acute canine distemper encephalitis is associated with rapid neuronal loss and local immune activation.

Rudd PA, Bastien-Hamel LE, von Messling V.

J Gen Virol. 2010 Apr;91(Pt 4):980-9. doi: 10.1099/vir.0.017780-0. Epub 2009 Dec 16.


Influenza pathogenesis: lessons learned from animal studies with H5N1, H1N1 Spanish, and pandemic H1N1 2009 influenza.

Meunier I, Pillet S, Simonsen JN, von Messling V.

Crit Care Med. 2010 Apr;38(4 Suppl):e21-9. doi: 10.1097/CCM.0b013e3181c8b4d5.


A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.

Rouxel RN, Svitek N, von Messling V.

Vaccine. 2009 Aug 6;27(36):4961-6. doi: 10.1016/j.vaccine.2009.05.096. Epub 2009 Jun 18.


Canine distemper virus selectively inhibits apoptosis progression in infected immune cells.

Pillet S, von Messling V.

J Virol. 2009 Jun;83(12):6279-87. doi: 10.1128/JVI.00050-09. Epub 2009 Apr 8.


Ferrets as a model for morbillivirus pathogenesis, complications, and vaccines.

Pillet S, Svitek N, von Messling V.

Curr Top Microbiol Immunol. 2009;330:73-87. Review.


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