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Items: 1 to 50 of 84

1.

New methods for extracting function from the mammalian genome.

Francis Stewart A, von Melchner H.

Methods. 2019 Jul 15;164-165:1-2. doi: 10.1016/j.ymeth.2019.06.026. Epub 2019 Jun 29. No abstract available.

PMID:
31265889
2.

CRISPR/Cas9-mediated generic protein tagging in mammalian cells.

Thöne FMB, Kurrle NS, von Melchner H, Schnütgen F.

Methods. 2019 Jul 15;164-165:59-66. doi: 10.1016/j.ymeth.2019.02.018. Epub 2019 Feb 22.

PMID:
30797903
3.

CRISPR/Cas9 genome engineering in hematopoietic cells.

Sürün D, von Melchner H, Schnütgen F.

Drug Discov Today Technol. 2018 Aug;28:33-39. doi: 10.1016/j.ddtec.2018.08.001. Epub 2018 Aug 25. Review.

4.

Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells.

Cencioni C, Spallotta F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehage M, Sürün D, Siragusa M, Smith JG, Schnütgen F, von Melchner H, Rieger MA, Martelli F, Riccio A, Fleming I, Braun T, Zeiher AM, Farsetti A, Gaetano C.

Nat Commun. 2018 Mar 29;9(1):1281. doi: 10.1038/s41467-018-03668-0.

5.

High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing.

Sürün D, Schwäble J, Tomasovic A, Ehling R, Stein S, Kurrle N, von Melchner H, Schnütgen F.

Mol Ther Nucleic Acids. 2018 Mar 2;10:1-8. doi: 10.1016/j.omtn.2017.11.001. Epub 2017 Nov 10.

6.

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation.

Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Sürün D, Schnütgen F, von Melchner H, Di Stilo A, Aragno M, Braspenning M, van Criekinge W, De Blasio MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C.

Circ Res. 2018 Jan 5;122(1):31-46. doi: 10.1161/CIRCRESAHA.117.311300. Epub 2017 Nov 20.

PMID:
29158345
7.

Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping.

Strassman A, Schnütgen F, Dai Q, Jones JC, Gomez AC, Pitstick L, Holton NE, Moskal R, Leslie ER, von Melchner H, Beier DR, Bjork BC.

Dis Model Mech. 2017 Jul 1;10(7):909-922. doi: 10.1242/dmm.029561. Epub 2017 Apr 19.

8.

Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development.

Fujikawa Y, Yoshida H, Inoue T, Ohbayashi T, Noda K, von Melchner H, Iwasaka T, Shiojima I, Akama TO, Nakamura T.

Sci Rep. 2017 Mar 2;7:43714. doi: 10.1038/srep43714.

9.

Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.

Tomasovic A, Kurrle N, Wempe F, De-Zolt S, Scheibe S, Koli K, Serchinger M, Schnütgen F, Sürün D, Sterner-Kock A, Weissmann N, von Melchner H.

Matrix Biol. 2017 May;59:109-120. doi: 10.1016/j.matbio.2016.09.006. Epub 2016 Sep 17.

10.

Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice.

Bultmann-Mellin I, Essers J, van Heijingen PM, von Melchner H, Sengle G, Sterner-Kock A.

Dis Model Mech. 2016 Nov 1;9(11):1367-1374. Epub 2016 Sep 1.

11.

Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.

Rabenhorst U, Thalheimer FB, Gerlach K, Kijonka M, Böhm S, Krause DS, Vauti F, Arnold HH, Schroeder T, Schnütgen F, von Melchner H, Rieger MA, Zörnig M.

Cell Rep. 2015 Jun 30;11(12):1847-55. doi: 10.1016/j.celrep.2015.05.038. Epub 2015 Jun 18.

12.

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H.

J Biol Chem. 2015 Apr 10;290(15):9738-52. doi: 10.1074/jbc.M114.632133. Epub 2015 Feb 25.

13.

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.

Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A.

Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20.

14.

Gene targeting and site-specific recombination in mouse ES cells.

Anastassiadis K, Schnütgen F, von Melchner H, Stewart AF.

Methods Enzymol. 2013;533:133-55. doi: 10.1016/B978-0-12-420067-8.00009-X.

PMID:
24182921
15.

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.

Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H.

Dis Model Mech. 2013 Nov;6(6):1378-87. doi: 10.1242/dmm.013482. Epub 2013 Aug 29.

16.

Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.

Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Wörz S, Sadic D, Schulte M, Mallm JP, Maiser A, Debs P, von Melchner H, Leonhardt H, Schermelleh L, Rohr K, Rippe K, Storchova Z, Schotta G.

Genes Dev. 2013 Apr 15;27(8):859-72. doi: 10.1101/gad.210377.112. Epub 2013 Apr 18.

17.

Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.

Kallenborn-Gerhardt W, Lu R, Syhr KM, Heidler J, von Melchner H, Geisslinger G, Bangsow T, Schmidtko A.

Antioxid Redox Signal. 2013 Dec 10;19(17):2013-23. doi: 10.1089/ars.2012.4958. Epub 2013 Apr 19.

18.

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.

Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2852-7. doi: 10.1073/pnas.1215779110. Epub 2013 Feb 4.

19.

The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.

Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.

20.

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schmauss G, Schramek D, Schnuetgen F, von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A, Penninger JM.

Cell Stem Cell. 2011 Dec 2;9(6):563-74. doi: 10.1016/j.stem.2011.10.012.

21.

Methods for extracting function from mammalian genomes.

von Melchner H, Stewart AF.

Methods. 2011 Apr;53(4):329-30. doi: 10.1016/j.ymeth.2011.03.002. No abstract available.

PMID:
21392581
22.

High throughput gene trapping and postinsertional modifications of gene trap alleles.

Schnütgen F, Ehrmann F, Ruiz-Noppinger P, von Melchner H.

Methods. 2011 Apr;53(4):347-55. doi: 10.1016/j.ymeth.2010.12.037. Epub 2011 Feb 19.

PMID:
21334922
23.

Resources for proteomics in mouse embryonic stem cells.

Schnütgen F, Ehrmann F, Poser I, Hubner NC, Hansen J, Floss T, deVries I, Wurst W, Hyman A, Mann M, von Melchner H.

Nat Methods. 2011 Feb;8(2):103-4. doi: 10.1038/nmeth0211-103. No abstract available.

PMID:
21278719
24.

Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.

Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T.

Nucleic Acids Res. 2010 May;38(9):e106. doi: 10.1093/nar/gkq044. Epub 2010 Feb 5.

25.

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J, von Melchner H.

Dis Model Mech. 2010 Mar-Apr;3(3-4):246-53. doi: 10.1242/dmm.004234. Epub 2010 Jan 27.

26.

Gene-trap vectors and mutagenesis.

De-Zolt S, Altschmied J, Ruiz P, von Melchner H, Schnütgen F.

Methods Mol Biol. 2009;530:29-47. doi: 10.1007/978-1-59745-471-1_3.

PMID:
19266330
27.

Unsung hero Robert C. Gallo.

Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D.

Science. 2009 Jan 9;323(5911):206-7. doi: 10.1126/science.323.5911.206. No abstract available.

PMID:
19131607
28.

Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity.

Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, von Melchner H, Davis EC, Rifkin DB.

J Cell Physiol. 2009 Apr;219(1):14-22. doi: 10.1002/jcp.21643.

29.

Wnt/beta-catenin signaling controls development of the blood-brain barrier.

Liebner S, Corada M, Bangsow T, Babbage J, Taddei A, Czupalla CJ, Reis M, Felici A, Wolburg H, Fruttiger M, Taketo MM, von Melchner H, Plate KH, Gerhardt H, Dejana E.

J Cell Biol. 2008 Nov 3;183(3):409-17. doi: 10.1083/jcb.200806024. Epub 2008 Oct 27.

30.

Enhanced gene trapping in mouse embryonic stem cells.

Schnütgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H.

Nucleic Acids Res. 2008 Nov;36(20):e133. doi: 10.1093/nar/gkn603. Epub 2008 Sep 23.

31.

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K.

Cancer Cell. 2008 May;13(5):407-19. doi: 10.1016/j.ccr.2008.02.020.

32.

The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier.

Bangsow T, Baumann E, Bangsow C, Jaeger MH, Pelzer B, Gruhn P, Wolf S, von Melchner H, Stanimirovic DB.

J Cereb Blood Flow Metab. 2008 Jun;28(6):1249-60. doi: 10.1038/jcbfm.2008.19. Epub 2008 Apr 2.

PMID:
18382472
33.

Splinkerette PCR for more efficient characterization of gene trap events.

Horn C, Hansen J, Schnütgen F, Seisenberger C, Floss T, Irgang M, De-Zolt S, Wurst W, von Melchner H, Noppinger PR.

Nat Genet. 2007 Aug;39(8):933-4. No abstract available. Erratum in: Nat Genet. 2007 Dec;39(12):1528.

PMID:
17660805
34.

Engineering embryonic stem cells with recombinase systems.

Schnütgen F, Stewart AF, von Melchner H, Anastassiadis K.

Methods Enzymol. 2006;420:100-36.

PMID:
17161696
35.

Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death.

Lutz M, Wempe F, Bahr I, Zopf D, von Melchner H.

FEBS Lett. 2006 Jul 10;580(16):3921-30. Epub 2006 Jun 21.

36.

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.

De-Zolt S, Schnütgen F, Seisenberger C, Hansen J, Hollatz M, Floss T, Ruiz P, Wurst W, von Melchner H.

Nucleic Acids Res. 2006 Feb 13;34(3):e25.

37.

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.

Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D642-8.

38.

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.

Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7221-6. Epub 2005 May 3.

39.

TGF-beta activation by traction?

Keski-Oja J, Koli K, von Melchner H.

Trends Cell Biol. 2004 Dec;14(12):657-9. Review.

PMID:
15564041
40.

Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.

Koli K, Wempe F, Sterner-Kock A, Kantola A, Komor M, Hofmann WK, von Melchner H, Keski-Oja J.

J Cell Biol. 2004 Oct 11;167(1):123-33. Epub 2004 Oct 4.

41.

The European dimension for the mouse genome mutagenesis program.

Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Müller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W.

Nat Genet. 2004 Sep;36(9):925-7. Erratum in: Nat Genet. 2004 Nov;36(11):1238.

42.

The knockout mouse project.

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B.

Nat Genet. 2004 Sep;36(9):921-4.

43.

A public gene trap resource for mouse functional genomics.

Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J; International Gene Trap Consortium.

Nat Genet. 2004 Jun;36(6):543-4. No abstract available.

44.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22. Epub 2003 Aug 6.

45.

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.

Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H.

Genes Dev. 2002 Sep 1;16(17):2264-73.

46.
47.

Self-deleting suicide vectors (SDSV): selective killing of p53-deficient cancer cells.

Andreú T, Ebensperger C, Westphal EM, Klenner T, Stewart AF, Westhof A, Müller P, Knaus R, von Melchner H.

Cancer Res. 2001 Sep 15;61(18):6925-30.

48.

Gene trapping identifies transiently induced survival genes during programmed cell death.

Wempe F, Yang JY, Hammann J, von Melchner H.

Genome Biol. 2001;2(7):RESEARCH0023. Epub 2001 Jun 27.

49.

New vectors for gene therapy.

Grez M, von Melchner H.

Stem Cells. 1998;16 Suppl 1:235-43.

50.

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.

Wiles MV, Vauti F, Otte J, Füchtbauer EM, Ruiz P, Füchtbauer A, Arnold HH, Lehrach H, Metz T, von Melchner H, Wurst W.

Nat Genet. 2000 Jan;24(1):13-4. No abstract available.

PMID:
10615117

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