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Items: 1 to 50 of 55

1.

Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization.

Kasper MA, Glanz M, Oder A, Schmieder P, von Kries JP, Hackenberger CPR.

Chem Sci. 2019 May 16;10(25):6322-6329. doi: 10.1039/c9sc01345h. eCollection 2019 Jul 7.

2.

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.

Ullrich F, Blin S, Lazarow K, Daubitz T, von Kries JP, Jentsch TJ.

Elife. 2019 Jul 18;8. pii: e49187. doi: 10.7554/eLife.49187.

3.

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.

Merkert S, Schubert M, Olmer R, Engels L, Radetzki S, Veltman M, Scholte BJ, Zöllner J, Pedemonte N, Galietta LJV, von Kries JP, Martin U.

Stem Cell Reports. 2019 Jun 11;12(6):1389-1403. doi: 10.1016/j.stemcr.2019.04.014. Epub 2019 May 9.

4.

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P.

SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7.

PMID:
30616481
5.

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.

Klein W, Rutz C, Eckhard J, Provinciael B, Specker E, Neuenschwander M, Kleinau G, Scheerer P, von Kries JP, Nazaré M, Vermeire K, Schülein R.

PLoS One. 2018 Dec 13;13(12):e0208641. doi: 10.1371/journal.pone.0208641. eCollection 2018.

6.

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.

Marcinkowski P, Hoyer I, Specker E, Furkert J, Rutz C, Neuenschwander M, Sobottka S, Sun H, Nazare M, Berchner-Pfannschmidt U, von Kries JP, Eckstein A, Schülein R, Krause G.

Thyroid. 2019 Jan;29(1):111-123. doi: 10.1089/thy.2018.0349. Epub 2018 Dec 15.

PMID:
30351237
7.

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.

Otten C, Knox J, Boulday G, Eymery M, Haniszewski M, Neuenschwander M, Radetzki S, Vogt I, Hähn K, De Luca C, Cardoso C, Hamad S, Igual Gil C, Roy P, Albiges-Rizo C, Faurobert E, von Kries JP, Campillos M, Tournier-Lasserve E, Derry WB, Abdelilah-Seyfried S.

EMBO Mol Med. 2018 Oct;10(10). pii: e9155. doi: 10.15252/emmm.201809155.

8.

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Liss M, Radke MH, Eckhard J, Neuenschwander M, Dauksaite V, von Kries JP, Gotthardt M.

PLoS One. 2018 Jun 11;13(6):e0198492. doi: 10.1371/journal.pone.0198492. eCollection 2018.

9.

Loss-of-function uORF mutations in human malignancies.

Schulz J, Mah N, Neuenschwander M, Kischka T, Ratei R, Schlag PM, Castaños-Vélez E, Fichtner I, Tunn PU, Denkert C, Klaas O, Berdel WE, von Kries JP, Makalowski W, Andrade-Navarro MA, Leutz A, Wethmar K.

Sci Rep. 2018 Feb 5;8(1):2395. doi: 10.1038/s41598-018-19201-8.

10.

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E.

PLoS One. 2018 Jan 26;13(1):e0191423. doi: 10.1371/journal.pone.0191423. eCollection 2018.

11.

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M.

J Med Chem. 2017 Dec 28;60(24):10013-10025. doi: 10.1021/acs.jmedchem.7b00883. Epub 2017 Dec 8.

PMID:
29155568
12.

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.

Fetzer C, Korotkov VS, Thänert R, Lee KM, Neuenschwander M, von Kries JP, Medina E, Sieber SA.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15746-15750. doi: 10.1002/anie.201708454. Epub 2017 Oct 12.

PMID:
28906057
13.

Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of aqp-8 in C. elegans.

Igual Gil C, Jarius M, von Kries JP, Rohlfing AK.

Front Physiol. 2017 Jun 9;8:380. doi: 10.3389/fphys.2017.00380. eCollection 2017.

14.

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

Juneja M, Kobelt D, Walther W, Voss C, Smith J, Specker E, Neuenschwander M, Gohlke BO, Dahlmann M, Radetzki S, Preissner R, von Kries JP, Schlag PM, Stein U.

PLoS Biol. 2017 Jun 1;15(6):e2000784. doi: 10.1371/journal.pbio.2000784. eCollection 2017 Jun.

15.

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

Carter DM, Specker E, Przygodda J, Neuenschwander M, von Kries JP, Heinemann U, Nazaré M, Gohlke U.

SLAS Discov. 2017 Aug;22(7):801-812. doi: 10.1177/2472555217699157. Epub 2017 Mar 27.

PMID:
28346812
16.

Small Molecules Targeting Human N-Acetylmannosamine Kinase.

Hinderlich S, Neuenschwander M, Wratil PR, Oder A, Lisurek M, Nguyen LD, von Kries JP, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1279-1285. doi: 10.1002/cbic.201700066. Epub 2017 Apr 27.

PMID:
28346741
17.

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR.

Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12.

PMID:
27941788
18.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.

J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.

19.

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.

Du J, Neuenschwander M, Yu Y, Däbritz JH, Neuendorff NR, Schleich K, Bittner A, Milanovic M, Beuster G, Radetzki S, Specker E, Reimann M, Rosenbauer F, Mathas S, Lohneis P, Hummel M, Dörken B, von Kries JP, Lee S, Schmitt CA.

Blood. 2017 Jan 5;129(1):71-81. doi: 10.1182/blood-2016-02-700773. Epub 2016 Oct 12.

PMID:
27733358
20.

A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis.

Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, von Kries JP, Birchmeier W.

Cancer Res. 2016 Feb 15;76(4):891-901. doi: 10.1158/0008-5472.CAN-15-1519. Epub 2015 Dec 8.

21.

Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.

Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R.

Chembiochem. 2016 Jan 1;17(1):90-101. doi: 10.1002/cbic.201500420. Epub 2015 Nov 20.

PMID:
26478560
22.

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.

Grosskopf S, Eckert C, Arkona C, Radetzki S, Böhm K, Heinemann U, Wolber G, von Kries JP, Birchmeier W, Rademann J.

ChemMedChem. 2015 May;10(5):815-26. doi: 10.1002/cmdc.201500015. Epub 2015 Apr 15.

PMID:
25877780
23.

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T, Jentsch TJ.

Science. 2014 May 9;344(6184):634-8. doi: 10.1126/science.1252826. Epub 2014 Apr 10.

24.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

25.

Small-molecule screening identifies modulators of aquaporin-2 trafficking.

Bogum J, Faust D, Zühlke K, Eichhorst J, Moutty MC, Furkert J, Eldahshan A, Neuenschwander M, von Kries JP, Wiesner B, Trimpert C, Deen PM, Valenti G, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2013 Apr;24(5):744-58. doi: 10.1681/ASN.2012030295. Epub 2013 Apr 4.

26.

Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression.

Habermann K, Mirgorodskaya E, Gobom J, Lehmann V, Müller H, Blümlein K, Deery MJ, Czogiel I, Erdmann C, Ralser M, von Kries JP, Lange BM.

Mol Cell Biol. 2012 Sep;32(17):3554-69. doi: 10.1128/MCB.00814-12. Epub 2012 Jul 2.

27.

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S.

Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22.

28.
29.

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, MacGregor KA, Tomilin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kräusslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V.

Cell. 2011 Aug 5;146(3):471-84. doi: 10.1016/j.cell.2011.06.025. Erratum in: Cell. 2011 Sep 2;146(5):841. Tomlin, Nikolay [corrected to Tomilin, Nikolay].

30.

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis.

Due AV, Kuper J, Geerlof A, von Kries JP, Wilmanns M.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3554-9. doi: 10.1073/pnas.1015996108. Epub 2011 Feb 14.

31.

Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase.

Bleif S, Hannemann F, Lisurek M, von Kries JP, Zapp J, Dietzen M, Antes I, Bernhardt R.

Chembiochem. 2011 Mar 7;12(4):576-82. doi: 10.1002/cbic.201000404. Epub 2011 Jan 26.

PMID:
21271628
32.

Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.

Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, Gradl D, Paulsen JE, Machonova O, Dembinski JL, Dinh H, Krauss S.

Cancer Res. 2011 Jan 1;71(1):197-205. doi: 10.1158/0008-5472.CAN-10-1282.

33.

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.

Christian F, Szaszák M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Götz F, Zühlke K, Moutty M, Göttert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gáspár R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E.

J Biol Chem. 2011 Mar 18;286(11):9079-96. doi: 10.1074/jbc.M110.160614. Epub 2010 Dec 22.

34.

The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction.

Choi M, Eulenberg C, Rolle S, von Kries JP, Luft FC, Kettritz R.

Clin Exp Immunol. 2010 Aug;161(2):389-96. doi: 10.1111/j.1365-2249.2010.04174.x. Epub 2010 May 7.

35.

Identification of small-molecule scaffolds for p450 inhibitors.

von Kries JP, Warrier T, Podust LM.

Curr Protoc Microbiol. 2010 Feb;Chapter 17:Unit17.4. doi: 10.1002/9780471729259.mc1704s16.

36.

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.

Lisurek M, Rupp B, Wichard J, Neuenschwander M, von Kries JP, Frank R, Rademann J, Kühne R.

Mol Divers. 2010 May;14(2):401-8. doi: 10.1007/s11030-009-9187-z. Epub 2009 Aug 15.

PMID:
19685275
37.

Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.

Podust LM, Ouellet H, von Kries JP, de Montellano PR.

J Biol Chem. 2009 Sep 11;284(37):25211-9. doi: 10.1074/jbc.M109.017632. Epub 2009 Jul 15.

38.

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI.

J Med Chem. 2009 May 14;52(9):2846-53. doi: 10.1021/jm801643b.

39.

Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.

Fetz V, Knauer SK, Bier C, von Kries JP, Stauber RH.

Sensors (Basel). 2009;9(7):5423-45. doi: 10.3390/s90705423. Epub 2009 Jul 9.

40.

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

Hellmuth K, Grosskopf S, Lum CT, Würtele M, Röder N, von Kries JP, Rosario M, Rademann J, Birchmeier W.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80. doi: 10.1073/pnas.0710468105. Epub 2008 May 14.

41.

X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).

Eddine AN, von Kries JP, Podust MV, Warrier T, Kaufmann SH, Podust LM.

J Biol Chem. 2008 May 30;283(22):15152-9. doi: 10.1074/jbc.M801145200. Epub 2008 Mar 26.

42.

Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.

Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, Ouellet H, Warrier T, Alteköster M, Lee JS, Rademann J, Oschkinat H, Kaufmann SH, Waterman MR.

Antimicrob Agents Chemother. 2007 Nov;51(11):3915-23. Epub 2007 Sep 10.

43.

The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.

Mueller-Dieckmann C, Kernstock S, Lisurek M, von Kries JP, Haag F, Weiss MS, Koch-Nolte F.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15026-31. Epub 2006 Oct 2.

44.

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.

Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ.

Biochem J. 2006 May 1;395(3):483-91.

45.

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.

Manger M, Scheck M, Prinz H, von Kries JP, Langer T, Saxena K, Schwalbe H, Fürstner A, Rademann J, Waldmann H.

Chembiochem. 2005 Oct;6(10):1749-53. No abstract available.

PMID:
16196020
46.

The high-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis.

Singh RK, Kefala G, Janowski R, Mueller-Dieckmann C, von Kries JP, Weiss MS.

J Mol Biol. 2005 Feb 11;346(1):1-11. Epub 2004 Dec 23.

PMID:
15663922
47.

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.

von Kries JP, Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, Behrens J, Birchmeier W.

Nat Struct Biol. 2000 Sep;7(9):800-7.

PMID:
10966653
48.

Functional interaction of beta-catenin with the transcription factor LEF-1.

Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W.

Nature. 1996 Aug 15;382(6592):638-42.

PMID:
8757136
49.

Nuclear matrix protein ARBP recognizes a novel DNA sequence motif with high affinity.

Buhrmester H, von Kries JP, Strätling WH.

Biochemistry. 1995 Mar 28;34(12):4108-117.

PMID:
7696275
50.

Chicken MAR binding protein p120 is identical to human heterogeneous nuclear ribonucleoprotein (hnRNP) U.

von Kries JP, Buck F, Strätling WH.

Nucleic Acids Res. 1994 Apr 11;22(7):1215-20.

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