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Items: 1 to 50 of 104

1.

An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights.

Köse M, Pillaiyar T, Namasivayam V, De Filippo E, Sylvester K, Ulven T, von Kügelgen I, Müller CE.

J Med Chem. 2019 Nov 27. doi: 10.1021/acs.jmedchem.9b01339. [Epub ahead of print]

PMID:
31721581
2.

Pharmacology of P2Y receptors.

von Kügelgen I.

Brain Res Bull. 2019 Sep;151:12-24. doi: 10.1016/j.brainresbull.2019.03.010. Epub 2019 Mar 25. Review.

PMID:
30922852
3.

6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).

Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von Kügelgen I, Müller CE.

ACS Omega. 2018 Mar 31;3(3):3365-3383. doi: 10.1021/acsomega.7b02092. Epub 2018 Mar 20.

4.

Letter by Cattaneo and von Kügelgen Regarding Article, "International Expert Consensus on Switching Platelet P2Y12 Receptor-Inhibiting Therapies".

Cattaneo M, von Kügelgen I.

Circulation. 2018 May 22;137(21):2309. doi: 10.1161/CIRCULATIONAHA.117.033379. No abstract available.

PMID:
29784689
5.

Structure, Pharmacology and Roles in Physiology of the P2Y12 Receptor.

von Kügelgen I.

Adv Exp Med Biol. 2017;1051:123-138. doi: 10.1007/5584_2017_98. Review.

PMID:
28921447
6.

Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.

Pillaiyar T, Köse M, Sylvester K, Weighardt H, Thimm D, Borges G, Förster I, von Kügelgen I, Müller CE.

J Med Chem. 2017 May 11;60(9):3636-3655. doi: 10.1021/acs.jmedchem.6b01593. Epub 2017 May 1.

PMID:
28406627
7.

Pharmacology and structure of P2Y receptors.

von Kügelgen I, Hoffmann K.

Neuropharmacology. 2016 May;104:50-61. doi: 10.1016/j.neuropharm.2015.10.030. Epub 2015 Oct 28. Review.

PMID:
26519900
8.

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information.

Paoletta S, Sabbadin D, von Kügelgen I, Hinz S, Katritch V, Hoffmann K, Abdelrahman A, Straßburger J, Baqi Y, Zhao Q, Stevens RC, Moro S, Müller CE, Jacobson KA.

J Comput Aided Mol Des. 2015 Aug;29(8):737-56. doi: 10.1007/s10822-015-9858-z. Epub 2015 Jul 21.

9.

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.

Gnad T, Scheibler S, von Kügelgen I, Scheele C, Kilić A, Glöde A, Hoffmann LS, Reverte-Salisa L, Horn P, Mutlu S, El-Tayeb A, Kranz M, Deuther-Conrad W, Brust P, Lidell ME, Betz MJ, Enerbäck S, Schrader J, Yegutkin GG, Müller CE, Pfeifer A.

Nature. 2014 Dec 18;516(7531):395-9. doi: 10.1038/nature13816. Epub 2014 Oct 15.

PMID:
25317558
10.

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor.

Hoffmann K, Lutz DA, Straßburger J, Baqi Y, Müller CE, von Kügelgen I.

J Thromb Haemost. 2014 Nov;12(11):1898-905. doi: 10.1111/jth.12719. Epub 2014 Sep 29.

11.

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.

Horváth G, Gölöncsér F, Csölle C, Király K, Andó RD, Baranyi M, Koványi B, Máté Z, Hoffmann K, Algaier I, Baqi Y, Müller CE, Von Kügelgen I, Sperlágh B.

Neurobiol Dis. 2014 Oct;70:162-78. doi: 10.1016/j.nbd.2014.06.011. Epub 2014 Jun 25.

12.

Dual regulation of β2-adrenoceptor messenger RNA expression in human lung fibroblasts by β2-cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression.

Kämpfer N, Lamyel F, Schütz I, Warnken M, Hoffmann K, von Kügelgen I, Racké K.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Jul;387(7):649-57. doi: 10.1007/s00210-014-0971-7. Epub 2014 Apr 8.

13.

P2X1 receptor-mediated inhibition of the proliferation of human coronary smooth muscle cells involving the transcription factor NR4A1.

Hinze AV, Mayer P, Harst A, von Kügelgen I.

Purinergic Signal. 2013 Dec;9(4):677-86. doi: 10.1007/s11302-013-9380-5. Epub 2013 Jul 20.

14.

Characterization of new G protein-coupled adenine receptors in mouse and hamster.

Thimm D, Knospe M, Abdelrahman A, Moutinho M, Alsdorf BB, von Kügelgen I, Schiedel AC, Müller CE.

Purinergic Signal. 2013 Sep;9(3):415-26. doi: 10.1007/s11302-013-9360-9. Epub 2013 Apr 23.

15.

The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site.

Knospe M, Müller CE, Rosa P, Abdelrahman A, von Kügelgen I, Thimm D, Schiedel AC.

Purinergic Signal. 2013 Sep;9(3):367-81. doi: 10.1007/s11302-013-9355-6. Epub 2013 Feb 15.

16.

Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells.

Hoffmann K, Xifró RA, Hartweg JL, Spitzlei P, Meis K, Molderings GJ, von Kügelgen I.

Eur J Pharmacol. 2013 Jan 30;700(1-3):152-8. doi: 10.1016/j.ejphar.2012.12.003. Epub 2012 Dec 22.

PMID:
23266380
17.

Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes.

Hinze AV, Mayer P, Harst A, von Kügelgen I.

J Mol Cell Cardiol. 2012 Nov;53(5):639-45. doi: 10.1016/j.yjmcc.2012.08.003. Epub 2012 Aug 12.

PMID:
22906537
18.

Molecular pharmacology, physiology, and structure of the P2Y receptors.

von Kügelgen I, Harden TK.

Adv Pharmacol. 2011;61:373-415. doi: 10.1016/B978-0-12-385526-8.00012-6. Review.

PMID:
21586365
19.

A₂B receptors mediate the induction of early genes and inhibition of arterial smooth muscle cell proliferation via Epac.

Mayer P, Hinze AV, Harst A, von Kügelgen I.

Cardiovasc Res. 2011 Apr 1;90(1):148-56. doi: 10.1093/cvr/cvq371. Epub 2010 Nov 25.

PMID:
21109603
20.

Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor.

Hoffmann K, Baqi Y, Morena MS, Glänzel M, Müller CE, von Kügelgen I.

J Pharmacol Exp Ther. 2009 Nov;331(2):648-55. doi: 10.1124/jpet.109.156687. Epub 2009 Aug 18.

PMID:
19690189
21.

In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth.

Pasternack SM, von Kügelgen I, Müller M, Oji V, Traupe H, Sprecher E, Nöthen MM, Janecke AR, Betz RC.

J Invest Dermatol. 2009 Dec;129(12):2772-6. doi: 10.1038/jid.2009.154. Epub 2009 Jun 18.

22.

Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics.

Molderings GJ, Solleder G, Kolck UW, Homann J, Schröder D, von Kügelgen I, Vorreuther R.

Urol Res. 2009 Aug;37(4):227-9. doi: 10.1007/s00240-009-0198-0. Epub 2009 Jun 10.

PMID:
19513706
23.

Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.

Hillmann P, Ko GY, Spinrath A, Raulf A, von Kügelgen I, Wolff SC, Nicholas RA, Kostenis E, Höltje HD, Müller CE.

J Med Chem. 2009 May 14;52(9):2762-75. doi: 10.1021/jm801442p.

PMID:
19419204
24.

Regulatory mechanisms underlying agmatine homeostasis in humans.

Haenisch B, von Kügelgen I, Bönisch H, Göthert M, Sauerbruch T, Schepke M, Marklein G, Höfling K, Schröder D, Molderings GJ.

Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1104-10. doi: 10.1152/ajpgi.90374.2008. Epub 2008 Oct 2.

25.

Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor.

Hoffmann K, Sixel U, Di Pasquale F, von Kügelgen I.

Biochem Pharmacol. 2008 Nov 15;76(10):1201-13. doi: 10.1016/j.bcp.2008.08.029. Epub 2008 Sep 3.

PMID:
18809389
26.

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor.

Algaier I, Jakubowski JA, Asai F, von Kügelgen I.

J Thromb Haemost. 2008 Nov;6(11):1908-14. doi: 10.1111/j.1538-7836.2008.03136.x. Epub 2008 Aug 22.

27.

New aspects of liver abnormalities as part of the systemic mast cell activation syndrome.

Alfter K, von Kügelgen I, Haenisch B, Frieling T, Hülsdonk A, Haars U, Rolfs A, Noe G, Kolck UW, Homann J, Molderings GJ.

Liver Int. 2009 Feb;29(2):181-6. doi: 10.1111/j.1478-3231.2008.01839.x. Epub 2008 Jul 23.

PMID:
18662284
28.

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.

Pasternack SM, von Kügelgen I, Al Aboud K, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC.

Nat Genet. 2008 Mar;40(3):329-34. doi: 10.1038/ng.84. Epub 2008 Feb 24.

PMID:
18297070
29.

Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells.

Molderings GJ, Göthert M, von Kügelgen I.

Pharmacol Rep. 2007 Nov-Dec;59(6):789-94.

30.

Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.

von Kügelgen I, Schiedel AC, Hoffmann K, Alsdorf BB, Abdelrahman A, Müller CE.

Mol Pharmacol. 2008 Feb;73(2):469-77. Epub 2007 Nov 1.

PMID:
17975009
31.

Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder.

Molderings GJ, Kolck UW, Scheurlen C, Brüss M, Homann J, Von Kügelgen I.

Scand J Gastroenterol. 2007 Sep;42(9):1045-53.

PMID:
17710669
32.

S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.

Molderings GJ, Bönisch H, Brüss M, Wolf C, von Kügelgen I, Göthert M.

Neurochem Int. 2007 Dec;51(8):476-85. Epub 2007 May 7.

PMID:
17559976
33.

Cardiac mast cells: implications for heart failure.

Kolck UW, Alfter K, Homann J, von Kügelgen I, Molderings GJ.

J Am Coll Cardiol. 2007 Mar 13;49(10):1107; author reply 1107-8. Epub 2007 Feb 23. No abstract available.

34.

Molecular basis for the antiproliferative effect of agmatine in tumor cells of colonic, hepatic, and neuronal origin.

Wolf C, Brüss M, Hänisch B, Göthert M, von Kügelgen I, Molderings GJ.

Mol Pharmacol. 2007 Jan;71(1):276-83. Epub 2006 Oct 17.

PMID:
17047095
35.
36.

Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.

von Kügelgen I.

Pharmacol Ther. 2006 Jun;110(3):415-32. Epub 2005 Oct 28. Review.

PMID:
16257449
37.

Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.

Gorzalka S, Vittori S, Volpini R, Cristalli G, von Kügelgen I, Müller CE.

Mol Pharmacol. 2005 Mar;67(3):955-64. Epub 2004 Dec 16.

PMID:
15604413
38.

Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.

Mamedova LK, Joshi BV, Gao ZG, von Kügelgen I, Jacobson KA.

Biochem Pharmacol. 2004 May 1;67(9):1763-70.

39.

P2Y-receptors stimulating the proliferation of human mesangial cells through the MAPK42/44 pathway.

Vonend O, Grote T, Oberhauser V, Von Kügelgen I, Rump LC.

Br J Pharmacol. 2003 Jul;139(6):1119-26.

40.

Evidence for the Recognition of Non-Nucleotide Antagonists Within the Transmembrane Domains of the Human P2Y(1) Receptor.

Guo D, von Kügelgen I, Moro S, Kim YC, Jacobson KA.

Drug Dev Res. 2002 Dec 1;57(4):173-181. Epub 2003 Jan 22.

41.
42.

ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells.

Vonend O, Oberhauser V, von Kügelgen I, Apel TW, Amann K, Ritz E, Rump LC.

Kidney Int. 2002 May;61(5):1617-26.

43.

Molecular pharmacology of P2Y-receptors.

von Kügelgen I, Wetter A.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):310-23. Review.

PMID:
11111826
44.

Adenosine mediates nitric-oxide-independent renal vasodilation by activation of A2A receptors.

Rump LC, Jabbari-T J, von Kügelgen I, Oberhauser V.

J Hypertens. 1999 Dec;17(12 Pt 2):1987-93.

PMID:
10703900
45.

M-type K+ currents in rat cultured thoracolumbar sympathetic neurones and their role in uracil nucleotide-evoked noradrenaline release.

Nörenberg W, von Kügelgen I, Meyer A, Illes P, Starke K.

Br J Pharmacol. 2000 Feb;129(4):709-23.

46.

P2 receptor-mediated activation of noradrenergic and dopaminergic neurons in the rat brain.

Kittner H, Krügel U, Poelchen W, Sieler D, Reinhardt R, von Kügelgen I, Illes P.

Prog Brain Res. 1999;120:223-35. Review. No abstract available.

PMID:
10551000
47.

Electrophysiological analysis of P2-receptor mechanisms in rat sympathetic neurones.

Nörenberg W, von Kügelgen I, Meyer A, Illes P.

Prog Brain Res. 1999;120:209-21. Review. No abstract available.

PMID:
10550999
48.

P2-receptors controlling neurotransmitter release from postganglionic sympathetic neurones.

von Kügelgen I, Nörenberg W, Koch H, Meyer A, Illes P, Starke K.

Prog Brain Res. 1999;120:173-82. Review. No abstract available.

PMID:
10550996
49.

Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis.

Jacobson KA, Hoffmann C, Kim YC, Camaioni E, Nandanan E, Jang SY, Guo DP, Ji XD, von Kügelgen I, Moro S, Ziganshin AU, Rychkov A, King BF, Brown SG, Wildman SS, Burnstock G, Boyer JL, Mohanram A, Harden TK.

Prog Brain Res. 1999;120:119-32. Review. No abstract available.

50.

Role of action potentials and calcium influx in ATP- and UDP-induced noradrenaline release from rat cultured sympathetic neurones.

von Kügelgen I, Nörenberg W, Meyer A, Illes P, Starke K.

Naunyn Schmiedebergs Arch Pharmacol. 1999 May;359(5):360-9.

PMID:
10498285

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