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Items: 6

1.

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaav5989. doi: 10.1126/scitranslmed.aav5989.

PMID:
31189721
2.

Modeling of bispecific antibody elution in mixed-mode cation-exchange chromatography.

Lee YF, Kluters S, Hillmann M, von Hirschheydt T, Frech C.

J Sep Sci. 2017 Sep;40(18):3632-3645. doi: 10.1002/jssc.201700313. Epub 2017 Aug 14.

PMID:
28714211
3.

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.

Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer W, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes C, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umaña P.

Clin Cancer Res. 2016 Jul 1;22(13):3286-97. doi: 10.1158/1078-0432.CCR-15-1696. Epub 2016 Feb 9.

4.

Solvent modulation strategy for superior antibody monomer/aggregate separation in cation exchange chromatography.

Kluters S, Frech C, von Hirschheydt T, Schaubmar A, Neumann S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 1;1006:37-46. doi: 10.1016/j.jchromb.2015.10.023. Epub 2015 Oct 20.

PMID:
26520020
5.

Solvent modulated linear pH gradient elution for the purification of conventional and bispecific antibodies: Modeling and application.

Kluters S, Hafner M, von Hirschheydt T, Frech C.

J Chromatogr A. 2015 Oct 30;1418:119-129. doi: 10.1016/j.chroma.2015.09.053. Epub 2015 Sep 25.

PMID:
26431858
6.

Mechanism of improved antibody aggregate separation in polyethylene glycol-modulated cation exchange chromatography.

Kluters S, Neumann S, von Hirschheydt T, Grossmann A, Schaubmar A, Frech C.

J Sep Sci. 2012 Nov;35(22):3130-8. doi: 10.1002/jssc.201200715. Epub 2012 Oct 30.

PMID:
23111946

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