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Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Anquetil F, Mondanelli G, Gonzalez N, Rodriguez Calvo T, Zapardiel Gonzalo J, Krogvold L, Dahl-Jørgensen K, Van den Eynde B, Orabona C, Grohmann U, von Herrath MG.

Diabetes. 2018 Sep;67(9):1858-1866. doi: 10.2337/db17-1281. Epub 2018 Jun 26.


Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes.

Sbierski-Kind J, Kath J, Brachs S, Streitz M, von Herrath MG, Kühl AA, Schmidt-Bleek K, Mai K, Spranger J, Volk HD.

Front Immunol. 2018 May 28;9:1069. doi: 10.3389/fimmu.2018.01069. eCollection 2018.


Oral insulin does not alter gut microbiota composition of NOD mice.

Kihl P, Krych L, Buschard K, Wesley JD, Kot W, Hansen AK, Nielsen DS, von Herrath MG.

Diabetes Metab Res Rev. 2018 Sep;34(6):e3010. doi: 10.1002/dmrr.3010. Epub 2018 May 1.


Suppression of diabetes by accumulation of non-islet-specific CD8+ effector T cells in pancreatic islets.

Christoffersson G, Chodaczek G, Ratliff SS, Coppieters K, von Herrath MG.

Sci Immunol. 2018 Mar 23;3(21). pii: eaam6533. doi: 10.1126/sciimmunol.aam6533.


OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration.

Sabouri S, Mikulski Z, von Herrath MG.

Clin Immunol. 2018 Jun;191:34-36. doi: 10.1016/j.clim.2018.03.006. Epub 2018 Mar 15. No abstract available.


α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC.

Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032.


Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.

Rydén AK, Perdue NR, Pagni PP, Gibson CB, Ratliff SS, Kirk RK, Friesen TJ, Haase C, Coppieters K, von Herrath MG, Boursalian TE.

J Autoimmun. 2017 Nov;84:65-74. doi: 10.1016/j.jaut.2017.07.006. Epub 2017 Jul 12.


Alpha cells, the main source of IL-1β in human pancreas.

Anquetil F, Sabouri S, Thivolet C, Rodriguez-Calvo T, Zapardiel-Gonzalo J, Amirian N, Schneider D, Castillo E, Lajevardi Y, von Herrath MG.

J Autoimmun. 2017 Jul;81:68-73. doi: 10.1016/j.jaut.2017.03.006. Epub 2017 Mar 18.


Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset.

Rodriguez-Calvo T, Zapardiel-Gonzalo J, Amirian N, Castillo E, Lajevardi Y, Krogvold L, Dahl-Jørgensen K, von Herrath MG.

Diabetes. 2017 May;66(5):1334-1345. doi: 10.2337/db16-1343. Epub 2017 Jan 30.


Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.

Kirk RK, Pyke C, von Herrath MG, Hasselby JP, Pedersen L, Mortensen PG, Knudsen LB, Coppieters K.

Diabetes Obes Metab. 2017 May;19(5):705-712. doi: 10.1111/dom.12879. Epub 2017 Mar 10.


Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA.

Diabetologia. 2017 Apr;60(4):753-755. doi: 10.1007/s00125-016-4195-x. Epub 2017 Jan 9. No abstract available.


A Deeper Look into Type 1 Diabetes - Imaging Immune Responses during Onset of Disease.

Christoffersson G, von Herrath MG.

Front Immunol. 2016 Aug 15;7:313. doi: 10.3389/fimmu.2016.00313. eCollection 2016. Review.


The viral paradigm in type 1 diabetes: Who are the main suspects?

Rodriguez-Calvo T, Sabouri S, Anquetil F, von Herrath MG.

Autoimmun Rev. 2016 Oct;15(10):964-9. doi: 10.1016/j.autrev.2016.07.019. Epub 2016 Aug 1. Review.


Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes.

Pham MN, von Herrath MG, Vela JL.

Front Immunol. 2016 Jan 11;6:651. doi: 10.3389/fimmu.2015.00651. eCollection 2015. Review.


Erratum. Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes. Diabetes 2014;63:3880-3890.

Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardiel-Gonzalo J, von Herrath MG.

Diabetes. 2016 Jan;65(1):303. doi: 10.2337/db16-er01. No abstract available.


Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase.

Rodriguez-Calvo T, Suwandi JS, Amirian N, Zapardiel-Gonzalo J, Anquetil F, Sabouri S, von Herrath MG.

J Histochem Cytochem. 2015 Aug;63(8):626-36. doi: 10.1369/0022155415576543.


Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success.

Rekers NV, von Herrath MG, Wesley JD.

Clin Immunol. 2015 Nov;161(1):37-43. doi: 10.1016/j.clim.2015.05.021. Epub 2015 Jun 27. Review.


Factors impeding the discovery of an intervention-based treatment for type 1 diabetes.

von Herrath MG, Korsgren O, Atkinson MA.

Clin Exp Immunol. 2016 Jan;183(1):1-7. doi: 10.1111/cei.12656. Epub 2015 Jul 24. Review.


Enterovirus infection and type 1 diabetes: closing in on a link?

Rodriguez-Calvo T, von Herrath MG.

Diabetes. 2015 May;64(5):1503-5. doi: 10.2337/db14-1931. No abstract available.


The type 1 diabetes signature: hardwired to trigger inflammation?

Coppieters KT, von Herrath MG.

Diabetes. 2014 Nov;63(11):3581-3. doi: 10.2337/db14-0824. No abstract available.


Potential viral pathogenic mechanism in human type 1 diabetes.

Schneider DA, von Herrath MG.

Diabetologia. 2014 Oct;57(10):2009-18. doi: 10.1007/s00125-014-3340-7. Epub 2014 Jul 30. Review.


Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.

Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardiel-Gonzalo J, von Herrath MG.

Diabetes. 2014 Nov;63(11):3880-90. doi: 10.2337/db14-0549. Epub 2014 Jun 19. Erratum in: Diabetes. 2016 Jan;65(1):303.


Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapies.

Coppieters KT, von Herrath MG.

Mol Metab. 2014 Jan 21;3(3):275-83. doi: 10.1016/j.molmet.2013.12.005. eCollection 2014 Jun. Review.


Viruses and Type 1 diabetes: a dynamic labile equilibrium.

Schneider DA, von Herrath MG.

Diabetes Manag (Lond). 2013 May;3(3):217-223.


Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.

Van Belle TL, Pagni PP, Liao J, Sachithanantham S, Dave A, Bel Hani A, Manenkova Y, Amirian N, Yang C, Morin B, Zhang H, Campbell IL, von Herrath MG.

J Autoimmun. 2014 Dec;55:24-32. doi: 10.1016/j.jaut.2014.02.002. Epub 2014 Feb 26.


Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model.

Pagni PP, Bresson D, Rodriguez-Calvo T, Bel Hani A, Manenkova Y, Amirian N, Blaszczak A, Faton S, Sachithanantham S, von Herrath MG.

Diabetes. 2014 Jun;63(6):2015-25. doi: 10.2337/db13-1257. Epub 2014 Feb 11.


Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance.

Schneider DA, Sarikonda G, Montero E, von Herrath MG.

Clin Immunol. 2013 Dec;149(3):440-1. doi: 10.1016/j.clim.2013.08.004. Epub 2013 Aug 15. No abstract available. Erratum in: Clin Immunol. 2014 Apr;151(2):100. Schneider, Darius A [added]; Sarikonda, Ghanashyam [added]; Montero, Enrique [added].


Non-antigenic and antigenic interventions in type 1 diabetes.

Rydén AK, Wesley JD, Coppieters KT, Von Herrath MG.

Hum Vaccin Immunother. 2014;10(4):838-46. Epub 2013 Oct 28. Review.


The diagnosis of insulitis in human type 1 diabetes.

Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Korsgren O, Morgan NG, Powers AC, Pugliese A, Richardson SJ, Rowe PA, Tracy S, In't Veld PA.

Diabetologia. 2013 Nov;56(11):2541-3. doi: 10.1007/s00125-013-3043-5. Epub 2013 Sep 5. No abstract available.


Trials in type 1 diabetes: Antigen-specific therapies.

Coppieters KT, Harrison LC, von Herrath MG.

Clin Immunol. 2013 Dec;149(3):345-55. doi: 10.1016/j.clim.2013.02.002. Epub 2013 Feb 15. Review.


Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model.

Coppieters KT, Amirian N, Pagni PP, Baca Jones C, Wiberg A, Lasch S, Hintermann E, Christen U, von Herrath MG.

Diabetes. 2013 Jul;62(7):2492-9. doi: 10.2337/db12-1370. Epub 2013 Feb 22.


Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice.

Christen S, Coppieters K, Rose K, Holdener M, Bayer M, Pfeilschifter JM, Hintermann E, von Herrath MG, Aurrand-Lions M, Imhof BA, Christen U.

PLoS One. 2013;8(1):e54675. doi: 10.1371/journal.pone.0054675. Epub 2013 Jan 25.


Emerging immune therapies in type 1 diabetes and pancreatic islet transplantation.

Schneider DA, Kretowicz AM, von Herrath MG.

Diabetes Obes Metab. 2013 Jul;15(7):581-92. doi: 10.1111/dom.12046. Epub 2013 Jan 21. Review.


Viral infections and molecular mimicry in type 1 diabetes.

Coppieters KT, Wiberg A, von Herrath MG.

APMIS. 2012 Dec;120(12):941-9. doi: 10.1111/apm.12011. Epub 2012 Oct 11. Review.


OX40 facilitates control of a persistent virus infection.

Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG.

PLoS Pathog. 2012 Sep;8(9):e1002913. doi: 10.1371/journal.ppat.1002913. Epub 2012 Sep 6.


NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes.

Van Belle TL, Ling E, Haase C, Bresson D, Ursø B, von Herrath MG.

J Autoimmun. 2013 Feb;40:66-73. doi: 10.1016/j.jaut.2012.08.001. Epub 2012 Sep 1.


Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.

Van Belle TL, Nierkens S, Arens R, von Herrath MG.

Immunity. 2012 Jun 29;36(6):1060-72. doi: 10.1016/j.immuni.2012.04.005. Epub 2012 May 10.


Infection as a cause of type 1 diabetes?

Christen U, Bender C, von Herrath MG.

Curr Opin Rheumatol. 2012 Jul;24(4):417-23. doi: 10.1097/BOR.0b013e3283533719. Review.


Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma.

Coppieters KT, Wiberg A, Tracy SM, von Herrath MG.

Clin Exp Immunol. 2012 Apr;168(1):5-11. doi: 10.1111/j.1365-2249.2011.04554.x. Review.


Motifs for a deadly encounter.

Coppieters KT, von Herrath MG.

Nat Immunol. 2012 Feb 16;13(3):205-6. doi: 10.1038/ni.2226. No abstract available.


Combination therapy with InsB9-23 peptide immunization and CTLA4-IgG does not reverse diabetes in NOD mice.

Schneider DA, Sarikonda G, von Herrath MG.

Clin Immunol. 2012 Mar;142(3):402-3. doi: 10.1016/j.clim.2011.12.005. Epub 2011 Dec 23. No abstract available.


Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TW, Atkinson MA, Roep BO, von Herrath MG.

J Exp Med. 2012 Jan 16;209(1):51-60. doi: 10.1084/jem.20111187. Epub 2012 Jan 2.


Clinical potential of antigen-specific therapies in type 1 diabetes.

Coppieters KT, Sehested Hansen B, von Herrath MG.

Rev Diabet Stud. 2012 Winter;9(4):328-37. doi: 10.1900/RDS.2012.9.328. Epub 2012 Dec 28. Review.


Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals.

Coppieters KT, Wiberg A, Amirian N, Kay TW, von Herrath MG.

Diabetes Metab Res Rev. 2011 Nov;27(8):746-54. doi: 10.1002/dmrr.1246.


Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.

Van Belle TL, Esplugues E, Liao J, Juntti T, Flavell RA, von Herrath MG.

J Immunol. 2011 Sep 15;187(6):2915-22. doi: 10.4049/jimmunol.1000180. Epub 2011 Aug 10.


TLR2 signaling improves immunoregulation to prevent type 1 diabetes.

Filippi CM, Ehrhardt K, Estes EA, Larsson P, Oldham JE, von Herrath MG.

Eur J Immunol. 2011 May;41(5):1399-409. doi: 10.1002/eji.200939841.


Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis.

Fousteri G, Dave A, Morin B, Omid S, Croft M, von Herrath MG.

J Autoimmun. 2011 May;36(3-4):210-20. doi: 10.1016/j.jaut.2011.01.006. Epub 2011 Feb 17.


Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

Christen U, von Herrath MG.

Cell Mol Immunol. 2011 May;8(3):193-8. doi: 10.1038/cmi.2010.71. Epub 2011 Jan 24. Review.

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