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Reply to "Tolerogenic insulin peptide therapy precipitates type 1 diabetes".

Daniel C, Weigmann B, von Boehmer H.

J Exp Med. 2017 Jul 3;214(7):2157-2159. doi: 10.1084/jem.20170285. Epub 2017 May 23.


Cyclin C is a haploinsufficient tumour suppressor.

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P.

Nat Cell Biol. 2014 Nov;16(11):1080-91. doi: 10.1038/ncb3046. Epub 2014 Oct 26.


Deciphering thymic development.

Von Boehmer H.

Front Immunol. 2014 Oct 8;5:424. doi: 10.3389/fimmu.2014.00424. eCollection 2014. Review. No abstract available.


The thymus in immunity and in malignancy.

von Boehmer H.

Cancer Immunol Res. 2014 Jul;2(7):592-7. doi: 10.1158/2326-6066.CIR-14-0070. Review.


Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.

Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, von Boehmer H.

J Exp Med. 2013 Sep 23;210(10):1911-8. doi: 10.1084/jem.20130876. Epub 2013 Aug 26.


The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.

Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT.

J Exp Med. 2013 Jul 29;210(8):1545-57. doi: 10.1084/jem.20122516. Epub 2013 Jul 15.


The transcriptional landscape of αβ T cell differentiation.

Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.

Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5.


Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer.

von Boehmer H, Daniel C.

Nat Rev Drug Discov. 2013 Jan;12(1):51-63. doi: 10.1038/nrd3683. Review.


PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function.

Gleimer M, von Boehmer H, Kreslavsky T.

Front Immunol. 2012 Dec 21;3:374. doi: 10.3389/fimmu.2012.00374. eCollection 2012.


β-Selection-induced proliferation is required for αβ T cell differentiation.

Kreslavsky T, Gleimer M, Miyazaki M, Choi Y, Gagnon E, Murre C, Sicinski P, von Boehmer H.

Immunity. 2012 Nov 16;37(5):840-53. doi: 10.1016/j.immuni.2012.08.020.


The requirement for cyclin D function in tumor maintenance.

Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P.

Cancer Cell. 2012 Oct 16;22(4):438-51. doi: 10.1016/j.ccr.2012.09.015.


Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.

Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H.

J Exp Med. 2012 Aug 27;209(9):1529-35. doi: 10.1084/jem.20112646. Epub 2012 Aug 20.


Extrathymic generation of regulatory T cells--chances and challenges for prevention of autoimmune disease.

Daniel C, von Boehmer H.

Adv Immunol. 2011;112:177-213. doi: 10.1016/B978-0-12-387827-4.00005-X. Review.


Notch Signaling in T-Cell Development and T-ALL.

Li X, von Boehmer H.

ISRN Hematol. 2011;2011:921706. doi: 10.5402/2011/921706. Epub 2011 Jan 23.


Extra-thymically induced regulatory T cells: do they have potential in disease prevention?

Daniel C, von Boehmer H.

Semin Immunol. 2011 Dec;23(6):410-7. doi: 10.1016/j.smim.2011.06.004. Epub 2011 Jul 2. Review.


Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope.

Daniel C, Weigmann B, Bronson R, von Boehmer H.

J Exp Med. 2011 Jul 4;208(7):1501-10. doi: 10.1084/jem.20110574. Epub 2011 Jun 20.


Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.

Li X, Sanda T, Look AT, Novina CD, von Boehmer H.

J Exp Med. 2011 Apr 11;208(4):663-75. doi: 10.1084/jem.20102384. Epub 2011 Apr 4.


Antigen-specific induction of regulatory T cells in vivo and in vitro.

Daniel C, Ploegh H, von Boehmer H.

Methods Mol Biol. 2011;707:173-85. doi: 10.1007/978-1-61737-979-6_11.


αβ versus γδ fate choice: counting the T-cell lineages at the branch point.

Kreslavsky T, Gleimer M, Garbe AI, von Boehmer H.

Immunol Rev. 2010 Nov;238(1):169-81. doi: 10.1111/j.1600-065X.2010.00947.x. Review.


Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.

Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17280-5. doi: 10.1073/pnas.1010263107. Epub 2010 Sep 20.


Enhancement of antigen-specific Treg vaccination in vivo.

Daniel C, Wennhold K, Kim HJ, von Boehmer H.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16246-51. doi: 10.1073/pnas.1007422107. Epub 2010 Aug 30.


PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors.

Merkenschlager M, von Boehmer H.

J Exp Med. 2010 Jul 5;207(7):1347-50. doi: 10.1084/jem.20101156.


Mechanisms of self-nonself discrimination and possible clinical relevance.

Daniel C, Nolting J, von Boehmer H.

Immunotherapy. 2009 Jul;1(4):631-44. Review.


gammadeltaTCR ligands and lineage commitment.

Kreslavsky T, von Boehmer H.

Semin Immunol. 2010 Aug;22(4):214-21. doi: 10.1016/j.smim.2010.04.001. Epub 2010 May 5. Review.


Thymocyte selection: chemokine signaling is not only about the destination.

Gleimer M, von Boehmer H.

Curr Biol. 2010 Apr 13;20(7):R316-8. doi: 10.1016/j.cub.2010.02.018.


Genomic definition of multiple ex vivo regulatory T cell subphenotypes.

Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5919-24. doi: 10.1073/pnas.1002006107. Epub 2010 Mar 15.


Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint.

Kreslavsky T, Gleimer M, von Boehmer H.

Curr Opin Immunol. 2010 Apr;22(2):185-92. doi: 10.1016/j.coi.2009.12.006. Epub 2010 Jan 13. Review.


Immunological tolerance.

von Boehmer H, Waldmann H.

Front Immunol. 2010 Nov 22;1:102. doi: 10.3389/fimmu.2010.00102. eCollection 2010. No abstract available.


Checkpoints in lymphocyte development and autoimmune disease.

von Boehmer H, Melchers F.

Nat Immunol. 2010 Jan;11(1):14-20. doi: 10.1038/ni.1794. Epub 2009 Dec 17. Review.


Multiple extrathymic precursors contribute to T-cell development with different kinetics.

Saran N, Łyszkiewicz M, Pommerencke J, Witzlau K, Vakilzadeh R, Ballmaier M, von Boehmer H, Krueger A.

Blood. 2010 Feb 11;115(6):1137-44. doi: 10.1182/blood-2009-07-230821. Epub 2009 Dec 15.


Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.

Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT.

Blood. 2010 Mar 4;115(9):1735-45. doi: 10.1182/blood-2009-07-235143. Epub 2009 Dec 9.


Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.

Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H.

J Exp Med. 2009 Sep 28;206(10):2131-9. doi: 10.1084/jem.20090639. Epub 2009 Sep 8.


Central tolerance: essential for preventing autoimmune disease?

von Boehmer H.

Eur J Immunol. 2009 Sep;39(9):2313-6. doi: 10.1002/eji.200939575.


TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.

Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. doi: 10.1073/pnas.0903895106. Epub 2009 Jul 15.


Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.

Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW.

J Biol Chem. 2009 Sep 11;284(37):24914-24. doi: 10.1074/jbc.M109.000059. Epub 2009 Jul 14.


Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212.

Saint-Ruf C, Ungewiss K, Groettrup M, Bruno L, Fehling HJ, von Boehmer H.

J Immunol. 2009 May 1;182(9):5165-9. No abstract available.


Notch 1 keeps pro-T cells on track.

von Boehmer H.

Immunity. 2009 Jan 16;30(1):5-7. doi: 10.1016/j.immuni.2008.12.008.


Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.

Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H.

J Exp Med. 2008 Nov 24;205(12):2851-61. doi: 10.1084/jem.20081561. Epub 2008 Nov 3.


Peripherally induced Treg: mode, stability, and role in specific tolerance.

Apostolou I, Verginis P, Kretschmer K, Polansky J, Hühn J, von Boehmer H.

J Clin Immunol. 2008 Nov;28(6):619-24. doi: 10.1007/s10875-008-9254-8. Epub 2008 Oct 8.


Regulatory T cells and antigen-specific tolerance.

Kretschmer K, Apostolou I, Verginis P, von Boehmer H.

Chem Immunol Allergy. 2008;94:8-15. doi: 10.1159/000154846. Review.


Lymphocyte development: overview.

Rajewsky K, von Boehmer H.

Curr Opin Immunol. 2008 Apr;20(2):127-30. doi: 10.1016/j.coi.2008.04.005. Epub 2008 May 29. No abstract available.


DNA methylation controls Foxp3 gene expression.

Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J.

Eur J Immunol. 2008 Jun;38(6):1654-63. doi: 10.1002/eji.200838105.


Positive and negative selection in Basel.

von Boehmer H.

Nat Immunol. 2008 Jun;9(6):571-3. doi: 10.1038/ni0608-571. No abstract available.


T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis.

Kreslavsky T, Garbe AI, Krueger A, von Boehmer H.

J Exp Med. 2008 May 12;205(5):1173-86. doi: 10.1084/jem.20072425. Epub 2008 Apr 28.


Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.

Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, Khazaie K.

Gastroenterology. 2008 Apr;134(4):1028-37. doi: 10.1053/j.gastro.2008.01.070. Epub 2008 Jan 30.


Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression.

Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3479-84. doi: 10.1073/pnas.0800149105. Epub 2008 Feb 25.


Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.

Egawa T, Kreslavsky T, Littman DR, von Boehmer H.

PLoS One. 2008 Jan 30;3(1):e1512. doi: 10.1371/journal.pone.0001512.


What turns on Foxp3?

von Boehmer H, Nolting J.

Nat Immunol. 2008 Feb;9(2):121-2. doi: 10.1038/ni0208-121. No abstract available.


De novo production of antigen-specific suppressor cells in vivo.

Kretschmer K, Heng TS, von Boehmer H.

Nat Protoc. 2006;1(2):653-61.


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