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Items: 1 to 50 of 91

1.

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.

Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, Xu Q, Rawson RV, Mukhopadhyay P, Dummer R, Levesque MP, Jönsson G, Wang X, Yeh I, Wu H, Joseph N, Bastian BC, Long GV, Spillane AJ, Shannon KF, Thompson JF, Saw RPM, Adams DJ, Si L, Pearson JV, Hayward NK, Waddell N, Mann GJ, Guo J, Scolyer RA.

Nat Commun. 2019 Jul 18;10(1):3163. doi: 10.1038/s41467-019-11107-x.

2.

ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I, Pance A, Rütten A, Luzar B, Marusic Z, de Saint Aubain N, Ko JS, Billings SD, Chen S, Abi Daoud M, Hewinson J, Louzada S, Harms PW, Cerretelli G, Robles-Espinoza CD, Patel RM, van der Weyden L, Bakal C, Hornick JL, Arends MJ, Brenn T, Adams DJ.

Nat Commun. 2019 May 17;10(1):2213. doi: 10.1038/s41467-019-09979-0.

3.

FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A, Caetano S, Abu-Helil B, Kane L, Harcourt K, Goulding DA, Gleeson D, Ryder E, Doe B, White JK, van der Weyden L, Dougan G, Adams DJ, Speak AO.

PLoS One. 2019 Mar 6;14(3):e0212481. doi: 10.1371/journal.pone.0212481. eCollection 2019.

4.

Metastasis in the wild: investigating metastasis in non-laboratory animals.

Abu-Helil B, van der Weyden L.

Clin Exp Metastasis. 2019 Feb;36(1):15-28. doi: 10.1007/s10585-019-09956-3. Epub 2019 Feb 9. Review.

5.

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.

Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V, Kuijjer ML, Arends MJ, Brenn T, Harms PW, Wood GA, Adams DJ.

Nat Commun. 2019 Jan 21;10(1):353. doi: 10.1038/s41467-018-08081-1.

6.

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma.

Wong K, Robles-Espinoza CD, Rodriguez D, Rudat SS, Puig S, Potrony M, Wong CC, Hewinson J, Aguilera P, Puig-Butille JA, Bressac-de Paillerets B, Zattara H, van der Weyden L, Fletcher CDM, Brenn T, Arends MJ, Quesada V, Newton-Bishop JA, Lopez-Otin C, Bishop DT, Harms PW, Johnson TM, Durham AB, Lombard DB, Adams DJ.

JAMA Dermatol. 2019 May 1;155(5):604-609. doi: 10.1001/jamadermatol.2018.3662.

PMID:
30586141
7.

Pulmonary metastatic colonisation and granulomas in NOX2-deficient mice.

van der Weyden L, Speak AO, Swiatkowska A, Clare S, Schejtman A, Santilli G, Arends MJ, Adams DJ.

J Pathol. 2018 Nov;246(3):300-310. doi: 10.1002/path.5140. Epub 2018 Sep 19.

8.

CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation.

Hunte R, Alonso P, Thomas R, Bazile CA, Ramos JC, van der Weyden L, Dominguez-Bendala J, Khan WN, Shembade N.

PLoS Pathog. 2018 Apr 26;14(4):e1006968. doi: 10.1371/journal.ppat.1006968. eCollection 2018 Apr.

9.

Widespread spontaneous hyperproliferation, melanosis and melanoma in Hgf-Cdk4R24C mice.

van der Weyden L, Arends MJ, Brenn T, Tuting T, Adams DJ.

Melanoma Res. 2018 Feb;28(1):76-78. doi: 10.1097/CMR.0000000000000414. No abstract available.

10.

Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.

Del Castillo Velasco-Herrera M, van der Weyden L, Nsengimana J, Speak AO, Sjöberg MK, Bishop DT, Jönsson G, Newton-Bishop J, Adams DJ.

Mol Oncol. 2018 Feb;12(2):239-255. doi: 10.1002/1878-0261.12161. Epub 2018 Jan 7.

11.

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Speak AO, Swiatkowska A, Karp NA, Arends MJ, Adams DJ, van der Weyden L.

Nat Protoc. 2017 Dec;12(12):2465-2477. doi: 10.1038/nprot.2017.118. Epub 2017 Nov 2.

PMID:
29095442
12.

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.

van der Weyden L, Karp NA, Swiatkowska A, Adams DJ, Speak AO.

Sci Data. 2017 Sep 12;4:170129. doi: 10.1038/sdata.2017.129.

13.

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.

Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, Carlo AS, Moroni M, Siemens J, Heuser A, van der Weyden L, Birkenfeld AL, Niendorf T, Poulet JFA, Horvath TL, Tschöp MH, Heinig M, Trajkovski M, Haucke V, Poy MN.

Nat Neurosci. 2017 Aug;20(8):1096-1103. doi: 10.1038/nn.4590. Epub 2017 Jun 19.

14.

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.

15.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.

16.

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq.

Mann KM, Newberg JY, Black MA, Jones DJ, Amaya-Manzanares F, Guzman-Rojas L, Kodama T, Ward JM, Rust AG, van der Weyden L, Yew CC, Waters JL, Leung ML, Rogers K, Rogers SM, McNoe LA, Selvanesan L, Navin N, Jenkins NA, Copeland NG, Mann MB.

Nat Biotechnol. 2016 Sep;34(9):962-72. doi: 10.1038/nbt.3637. Epub 2016 Aug 1.

17.

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, Loveridge C, van der Weyden L, Edwards J, Sansom OJ, Adams DJ, Leung HY.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8290-5. doi: 10.1073/pnas.1601571113. Epub 2016 Jun 29.

18.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.

19.

Cross-species models of human melanoma.

van der Weyden L, Patton EE, Wood GA, Foote AK, Brenn T, Arends MJ, Adams DJ.

J Pathol. 2016 Jan;238(2):152-65. doi: 10.1002/path.4632. Epub 2015 Oct 9. Review.

20.

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

Giotopoulos G, van der Weyden L, Osaki H, Rust AG, Gallipoli P, Meduri E, Horton SJ, Chan WI, Foster D, Prinjha RK, Pimanda JE, Tenen DG, Vassiliou GS, Koschmieder S, Adams DJ, Huntly BJ.

J Exp Med. 2015 Sep 21;212(10):1551-69. doi: 10.1084/jem.20141661. Epub 2015 Aug 24.

21.

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.

van der Weyden L, Giotopoulos G, Wong K, Rust AG, Robles-Espinoza CD, Osaki H, Huntly BJ, Adams DJ.

BMC Cancer. 2015 Aug 13;15:585. doi: 10.1186/s12885-015-1586-1.

22.

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.

Dang J, Wei L, de Ridder J, Su X, Rust AG, Roberts KG, Payne-Turner D, Cheng J, Ma J, Qu C, Wu G, Song G, Huether RG, Schulman B, Janke L, Zhang J, Downing JR, van der Weyden L, Adams DJ, Mullighan CG.

Blood. 2015 Jun 4;125(23):3609-17. doi: 10.1182/blood-2015-02-626127. Epub 2015 Apr 8.

23.

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E.

Nat Cell Biol. 2015 Apr;17(4):531. doi: 10.1038/ncb3152. No abstract available.

PMID:
25812526
24.

Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.

Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N.

PLoS Pathog. 2015 Mar 16;11(3):e1004721. doi: 10.1371/journal.ppat.1004721. eCollection 2015 Mar.

25.

Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice.

Guerrero JA, Bennett C, van der Weyden L, McKinney H, Chin M, Nurden P, McIntyre Z, Cambridge EL, Estabel J, Wardle-Jones H, Speak AO, Erber WN, Rendon A, Ouwehand WH, Ghevaert C.

Blood. 2014 Dec 4;124(24):3624-35. doi: 10.1182/blood-2014-04-566760. Epub 2014 Sep 25.

PMID:
25258341
26.

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E.

Nat Cell Biol. 2014 Oct;16(10):962-71, 1-8. doi: 10.1038/ncb3035. Epub 2014 Sep 14. Erratum in: Nat Cell Biol. 2015 Apr;17(4):531.

27.

Cancer gene discovery goes mobile.

van der Weyden L, Ranzani M, Adams DJ.

Nat Genet. 2014 Sep;46(9):928-9. doi: 10.1038/ng.3072.

PMID:
25162801
28.

Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

Huser CA, Gilroy KL, de Ridder J, Kilbey A, Borland G, Mackay N, Jenkins A, Bell M, Herzyk P, van der Weyden L, Adams DJ, Rust AG, Cameron E, Neil JC.

PLoS Genet. 2014 Feb 27;10(2):e1004167. doi: 10.1371/journal.pgen.1004167. eCollection 2014 Feb.

29.

Cancer of mice and men: old twists and new tails.

van der Weyden L, Adams DJ.

J Pathol. 2013 May;230(1):4-16. doi: 10.1002/path.4184.

PMID:
23436574
30.

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ.

PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15.

31.

Generation of the Sotos syndrome deletion in mice.

Migdalska AM, van der Weyden L, Ismail O; Sanger Mouse Genetics Project, Rust AG, Rashid M, White JK, Sánchez-Andrade G, Lupski JR, Logan DW, Arends MJ, Adams DJ.

Mamm Genome. 2012 Dec;23(11-12):749-57. doi: 10.1007/s00335-012-9416-0. Epub 2012 Aug 29.

32.

Sequencing and characterization of the FVB/NJ mouse genome.

Wong K, Bumpstead S, Van Der Weyden L, Reinholdt LG, Wilming LG, Adams DJ, Keane TM.

Genome Biol. 2012 Aug 23;13(8):R72. doi: 10.1186/gb-2012-13-8-r72.

33.

Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

van der Weyden L, Papaspyropoulos A, Poulogiannis G, Rust AG, Rashid M, Adams DJ, Arends MJ, O'Neill E.

Cancer Res. 2012 Aug 1;72(15):3817-3827. doi: 10.1158/0008-5472.CAN-11-3343. Epub 2012 Jun 18.

34.

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA.

Nature. 2012 Apr 29;486(7402):266-70. doi: 10.1038/nature11114. Erratum in: Nature. 2013 Feb 21;494(7437):390. Scarlett, Christopher J [added]; Kaplan, Warren [added]; Scarpa, Aldo [added], Das, Amithabad [corrected to Das, Amitabha].

35.

Using mice to unveil the genetics of cancer resistance.

van der Weyden L, Adams DJ.

Biochim Biophys Acta. 2012 Dec;1826(2):312-30. doi: 10.1016/j.bbcan.2012.05.003. Epub 2012 May 19. Review.

PMID:
22613679
36.

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.

van der Weyden L, Arends MJ, Rust AG, Poulogiannis G, McIntyre RE, Adams DJ.

Mol Cancer. 2012 May 3;11:29. doi: 10.1186/1476-4598-11-29.

37.

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

Wilson CH, Crombie C, van der Weyden L, Poulogiannis G, Rust AG, Pardo M, Gracia T, Yu L, Choudhary J, Poulin GB, McIntyre RE, Winton DJ, March HN, Arends MJ, Fraser AG, Adams DJ.

EMBO J. 2012 May 30;31(11):2486-97. doi: 10.1038/emboj.2012.91. Epub 2012 Apr 17.

38.

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.

van der Weyden L, Rust AG, McIntyre RE, Robles-Espinoza CD, del Castillo Velasco-Herrera M, Strogantsev R, Ferguson-Smith AC, McCarthy S, Keane TM, Arends MJ, Adams DJ.

Oncogene. 2013 Jan 17;32(3):397-402. doi: 10.1038/onc.2012.56. Epub 2012 Feb 27.

39.

Modeling partial monosomy for human chromosome 21q11.2-q21.1 reveals haploinsufficient genes influencing behavior and fat deposition.

Migdalska AM, van der Weyden L, Ismail O, White JK; Sanger Mouse Genetics Project, Sánchez-Andrade G, Logan DW, Arends MJ, Adams DJ.

PLoS One. 2012;7(1):e29681. doi: 10.1371/journal.pone.0029681. Epub 2012 Jan 20. Erratum in: PLoS One. 2012;7(3). doi: 10.1371/annotation/26a586df-e769-4efc-884f-6e7d448003bc.

40.

Cancer gene discovery in the mouse.

McIntyre RE, van der Weyden L, Adams DJ.

Curr Opin Genet Dev. 2012 Feb;22(1):14-20. doi: 10.1016/j.gde.2011.12.003. Epub 2012 Jan 20. Review.

PMID:
22265936
41.

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.

March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ, Adams DJ.

Nat Genet. 2011 Nov 6;43(12):1202-9. doi: 10.1038/ng.990.

42.

Mouse genomic variation and its effect on phenotypes and gene regulation.

Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ.

Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413.

43.

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors.

Koudijs MJ, Klijn C, van der Weyden L, Kool J, ten Hoeve J, Sie D, Prasetyanti PR, Schut E, Kas S, Whipp T, Cuppen E, Wessels L, Adams DJ, Jonkers J.

Genome Res. 2011 Dec;21(12):2181-9. doi: 10.1101/gr.112763.110. Epub 2011 Aug 18.

44.

The mouse genetics toolkit: revealing function and mechanism.

van der Weyden L, White JK, Adams DJ, Logan DW.

Genome Biol. 2011 Jun 24;12(6):224. doi: 10.1186/gb-2011-12-6-224. Review.

45.

Computational identification of insertional mutagenesis targets for cancer gene discovery.

de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M, Berns A, van Lohuizen M, Jonkers J, Adams DJ, Wessels LF.

Nucleic Acids Res. 2011 Aug;39(15):e105. doi: 10.1093/nar/gkr447. Epub 2011 Jun 7.

46.

Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

van der Weyden L, Giotopoulos G, Rust AG, Matheson LS, van Delft FW, Kong J, Corcoran AE, Greaves MF, Mullighan CG, Huntly BJ, Adams DJ.

Blood. 2011 Jul 28;118(4):1041-51. doi: 10.1182/blood-2011-02-338848. Epub 2011 May 31.

47.

Acute sensitivity of the oral mucosa to oncogenic K-ras.

van der Weyden L, Alcolea MP, Jones PH, Rust AG, Arends MJ, Adams DJ.

J Pathol. 2011 May;224(1):22-32. doi: 10.1002/path.2853. Epub 2011 Mar 7.

48.

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PHL, McIntyre RE; Sanger Mouse Genetics Project, Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ.

Nat Genet. 2011 Feb;43(2):147-52. doi: 10.1038/ng.752. Epub 2011 Jan 16.

49.

Cadm1 expression and function in the mouse lens.

De Maria A, Shi Y, Luo X, Van Der Weyden L, Bassnett S.

Invest Ophthalmol Vis Sci. 2011 Apr 8;52(5):2293-9. doi: 10.1167/iovs.10-6677. Print 2011 Apr.

50.

Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.

Tachibana-Konwalski K, Godwin J, van der Weyden L, Champion L, Kudo NR, Adams DJ, Nasmyth K.

Genes Dev. 2010 Nov 15;24(22):2505-16. doi: 10.1101/gad.605910. Epub 2010 Oct 22.

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