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Items: 49

1.

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes.

Ronacher K, Chegou NN, Kleynhans L, Djoba Siawaya JF, du Plessis N, Loxton AG, Maasdorp E, Tromp G, Kidd M, Stanley K, Kriel M, Menezes A, Gutschmidt A, van der Spuy GD, Warren RM, Dietze R, Okwera A, Thiel B, Belisle JT, Cliff JM, Boom WH, Johnson JL, van Helden PD, Dockrell HM, Walzl G.

Tuberculosis (Edinb). 2019 Aug 12;118:101859. doi: 10.1016/j.tube.2019.101859. [Epub ahead of print]

2.

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

Chegou NN, Sutherland JS, Namuganga AR, Corstjens PL, Geluk A, Gebremichael G, Mendy J, Malherbe S, Stanley K, van der Spuy GD, Kriel M, Loxton AG, Kriel B, Simukonda F, Bekele Y, Sheehama JA, Nelongo J, van der Vyver M, Gebrexabher A, Hailu H, Esterhuyse MM, Rosenkrands I, Aagard C, Kidd M, Kassa D, Mihret A, Howe R, Cliff JM, Crampin AC, Mayanja-Kizza H, Kaufmann SHE, Dockrell HM, Ottenhoff THM, Walzl G; AE-TBC consortium.

Sci Rep. 2018 Feb 8;8(1):2675. doi: 10.1038/s41598-018-20855-7.

3.

Changes in Host Immune-Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes.

Kleynhans L, Ruzive S, Ehlers L, Thiart L, Chegou NN, Conradie M, Kriel M, Stanley K, van der Spuy GD, Kidd M, van Helden PD, Walzl G, Ronacher K.

Front Immunol. 2017 Jun 15;8:690. doi: 10.3389/fimmu.2017.00690. eCollection 2017.

4.

Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.

Salie M, Daya M, Lucas LA, Warren RM, van der Spuy GD, van Helden PD, Hoal EG, Möller M.

Infect Genet Evol. 2015 Aug;34:221-9. doi: 10.1016/j.meegid.2015.07.004. Epub 2015 Jul 6.

PMID:
26160538
5.

The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study.

Marx FM, Dunbar R, Enarson DA, Williams BG, Warren RM, van der Spuy GD, van Helden PD, Beyers N.

Clin Infect Dis. 2014 Jun;58(12):1676-83. doi: 10.1093/cid/ciu186. Epub 2014 Mar 18.

PMID:
24647020
6.

Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis.

Phalane KG, Kriel M, Loxton AG, Menezes A, Stanley K, van der Spuy GD, Walzl G, Chegou NN.

Mediators Inflamm. 2013;2013:981984. doi: 10.1155/2013/981984. Epub 2013 Nov 13.

7.

Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.

Salie M, van der Merwe L, Möller M, Daya M, van der Spuy GD, van Helden PD, Martin MP, Gao XJ, Warren RM, Carrington M, Hoal EG.

J Infect Dis. 2014 Jan 15;209(2):216-23. doi: 10.1093/infdis/jit443. Epub 2013 Aug 14.

8.

Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.

Chegou NN, Essone PN, Loxton AG, Stanley K, Black GF, van der Spuy GD, van Helden PD, Franken KL, Parida SK, Klein MR, Kaufmann SH, Ottenhoff TH, Walzl G.

PLoS One. 2012;7(6):e38501. doi: 10.1371/journal.pone.0038501. Epub 2012 Jun 5. Erratum in: PLoS One. 2012;7(8). doi:10.1371/annotation/bc36a9c6-d5c0-4d55-bc92-9ce4a07b4f70.

9.

Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa.

Mukinda FK, Theron D, van der Spuy GD, Jacobson KR, Roscher M, Streicher EM, Musekiwa A, Coetzee GJ, Victor TC, Marais BJ, Nachega JB, Warren RM, Schaaf HS.

Int J Tuberc Lung Dis. 2012 Feb;16(2):196-202. doi: 10.5588/ijtld.11.0116.

10.

Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa.

Chihota VN, Müller B, Mlambo CK, Pillay M, Tait M, Streicher EM, Marais E, van der Spuy GD, Hanekom M, Coetzee G, Trollip A, Hayes C, Bosman ME, Gey van Pittius NC, Victor TC, van Helden PD, Warren RM.

J Clin Microbiol. 2012 Mar;50(3):995-1002. doi: 10.1128/JCM.05832-11. Epub 2011 Dec 14.

11.

Mycobacterial interspersed repetitive-unit-variable-number tandem-repeat analysis and Beijing/W family of Mycobacterium tuberculosis.

Carugati M, Zanini F, Schiroli C, Gori A, Franzetti F, Hanekom M, van der Spuy GD, Gey van Pittius NC, McEvoy CR, Ndabambi SL, Victor TC, Hoal EG, van Helden PD, Warren RM.

J Clin Microbiol. 2011 Jul;49(7):2780; author reply 2781. doi: 10.1128/JCM.02089-09. No abstract available.

12.

Improving nutritional status of children with cystic fibrosis at Red Cross War Memorial Children's Hospital.

van der Spuy DA, Cader S, van der Spuy GD, Westwood AT.

J Paediatr Child Health. 2011 May;47(5):282-6. doi: 10.1111/j.1440-1754.2010.01954.x. Epub 2011 Jan 18.

PMID:
21244558
13.

Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain.

Johnson R, Warren RM, van der Spuy GD, Gey van Pittius NC, Theron D, Streicher EM, Bosman M, Coetzee GJ, van Helden PD, Victor TC.

Int J Tuberc Lung Dis. 2010 Jan;14(1):119-21.

PMID:
20003705
14.

The clinical relevance of Mycobacterial pharmacogenetics.

Warren RM, Streicher EM, Gey van Pittius NC, Marais BJ, van der Spuy GD, Victor TC, Sirgel F, Donald PR, van Helden PD.

Tuberculosis (Edinb). 2009 May;89(3):199-202. doi: 10.1016/j.tube.2009.03.001. Epub 2009 May 1.

PMID:
19409848
15.

The role of molecular epidemiology in low-income, high-burden countries.

van der Spuy GD, Warren RM, van Helden PD.

Int J Tuberc Lung Dis. 2009 Apr;13(4):419-20. No abstract available.

PMID:
19335944
16.

Effect of study duration on the interpretation of tuberculosis molecular epidemiology investigations.

van der Spuy GD, van Helden PD, Warren RM.

Tuberculosis (Edinb). 2009 May;89(3):238-42. doi: 10.1016/j.tube.2009.01.006. Epub 2009 Feb 26.

PMID:
19249244
17.

Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics.

van der Spuy GD, Kremer K, Ndabambi SL, Beyers N, Dunbar R, Marais BJ, van Helden PD, Warren RM.

Tuberculosis (Edinb). 2009 Mar;89(2):120-5. doi: 10.1016/j.tube.2008.09.003. Epub 2008 Dec 2.

PMID:
19054717
18.

Discordance between mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing and IS6110 restriction fragment length polymorphism genotyping for analysis of Mycobacterium tuberculosis Beijing strains in a setting of high incidence of tuberculosis.

Hanekom M, van der Spuy GD, Gey van Pittius NC, McEvoy CR, Hoek KG, Ndabambi SL, Jordaan AM, Victor TC, van Helden PD, Warren RM.

J Clin Microbiol. 2008 Oct;46(10):3338-45. doi: 10.1128/JCM.00770-08. Epub 2008 Aug 20.

19.

Fluorometric assay for testing rifampin susceptibility of Mycobacterium tuberculosis complex.

Hoek KG, Gey van Pittius NC, Moolman-Smook H, Carelse-Tofa K, Jordaan A, van der Spuy GD, Streicher E, Victor TC, van Helden PD, Warren RM.

J Clin Microbiol. 2008 Apr;46(4):1369-73. doi: 10.1128/JCM.02343-07. Epub 2008 Feb 27.

20.

Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent.

Hanekom M, van der Spuy GD, Gey van Pittius NC, McEvoy CR, Ndabambi SL, Victor TC, Hoal EG, van Helden PD, Warren RM.

J Clin Microbiol. 2007 Jul;45(7):2263-6. Epub 2007 May 2. Erratum in: J Clin Microbiol. 2011 Jul;49(7):2783.

21.

A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease.

Hanekom M, van der Spuy GD, Streicher E, Ndabambi SL, McEvoy CR, Kidd M, Beyers N, Victor TC, van Helden PD, Warren RM.

J Clin Microbiol. 2007 May;45(5):1483-90. Epub 2007 Mar 14.

22.

Predominance of a single genotype of Mycobacterium tuberculosis in regions of Southern Africa.

Chihota V, Apers L, Mungofa S, Kasongo W, Nyoni IM, Tembwe R, Mbulo G, Tembo M, Streicher EM, van der Spuy GD, Victor TC, van Helden P, Warren RM.

Int J Tuberc Lung Dis. 2007 Mar;11(3):311-8.

PMID:
17352098
23.

Spread of an emerging Mycobacterium tuberculosis drug-resistant strain in the western Cape of South Africa.

Victor TC, Streicher EM, Kewley C, Jordaan AM, van der Spuy GD, Bosman M, Louw H, Murray M, Young D, van Helden PD, Warren RM.

Int J Tuberc Lung Dis. 2007 Feb;11(2):195-201.

PMID:
17263291
24.

Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns.

van Rie A, Victor TC, Richardson M, Johnson R, van der Spuy GD, Murray EJ, Beyers N, Gey van Pittius NC, van Helden PD, Warren RM.

Am J Respir Crit Care Med. 2005 Sep 1;172(5):636-42. Epub 2005 Jun 9.

25.

Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis.

Verver S, Warren RM, Beyers N, Richardson M, van der Spuy GD, Borgdorff MW, Enarson DA, Behr MA, van Helden PD.

Am J Respir Crit Care Med. 2005 Jun 15;171(12):1430-5. Epub 2005 Apr 14.

PMID:
15831840
26.

Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers.

Warren RM, Victor TC, Streicher EM, Richardson M, van der Spuy GD, Johnson R, Chihota VN, Locht C, Supply P, van Helden PD.

J Clin Microbiol. 2004 Dec;42(12):5774-82.

27.

Transmission of tuberculosis in a high incidence urban community in South Africa.

Verver S, Warren RM, Munch Z, Vynnycky E, van Helden PD, Richardson M, van der Spuy GD, Enarson DA, Borgdorff MW, Behr MA, Beyers N.

Int J Epidemiol. 2004 Apr;33(2):351-7.

PMID:
15082639
28.

Stability of polymorphic GC-rich repeat sequence-containing regions of Mycobacterium tuberculosis.

Richardson M, van der Spuy GD, Sampson SL, Beyers N, van Helden PD, Warren RM.

J Clin Microbiol. 2004 Mar;42(3):1302-4.

29.

Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa.

Streicher EM, Warren RM, Kewley C, Simpson J, Rastogi N, Sola C, van der Spuy GD, van Helden PD, Victor TC.

J Clin Microbiol. 2004 Feb;42(2):891-4.

30.

Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotype.

Victor TC, de Haas PE, Jordaan AM, van der Spuy GD, Richardson M, van Soolingen D, van Helden PD, Warren R.

J Clin Microbiol. 2004 Feb;42(2):769-72.

31.

Proportion of tuberculosis transmission that takes place in households in a high-incidence area.

Verver S, Warren RM, Munch Z, Richardson M, van der Spuy GD, Borgdorff MW, Behr MA, Beyers N, van Helden PD.

Lancet. 2004 Jan 17;363(9404):212-4.

PMID:
14738796
32.

Use of genetic distance as a measure of ongoing transmission of Mycobacterium tuberculosis.

van der Spuy GD, Warren RM, Richardson M, Beyers N, Behr MA, van Helden PD.

J Clin Microbiol. 2003 Dec;41(12):5640-4.

33.

IS6110-mediated deletion polymorphism in the direct repeat region of clinical isolates of Mycobacterium tuberculosis.

Sampson SL, Warren RM, Richardson M, Victor TC, Jordaan AM, van der Spuy GD, van Helden PD.

J Bacteriol. 2003 May;185(9):2856-66.

34.

Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence area.

Supply P, Warren RM, Bañuls AL, Lesjean S, Van Der Spuy GD, Lewis LA, Tibayrenc M, Van Helden PD, Locht C.

Mol Microbiol. 2003 Jan;47(2):529-38.

35.

Historic and recent events contribute to the disease dynamics of Beijing-like Mycobacterium tuberculosis isolates in a high incidence region.

Richardson M, van Lill SW, van der Spuy GD, Munch Z, Booysen CN, Beyers N, van Helden PD, Warren RM.

Int J Tuberc Lung Dis. 2002 Nov;6(11):1001-11.

PMID:
12475147
36.

Stability of variable-number tandem repeats of mycobacterial interspersed repetitive units from 12 loci in serial isolates of Mycobacterium tuberculosis.

Savine E, Warren RM, van der Spuy GD, Beyers N, van Helden PD, Locht C, Supply P.

J Clin Microbiol. 2002 Dec;40(12):4561-6.

37.

Microevolution of the direct repeat region of Mycobacterium tuberculosis: implications for interpretation of spoligotyping data.

Warren RM, Streicher EM, Sampson SL, van der Spuy GD, Richardson M, Nguyen D, Behr MA, Victor TC, van Helden PD.

J Clin Microbiol. 2002 Dec;40(12):4457-65.

38.

Use of spoligotyping for accurate classification of recurrent tuberculosis.

Warren RM, Streicher EM, Charalambous S, Churchyard G, van der Spuy GD, Grant AD, van Helden PD, Victor TC.

J Clin Microbiol. 2002 Oct;40(10):3851-3.

39.

Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting.

Richardson M, Carroll NM, Engelke E, Van Der Spuy GD, Salker F, Munch Z, Gie RP, Warren RM, Beyers N, Van Helden PD.

J Clin Microbiol. 2002 Aug;40(8):2750-4.

40.

Molecular analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with persistent disease in the Khartoum region of Sudan.

Sharaf-Eldin GS, Saeed NS, Hamid ME, Jordaan AM, Van der Spuy GD, Warren RM, Van Helden PD, Victor TC.

J Infect. 2002 May;44(4):244-51.

PMID:
12099732
41.

Calculation of the stability of the IS6110 banding pattern in patients with persistent Mycobacterium tuberculosis disease.

Warren RM, van der Spuy GD, Richardson M, Beyers N, Borgdorff MW, Behr MA, van Helden PD.

J Clin Microbiol. 2002 May;40(5):1705-8.

42.

Evolution of the IS6110-based restriction fragment length polymorphism pattern during the transmission of Mycobacterium tuberculosis.

Warren RM, van der Spuy GD, Richardson M, Beyers N, Booysen C, Behr MA, van Helden PD.

J Clin Microbiol. 2002 Apr;40(4):1277-82.

43.

Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance.

Victor TC, van Rie A, Jordaan AM, Richardson M, van Der Spuy GD, Beyers N, van Helden PD, Warren R.

J Clin Microbiol. 2001 Nov;39(11):4184-6.

44.

Molecular evolution of Mycobacterium tuberculosis: phylogenetic reconstruction of clonal expansion.

Warren RM, Richardson M, Sampson SL, van der Spuy GD, Bourn W, Hauman JH, Heersma H, Hide W, Beyers N, van Helden PD.

Tuberculosis (Edinb). 2001;81(4):291-302.

PMID:
11584597
45.

Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community.

Van Rie A, Warren R, Mshanga I, Jordaan AM, van der Spuy GD, Richardson M, Simpson J, Gie RP, Enarson DA, Beyers N, van Helden PD, Victor TC.

J Clin Microbiol. 2001 Feb;39(2):636-41.

46.

Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tuberculosis demonstrates genome plasticity.

Warren RM, Sampson SL, Richardson M, Van Der Spuy GD, Lombard CJ, Victor TC, van Helden PD.

Mol Microbiol. 2000 Sep;37(6):1405-16.

47.

Disruption of coding regions by IS6110 insertion in Mycobacterium tuberculosis.

Sampson SL, Warren RM, Richardson M, van der Spuy GD, van Helden PD.

Tuber Lung Dis. 1999;79(6):349-59.

PMID:
10694979
48.

Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy.

Victor TC, Jordaan AM, van Rie A, van der Spuy GD, Richardson M, van Helden PD, Warren R.

Tuber Lung Dis. 1999;79(6):343-8.

PMID:
10694978
49.

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