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Items: 26


The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles.

Melia CE, van der Schaar HM, de Jong AWM, Lyoo HR, Snijder EJ, Koster AJ, van Kuppeveld FJM, Bárcena M.

MBio. 2018 Apr 17;9(2). pii: e00420-18. doi: 10.1128/mBio.00420-18.


Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.

Melia CE, van der Schaar HM, Lyoo H, Limpens RWAL, Feng Q, Wahedi M, Overheul GJ, van Rij RP, Snijder EJ, Koster AJ, Bárcena M, van Kuppeveld FJM.

Cell Rep. 2017 Oct 17;21(3):587-599. doi: 10.1016/j.celrep.2017.09.068.


Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein.

Lyoo H, Dorobantu CM, van der Schaar HM, van Kuppeveld FJM.

Antiviral Res. 2017 Nov;147:86-90. doi: 10.1016/j.antiviral.2017.10.006. Epub 2017 Oct 9.


Direct-acting antivirals and host-targeting strategies to combat enterovirus infections.

Bauer L, Lyoo H, van der Schaar HM, Strating JR, van Kuppeveld FJ.

Curr Opin Virol. 2017 Jun;24:1-8. doi: 10.1016/j.coviro.2017.03.009. Epub 2017 Apr 12. Review.


Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

Albulescu L, Bigay J, Biswas B, Weber-Boyvat M, Dorobantu CM, Delang L, van der Schaar HM, Jung YS, Neyts J, Olkkonen VM, van Kuppeveld FJM, Strating JRPM.

Antiviral Res. 2017 Apr;140:37-44. doi: 10.1016/j.antiviral.2017.01.008. Epub 2017 Jan 11.


Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

Dorobantu CM, Harak C, Klein R, van der Linden L, Strating JR, van der Schaar HM, Lohmann V, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6. doi: 10.1128/AAC.01331-16. Print 2016 Oct.


Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein.

van der Schaar HM, Melia CE, van Bruggen JA, Strating JR, van Geenen ME, Koster AJ, Bárcena M, van Kuppeveld FJ.

mSphere. 2016 Jul 6;1(4). pii: e00104-16. doi: 10.1128/mSphere.00104-16. eCollection 2016 Jul-Aug.


How antibodies alter the cell entry pathway of dengue virus particles in macrophages.

Ayala-Nunez NV, Hoornweg TE, van de Pol DP, Sjollema KA, Flipse J, van der Schaar HM, Smit JM.

Sci Rep. 2016 Jul 7;6:28768. doi: 10.1038/srep28768.


Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein.

Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ.

mSphere. 2016 May 11;1(3). pii: e00068-16. doi: 10.1128/mSphere.00068-16. eCollection 2016 May-Jun.


Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles.

van der Schaar HM, Dorobantu CM, Albulescu L, Strating JRPM, van Kuppeveld FJM.

Trends Microbiol. 2016 Jul;24(7):535-546. doi: 10.1016/j.tim.2016.02.017. Epub 2016 Mar 22. Review.


Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus.

Dorobantu CM, Albulescu L, Harak C, Feng Q, van Kampen M, Strating JR, Gorbalenya AE, Lohmann V, van der Schaar HM, van Kuppeveld FJ.

PLoS Pathog. 2015 Sep 25;11(9):e1005185. doi: 10.1371/journal.ppat.1005185. eCollection 2015 Sep.


Targeting of the hydrophobic metabolome by pathogens.

Helms JB, Kaloyanova DV, Strating JR, van Hellemond JJ, van der Schaar HM, Tielens AG, van Kuppeveld FJ, Brouwers JF.

Traffic. 2015 May;16(5):439-60. doi: 10.1111/tra.12280. Review.


Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ.

Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29.


GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins.

Dorobantu CM, Ford-Siltz LA, Sittig SP, Lanke KH, Belov GA, van Kuppeveld FJ, van der Schaar HM.

J Virol. 2015 Feb;89(3):1913-8. doi: 10.1128/JVI.02830-14. Epub 2014 Nov 19.


Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta.

Thibaut HJ, van der Schaar HM, Lanke KH, Verbeken E, Andrews M, Leyssen P, Neyts J, van Kuppeveld FJ.

J Virol. 2014 Mar;88(5):3048-51. doi: 10.1128/JVI.03177-13. Epub 2013 Dec 26.


Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1.

Dorobantu CM, van der Schaar HM, Ford LA, Strating JR, Ulferts R, Fang Y, Belov G, van Kuppeveld FJ.

J Virol. 2014 Mar;88(5):2725-36. doi: 10.1128/JVI.03650-13. Epub 2013 Dec 18.


Cholesterol: fa(s)t-food for enterovirus genome replication.

Strating JR, van der Schaar HM, van Kuppeveld FJ.

Trends Microbiol. 2013 Nov;21(11):560-1. doi: 10.1016/j.tim.2013.09.007. Epub 2013 Oct 6.


A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. doi: 10.1128/AAC.01175-13. Epub 2013 Jul 29.


Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.

van der Schaar HM, van der Linden L, Lanke KH, Strating JR, Pürstinger G, de Vries E, de Haan CA, Neyts J, van Kuppeveld FJ.

Cell Res. 2012 Nov;22(11):1576-92. doi: 10.1038/cr.2012.129. Epub 2012 Sep 4.


The transformation of enterovirus replication structures: a three-dimensional study of single- and double-membrane compartments.

Limpens RW, van der Schaar HM, Kumar D, Koster AJ, Snijder EJ, van Kuppeveld FJ, Bárcena M.

MBio. 2011 Oct 4;2(5). pii: e00166-11. doi: 10.1128/mBio.00166-11. Print 2011.


Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication.

van der Linden L, van der Schaar HM, Lanke KH, Neyts J, van Kuppeveld FJ.

J Virol. 2010 Aug;84(15):7535-42. doi: 10.1128/JVI.02684-09. Epub 2010 May 26.


Immature dengue virus: a veiled pathogen?

Rodenhuis-Zybert IA, van der Schaar HM, da Silva Voorham JM, van der Ende-Metselaar H, Lei HY, Wilschut J, Smit JM.

PLoS Pathog. 2010 Jan;6(1):e1000718. doi: 10.1371/journal.ppat.1000718. Epub 2010 Jan 8.


GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication.

Lanke KH, van der Schaar HM, Belov GA, Feng Q, Duijsings D, Jackson CL, Ehrenfeld E, van Kuppeveld FJ.

J Virol. 2009 Nov;83(22):11940-9. doi: 10.1128/JVI.01244-09. Epub 2009 Sep 9.


Role of antibodies in controlling dengue virus infection.

van der Schaar HM, Wilschut JC, Smit JM.

Immunobiology. 2009;214(7):613-29. doi: 10.1016/j.imbio.2008.11.008. Epub 2009 Mar 3. Review.


Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells.

van der Schaar HM, Rust MJ, Chen C, van der Ende-Metselaar H, Wilschut J, Zhuang X, Smit JM.

PLoS Pathog. 2008 Dec;4(12):e1000244. doi: 10.1371/journal.ppat.1000244. Epub 2008 Dec 19.


Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking.

van der Schaar HM, Rust MJ, Waarts BL, van der Ende-Metselaar H, Kuhn RJ, Wilschut J, Zhuang X, Smit JM.

J Virol. 2007 Nov;81(21):12019-28. Epub 2007 Aug 29.

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