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Tenascin C Plasma Levels in Critically Ill Patients with or Without Sepsis: A Multicentre Observational Study.

Meijer MT, Uhel F, Cremer OL, Schultz MJ, van der Poll T; MARS consortium.

Shock. 2019 Nov 19. doi: 10.1097/SHK.0000000000001481. [Epub ahead of print]


Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS.

Morales-Quinteros L, Schultz MJ, Bringué J, Calfee CS, Camprubí M, Cremer OL, Horn J, van der Poll T, Sinha P, Artigas A, Bos LD; MARS Consortium.

Ann Intensive Care. 2019 Nov 21;9(1):128. doi: 10.1186/s13613-019-0601-0.


Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response.

Schouten LRA, Bos LDJ, Serpa Neto A, van Vught LA, Wiewel MA, Hoogendijk AJ, Bonten MJM, Cremer OL, Horn J, van der Poll T, Schultz MJ, Wösten-van Asperen RM; MARS consortium.

Intensive Care Med Exp. 2019 Oct 29;7(1):58. doi: 10.1186/s40635-019-0270-1.


Current gaps in sepsis immunology: new opportunities for translational research.

Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G, La Rosée P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Martin-Fernandez M, Almansa R, Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A, Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martín JF.

Lancet Infect Dis. 2019 Dec;19(12):e422-e436. doi: 10.1016/S1473-3099(19)30567-5. Epub 2019 Oct 17. Review.


Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.

Ding C, Scicluna BP, Stroo I, Yang J, Roelofs JJ, de Boer OJ, de Vos AF, Nürnberg P, Revenko AS, Crosby J, Van't Veer C, van der Poll T.

J Pathol. 2019 Oct 9. doi: 10.1002/path.5354. [Epub ahead of print]


Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice.

Perlee D, de Vos AF, Scicluna BP, Maag A, Mancheño P, de la Rosa O, Dalemans W, Florquin S, Van't Veer C, Lombardo E, van der Poll T.

Stem Cell Res Ther. 2019 Sep 23;10(1):286. doi: 10.1186/s13287-019-1391-x.


Effect of C1-inhibitor in adults with mild asthma: A randomized controlled trial.

Yang J, van Engelen TSR, Haak BW, Bonta PI, Majoor CJ, van 't Veer C, de Vos AF, Kemper EM, Lutter R, van Mierlo G, Zeerleder SS, Bel EH, van der Poll T.

Allergy. 2019 Sep 19. doi: 10.1111/all.14053. [Epub ahead of print] No abstract available.


Robustness of sepsis-3 criteria in critically ill patients.

Verboom DM, Frencken JF, Ong DSY, Horn J, van der Poll T, Bonten MJM, Cremer OL, Klein Klouwenberg PMC.

J Intensive Care. 2019 Aug 29;7:46. doi: 10.1186/s40560-019-0400-6. eCollection 2019.


Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation.

Iba T, Levy JH, Warkentin TE, Thachil J, van der Poll T, Levi M; Scientific and Standardization Committee on DIC, and the Scientific and Standardization Committee on Perioperative and Critical Care of the International Society on Thrombosis and Haemostasis.

J Thromb Haemost. 2019 Nov;17(11):1989-1994. doi: 10.1111/jth.14578. Epub 2019 Aug 13. No abstract available.


C3a signaling is not involved in eosinophil migration during experimental allergic lung inflammation in mice.

Yang J, Van't Veer C, Ten Brink MS, de Vos AF, van der Poll T.

Allergy. 2019 Aug 13. doi: 10.1111/all.14021. [Epub ahead of print] No abstract available.


Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia.

Leite GGF, Scicluna BP, van der Poll T, Salomão R.

NPJ Syst Biol Appl. 2019 Aug 1;5:26. doi: 10.1038/s41540-019-0105-4. eCollection 2019.


An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic.

Opal S, File TM, van der Poll T, Tzanis E, Chitra S, McGovern PC.

Clin Infect Dis. 2019 Aug 1;69(Supplement_1):S40-S47. doi: 10.1093/cid/ciz398.


Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.

Yang J, Ramirez Moral I, van 't Veer C, de Vos AF, de Beer R, Roelofs JJTH, Morgan BP, van der Poll T.

Respir Res. 2019 Jul 24;20(1):165. doi: 10.1186/s12931-019-1136-5.


Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia.

Khan HN, Perlee D, Schoenmaker L, van der Meer AJ, Franitza M, Toliat MR, Nürnberg P, Zwinderman AH, van der Poll T, Scicluna BP.

J Leukoc Biol. 2019 Nov;106(5):1153-1160. doi: 10.1002/JLB.4A0219-050R. Epub 2019 Jul 7.


Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis.

van de Groep K, Bos MP, Varkila MRJ, Savelkoul PHM, Ong DSY, Derde LPG, Juffermans NP, van der Poll T, Bonten MJM, Cremer OL; MARS consortium.

Eur J Clin Microbiol Infect Dis. 2019 Oct;38(10):1829-1836. doi: 10.1007/s10096-019-03616-w. Epub 2019 Jun 26.


Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?

Uhel F, Scicluna BP, van Vught LA, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T.

Crit Care. 2019 Jun 20;23(1):226. doi: 10.1186/s13054-019-2513-7. No abstract available.


Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis.

Birnie E, Weehuizen TAF, Lankelma JM, de Jong HK, Koh GCKW, van Lieshout MHP, Roelofs JJTH, Budding AE, de Vos AF, van der Poll T, Wiersinga WJ.

Infect Immun. 2019 Jul 23;87(8). pii: e00409-18. doi: 10.1128/IAI.00409-18. Print 2019 Aug.


Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.

Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC.

JAMA. 2019 May 28;321(20):2003-2017. doi: 10.1001/jama.2019.5791.


Recombinant Human Soluble Thrombomodulin in Patients With Sepsis-Associated Coagulopathy: Another Negative Sepsis Trial?

van der Poll T.

JAMA. 2019 May 28;321(20):1978-1980. doi: 10.1001/jama.2019.5792. No abstract available.


Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: The Role of Plasma Galactomannan.

van de Groep K, Verboom DM, van de Veerdonk FL, Haas PA, van der Poll T, Schultz MJ, Bonten MJM, Cremer OL.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):636-638. doi: 10.1164/rccm.201903-0587LE. No abstract available.


Human Adipose-Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae.

Perlee D, de Vos AF, Scicluna BP, Mancheño P, de la Rosa O, Dalemans W, Nürnberg P, Lombardo E, van der Poll T.

Stem Cells Transl Med. 2019 Aug;8(8):785-796. doi: 10.1002/sctm.18-0260. Epub 2019 Apr 29.


Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis.

Ding C, Yang J, Van't Veer C, van der Poll T.

Intensive Care Med Exp. 2019 Mar 12;7(1):14. doi: 10.1186/s40635-019-0228-3.


Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.

de Porto APNA, Claushuis TAM, van der Donk LEH, de Beer R, de Boer OJ, Florquin S, Roelofs JJTH, Hendriks RW, van der Poll T, Van't Veer C, de Vos AF.

Thromb Haemost. 2019 Jun;119(6):930-940. doi: 10.1055/s-0039-1681046. Epub 2019 Mar 14.


Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans.

van der Meer AJ, Kroeze A, Hoogendijk AJ, Soussan AA, Ellen van der Schoot C, Wuillemin WA, Voermans C, van der Poll T, Zeerleder S.

Blood Adv. 2019 Mar 12;3(5):724-728. doi: 10.1182/bloodadvances.2018018895. No abstract available.


Initiation of renal replacement therapy in patients with sepsis: more to it than meets the eye.

Uhel F, Peters-Sengers H, van der Poll T.

Ann Transl Med. 2018 Dec;6(Suppl 2):S130. doi: 10.21037/atm.2018.12.36. No abstract available.


Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia.

de Porto AP, Liu Z, de Beer R, Florquin S, de Boer OJ, Hendriks RW, van der Poll T, de Vos AF.

Mol Med. 2019 Jan 15;25(1):3. doi: 10.1186/s10020-018-0069-7.


Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles.

Bos LDJ, Scicluna BP, Ong DSY, Cremer O, van der Poll T, Schultz MJ.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):42-50. doi: 10.1164/rccm.201809-1808OC.


Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study.

van de Groep K, Nierkens S, Cremer OL, Peelen LM, Klein Klouwenberg PMC, Schultz MJ, Hack CE, van der Poll T, Bonten MJM, Ong DSY; MARS consortium.

Crit Care. 2018 Dec 18;22(1):348. doi: 10.1186/s13054-018-2261-0.


Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

Claushuis TAM, de Vos AF, Roelofs JJTH, de Boer OJ, van 't Veer C, van der Poll T.

J Innate Immun. 2019;11(2):168-180. doi: 10.1159/000494147. Epub 2018 Dec 17.


Correction to: What's new in immunostimulating strategies in the ICU.

Pickkers P, van der Poll T.

Intensive Care Med. 2019 Jan;45(1):137. doi: 10.1007/s00134-018-5482-4.


Myocardial Injury in Critically Ill Patients with Community-acquired Pneumonia. A Cohort Study.

Frencken JF, van Baal L, Kappen TH, Donker DW, Horn J, van der Poll T, van Klei WA, Bonten MJM, Cremer OL; Members of the MARS Consortium.

Ann Am Thorac Soc. 2019 May;16(5):606-612. doi: 10.1513/AnnalsATS.201804-286OC.


Kinase activity is impaired in neutrophils of sepsis patients.

Hoogendijk AJ, van Vught LA, Wiewel MA, Fuhler GM, Belkasim-Bohoudi H, Horn J, Schultz MJ, Scicluna BP, Peppelenbosch MP, van 't Veer C, de Vos AF, van der Poll T.

Haematologica. 2019 Jun;104(6):e233-e235. doi: 10.3324/haematol.2018.201913. Epub 2018 Dec 4. No abstract available.


Neutrophils mitigate the systemic host response during endotoxemia in mice.

van der Meer AJ, Ding C, Hoogendijk AJ, de Vos AF, Boon L, Zeerleder SS, van der Poll T.

Immunology. 2019 Mar;156(3):277-281. doi: 10.1111/imm.13026. Epub 2018 Dec 18.


What's new in immunostimulating strategies in the ICU.

Pickkers P, van der Poll T.

Intensive Care Med. 2019 Jan;45(1):110-112. doi: 10.1007/s00134-018-5462-8. Epub 2018 Nov 19. No abstract available. Erratum in: Intensive Care Med. 2018 Dec 7;:.


Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model.

Yang J, van 't Veer C, Roelofs JJTH, van Heijst JWJ, de Vos AF, McCrae KR, Revenko AS, Crosby J, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L187-L196. doi: 10.1152/ajplung.00162.2018. Epub 2018 Oct 25.


Thrombocytopenia Impairs Host Defense Against Burkholderia pseudomallei (Melioidosis).

Birnie E, Claushuis TAM, Koh GCKW, Limmathurotsakul D, Day NPJ, Roelofs JJTH, Ware J, Hou B, de Vos AF, van der Poll T, van 't Veer C, Wiersinga WJ.

J Infect Dis. 2019 Jan 29;219(4):648-659. doi: 10.1093/infdis/jiy541.


The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.


Inhibition of the extrinsic or intrinsic coagulation pathway during pneumonia-derived sepsis.

Stroo I, Ding C, Novak A, Yang J, Roelofs JJTH, Meijers JCM, Revenko AS, van 't Veer C, Zeerleder S, Crosby JR, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L799-L809. doi: 10.1152/ajplung.00014.2018. Epub 2018 Aug 23.


Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single-Blind, Parallel Group, Placebo Controlled Trial.

Perlee D, van Vught LA, Scicluna BP, Maag A, Lutter R, Kemper EM, van 't Veer C, Punchard MA, González J, Richard MP, Dalemans W, Lombardo E, de Vos AF, van der Poll T.

Stem Cells. 2018 Nov;36(11):1778-1788. doi: 10.1002/stem.2891. Epub 2018 Aug 20.


MRP8/14 does not contribute to dissemination or inflammation in a murine model of Lyme borreliosis.

Mason LMK, Coumou J, Ersöz JI, Oei A, Roelofs JJTH, Vogl T, van der Poll T, Hovius JWR.

Immunobiology. 2018 Nov;223(11):694-698. doi: 10.1016/j.imbio.2018.07.017. Epub 2018 Jul 17.


Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae-Induced Pneumonia-Derived Sepsis.

Claushuis TAM, van der Donk LEH, Luitse AL, van Veen HA, van der Wel NN, van Vught LA, Roelofs JJTH, de Boer OJ, Lankelma JM, Boon L, de Vos AF, van 't Veer C, van der Poll T.

J Immunol. 2018 Aug 15;201(4):1241-1252. doi: 10.4049/jimmunol.1800314. Epub 2018 Jul 9.


Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis.

Claushuis TAM, de Stoppelaar SF, de Vos AF, Grootemaat AE, van der Wel NN, Roelofs JJTH, Ware J, Van't Veer C, van der Poll T.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1772-1784. doi: 10.1161/ATVBAHA.118.311332.


Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coli.

Hoogland ICM, Westhoff D, Engelen-Lee JY, Melief J, Valls Serón M, Houben-Weerts JHMP, Huitinga I, van Westerloo DJ, van der Poll T, van Gool WA, van de Beek D.

Front Cell Neurosci. 2018 Apr 24;12:110. doi: 10.3389/fncel.2018.00110. eCollection 2018.


Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis.

van de Groep K, Bos MP, Savelkoul PHM, Rubenjan A, Gazenbeek C, Melchers WJG, van der Poll T, Juffermans NP, Ong DSY, Bonten MJM, Cremer OL; MARS consortium.

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1333-1344. doi: 10.1007/s10096-018-3255-1. Epub 2018 Apr 26.


Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU.

Miller RR 3rd, Lopansri BK, Burke JP, Levy M, Opal S, Rothman RE, D'Alessio FR, Sidhaye VK, Aggarwal NR, Balk R, Greenberg JA, Yoder M, Patel G, Gilbert E, Afshar M, Parada JP, Martin GS, Esper AM, Kempker JA, Narasimhan M, Tsegaye A, Hahn S, Mayo P, van der Poll T, Schultz MJ, Scicluna BP, Klein Klouwenberg P, Rapisarda A, Seldon TA, McHugh LC, Yager TD, Cermelli S, Sampson D, Rothwell V, Newman R, Bhide S, Fox BA, Kirk JT, Navalkar K, Davis RF, Brandon RA, Brandon RB.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):903-913. doi: 10.1164/rccm.201712-2472OC.


Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis.

Claushuis TAM, Van Der Veen AIP, Horn J, Schultz MJ, Houtkooper RH, Van 't Veer C, Van Der Poll T.

Platelets. 2019;30(3):296-304. doi: 10.1080/09537104.2018.1445841. Epub 2018 Mar 12.


Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure.

Koster-Brouwer ME, Verboom DM, Scicluna BP, van de Groep K, Frencken JF, Janssen D, Schuurman R, Schultz MJ, van der Poll T, Bonten MJM, Cremer OL; MARS Consortium.

Crit Care Med. 2018 Mar;46(3):368-374. doi: 10.1097/CCM.0000000000002735.


Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients.

Simonis FD, de Iudicibus G, Cremer OL, Ong DSY, van der Poll T, Bos LD, Schultz MJ; MARS consortium.

Ann Transl Med. 2018 Jan;6(2):24. doi: 10.21037/atm.2017.12.25.


Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia.

van den Boogaard FE, Brands X, Duitman J, de Stoppelaar SF, Borensztajn KS, Roelofs JJTH, Hollenberg MD, Spek CA, Schultz MJ, van 't Veer C, van der Poll T.

J Infect Dis. 2018 Apr 11;217(9):1462-1471. doi: 10.1093/infdis/jiy010.


Myocardial Injury in Patients With Sepsis and Its Association With Long-Term Outcome.

Frencken JF, Donker DW, Spitoni C, Koster-Brouwer ME, Soliman IW, Ong DSY, Horn J, van der Poll T, van Klei WA, Bonten MJM, Cremer OL.

Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e004040. doi: 10.1161/CIRCOUTCOMES.117.004040.


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