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Items: 1 to 50 of 60

1.

Mycobacteria employ two different mechanisms to cross the blood-brain barrier.

van Leeuwen LM, Boot M, Kuijl C, Picavet DI, van Stempvoort G, van der Pol SMA, de Vries HE, van der Wel NN, van der Kuip M, van Furth AM, van der Sar AM, Bitter W.

Cell Microbiol. 2018 May 10:e12858. doi: 10.1111/cmi.12858. [Epub ahead of print]

PMID:
29749044
2.

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner.

Derada Troletti C, Lopes Pinheiro MA, Charabati M, Gowing E, van Het Hof B, van der Pol SMA, Geerts D, Prat A, Fontijn RD, Unger WW, de Vries HE.

Brain Behav Immun. 2018 Mar;69:48-56. doi: 10.1016/j.bbi.2017.12.016. Epub 2017 Dec 28.

PMID:
29289661
3.

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.

Beaino W, Janssen B, Kooij G, van der Pol SMA, van Het Hof B, van Horssen J, Windhorst AD, de Vries HE.

J Neuroinflammation. 2017 Dec 22;14(1):259. doi: 10.1186/s12974-017-1034-z.

4.

Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis.

Dunham J, Bauer J, Campbell GR, Mahad DJ, van Driel N, van der Pol SMA, 't Hart BA, Lassmann H, Laman JD, van Horssen J, Kap YS.

J Neuropathol Exp Neurol. 2017 Jun 1;76(6):467-478. doi: 10.1093/jnen/nlx034.

PMID:
28505283
5.

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E.

J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9.

6.

An Economic Evaluation of Sacubitril/Valsartan for Heart Failure Patients in the Netherlands.

van der Pol S, Degener F, Postma MJ, Vemer P.

Value Health. 2017 Mar;20(3):388-396. doi: 10.1016/j.jval.2016.10.015. Epub 2016 Dec 22.

7.

Glutathione conjugation dose-dependently increases brain-specific liposomal drug delivery in vitro and in vivo.

Maussang D, Rip J, van Kregten J, van den Heuvel A, van der Pol S, van der Boom B, Reijerkerk A, Chen L, de Boer M, Gaillard P, de Vries H.

Drug Discov Today Technol. 2016 Jun;20:59-69. doi: 10.1016/j.ddtec.2016.09.003. Epub 2016 Oct 13.

PMID:
27986226
8.

Protandim Protects Oligodendrocytes against an Oxidative Insult.

Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J.

Antioxidants (Basel). 2016 Sep 7;5(3). pii: E30. doi: 10.3390/antiox5030030.

9.

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis.

van Horssen J, van der Pol S, Nijland P, Amor S, Perron H.

Mult Scler Relat Disord. 2016 Jul;8:11-8. doi: 10.1016/j.msard.2016.04.006. Epub 2016 Apr 22.

10.

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.

Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F.

Brain. 2016 Sep;139(Pt 9):2406-19. doi: 10.1093/brain/aww172. Epub 2016 Jul 19.

PMID:
27435092
11.

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.

Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW.

Elife. 2016 Jun 23;5. pii: e13149. doi: 10.7554/eLife.13149.

12.

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier.

Lim JL, van der Pol SM, Di Dio F, van Het Hof B, Kooij G, de Vries HE, van Horssen J.

Microvasc Res. 2016 May;105:61-9. doi: 10.1016/j.mvr.2015.12.003. Epub 2015 Dec 8.

PMID:
26679389
13.

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions.

Nijland PG, Molenaar RJ, van der Pol SM, van der Valk P, van Noorden CJ, de Vries HE, van Horssen J.

Acta Neuropathol Commun. 2015 Dec 4;3:79. doi: 10.1186/s40478-015-0261-8.

14.

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells.

Lopes Pinheiro MA, Kroon J, Hoogenboezem M, Geerts D, van Het Hof B, van der Pol SM, van Buul JD, de Vries HE.

J Immunol. 2016 Jan 1;196(1):72-9. doi: 10.4049/jimmunol.1500702. Epub 2015 Nov 23.

15.

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.

Raj DD, Moser J, van der Pol SM, van Os RP, Holtman IR, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW.

Aging Cell. 2015 Dec;14(6):1003-13. doi: 10.1111/acel.12370. Epub 2015 Aug 3.

16.

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis.

Kooij G, Braster R, Koning JJ, Laan LC, van Vliet SJ, Los T, Eveleens AM, van der Pol SM, Förster-Waldl E, Boztug K, Belot A, Szilagyi K, van den Berg TK, van Buul JD, van Egmond M, de Vries HE, Cummings RD, Dijkstra CD, van Die I.

Acta Neuropathol Commun. 2015 Jul 25;3:45. doi: 10.1186/s40478-015-0223-1.

17.

Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration.

van Strien ME, de Vries HE, Chrobok NL, Bol JGJM, Breve JJP, van der Pol SMP, Kooij G, van Buul JD, Karpuj M, Steinman L, Wilhelmus MM, Sestito C, Drukarch B, Van Dam AM.

Brain Behav Immun. 2015 Nov;50:141-154. doi: 10.1016/j.bbi.2015.06.023. Epub 2015 Jun 29.

PMID:
26133787
18.

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling.

Haarmann A, Nowak E, Deiß A, van der Pol S, Monoranu CM, Kooij G, Müller N, van der Valk P, Stoll G, de Vries HE, Berberich-Siebelt F, Buttmann M.

Acta Neuropathol. 2015 May;129(5):639-52. doi: 10.1007/s00401-015-1417-0. Epub 2015 Mar 27.

19.

IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.

Broux B, Mizee MR, Vanheusden M, van der Pol S, van Horssen J, Van Wijmeersch B, Somers V, de Vries HE, Stinissen P, Hellings N.

J Immunol. 2015 Mar 1;194(5):2099-109. doi: 10.4049/jimmunol.1401547. Epub 2015 Jan 23.

20.

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.

Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA.

J Cereb Blood Flow Metab. 2015 Mar;35(3):412-23. doi: 10.1038/jcbfm.2014.207. Epub 2014 Dec 17.

21.

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis.

Nijland PG, Witte ME, van het Hof B, van der Pol S, Bauer J, Lassmann H, van der Valk P, de Vries HE, van Horssen J.

Acta Neuropathol Commun. 2014 Dec 10;2:170. doi: 10.1186/s40478-014-0170-2.

22.

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis.

Mizee MR, Nijland PG, van der Pol SM, Drexhage JA, van Het Hof B, Mebius R, van der Valk P, van Horssen J, Reijerkerk A, de Vries HE.

Acta Neuropathol. 2014 Nov;128(5):691-703. doi: 10.1007/s00401-014-1335-6. Epub 2014 Aug 23.

PMID:
25149081
23.

In vivo MR imaging of intercellular adhesion molecule-1 expression in an animal model of multiple sclerosis.

Blezer EL, Deddens LH, Kooij G, Drexhage J, van der Pol SM, Reijerkerk A, Dijkhuizen RM, de Vries HE.

Contrast Media Mol Imaging. 2015 Mar-Apr;10(2):111-21. doi: 10.1002/cmmi.1602. Epub 2014 Apr 22.

PMID:
24753465
24.

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions.

Nijland PG, Michailidou I, Witte ME, Mizee MR, van der Pol SM, van Het Hof B, Reijerkerk A, Pellerin L, van der Valk P, de Vries HE, van Horssen J.

Glia. 2014 Jul;62(7):1125-41. doi: 10.1002/glia.22667. Epub 2014 Apr 1.

PMID:
24692237
25.

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma.

Kooij G, Kroon J, Paul D, Reijerkerk A, Geerts D, van der Pol SM, van Het Hof B, Drexhage JA, van Vliet SJ, Hekking LH, van Buul JD, Pachter JS, de Vries HE.

Acta Neuropathol. 2014 May;127(5):699-711. doi: 10.1007/s00401-014-1244-8. Epub 2014 Jan 16.

PMID:
24429546
26.

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.

Kooij G, Kopplin K, Blasig R, Stuiver M, Koning N, Goverse G, van der Pol SM, van Het Hof B, Gollasch M, Drexhage JA, Reijerkerk A, Meij IC, Mebius R, Willnow TE, Müller D, Blasig IE, de Vries HE.

Acta Neuropathol. 2014 Aug;128(2):267-77. doi: 10.1007/s00401-013-1227-1. Epub 2013 Dec 20.

PMID:
24356983
27.

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy.

Carrano A, Snkhchyan H, Kooij G, van der Pol S, van Horssen J, Veerhuis R, Hoozemans J, Rozemuller A, de Vries HE.

Neurobiol Aging. 2014 Mar;35(3):565-75. doi: 10.1016/j.neurobiolaging.2013.09.015. Epub 2013 Oct 15.

PMID:
24138987
28.

Roles for HB-EGF and CD9 in multiple sclerosis.

Schenk GJ, Dijkstra S, van het Hof AJ, van der Pol SM, Drexhage JA, van der Valk P, Reijerkerk A, van Horssen J, de Vries HE.

Glia. 2013 Nov;61(11):1890-905. doi: 10.1002/glia.22565. Epub 2013 Sep 3.

PMID:
24038577
29.

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.

van Horssen J, Singh S, van der Pol S, Kipp M, Lim JL, Peferoen L, Gerritsen W, Kooi EJ, Witte ME, Geurts JJ, de Vries HE, Peferoen-Baert R, van den Elsen PJ, van der Valk P, Amor S.

J Neuroinflammation. 2012 Jul 2;9:156. doi: 10.1186/1742-2094-9-156.

30.

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation.

Gaillard PJ, Appeldoorn CC, Rip J, Dorland R, van der Pol SM, Kooij G, de Vries HE, Reijerkerk A.

J Control Release. 2012 Dec 28;164(3):364-9. doi: 10.1016/j.jconrel.2012.06.022. Epub 2012 Jun 23.

PMID:
22732475
31.

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier.

van Doorn R, Lopes Pinheiro MA, Kooij G, Lakeman K, van het Hof B, van der Pol SM, Geerts D, van Horssen J, van der Valk P, van der Kam E, Ronken E, Reijerkerk A, de Vries HE.

J Neuroinflammation. 2012 Jun 20;9:133. doi: 10.1186/1742-2094-9-133.

32.

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation.

Kuijk LM, Klaver EJ, Kooij G, van der Pol SM, Heijnen P, Bruijns SC, Kringel H, Pinelli E, Kraal G, de Vries HE, Dijkstra CD, Bouma G, van Die I.

Mol Immunol. 2012 Jun;51(2):210-8. doi: 10.1016/j.molimm.2012.03.020. Epub 2012 Apr 5.

PMID:
22482518
33.

Nanoclusters of iron oxide: effect of core composition on structure, biocompatibility, and cell labeling efficacy.

van Tilborg GA, Cormode DP, Jarzyna PA, van der Toorn A, van der Pol SM, van Bloois L, Fayad ZA, Storm G, Mulder WJ, de Vries HE, Dijkhuizen RM.

Bioconjug Chem. 2012 May 16;23(5):941-50. doi: 10.1021/bc200543k. Epub 2012 May 3.

34.

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain.

Vanmierlo T, Weingärtner O, van der Pol S, Husche C, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch H, Grimm M, Hartmann T, Laufs U, Böhm M, de Vries HE, Mulder M, Lütjohann D.

J Lipid Res. 2012 Apr;53(4):726-35. doi: 10.1194/jlr.M017244. Epub 2012 Jan 25.

35.

CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients.

Broux B, Pannemans K, Zhang X, Markovic-Plese S, Broekmans T, Eijnde BO, Van Wijmeersch B, Somers V, Geusens P, van der Pol S, van Horssen J, Stinissen P, Hellings N.

J Autoimmun. 2012 Feb;38(1):10-9. doi: 10.1016/j.jaut.2011.11.006. Epub 2011 Nov 26.

PMID:
22123179
36.

Brain endothelial barrier passage by monocytes is controlled by the endothelin system.

Reijerkerk A, Lakeman KA, Drexhage JA, van Het Hof B, van Wijck Y, van der Pol SM, Kooij G, Geerts D, de Vries HE.

J Neurochem. 2012 Jun;121(5):730-7. doi: 10.1111/j.1471-4159.2011.07393.x. Epub 2011 Aug 12.

37.

Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.

Kooij G, Mizee MR, van Horssen J, Reijerkerk A, Witte ME, Drexhage JA, van der Pol SM, van Het Hof B, Scheffer G, Scheper R, Dijkstra CD, van der Valk P, de Vries HE.

Brain. 2011 Feb;134(Pt 2):555-70. doi: 10.1093/brain/awq330. Epub 2010 Dec 22.

PMID:
21183485
38.

Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions.

Wilhelmus MM, van der Pol SM, Jansen Q, Witte ME, van der Valk P, Rozemuller AJ, Drukarch B, de Vries HE, Van Horssen J.

Free Radic Biol Med. 2011 Feb 1;50(3):469-76. doi: 10.1016/j.freeradbiomed.2010.11.033. Epub 2010 Dec 8.

39.

Magnetic resonance imaging of monocytes labeled with ultrasmall superparamagnetic particles of iron oxide using magnetoelectroporation in an animal model of multiple sclerosis.

Engberink RD, van der Pol SM, Walczak P, van der Toorn A, Viergever MA, Dijkstra CD, Bulte JW, de Vries HE, Blezer EL.

Mol Imaging. 2010 Oct;9(5):268-77.

40.

Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis.

Oude Engberink RD, Blezer EL, Dijkstra CD, van der Pol SM, van der Toorn A, de Vries HE.

NMR Biomed. 2010 Nov;23(9):1087-96. doi: 10.1002/nbm.1536.

PMID:
20665906
41.

The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier.

Reijerkerk A, Kooij G, van der Pol SM, Leyen T, Lakeman K, van Het Hof B, Vivien D, de Vries HE.

J Neurochem. 2010 Apr;113(2):447-53. doi: 10.1111/j.1471-4159.2010.06598.x. Epub 2010 Jan 18.

42.

P-glycoprotein acts as an immunomodulator during neuroinflammation.

Kooij G, Backer R, Koning JJ, Reijerkerk A, van Horssen J, van der Pol SM, Drexhage J, Schinkel A, Dijkstra CD, den Haan JM, Geijtenbeek TB, de Vries HE.

PLoS One. 2009 Dec 8;4(12):e8212. doi: 10.1371/journal.pone.0008212.

43.

T lymphocytes impair P-glycoprotein function during neuroinflammation.

Kooij G, van Horssen J, de Lange EC, Reijerkerk A, van der Pol SM, van Het Hof B, Drexhage J, Vennegoor A, Killestein J, Scheffer G, Oerlemans R, Scheper R, van der Valk P, Dijkstra CD, de Vries HE.

J Autoimmun. 2010 Jun;34(4):416-25. doi: 10.1016/j.jaut.2009.10.006. Epub 2009 Dec 2.

PMID:
19959334
44.

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier.

Reijerkerk A, Kooij G, van der Pol SM, Leyen T, van Het Hof B, Couraud PO, Vivien D, Dijkstra CD, de Vries HE.

J Immunol. 2008 Sep 1;181(5):3567-74.

45.

Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE.

Dijkstra S, Kooij G, Verbeek R, van der Pol SM, Amor S, Geisert EE Jr, Dijkstra CD, van Noort JM, Vries HE.

Neurobiol Dis. 2008 Sep;31(3):413-21. doi: 10.1016/j.nbd.2008.05.018. Epub 2008 Jun 5.

PMID:
18586096
46.

Protective effects of peroxiredoxin-1 at the injured blood-brain barrier.

Schreibelt G, van Horssen J, Haseloff RF, Reijerkerk A, van der Pol SM, Nieuwenhuizen O, Krause E, Blasig IE, Dijkstra CD, Ronken E, de Vries HE.

Free Radic Biol Med. 2008 Aug 1;45(3):256-64. doi: 10.1016/j.freeradbiomed.2008.03.024. Epub 2008 Apr 16.

PMID:
18452719
47.

Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement.

Vellinga MM, Oude Engberink RD, Seewann A, Pouwels PJ, Wattjes MP, van der Pol SM, Pering C, Polman CH, de Vries HE, Geurts JJ, Barkhof F.

Brain. 2008 Mar;131(Pt 3):800-7. doi: 10.1093/brain/awn009. Epub 2008 Feb 1.

PMID:
18245785
48.

MRI of monocyte infiltration in an animal model of neuroinflammation using SPIO-labeled monocytes or free USPIO.

Oude Engberink RD, Blezer EL, Hoff EI, van der Pol SM, van der Toorn A, Dijkhuizen RM, de Vries HE.

J Cereb Blood Flow Metab. 2008 Apr;28(4):841-51. Epub 2007 Nov 14.

PMID:
18000513
49.

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling.

Schreibelt G, Kooij G, Reijerkerk A, van Doorn R, Gringhuis SI, van der Pol S, Weksler BB, Romero IA, Couraud PO, Piontek J, Blasig IE, Dijkstra CD, Ronken E, de Vries HE.

FASEB J. 2007 Nov;21(13):3666-76. Epub 2007 Jun 22.

PMID:
17586731
50.

Comparison of SPIO and USPIO for in vitro labeling of human monocytes: MR detection and cell function.

Oude Engberink RD, van der Pol SM, Döpp EA, de Vries HE, Blezer EL.

Radiology. 2007 May;243(2):467-74.

PMID:
17456871

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