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Items: 43


Platelet biology and functions: new concepts and clinical perspectives.

van der Meijden PEJ, Heemskerk JWM.

Nat Rev Cardiol. 2019 Mar;16(3):166-179. doi: 10.1038/s41569-018-0110-0. Review.


Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice.

Vries MJ, van der Meijden PE, Kuiper GJ, Nelemans PJ, Wetzels RJ, van Oerle RG, Lancé MD, Ten Cate H, Henskens YM.

Res Pract Thromb Haemost. 2018 Jul 27;2(4):767-777. doi: 10.1002/rth2.12114. eCollection 2018 Oct.


Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects.

Baaten CCFMJ, Swieringa F, Misztal T, Mastenbroek TG, Feijge MAH, Bock PE, Donners MMPC, Collins PW, Li R, van der Meijden PEJ, Heemskerk JWM.

Blood Adv. 2018 Sep 25;2(18):2320-2331. doi: 10.1182/bloodadvances.2017011544.


Integrating platelet and coagulation activation in fibrin clot formation.

Swieringa F, Spronk HMH, Heemskerk JWM, van der Meijden PEJ.

Res Pract Thromb Haemost. 2018 May 20;2(3):450-460. doi: 10.1002/rth2.12107. eCollection 2018 Jul. Review.


The coagulation system in atherothrombosis: Implications for new therapeutic strategies.

Olie RH, van der Meijden PEJ, Ten Cate H.

Res Pract Thromb Haemost. 2018 Feb 19;2(2):188-198. doi: 10.1002/rth2.12080. eCollection 2018 Apr.


Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ.

Haematologica. 2018 Sep;103(9):1557-1567. doi: 10.3324/haematol.2017.185165. Epub 2018 Jun 7.


Platelet populations and priming in hematological diseases.

Baaten CCFMJ, Ten Cate H, van der Meijden PEJ, Heemskerk JWM.

Blood Rev. 2017 Nov;31(6):389-399. doi: 10.1016/j.blre.2017.07.004. Epub 2017 Jul 22. Review.


Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients.

Vries MJ, Bouman HJ, Olie RH, Veenstra LF, Zwaveling S, Verhezen PW, Ten Cate-Hoek AJ, Ten Cate H, Henskens YM, van der Meijden PE.

Eur Heart J Cardiovasc Pharmacother. 2017 Jan;3(1):11-17. doi: 10.1093/ehjcvp/pvw026. Epub 2016 Sep 7.


Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury.

Zentai C, van der Meijden PE, Braunschweig T, Hueck N, Honickel M, Spronk HM, Rossaint R, Grottke O.

Anesth Analg. 2016 Jul;123(1):38-48. doi: 10.1213/ANE.0000000000001379.


PO-19 - Platelet (PLT) adhesion under flow condition in essential thrombocythemia (ET) and polycythemia vera (PV) is variably influenced according to patient mutational status.

Vignoli A, Tessarolo S, Marchetti M, Gamba S, Piras F, Finazzi G, van der Meijden PE, Swieringa F, Ten Cate H, Heemskerk JW, Rambaldi A, Falanga A.

Thromb Res. 2016 Apr;140 Suppl 1:S183. doi: 10.1016/S0049-3848(16)30152-9. Epub 2016 Apr 8.


OC-08 - Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CC, Moenen FC, Henskens YM, Swieringa F, Wetzels R, van Oerle R, Ten Cate H, Beckers EA, Heemskerk JW, van der Meijden PE.

Thromb Res. 2016 Apr;140 Suppl 1:S171. doi: 10.1016/S0049-3848(16)30125-6. Epub 2016 Apr 8.


Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow.

Swieringa F, Baaten CC, Verdoold R, Mastenbroek TG, Rijnveld N, van der Laan KO, Breel EJ, Collins PW, Lancé MD, Henskens YM, Cosemans JM, Heemskerk JW, van der Meijden PE.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):692-9. doi: 10.1161/ATVBAHA.115.306537. Epub 2016 Feb 4.


Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.

Mattheij NJ, Swieringa F, Mastenbroek TG, Berny-Lang MA, May F, Baaten CC, van der Meijden PE, Henskens YM, Beckers EA, Suylen DP, Nolte MW, Hackeng TM, McCarty OJ, Heemskerk JW, Cosemans JM.

Haematologica. 2016 Apr;101(4):427-36. doi: 10.3324/haematol.2015.131441. Epub 2015 Dec 31.


Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity.

Mastenbroek TG, Feijge MA, Kremers RM, van den Bosch MT, Swieringa F, De Groef L, Moons L, Bennett C, Ghevaert C, Johnson JL, van der Meijden PE, Cosemans JM.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2554-61. doi: 10.1161/ATVBAHA.115.306153. Epub 2015 Oct 15.


Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

van der Meijden PE, Ozaki Y, Ruf W, de Laat B, Mutch N, Diamond S, Nieuwland R, Peters TC, Heestermans M, Kremers RM, Moorlag M, Boender J, Ünlü B, Reitsma PH.

Thromb Res. 2015 Sep;136 Suppl 1:S3-7. doi: 10.1016/j.thromres.2015.07.034. No abstract available.


Maastricht Consensus Conference on Thrombosis (MCCT): A roadmap for future research, February 11-13, 2015, Maastricht, The Netherlands.

Ten Cate-Hoek AJ, Ten Cate H, Henskens Y, van der Meijden PE, Spronk HM, Wittens C.

Thromb Res. 2015 Sep;136 Suppl 1:S1-2. doi: 10.1016/j.thromres.2015.07.033. No abstract available.


Assessment of bleeding risk in patients with coronary artery disease on dual antiplatelet therapy. A systematic review.

Vries MJ, van der Meijden PE, Henskens YM, ten Cate-Hoek AJ, ten Cate H.

Thromb Haemost. 2016 Jan;115(1):7-24. doi: 10.1160/TH15-04-0355. Epub 2015 Aug 13. Review.


Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication.

Baaten CC, Veenstra LF, Wetzels R, van Geffen JP, Swieringa F, de Witt SM, Henskens YM, Crijns H, Nylander S, van Giezen JJ, Heemskerk JW, van der Meijden PE.

Haematologica. 2015 Sep;100(9):1131-8. doi: 10.3324/haematol.2014.122457. Epub 2015 Jun 25.


Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding.

Swieringa F, Lancé MD, Fuchs B, Feijge MA, Solecka BA, Verheijen LP, Hughes KR, van Oerle R, Deckmyn H, Kannicht C, Heemskerk JW, van der Meijden PE.

J Thromb Haemost. 2015 Aug;13(8):1503-13. doi: 10.1111/jth.13007. Epub 2015 Jun 11.


Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model.

Zentai C, Solomon C, van der Meijden PE, Spronk HM, Schnabel J, Rossaint R, Grottke O.

Clin Appl Thromb Hemost. 2016 Nov;22(8):749-759. Epub 2015 May 6.


Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow.

Swieringa F, Kuijpers MJ, Lamers MM, van der Meijden PE, Heemskerk JW.

Haematologica. 2015 Jun;100(6):748-56. doi: 10.3324/haematol.2014.116863. Epub 2015 Mar 13.


Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow.

Whyte CS, Swieringa F, Mastenbroek TG, Lionikiene AS, Lancé MD, van der Meijden PE, Heemskerk JW, Mutch NJ.

Blood. 2015 Apr 16;125(16):2568-78. doi: 10.1182/blood-2014-09-599480. Epub 2015 Feb 23.


Short- and Long-term exercise induced alterations in haemostasis: a review of the literature.

Posthuma JJ, van der Meijden PE, Ten Cate H, Spronk HM.

Blood Rev. 2015 May;29(3):171-8. doi: 10.1016/j.blre.2014.10.005. Epub 2014 Nov 6. Review.


Factor XII regulates the pathological process of thrombus formation on ruptured plaques.

Kuijpers MJ, van der Meijden PE, Feijge MA, Mattheij NJ, May F, Govers-Riemslag J, Meijers JC, Heemskerk JW, Renné T, Cosemans JM.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1674-80. doi: 10.1161/ATVBAHA.114.303315. Epub 2014 May 22.


Differential roles of tissue factor and phosphatidylserine in activation of coagulation.

Spronk HM, ten Cate H, van der Meijden PE.

Thromb Res. 2014 May;133 Suppl 1:S54-6. doi: 10.1016/j.thromres.2014.03.022.


Long-term strenuous exercise induces a hypercoagulable state through contact activation.

Posthuma JJ, Loeffen R, van Oerle R, Henskens YM, ten Cate H, Spronk HM, van der Meijden PE.

Thromb Haemost. 2014 Jun;111(6):1197-9. doi: 10.1160/TH13-11-0963. Epub 2014 Jan 30. No abstract available.


Targeting platelet receptor function in thrombus formation: the risk of bleeding.

Swieringa F, Kuijpers MJ, Heemskerk JW, van der Meijden PE.

Blood Rev. 2014 Jan;28(1):9-21. doi: 10.1016/j.blre.2013.12.001. Epub 2013 Dec 26. Review.


Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry.

Ninivaggi M, Feijge MA, Baaten CC, Kuiper GJ, Marcus MA, Ten Cate H, Lancé MD, Heemskerk JW, van der Meijden PE.

Thromb Haemost. 2014 Mar 3;111(3):447-57. doi: 10.1160/TH13-06-0493. Epub 2013 Nov 21.


Platelet dysfunction in thrombosis patients treated with vitamin K antagonists and recurrent bleeding.

van der Meijden PE, Bouman AC, Feijge MA, van Oerle R, Spronk HM, Hamulyák K, ten Cate-Hoek AJ, ten Cate H, Heemskerk JW.

PLoS One. 2013 May 28;8(5):e64112. doi: 10.1371/journal.pone.0064112. Print 2013.


Platelet protein shake as playmaker.

van der Meijden PE, Heemskerk JW.

Blood. 2012 Oct 11;120(15):2931-2. doi: 10.1182/blood-2012-08-450080. No abstract available.


Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation.

van der Meijden PE, Feijge MA, Swieringa F, Gilio K, Nergiz-Unal R, Hamulyák K, Heemskerk JW.

Cell Mol Life Sci. 2012 Oct;69(20):3481-92. doi: 10.1007/s00018-012-1033-2. Epub 2012 Jun 6.


Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa.

Van Der Meijden PE, Van Schilfgaarde M, Van Oerle R, Renné T, ten Cate H, Spronk HM.

J Thromb Haemost. 2012 Jul;10(7):1355-62. doi: 10.1111/j.1538-7836.2012.04758.x.


Polyphosphates: a link between platelet activation, intrinsic coagulation and inflammation?

van der Meijden PE, Heemskerk JW.

Expert Rev Hematol. 2010 Jun;3(3):269-72. doi: 10.1586/ehm.10.26.


Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation.

Gilio K, van Kruchten R, Braun A, Berna-Erro A, Feijge MA, Stegner D, van der Meijden PE, Kuijpers MJ, Varga-Szabo D, Heemskerk JW, Nieswandt B.

J Biol Chem. 2010 Jul 30;285(31):23629-38. doi: 10.1074/jbc.M110.108696. Epub 2010 Jun 2.


Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques.

Nergiz-Unal R, Cosemans JM, Feijge MA, van der Meijden PE, Storey RF, van Giezen JJ, oude Egbrink MG, Heemskerk JW, Kuijpers MJ.

PLoS One. 2010 Apr 12;5(4):e10130. doi: 10.1371/journal.pone.0010130.


Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

Gilio K, Munnix IC, Mangin P, Cosemans JM, Feijge MA, van der Meijden PE, Olieslagers S, Chrzanowska-Wodnicka MB, Lillian R, Schoenwaelder S, Koyasu S, Sage SO, Jackson SP, Heemskerk JW.

J Biol Chem. 2009 Dec 4;284(49):33750-62. doi: 10.1074/jbc.M109.048439. Epub 2009 Oct 8.


Dual role of collagen in factor XII-dependent thrombus formation.

van der Meijden PE, Munnix IC, Auger JM, Govers-Riemslag JW, Cosemans JM, Kuijpers MJ, Spronk HM, Watson SP, Renné T, Heemskerk JW.

Blood. 2009 Jul 23;114(4):881-90. doi: 10.1182/blood-2008-07-171066. Epub 2009 Apr 16.


Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.

Vanschoonbeek K, Wouters K, van der Meijden PE, van Gorp PJ, Feijge MA, Herfs M, Schurgers LJ, Hofker MH, de Maat MP, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2023-9. doi: 10.1161/ATVBAHA.107.156992. Epub 2008 Aug 28.


Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleeding.

Schols SE, van der Meijden PE, van Oerle R, Curvers J, Heemskerk JW, van Pampus EC.

Thromb Haemost. 2008 Jan;99(1):64-70. doi: 10.1160/TH07-07-0438.


Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

van der Meijden PE, Schoenwaelder SM, Feijge MA, Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW.

FEBS J. 2008 Jan;275(2):371-85. Epub 2007 Dec 13. Erratum in: FEBS J. 2008 Feb;275(4):811.


Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets.

Strehl A, Munnix IC, Kuijpers MJ, van der Meijden PE, Cosemans JM, Feijge MA, Nieswandt B, Heemskerk JW.

J Biol Chem. 2007 Mar 9;282(10):7046-55. Epub 2007 Jan 8.


The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo.

Munnix IC, Strehl A, Kuijpers MJ, Auger JM, van der Meijden PE, van Zandvoort MA, oude Egbrink MG, Nieswandt B, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2673-8. Epub 2005 Oct 27.


Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk.

van der Meijden PE, Feijge MA, Giesen PL, Huijberts M, van Raak LP, Heemskerk JW.

Thromb Haemost. 2005 Jun;93(6):1128-36.


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