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Immune recognition of putative alien microbial structures: Host-pathogen interactions in the age of space travel.

Netea MG, Domínguez-Andrés J, Eleveld M, Op den Camp HJM, van der Meer JWM, Gow NAR, de Jonge MI.

PLoS Pathog. 2020 Jan 30;16(1):e1008153. doi: 10.1371/journal.ppat.1008153. eCollection 2020 Jan. Review.


Mediation analysis shows that a decline in self-efficacy mediates the increase in fatigue severity following an initial positive response to cognitive behavioural therapy in Q fever fatigue syndrome.

Breukers EMC, Raijmakers RPH, Nieuwkerk PT, Bleijenberg G, van der Meer JWM, Bleeker-Rovers CP, Keijmel SP, Knoop H.

J Psychosom Res. 2019 Dec;127:109841. doi: 10.1016/j.jpsychores.2019.109841. Epub 2019 Oct 23.


Globalization of Traditional Chinese Medicine: what are the issues for ensuring evidence-based diagnosis and therapy?

Fears R, Griffin GE, Larhammar D, Ter Meulen V, van der Meer JWM.

J Intern Med. 2020 Feb;287(2):210-213. doi: 10.1111/joim.12989. Epub 2019 Nov 7. No abstract available.


Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients.

Raijmakers RP, Stenos J, Keijmel SP, Ter Horst R, Novakovic B, Nguyen C, Van Der Meer JW, Netea MG, Bleeker-Rovers CP, Joosten LA, Graves SR.

Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz296. doi: 10.1093/ofid/ofz296.


A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, Ter Horst R, Roerink ME, Novakovic B, Joosten LAB, van der Meer JWM, Netea MG, Bleeker-Rovers CP.

J Transl Med. 2019 May 14;17(1):157. doi: 10.1186/s12967-019-1906-3.


A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, van der Meer JWM, Joosten LAB, Netea MG, Bleeker-Rovers CP.

Eur J Immunol. 2019 Jul;49(7):1015-1022. doi: 10.1002/eji.201848012. Epub 2019 May 9.


Cytokine profiles in patients with Q fever fatigue syndrome.

Raijmakers RPH, Koeken VACM, Jansen AFM, Keijmel SP, Roerink ME, Joosten LAB, Netea MG, van der Meer JWM, Bleeker-Rovers CP.

J Infect. 2019 May;78(5):349-357. doi: 10.1016/j.jinf.2019.01.006. Epub 2019 Jan 23.


Long-term effect of cognitive behavioural therapy and doxycycline treatment for patients with Q fever fatigue syndrome: One-year follow-up of the Qure study.

Raijmakers RPH, Keijmel SP, Breukers EMC, Bleijenberg G, van der Meer JWM, Bleeker-Rovers CP, Knoop H.

J Psychosom Res. 2019 Jan;116:62-67. doi: 10.1016/j.jpsychores.2018.11.007. Epub 2018 Nov 12.


Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit.

Vandenbroucke-Grauls CMJE, van der Meer JWM.

JAMA. 2018 Nov 27;320(20):2081-2083. doi: 10.1001/jama.2018.13764. No abstract available.


Pitfalls in cytokine measurements - Plasma TGF-β1 in chronic fatigue syndrome.

Roerink ME, van der Schaaf ME, Hawinkels LJAC, Raijmakers RPH, Knoop H, Joosten LAB, van der Meer JWM.

Neth J Med. 2018 Sep;76(7):310-313.


Long-term prognosis, treatment, and outcome of patients with fever of unknown origin in whom no diagnosis was made despite extensive investigation: A questionnaire based study.

Mulders-Manders CM, Engwerda C, Simon A, van der Meer JWM, Bleeker-Rovers CP.

Medicine (Baltimore). 2018 Jun;97(25):e11241. doi: 10.1097/MD.0000000000011241.


Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature.

Jansen AFM, Raijmakers RPH, Keijmel SP, van der Molen RG, Vervoort GM, van der Meer JWM, van Deuren M, Bleeker-Rovers CP.

Eur J Intern Med. 2018 Aug;54:6-12. doi: 10.1016/j.ejim.2018.06.007. Epub 2018 Jun 19. Review.


Hair and salivary cortisol in a cohort of women with chronic fatigue syndrome.

Roerink ME, Roerink SHPP, Skoluda N, van der Schaaf ME, Hermus ARMM, van der Meer JWM, Knoop H, Nater UM.

Horm Behav. 2018 Jul;103:1-6. doi: 10.1016/j.yhbeh.2018.05.016. Epub 2018 May 29.


Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, Schoffelen T, Scholzen A, van der Meer JWM, Joosten LAB, Netea MG, van Deuren M, Bleeker-Rovers CP.

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1385-1391. doi: 10.1007/s10096-018-3265-z. Epub 2018 May 26.


Innate immune memory: An evolutionary perspective.

Gourbal B, Pinaud S, Beckers GJM, Van Der Meer JWM, Conrath U, Netea MG.

Immunol Rev. 2018 May;283(1):21-40. doi: 10.1111/imr.12647. Review.


Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome.

van der Schaaf ME, Roelofs K, de Lange FP, Geurts DEM, van der Meer JWM, Knoop H, Toni I.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Apr;3(4):392-404. doi: 10.1016/j.bpsc.2018.01.015. Epub 2018 Feb 12.


[Report of the Dutch National Health Council on chronic fatigue syndrome].

van der Meer JWM, Roerink ME, van de Putte EM.

Ned Tijdschr Geneeskd. 2018;162:D2845. Dutch.


[Bacteriophages in the battle against multidrug resistant bacteria].

van der Meer JWM, Vandenbroucke-Grauls CMJE.

Ned Tijdschr Geneeskd. 2018;162:D2433. Dutch.


High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells.

Arts RJW, Huang PK, Yang, Joosten LAB, van der Meer JWM, Oppenheim JJ, Netea MG, Cheng SC.

Front Immunol. 2018 Mar 14;9:526. doi: 10.3389/fimmu.2018.00526. eCollection 2018.


Diagnostic yield of FDG-PET/CT in fever of unknown origin: a systematic review, meta-analysis, and Delphi exercise.

Kouijzer IJE, van der Meer JWM, Oyen WJG, Bleeker-Rovers CP.

Clin Radiol. 2018 Jun;73(6):588-589. doi: 10.1016/j.crad.2018.02.004. Epub 2018 Mar 19. No abstract available.


Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Bekkering S, Arts RJW, Novakovic B, Kourtzelis I, van der Heijden CDCC, Li Y, Popa CD, Ter Horst R, van Tuijl J, Netea-Maier RT, van de Veerdonk FL, Chavakis T, Joosten LAB, van der Meer JWM, Stunnenberg H, Riksen NP, Netea MG.

Cell. 2018 Jan 11;172(1-2):135-146.e9. doi: 10.1016/j.cell.2017.11.025.


Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment.

Roerink ME, Knoop H, Bronkhorst EM, Mouthaan HA, Hawinkels LJAC, Joosten LAB, van der Meer JWM.

J Transl Med. 2017 Dec 29;15(1):267. doi: 10.1186/s12967-017-1371-9.


Cytokine signature in chronic fatigue syndrome.

Roerink ME, Buckland M, Lloyd AR, van der Meer JWM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9435. doi: 10.1073/pnas.1714011114. Epub 2017 Oct 30. No abstract available.


Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer.

Netea MG, Joosten LAB, van der Meer JWM.

J Leukoc Biol. 2017 Dec;102(6):1323-1332. doi: 10.1189/jlb.5RI0217-064RR. Epub 2017 Oct 10. Review.


Cytokine Inhibition in Patients With Chronic Fatigue Syndrome.

Roerink ME, Van der Meer JWM.

Ann Intern Med. 2017 Sep 19;167(6):448. doi: 10.7326/L17-0317. No abstract available.


Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans.

Draper A, Koch RM, van der Meer JW, Aj Apps M, Pickkers P, Husain M, van der Schaaf ME.

Neuropsychopharmacology. 2018 Apr;43(5):1107-1118. doi: 10.1038/npp.2017.231. Epub 2017 Sep 26.


Assessing and regulating homeopathic products.

Fears R, Griffin G, Larhammar D, Ter Meulen V, van der Meer JWM.

J Intern Med. 2017 Dec;282(6):563-565. doi: 10.1111/joim.12676. Epub 2017 Sep 25. No abstract available.


Observable phenomena that reveal medical students' clinical reasoning ability during expert assessment of their history taking: a qualitative study.

Haring CM, Cools BM, van Gurp PJM, van der Meer JWM, Postma CT.

BMC Med Educ. 2017 Aug 29;17(1):147. doi: 10.1186/s12909-017-0983-3.


Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease.

Spierings EJW, van der Meer JWM, Simon A.

Neth J Med. 2017 Jul;75(6):247-249.


A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.


Long-term follow-up after cognitive behaviour therapy for chronic fatigue syndrome.

Janse A, Nikolaus S, Wiborg JF, Heins M, van der Meer JWM, Bleijenberg G, Tummers M, Twisk J, Knoop H.

J Psychosom Res. 2017 Jun;97:45-51. doi: 10.1016/j.jpsychores.2017.03.016. Epub 2017 Mar 27.


Reply to Raoult.

Keijmel SP, Bleijenberg G, van der Meer JWM, Knoop H, Bleeker-Rovers CP.

Clin Infect Dis. 2017 Sep 15;65(6):1055-1056. doi: 10.1093/cid/cix470. No abstract available.


Risk of infections in patients with gout: a population-based cohort study.

Spaetgens B, de Vries F, Driessen JHM, Leufkens HG, Souverein PC, Boonen A, van der Meer JWM, Joosten LAB.

Sci Rep. 2017 May 3;7(1):1429. doi: 10.1038/s41598-017-01588-5.


Effectiveness of Long-term Doxycycline Treatment and Cognitive-Behavioral Therapy on Fatigue Severity in Patients with Q Fever Fatigue Syndrome (Qure Study): A Randomized Controlled Trial.

Keijmel SP, Delsing CE, Bleijenberg G, van der Meer JWM, Donders RT, Leclercq M, Kampschreur LM, van den Berg M, Sprong T, Nabuurs-Franssen MH, Knoop H, Bleeker-Rovers CP.

Clin Infect Dis. 2017 Apr 15;64(8):998-1005. doi: 10.1093/cid/cix013.


Trained Immunity: An Ancient Way of Remembering.

Netea MG, van der Meer JW.

Cell Host Microbe. 2017 Mar 8;21(3):297-300. doi: 10.1016/j.chom.2017.02.003. Review.


Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial.

Roerink ME, Bredie SJH, Heijnen M, Dinarello CA, Knoop H, Van der Meer JWM.

Ann Intern Med. 2017 Apr 18;166(8):557-564. doi: 10.7326/M16-2391. Epub 2017 Mar 7.


Metabolome of chronic fatigue syndrome.

Roerink ME, Bronkhorst EM, van der Meer JW.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E910. doi: 10.1073/pnas.1618447114. Epub 2017 Jan 26. No abstract available.


Interleukin-1 as a mediator of fatigue in disease: a narrative review.

Roerink ME, van der Schaaf ME, Dinarello CA, Knoop H, van der Meer JW.

J Neuroinflammation. 2017 Jan 21;14(1):16. doi: 10.1186/s12974-017-0796-7. Review.


NFKB1 regulates human NK cell maturation and effector functions.

Lougaris V, Patrizi O, Baronio M, Tabellini G, Tampella G, Damiati E, Frede N, van der Meer JWM, Fliegauf M, Grimbacher B, Parolini S, Plebani A.

Clin Immunol. 2017 Feb;175:99-108. doi: 10.1016/j.clim.2016.11.012. Epub 2016 Dec 3.


Intact interferon-γ response against Coxiella burnetii by peripheral blood mononuclear cells in chronic Q fever.

Schoffelen T, Textoris J, Bleeker-Rovers CP, Ben Amara A, van der Meer JW, Netea MG, Mege JL, van Deuren M, van de Vosse E.

Clin Microbiol Infect. 2017 Mar;23(3):209.e9-209.e15. doi: 10.1016/j.cmi.2016.11.008. Epub 2016 Nov 20.


Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG.

Cell Metab. 2016 Dec 13;24(6):807-819. doi: 10.1016/j.cmet.2016.10.008. Epub 2016 Nov 17.


The challenge of autoinflammatory syndromes: with an emphasis on hyper-IgD syndrome.

van der Meer JW, Simon A.

Rheumatology (Oxford). 2016 Dec;55(suppl 2):ii23-ii29. Review.


Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.

van der Schaaf ME, De Lange FP, Schmits IC, Geurts DEM, Roelofs K, van der Meer JWM, Toni I, Knoop H.

Biol Psychiatry. 2017 Feb 15;81(4):358-365. doi: 10.1016/j.biopsych.2016.07.016. Epub 2016 Aug 31.


Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FCGJ, Smit JW, Netea-Maier RT, Koenders MMJF, Xavier RJ, van der Meer JWM, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA, Joosten LAB, Netea MG.

Cell. 2016 Nov 3;167(4):1111-1124.e13. doi: 10.1016/j.cell.2016.10.018.


A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Li Y, Oosting M, Smeekens SP, Jaeger M, Aguirre-Gamboa R, Le KTT, Deelen P, Ricaño-Ponce I, Schoffelen T, Jansen AFM, Swertz MA, Withoff S, van de Vosse E, van Deuren M, van de Veerdonk F, Zhernakova A, van der Meer JWM, Xavier RJ, Franke L, Joosten LAB, Wijmenga C, Kumar V, Netea MG.

Cell. 2016 Nov 3;167(4):1099-1110.e14. doi: 10.1016/j.cell.2016.10.017.


The Impact of Central and Peripheral Cyclooxygenase Enzyme Inhibition on Exercise-Induced Elevations in Core Body Temperature.

Veltmeijer MTW, Veeneman D, Bongers CCCW, Netea MG, van der Meer JW, Eijsvogels TMH, Hopman MTE.

Int J Sports Physiol Perform. 2017 May;12(5):662-667. doi: 10.1123/ijspp.2016-0382. Epub 2016 Sep 26.


Postural orthostatic tachycardia is not a useful diagnostic marker for chronic fatigue syndrome.

Roerink ME, Lenders JW, Schmits IC, Pistorius AM, Smit JW, Knoop H, van der Meer JW.

J Intern Med. 2017 Feb;281(2):179-188. doi: 10.1111/joim.12564. Epub 2016 Oct 2.


Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications.

Malgorzata-Miller G, Heinbockel L, Brandenburg K, van der Meer JW, Netea MG, Joosten LA.

Sci Rep. 2016 Sep 27;6:34221. doi: 10.1038/srep34221.


Early and late B-cell developmental impairment in nuclear factor kappa B, subunit 1-mutated common variable immunodeficiency disease.

Lougaris V, Moratto D, Baronio M, Tampella G, van der Meer JWM, Badolato R, Fliegauf M, Plebani A.

J Allergy Clin Immunol. 2017 Jan;139(1):349-352.e1. doi: 10.1016/j.jaci.2016.05.045. Epub 2016 Jul 16. No abstract available.


Adaptation and memory in innate immunity.

Netea MG, Joosten LA, van der Meer JW.

Semin Immunol. 2016 Aug;28(4):317-8. doi: 10.1016/j.smim.2016.07.002. No abstract available.


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