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Items: 1 to 50 of 466

1.

New irreversible α-L-iduronidase inhibitors and activity-based probes.

Artola M, Kuo CL, McMahon SA, Oehler V, Hansen T, van der Lienden M, He X, van den Elst H, Florea BI, Kermode AR, Gloster TM, van der Marel GA, Codée JDC, Overkleeft HS, Aerts JMFG.

Chemistry. 2018 Oct 11. doi: 10.1002/chem.201804662. [Epub ahead of print]

PMID:
30307091
2.

Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer.

Voorneveld J, Rack JGM, Ahel I, Overkleeft HS, van der Marel GA, Filippov DV.

Org Lett. 2018 Jul 6;20(13):4140-4143. doi: 10.1021/acs.orglett.8b01742. Epub 2018 Jun 27.

3.

Spiro-epoxyglycosides as Activity-Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase.

Schröder SP, Kallemeijn WW, Debets MF, Hansen T, Sobala LF, Hakki Z, Williams SJ, Beenakker TJM, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS.

Chemistry. 2018 Jul 11;24(39):9983-9992. doi: 10.1002/chem.201801902. Epub 2018 Jun 21.

4.

Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System.

Fletcher EAK, van Maren W, Cordfunke R, Dinkelaar J, Codee JDC, van der Marel G, Melief CJM, Ossendorp F, Drijfhout JW, Mangsbo SM.

J Immunol. 2018 Jul 1;201(1):87-97. doi: 10.4049/jimmunol.1700911. Epub 2018 May 11.

PMID:
29752315
5.

Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity.

van der Vorm S, van Hengst JMA, Bakker M, Overkleeft HS, van der Marel GA, Codée JDC.

Angew Chem Int Ed Engl. 2018 Jul 2;57(27):8240-8244. doi: 10.1002/anie.201802899. Epub 2018 Apr 26.

6.

Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.

Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4.

7.

Reagent Controlled Stereoselective Synthesis of α-Glucans.

Wang L, Overkleeft HS, van der Marel GA, Codée JDC.

J Am Chem Soc. 2018 Apr 4;140(13):4632-4638. doi: 10.1021/jacs.8b00669. Epub 2018 Mar 23.

8.

Streamlined Synthesis and Evaluation of Teichoic Acid Fragments.

van der Es D, Berni F, Hogendorf WFJ, Meeuwenoord N, Laverde D, van Diepen A, Overkleeft HS, Filippov DV, Hokke CH, Huebner J, van der Marel GA, Codée JDC.

Chemistry. 2018 Mar 15;24(16):4014-4018. doi: 10.1002/chem.201800153. Epub 2018 Feb 19.

9.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1659-1662. doi: 10.1002/anie.201710527. Epub 2018 Jan 8.

PMID:
29215186
10.

Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses.

Mangsbo SM, Fletcher EAK, van Maren WWC, Redeker A, Cordfunke RA, Dillmann I, Dinkelaar J, Ouchaou K, Codee JDC, van der Marel GA, Hoogerhout P, Melief CJM, Ossendorp F, Drijfhout JW.

Mol Immunol. 2018 Jan;93:115-124. doi: 10.1016/j.molimm.2017.11.004. Epub 2017 Nov 22.

PMID:
29175591
11.

Cyanopivaloyl Ester in the Automated Solid-Phase Synthesis of Oligorhamnans.

Geert Volbeda A, van Mechelen J, Meeuwenoord N, Overkleeft HS, van der Marel GA, Codée JDC.

J Org Chem. 2017 Dec 15;82(24):12992-13002. doi: 10.1021/acs.joc.7b02511. Epub 2017 Dec 1.

12.

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.

Schröder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codée JDC, van der Marel GA, Overkleeft HS.

Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k.

PMID:
29116266
13.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.

14.

Synthetic zwitterionic polysaccharides.

Zhang Q, Overkleeft HS, van der Marel GA, Codée JD.

Curr Opin Chem Biol. 2017 Oct;40:95-101. doi: 10.1016/j.cbpa.2017.07.010. Epub 2017 Sep 7. Review.

PMID:
28888143
15.

Synthesis of ribosyl-ribosyl-adenosine-5',5'',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose).

Liu Q, Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV.

Chem Commun (Camb). 2017 Sep 14;53(74):10255-10258. doi: 10.1039/c7cc05755e.

PMID:
28868552
16.

Chemical synthesis of guanosine diphosphate mannuronic acid (GDP-ManA) and its C-4-O-methyl and C-4-deoxy congeners.

Zhang Q, Howell PL, Overkleeft HS, Filippov DV, van der Marel GA, Codée JDC.

Carbohydr Res. 2017 Oct 10;450:12-18. doi: 10.1016/j.carres.2017.08.005. Epub 2017 Aug 11.

PMID:
28822279
17.

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.

Artola M, Wu L, Ferraz MJ, Kuo CL, Raich L, Breen IZ, Offen WA, Codée JDC, van der Marel GA, Rovira C, Aerts JMFG, Davies GJ, Overkleeft HS.

ACS Cent Sci. 2017 Jul 26;3(7):784-793. doi: 10.1021/acscentsci.7b00214. Epub 2017 Jul 13.

18.

Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory.

Narhe BD, Breman AC, Padwal J, Vandenput DAL, Scheidt JM, Benningshof JCJ, van der Marel GA, Overkleeft HS, van der Stelt M, Filippov DV.

Bioorg Med Chem. 2017 Oct 1;25(19):5160-5170. doi: 10.1016/j.bmc.2017.07.016. Epub 2017 Jul 10.

19.

Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes".

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Overkleeft HS, Aerts JMFG.

ACS Cent Sci. 2017 Jun 28;3(6):673. doi: 10.1021/acscentsci.7b00185. Epub 2017 May 18.

20.

Activity-based probes for functional interrogation of retaining β-glucuronidases.

Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ.

Nat Chem Biol. 2017 Aug;13(8):867-873. doi: 10.1038/nchembio.2395. Epub 2017 Jun 5.

21.

The influence of acceptor nucleophilicity on the glycosylation reaction mechanism.

van der Vorm S, Hansen T, Overkleeft HS, van der Marel GA, Codée JDC.

Chem Sci. 2017 Mar 1;8(3):1867-1875. doi: 10.1039/c6sc04638j. Epub 2016 Nov 9.

22.

Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit.

Hagen B, van Dijk JHM, Zhang Q, Overkleeft HS, van der Marel GA, Codée JDC.

Org Lett. 2017 May 19;19(10):2514-2517. doi: 10.1021/acs.orglett.7b00747. Epub 2017 May 9.

23.

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.

Beenakker TJM, Wander DPA, Offen WA, Artola M, Raich L, Ferraz MJ, Li KY, Houben JHPM, van Rijssel ER, Hansen T, van der Marel GA, Codée JDC, Aerts JMFG, Rovira C, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2017 May 17;139(19):6534-6537. doi: 10.1021/jacs.7b01773. Epub 2017 May 5.

24.

Stereoselectivity of Conformationally Restricted Glucosazide Donors.

van der Vorm S, Overkleeft HS, van der Marel GA, Codée JDC.

J Org Chem. 2017 May 5;82(9):4793-4811. doi: 10.1021/acs.joc.7b00470. Epub 2017 Apr 25.

25.

Conformational Behaviour of Azasugars Based on Mannuronic Acid.

van Rijssel ER, Janssen APA, Males A, Davies GJ, van der Marel GA, Overkleeft HS, Codée JDC.

Chembiochem. 2017 Jul 4;18(13):1297-1304. doi: 10.1002/cbic.201700080. Epub 2017 Apr 18.

PMID:
28256791
26.

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates.

Engelsma SB, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2955-2959. doi: 10.1002/anie.201611878. Epub 2017 Feb 7.

PMID:
28170152
27.

Simultaneous quantitation of sphingoid bases by UPLC-ESI-MS/MS with identical 13C-encoded internal standards.

Mirzaian M, Wisse P, Ferraz MJ, Marques ARA, Gaspar P, Oussoren SV, Kytidou K, Codée JDC, van der Marel G, Overkleeft HS, Aerts JM.

Clin Chim Acta. 2017 Mar;466:178-184. doi: 10.1016/j.cca.2017.01.014. Epub 2017 Jan 13.

PMID:
28089753
28.

Mapping the Reactivity and Selectivity of 2-Azidofucosyl Donors for the Assembly of N-Acetylfucosamine-Containing Bacterial Oligosaccharides.

Hagen B, Ali S, Overkleeft HS, van der Marel GA, Codée JD.

J Org Chem. 2017 Jan 20;82(2):848-868. doi: 10.1021/acs.joc.6b02593. Epub 2017 Jan 10.

29.

Teichoic acids: synthesis and applications.

van der Es D, Hogendorf WF, Overkleeft HS, van der Marel GA, Codée JD.

Chem Soc Rev. 2017 Mar 6;46(5):1464-1482. doi: 10.1039/c6cs00270f. Review.

PMID:
27990523
30.

TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.

Zom GG, Welters MJ, Loof NM, Goedemans R, Lougheed S, Valentijn RR, Zandvliet ML, Meeuwenoord NJ, Melief CJ, de Gruijl TD, Van der Marel GA, Filippov DV, Ossendorp F, Van der Burg SH.

Oncotarget. 2016 Oct 11;7(41):67087-67100. doi: 10.18632/oncotarget.11512.

31.

Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides.

Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10634-8. doi: 10.1002/anie.201604058. Epub 2016 Jul 28.

PMID:
27464500
32.

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.

Xin BT, de Bruin G, Huber EM, Besse A, Florea BI, Filippov DV, van der Marel GA, Kisselev AF, van der Stelt M, Driessen C, Groll M, Overkleeft HS.

J Med Chem. 2016 Aug 11;59(15):7177-87. doi: 10.1021/acs.jmedchem.6b00705. Epub 2016 Aug 1.

PMID:
27438186
33.

Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates.

Gential GP, Ho NI, Chiodo F, Meeuwenoord N, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3641-5. doi: 10.1016/j.bmcl.2016.05.094. Epub 2016 Jun 1.

PMID:
27289322
34.

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes.

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JD, Boot RG, Davies GJ, Overkleeft HS, Aerts JM.

ACS Cent Sci. 2016 May 25;2(5):351-8. doi: 10.1021/acscentsci.6b00057. Epub 2016 Apr 26. Erratum in: ACS Cent Sci. 2017 Jun 28;3(6):673.

35.

Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard.

Mirzaian M, Wisse P, Ferraz MJ, Marques ARA, Gabriel TL, van Roomen CPAA, Ottenhoff R, van Eijk M, Codée JDC, van der Marel GA, Overkleeft HS, Aerts JM.

Clin Chim Acta. 2016 Aug 1;459:36-44. doi: 10.1016/j.cca.2016.05.017. Epub 2016 May 21.

PMID:
27221202
36.

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes.

Stolze SC, Liu N, Wijdeven RH, Tuin AW, van den Nieuwendijk AM, Florea BI, van der Stelt M, van der Marel GA, Neefjes JJ, Overkleeft HS.

Mol Biosyst. 2016 May 24;12(6):1809-17. doi: 10.1039/c6mb00257a.

PMID:
27138522
37.

Development of new Malt1 inhibitors and probes.

Xin BT, Schimmack G, Du Y, Florea BI, van der Marel GA, Driessen C, Krappmann D, Overkleeft HS.

Bioorg Med Chem. 2016 Aug 1;24(15):3312-29. doi: 10.1016/j.bmc.2016.03.035. Epub 2016 Mar 28.

PMID:
27085674
38.

Synthesis of E. faecium wall teichoic acid fragments.

van der Es D, Groenia NA, Laverde D, Overkleeft HS, Huebner J, van der Marel GA, Codée JDC.

Bioorg Med Chem. 2016 Sep 1;24(17):3893-3907. doi: 10.1016/j.bmc.2016.03.019. Epub 2016 Mar 9.

PMID:
26993744
39.

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib.

de Bruin G, Mock ED, Hoogendoorn S, van den Nieuwendijk AM, Mazurek J, van der Marel GA, Florea BI, Overkleeft HS.

Chem Commun (Camb). 2016 Mar 14;52(21):4064-7. doi: 10.1039/c6cc01156j.

PMID:
26894389
40.

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities.

de Bruin G, Xin BT, Kraus M, van der Stelt M, van der Marel GA, Kisselev AF, Driessen C, Florea BI, Overkleeft HS.

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4199-203. doi: 10.1002/anie.201509092. Epub 2015 Oct 29.

PMID:
26511210
41.

Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors.

van den Berg RJ, van Rijssel ER, Ferraz MJ, Houben J, Strijland A, Donker-Koopman WE, Wennekes T, Bonger KM, Ghisaidoobe AB, Hoogendoorn S, van der Marel GA, Codée JD, Overkleeft HS, Aerts JM.

ChemMedChem. 2015 Dec;10(12):2042-62. doi: 10.1002/cmdc.201500407. Epub 2015 Oct 23.

PMID:
26492941
42.

Branching of poly(ADP-ribose): Synthesis of the Core Motif.

Kistemaker HA, Overkleeft HS, van der Marel GA, Filippov DV.

Org Lett. 2015 Sep 4;17(17):4328-31. doi: 10.1021/acs.orglett.5b02143. Epub 2015 Aug 26.

PMID:
26307949
43.

Chemoselective Cleavage of p-Methoxybenzyl and 2-Naphthylmethyl Ethers Using a Catalytic Amount of HCl in Hexafluoro-2-propanol.

Volbeda AG, Kistemaker HA, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

J Org Chem. 2015 Sep 4;80(17):8796-806. doi: 10.1021/acs.joc.5b01030. Epub 2015 Aug 14.

PMID:
26230920
44.

Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes.

Jiang J, Beenakker TJ, Kallemeijn WW, van der Marel GA, van den Elst H, Codée JD, Aerts JM, Overkleeft HS.

Chemistry. 2015 Jul 20;21(30):10861-9. doi: 10.1002/chem.201501313. Epub 2015 Jun 12.

PMID:
26073749
45.

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.

Wisse P, de Geus MA, Cross G, van den Nieuwendijk AM, van Rooden EJ, van den Berg RJ, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS.

J Org Chem. 2015 Jul 17;80(14):7258-65. doi: 10.1021/acs.joc.5b00823. Epub 2015 Jun 25.

PMID:
26061009
46.

Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents.

Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

ChemMedChem. 2016 Jan 19;11(2):190-8. doi: 10.1002/cmdc.201500196. Epub 2015 Jun 9.

PMID:
26059481
47.

Acceptor reactivity in the total synthesis of alginate fragments containing α-L-guluronic acid and β-D-mannuronic acid.

Zhang Q, van Rijssel ER, Walvoort MT, Overkleeft HS, van der Marel GA, Codée JD.

Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7670-3. doi: 10.1002/anie.201502581. Epub 2015 May 8.

PMID:
25960101
48.

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.

Jiang J, Kallemeijn WW, Wright DW, van den Nieuwendijk AMCH, Rohde VC, Folch EC, van den Elst H, Florea BI, Scheij S, Donker-Koopman WE, Verhoek M, Li N, Schürmann M, Mink D, Boot RG, Codée JDC, van der Marel GA, Davies GJ, Aerts JMFG, Overkleeft HS.

Chem Sci. 2015 May 1;6(5):2782-false. doi: 10.1039/c4sc03739a. Epub 2015 Feb 9.

49.

Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study.

Liu N, Hoogendoorn S, van de Kar B, Kaptein A, Barf T, Driessen C, Filippov DV, van der Marel GA, van der Stelt M, Overkleeft HS.

Org Biomol Chem. 2015 May 14;13(18):5147-57. doi: 10.1039/c5ob00474h.

PMID:
25849561
50.

Stereoselectivity in the Lewis acid mediated reduction of ketofuranoses.

van Rijssel ER, van Delft P, van Marle DV, Bijvoets SM, Lodder G, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

J Org Chem. 2015 May 1;80(9):4553-65. doi: 10.1021/acs.joc.5b00419. Epub 2015 Apr 13.

PMID:
25826382

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