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Detecting molecular forms of antithrombin by LC-MRM-MS: defining the measurands.

Ruhaak LR, Romijn FPHTM, Smit NPM, van der Laarse A, Pieterse MM, de Maat MPM, Haas FJLM, Kluft C, Amiral J, Meijer P, Cobbaert CM.

Clin Chem Lab Med. 2018 May 1. pii: /j/cclm.ahead-of-print/cclm-2017-1111/cclm-2017-1111.xml. doi: 10.1515/cclm-2017-1111. [Epub ahead of print]


A Rapid (Differential) Effect of Rosuvastatin and Atorvastatin on High-Sensitivity Cardiac Troponin-I in Subjects With Stable Cardiovascular Disease.

Bodde MC, Welsh P, Bergheanu SC, Lijfering WM, Mertens B, Liem AH, van der Laarse A, Sattar N, Jukema JW.

Clin Pharmacol Ther. 2018 Apr 19. doi: 10.1002/cpt.1095. [Epub ahead of print]


Robust and Accurate 2-Year Performance of a Quantitative Mass Spectrometry-Based Apolipoprotein Test in a Clinical Chemistry Laboratory.

Ruhaak LR, Smit NPM, Romijn FPHTM, Pieterse MM, van der Laarse A, van der Burgt YEM, Cobbaert CM.

Clin Chem. 2018 Apr;64(4):747-749. doi: 10.1373/clinchem.2017.285098. Epub 2018 Jan 29. No abstract available.


RGDfK-Peptide Modified Alginate Scaffold for Cell Transplantation and Cardiac Neovascularization.

Sondermeijer HP, Witkowski P, Seki T, van der Laarse A, Itescu S, Hardy MA.

Tissue Eng Part A. 2018 May;24(9-10):740-751. doi: 10.1089/ten.TEA.2017.0221. Epub 2017 Nov 13.


Low levels of apolipoprotein-CII in normotriglyceridemic patients with very premature coronary artery disease: Observations from the MISSION! Intervention study.

Hermans MPJ, Bodde MC, Jukema JW, Schalij MJ, van der Laarse A, Cobbaert CM.

J Clin Lipidol. 2017 Nov - Dec;11(6):1407-1414. doi: 10.1016/j.jacl.2017.08.002. Epub 2017 Aug 8.


Optimization of alginate purification using polyvinylidene difluoride membrane filtration: Effects on immunogenicity and biocompatibility of three-dimensional alginate scaffolds.

Sondermeijer HP, Witkowski P, Woodland D, Seki T, Aangenendt FJ, van der Laarse A, Itescu S, Hardy MA.

J Biomater Appl. 2016 Oct;31(4):510-520. Epub 2016 Apr 25.


Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping.

van den Broek I, Romijn FP, Nouta J, van der Laarse A, Drijfhout JW, Smit NP, van der Burgt YE, Cobbaert CM.

Clin Chem. 2016 Jan;62(1):188-97. doi: 10.1373/clinchem.2015.246702. Epub 2015 Nov 19.


Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.

Buiten MS, de Bie MK, Rotmans JI, Dekker FW, van Buren M, Rabelink TJ, Cobbaert CM, Schalij MJ, van der Laarse A, Jukema JW.

PLoS One. 2015 Aug 3;10(8):e0134245. doi: 10.1371/journal.pone.0134245. eCollection 2015.


Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction.

Dharma S, Hapsari R, Siswanto BB, van der Laarse A, Jukema JW.

Int J Angiol. 2015 Jun;24(2):127-32. doi: 10.1055/s-0035-1544178.


Stem and progenitor cell therapy for pulmonary arterial hypertension: effects on the right ventricle (2013 Grover Conference Series).

van der Laarse A, Cobbaert CM, Umar S.

Pulm Circ. 2015 Mar;5(1):73-80. doi: 10.1086/679701. Review.


Quantifying protein measurands by peptide measurements: where do errors arise?

van den Broek I, Romijn FP, Smit NP, van der Laarse A, Drijfhout JW, van der Burgt YE, Cobbaert CM.

J Proteome Res. 2015 Feb 6;14(2):928-42. doi: 10.1021/pr5011179. Epub 2015 Jan 6.


Impact of Timing of Eptifibatide Administration on Preprocedural Infarct-Related Artery Patency in Acute STEMI Patients Undergoing Primary PCI.

Dharma S, Firdaus I, Danny SS, Juzar DA, Wardeh AJ, Jukema JW, van der Laarse A.

Int J Angiol. 2014 Sep;23(3):207-14. doi: 10.1055/s-0034-1382158.


Metrological traceability in mass spectrometry-based targeted protein quantitation: a proof-of-principle study for serum apolipoproteins A-I and B100.

Smit NP, Romijn FP, van den Broek I, Drijfhout JW, Haex M, van der Laarse A, van der Burgt YE, Cobbaert CM.

J Proteomics. 2014 Sep 23;109:143-61. doi: 10.1016/j.jprot.2014.06.015. Epub 2014 Jun 25.


Clinical impact of direct HDLc and LDLc method bias in hypertriglyceridemia. A simulation study of the EAS-EFLM Collaborative Project Group.

Langlois MR, Descamps OS, van der Laarse A, Weykamp C, Baum H, Pulkki K, von Eckardstein A, De Bacquer D, Borén J, Wiklund O, Laitinen P, Oosterhuis WP, Cobbaert C; EAS-EFLM Collaborative Project.

Atherosclerosis. 2014 Mar;233(1):83-90. doi: 10.1016/j.atherosclerosis.2013.12.016. Epub 2014 Jan 4.


Temporal trends of system of care for STEMI: insights from the Jakarta Cardiovascular Care Unit Network System.

Dharma S, Siswanto BB, Firdaus I, Dakota I, Andriantoro H, Wardeh AJ, van der Laarse A, Jukema JW.

PLoS One. 2014 Feb 10;9(2):e86665. doi: 10.1371/journal.pone.0086665. eCollection 2014.


Confounding factors in the relation between high sensitivity cardiac troponin T levels in serum and infarct size of patients with first ST-elevation myocardial infarction.

Cobbaert CM, Bootsma M, Boden H, Ahmed TA, Hoogslag GE, Romijn FP, Ballieux BE, Wolterbeek R, Hermens WT, Schalij MJ, van der Laarse A.

Int J Cardiol. 2014 Mar 1;172(1):e3-5. doi: 10.1016/j.ijcard.2013.12.141. Epub 2014 Jan 4. No abstract available.


Evaluation of interspecimen trypsin digestion efficiency prior to multiple reaction monitoring-based absolute protein quantification with native protein calibrators.

van den Broek I, Smit NP, Romijn FP, van der Laarse A, Deelder AM, van der Burgt YE, Cobbaert CM.

J Proteome Res. 2013 Dec 6;12(12):5760-74. doi: 10.1021/pr400763d. Epub 2013 Nov 13.


Exercise-resembling effects of periodic somatosensory stimulation in heart failure.

Gademan MG, van Exel HJ, van de Vooren H, Haest JC, van Pelt J, van der Laarse A, Cannegieter SC, Lucas CM, Somer S, Verwey HF, Schalij MJ, van der Wall EE, Swenne CA.

Int J Cardiol. 2013 Oct 9;168(4):3327-33. doi: 10.1016/j.ijcard.2013.04.040. Epub 2013 May 3.


Will future troponin measurement overrule the ECG as the primary diagnostic tool in patients with acute coronary syndrome?

van der Laarse A, Cobbaert CM, Gorgels AP, Swenne CA.

J Electrocardiol. 2013 Jul-Aug;46(4):312-7. doi: 10.1016/j.jelectrocard.2013.02.007. Epub 2013 Mar 13.


Peak and fixed-time high-sensitive troponin for prediction of infarct size, impaired left ventricular function, and adverse outcomes in patients with first ST-segment elevation myocardial infarction receiving percutaneous coronary intervention.

Boden H, Ahmed TA, Velders MA, van der Hoeven BL, Hoogslag GE, Bootsma M, le Cessie S, Cobbaert CM, Delgado V, van der Laarse A, Schalij MJ.

Am J Cardiol. 2013 May 15;111(10):1387-93. doi: 10.1016/j.amjcard.2013.01.284. Epub 2013 Apr 24.


Depolarization-induced automaticity in rat ventricular cardiomyocytes is based on the gating properties of L-type calcium and slow Kv channels.

Ypey DL, van Meerwijk WP, Umar S, Pijnappels DA, Schalij MJ, van der Laarse A.

Eur Biophys J. 2013 Apr;42(4):241-55. doi: 10.1007/s00249-012-0866-9. Epub 2012 Oct 23.


Pre-infarction angina predicts thrombus burden in patients admitted for ST-segment elevation myocardial infarction.

Ahmed TA, Sorgdrager BJ, Cannegieter SC, van der Laarse A, Schalij MJ, Jukema W.

EuroIntervention. 2012 Apr;7(12):1396-405. doi: 10.4244/EIJV7I12A219.


Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension.

Umar S, Lee JH, de Lange E, Iorga A, Partow-Navid R, Bapat A, van der Laarse A, Saggar R, Saggar R, Ypey DL, Karagueuzian HS, Eghbali M.

Circ Arrhythm Electrophysiol. 2012 Feb;5(1):181-90. doi: 10.1161/CIRCEP.111.967265. Epub 2011 Dec 22.


Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential.

Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA.

Cardiovasc Res. 2012 Mar 1;93(3):434-44. doi: 10.1093/cvr/cvr351. Epub 2011 Dec 22.


Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts.

den Haan MC, Grauss RW, Smits AM, Winter EM, van Tuyn J, Pijnappels DA, Steendijk P, Gittenberger-De Groot AC, van der Laarse A, Fibbe WE, de Vries AA, Schalij MJ, Doevendans PA, Goumans MJ, Atsma DE.

J Cell Mol Med. 2012 Jul;16(7):1508-21. doi: 10.1111/j.1582-4934.2011.01468.x.


Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats.

de Visser YP, Walther FJ, Laghmani el H, Steendijk P, Middeldorp M, van der Laarse A, Wagenaar GT.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L56-67. doi: 10.1152/ajplung.00041.2011. Epub 2011 Sep 23.


Myocardial collagen turnover after surgical ventricular restoration in heart failure patients.

ten Brinke EA, Witkowski TG, Delgado V, Klein P, Klok M, Marsan NA, Klautz RJ, van der Wall EE, Bax JJ, van der Laarse A, Steendijk P.

Eur J Heart Fail. 2011 Nov;13(11):1202-10. doi: 10.1093/eurjhf/hfr097. Epub 2011 Aug 16.


Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats.

Umar S, Nadadur RD, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M.

Hypertension. 2011 Sep;58(3):512-8. doi: 10.1161/HYPERTENSIONAHA.110.168781. Epub 2011 Jul 11.


Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction.

Bergheanu SC, van der Laarse A, van der Bom JG, van der Hoeven BL, le Cessie S, de Jong MG, Liem SS, Schalij MJ, Jukema JW.

Dis Markers. 2011;30(5):245-52. doi: 10.3233/DMA-2011-0781.


Estrogen rescues preexisting severe pulmonary hypertension in rats.

Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der Laarse A, Eghbali M.

Am J Respir Crit Care Med. 2011 Sep 15;184(6):715-23. doi: 10.1164/rccm.201101-0078OC. Epub 2011 Jun 23.


The quest for an atrium-specific biomarker.

van der Laarse A, de Vries AA.

Neth Heart J. 2011 Mar;19(3):151-152. Epub 2011 Feb 12. No abstract available.


Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization.

Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA.

Cardiovasc Res. 2011 May 1;90(2):295-304. doi: 10.1093/cvr/cvr011. Epub 2011 Jan 13.


Integrin stimulation favors uptake of macromolecules by cardiomyocytes in vitro.

Swildens J, de Vries AA, Li Z, Umar S, Atsma DE, Schalij MJ, van der Laarse A.

Cell Physiol Biochem. 2010;26(6):999-1010. doi: 10.1159/000324013. Epub 2011 Jan 4.


Natriuretic peptide levels predict recurrence of atrial fibrillation after radiofrequency catheter ablation.

den Uijl DW, Delgado V, Tops LF, Ng AC, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, van der Laarse A, Bax JJ.

Am Heart J. 2011 Jan;161(1):197-203. doi: 10.1016/j.ahj.2010.09.031.


Evaluation of pulmonary arterial hypertension: invasive or noninvasive?

van der Laarse A, Steendijk P, van der Wall EE.

Int J Cardiovasc Imaging. 2011 Oct;27(7):943-5. doi: 10.1007/s10554-010-9642-z. Epub 2010 May 17. No abstract available.


Novel approaches to treat experimental pulmonary arterial hypertension: a review.

Umar S, Steendijk P, Ypey DL, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A.

J Biomed Biotechnol. 2010;2010:702836. doi: 10.1155/2010/702836. Epub 2010 Mar 22. Review.


Cardiac resynchronization therapy; the importance of evaluating cardiac metabolism.

van der Wall EE, Schalij MJ, van der Laarse A, Bax JJ.

Int J Cardiovasc Imaging. 2010 Mar;26(3):293-7. doi: 10.1007/s10554-010-9597-0. Epub 2010 Feb 12. No abstract available.


Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention.

Monraats PS, Fang Y, Pons D, Pires NM, Pols HA, Zwinderman AH, de Maat MP, Doevendans PA, DeWinter RJ, Tio RA, Waltenberger J, Frants RR, Quax PH, van der Laarse A, van der Wall EE, Uitterlinden AG, Jukema JW.

Expert Opin Ther Targets. 2010 Mar;14(3):243-51. doi: 10.1517/14728220903520929.


Oxygen uptake in heart failure: how much, how fast?

Gademan MG, van der Laarse A, Swenne CA, van der Wall EE.

Neth Heart J. 2009 Jun;17(6):224-5. No abstract available.


Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.

Umar S, de Visser YP, Steendijk P, Schutte CI, Laghmani el H, Wagenaar GT, Bax WH, Mantikou E, Pijnappels DA, Atsma DE, Schalij MJ, van der Wall EE, van der Laarse A.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1606-16. doi: 10.1152/ajpheart.00590.2009. Epub 2009 Sep 25.


Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.

Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A.

Cell Physiol Biochem. 2009;24(3-4):201-10. doi: 10.1159/000233246. Epub 2009 Aug 3.


In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment optimization program.

Hassan AK, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, Bootsma M, Zeppenfeld K, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ.

Catheter Cardiovasc Interv. 2009 Aug 1;74(2):335-43. doi: 10.1002/ccd.21980.


Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart.

Umar S, van der Laarse A.

Mol Cell Biochem. 2010 Jan;333(1-2):191-201. doi: 10.1007/s11010-009-0219-x. Epub 2009 Jul 19. Review.


Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury.

de Visser YP, Walther FJ, Laghmani el H, Boersma H, van der Laarse A, Wagenaar GT.

Respir Res. 2009 Apr 29;10:30. doi: 10.1186/1465-9921-10-30.


Incidence, patient characteristics and predictors of aborted myocardial infarction in patients undergoing primary PCI: prospective study comparing pre- and in-hospital abciximab pretreatment.

Hassan AK, Jukema JW, van der Laarse A, Hasan-Ali H, Wolterbeek R, van der Kley F, Spano F, Atsma DE, Schalij MJ.

EuroIntervention. 2009 Mar;4(5):662-8.


Signal intensity enhances diagnostic capacity in myocardial infarction.

van der Laarse A, van der Wall EE.

Int J Cardiovasc Imaging. 2009 Jun;25(5):545-7. doi: 10.1007/s10554-009-9452-3. Epub 2009 Mar 17. No abstract available.


Usefulness of peak troponin-T to predict infarct size and long-term outcome in patients with first acute myocardial infarction after primary percutaneous coronary intervention.

Hassan AK, Bergheanu SC, Hasan-Ali H, Liem SS, van der Laarse A, Wolterbeek R, Atsma DE, Schalij MJ, Jukema JW.

Am J Cardiol. 2009 Mar 15;103(6):779-84. doi: 10.1016/j.amjcard.2008.11.031. Epub 2009 Jan 24.


Rabbit models: ideal for imaging purposes?

van der Laarse A, van der Wall EE.

Int J Cardiovasc Imaging. 2009 Mar;25(3):299-301. doi: 10.1007/s10554-008-9401-6. Epub 2008 Dec 16. No abstract available.


Atherosclerotic plaque imaging by PET/CT; can inactive, active and mixed plaques be discerned?

van der Wall EE, Schuijf JD, Jukema JW, Bax JJ, van der Laarse A.

Int J Cardiovasc Imaging. 2009 Feb;25(2):141-4. doi: 10.1007/s10554-008-9395-0. Epub 2008 Dec 5. No abstract available.


Aortic and coronary atherosclerosis: a natural association?

van der Wall EE, van der Laarse A.

Int J Cardiovasc Imaging. 2009 Feb;25(2):219-22. doi: 10.1007/s10554-008-9389-y. Epub 2008 Nov 27. No abstract available.


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