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Items: 17

1.

High impact of Oatp1a/1b transporters on in vivo disposition of the hydrophobic anticancer drug paclitaxel.

van de Steeg E, van Esch A, Wagenaar E, van der Kruijssen CM, van Tellingen O, Kenworthy KE, Schinkel AH.

Clin Cancer Res. 2011 Jan 15;17(2):294-301. doi: 10.1158/1078-0432.CCR-10-1980. Epub 2010 Nov 19.

2.

Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.

van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, Kenworthy KE, Schinkel AH.

J Clin Invest. 2010 Aug;120(8):2942-52. doi: 10.1172/JCI42168. Epub 2010 Jul 19.

3.

Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.

van Waterschoot RA, ter Heine R, Wagenaar E, van der Kruijssen CM, Rooswinkel RW, Huitema AD, Beijnen JH, Schinkel AH.

Br J Pharmacol. 2010 Jul;160(5):1224-33. doi: 10.1111/j.1476-5381.2010.00759.x.

4.

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity.

van Waterschoot RA, Eman RM, Wagenaar E, van der Kruijssen CM, Rosing H, Beijnen JH, Schinkel AH.

Clin Cancer Res. 2009 Dec 15;15(24):7616-7623.

5.

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

van Waterschoot RA, Lagas JS, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Song JY, Rooswinkel RW, van Tellingen O, Rosing H, Beijnen JH, Schinkel AH.

Cancer Res. 2009 Dec 1;69(23):8996-9002. doi: 10.1158/0008-5472.CAN-09-2915. Epub 2009 Nov 17.

6.

Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo.

Vlaming ML, Pala Z, van Esch A, Wagenaar E, de Waart DR, van de Wetering K, van der Kruijssen CM, Oude Elferink RP, van Tellingen O, Schinkel AH.

Clin Cancer Res. 2009 May 1;15(9):3084-93. doi: 10.1158/1078-0432.CCR-08-2940. Epub 2009 Apr 21.

7.

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.

Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH, Schellens JH.

Drug Metab Dispos. 2009 Apr;37(4):917-23. doi: 10.1124/dmd.108.024901. Epub 2009 Jan 12.

PMID:
19139163
8.

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

van de Steeg E, van der Kruijssen CM, Wagenaar E, Burggraaff JE, Mesman E, Kenworthy KE, Schinkel AH.

Drug Metab Dispos. 2009 Feb;37(2):277-81. doi: 10.1124/dmd.108.024315. Epub 2008 Nov 20.

PMID:
19022939
9.

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.

Lagas JS, van der Kruijssen CM, van de Wetering K, Beijnen JH, Schinkel AH.

Drug Metab Dispos. 2009 Jan;37(1):129-36. doi: 10.1124/dmd.108.023200. Epub 2008 Oct 9.

PMID:
18845662
10.

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.

van Waterschoot RA, Rooswinkel RW, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Schinkel AH.

FASEB J. 2009 Jan;23(1):224-31. doi: 10.1096/fj.08-114876. Epub 2008 Sep 15.

PMID:
18794335
11.

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

van Waterschoot RA, van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH.

Mol Pharmacol. 2008 Mar;73(3):1029-36. Epub 2007 Dec 21.

12.

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH.

J Clin Invest. 2007 Nov;117(11):3583-92.

13.

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

van Herwaarden AE, Smit JW, Sparidans RW, Wagenaar E, van der Kruijssen CM, Schellens JH, Beijnen JH, Schinkel AH.

Drug Metab Dispos. 2005 Jul;33(7):892-5. Epub 2005 Apr 21.

PMID:
15845749
14.

Localization of activin subunits in early murine development determined by subunit-specific antibodies.

Paulusma CC, Van der Kruijssen CM, Van den Eijnden-Van Raaij AJ.

J Immunol Methods. 1994 Mar 10;169(2):143-52.

PMID:
8133077
15.

Modulation of activin expression by type beta transforming growth factors.

van der Kruijssen CM, Feijen A, Huylebroeck D, van den Eijnden-van Raaij AJ.

Exp Cell Res. 1993 Aug;207(2):407-12.

PMID:
8344388
16.

Heat-induced unresponsiveness of heat shock gene expression is regulated at the transcriptional level.

Tuijl MJ, Cluistra S, van der Kruijssen CM, Van Wijk R.

Int J Hyperthermia. 1993 Jan-Feb;9(1):125-36.

PMID:
8433022
17.

Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A.

van den Eijnden-van Raaij AJ, van Achterberg TA, van der Kruijssen CM, Piersma AH, Huylebroeck D, de Laat SW, Mummery CL.

Mech Dev. 1991 Feb;33(2):157-65.

PMID:
2031854

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