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Items: 1 to 50 of 190

1.

TGFβ/BMP Signaling Pathway in Cartilage Homeostasis.

Thielen NGM, van der Kraan PM, van Caam APM.

Cells. 2019 Aug 24;8(9). pii: E969. doi: 10.3390/cells8090969. Review.

2.

The Interaction between Joint Inflammation and Cartilage Repair.

van der Kraan PM.

Tissue Eng Regen Med. 2019 Jul 26;16(4):327-334. doi: 10.1007/s13770-019-00204-z. eCollection 2019 Aug. Review.

3.

Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice.

Rogier R, Ederveen THA, Wopereis H, Hartog A, Boekhorst J, van Hijum SAFT, Knol J, Garssen J, Walgreen B, Helsen MM, van der Kraan PM, van Lent PLEM, van de Loo FAJ, Abdollahi-Roodsaz S, Koenders MI.

PLoS One. 2019 Jul 8;14(7):e0219366. doi: 10.1371/journal.pone.0219366. eCollection 2019.

4.

The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK.

Di Ceglie I, Blom AB, Davar R, Logie C, Martens JHA, Habibi E, Böttcher LM, Roth J, Vogl T, Goodyear CS, van der Kraan PM, van Lent PL, van den Bosch MH.

FASEB J. 2019 Sep;33(9):10104-10115. doi: 10.1096/fj.201802691RR. Epub 2019 Jun 14.

PMID:
31199668
5.

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology.

van Dalen SCM, Blom AB, Walgreen B, Slöetjes AW, Helsen MMA, Geven EJW, Ter Huurne M, Vogl T, Roth J, van de Loo FAJ, Koenders MI, Casteilla L, van der Kraan PM, van den Bosch MHJ, van Lent PLEM.

Front Immunol. 2019 May 27;10:1075. doi: 10.3389/fimmu.2019.01075. eCollection 2019.

6.

High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Ascone G, Di Ceglie I, van den Bosch MHJ, Kruisbergen NNL, Walgreen B, Sloetjes AW, Lindhout E, Joosten LAB, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van Lent PLEM.

Clin Exp Rheumatol. 2019 May 7. [Epub ahead of print]

PMID:
31074720
7.

Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production.

van den Bosch MHJ, Ramos YFM, den Hollander W, Bomer N, Nelissen RGHH, Bovée JVMG, van den Berg WB, van Lent PLEM, Blom AB, van der Kraan PM, Meulenbelt I.

Rheumatology (Oxford). 2019 Jun 1;58(6):1065-1074. doi: 10.1093/rheumatology/key426.

PMID:
30649473
8.

Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment.

van Geffen EW, van Caam APM, Vitters EL, van Beuningen HM, van de Loo FA, van Lent PLEM, Koenders MI, van der Kraan PM.

Tissue Eng Part A. 2019 Aug;25(15-16):1155-1166. doi: 10.1089/ten.TEA.2018.0267. Epub 2019 Mar 28.

PMID:
30526407
9.

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Waterborg CEJ, Broeren MGA, Blaney Davidson EN, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ.

Rheumatology (Oxford). 2019 Mar 1;58(3):536-546. doi: 10.1093/rheumatology/key337.

PMID:
30508140
10.

Exploring longitudinal associations of histologically assessed inflammation with symptoms and radiographic damage in knee osteoarthritis: combined results of three prospective cohort studies.

Minten MJM, Blom A, Snijders GF, Kloppenburg M, van den Hoogen FHJ, den Broeder AA, van der Kraan PM, van den Ende CHM.

Osteoarthritis Cartilage. 2019 Jan;27(1):71-79. doi: 10.1016/j.joca.2018.10.014. Epub 2018 Nov 16.

PMID:
30448532
11.

Rheumatoid Arthritis Patients With Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity.

Arntz OJ, Pieters BCH, Thurlings RM, Wenink MH, van Lent PLEM, Koenders MI, van den Hoogen FHJ, van der Kraan PM, van de Loo FAJ.

Front Immunol. 2018 Oct 29;9:2388. doi: 10.3389/fimmu.2018.02388. eCollection 2018.

12.

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.

Waterborg CEJ, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ.

PLoS One. 2018 Oct 18;13(10):e0205902. doi: 10.1371/journal.pone.0205902. eCollection 2018.

13.

A three-dimensional model to study human synovial pathology.

Broeren MGA, Waterborg CEJ, Wiegertjes R, Thurlings RM, Koenders MI, Van Lent PLEM, Van der Kraan PM, Van de Loo FAJ.

ALTEX. 2019;36(1):18-28. doi: 10.14573/altex.1804161. Epub 2018 Oct 9.

14.

IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3.

van Geffen EW, van Caam APM, Schreurs W, van de Loo FA, van Lent PLEM, Koenders MI, Thudium CS, Bay-Jensen AC, Blaney Davidson EN, van der Kraan PM.

Osteoarthritis Cartilage. 2019 Jan;27(1):148-157. doi: 10.1016/j.joca.2018.08.016. Epub 2018 Sep 7.

PMID:
30201492
15.

The role of NOX2-derived reactive oxygen species in collagenase-induced osteoarthritis.

van Dalen SCM, Kruisbergen NNL, Walgreen B, Helsen MMA, Slöetjes AW, Cremers NAJ, Koenders MI, van de Loo FAJ, Roth J, Vogl T, Blom AB, van der Kraan PM, van Lent PLEM, van den Bosch MHJ.

Osteoarthritis Cartilage. 2018 Dec;26(12):1722-1732. doi: 10.1016/j.joca.2018.08.014. Epub 2018 Sep 5.

PMID:
30195046
16.

Hit hard and early: analysing the effects of high-dose methylprednisolone on nailfold capillary changes and biomarkers in very early systemic sclerosis: study protocol for a 12-week randomised controlled trial.

van den Hombergh WMT, Kersten BE, Knaapen-Hans HKA, Thurlings RM, van der Kraan PM, van den Hoogen FHJ, Fransen J, Vonk MC.

Trials. 2018 Aug 22;19(1):449. doi: 10.1186/s13063-018-2798-x.

17.

Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets.

de Kroon LMG, van den Akker GGH, Brachvogel B, Narcisi R, Belluoccio D, Jenner F, Bateman JF, Little CB, Brama PAJ, Blaney Davidson EN, van der Kraan PM, van Osch GJVM.

Bone. 2018 Nov;116:67-77. doi: 10.1016/j.bone.2018.07.008. Epub 2018 Jul 21.

PMID:
30010080
18.

Microbiota-Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis.

Evans-Marin H, Rogier R, Koralov SB, Manasson J, Roeleveld D, van der Kraan PM, Scher JU, Koenders MI, Abdollahi-Roodsaz S.

Arthritis Rheumatol. 2018 Dec;70(12):1971-1983. doi: 10.1002/art.40657.

19.

Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint.

van der Kraan PM.

J Bone Metab. 2018 May;25(2):65-72. doi: 10.11005/jbm.2018.25.2.65. Epub 2018 May 31. Review.

20.

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation.

Broeren MGA, Di Ceglie I, Bennink MB, van Lent PLEM, van den Berg WB, Koenders MI, Blaney Davidson EN, van der Kraan PM, van de Loo FAJ.

PeerJ. 2018 May 30;6:e4771. doi: 10.7717/peerj.4771. eCollection 2018.

21.

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis.

Di Ceglie I, Ascone G, Cremers NAJ, Sloetjes AW, Walgreen B, Vogl T, Roth J, Verbeek JS, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van den Bosch MHJ, van Lent PLEM.

Arthritis Res Ther. 2018 May 2;20(1):80. doi: 10.1186/s13075-018-1584-1.

22.

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models.

Waterborg CEJ, Beermann S, Broeren MGA, Bennink MB, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ.

Front Immunol. 2018 Apr 13;9:742. doi: 10.3389/fimmu.2018.00742. eCollection 2018.

23.

Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis.

van der Geest T, Roeleveld DM, Walgreen B, Helsen MM, Nayak TK, Klein C, Hegen M, Storm G, Metselaar JM, van den Berg WB, van der Kraan PM, Laverman P, Boerman OC, Koenders MI.

Rheumatology (Oxford). 2018 Apr 1;57(4):737-747. doi: 10.1093/rheumatology/kex456.

PMID:
29361119
24.

Unidirectional BMP2-loaded collagen scaffolds induce chondrogenic differentiation.

Pot MW, de Kroon LMG, van der Kraan PM, van Kuppevelt TH, Daamen WF.

Biomed Mater. 2017 Nov 22;13(1):015007. doi: 10.1088/1748-605X/aa8960.

PMID:
29165318
25.

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis.

Rogier R, Evans-Marin H, Manasson J, van der Kraan PM, Walgreen B, Helsen MM, van den Bersselaar LA, van de Loo FA, van Lent PL, Abramson SB, van den Berg WB, Koenders MI, Scher JU, Abdollahi-Roodsaz S.

Sci Rep. 2017 Nov 15;7(1):15613. doi: 10.1038/s41598-017-15802-x.

26.

Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells.

van den Akker GG, van Beuningen HM, Vitters EL, Koenders MI, van de Loo FA, van Lent PL, Blaney Davidson EN, van der Kraan PM.

Cell Signal. 2017 Dec;40:190-199. doi: 10.1016/j.cellsig.2017.09.010. Epub 2017 Sep 21.

PMID:
28943409
27.

WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis.

van den Bosch MH, Blom AB, Kram V, Maeda A, Sikka S, Gabet Y, Kilts TM, van den Berg WB, van Lent PL, van der Kraan PM, Young MF.

Osteoarthritis Cartilage. 2017 Nov;25(11):1900-1911. doi: 10.1016/j.joca.2017.07.012. Epub 2017 Jul 19.

28.

Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis.

van den Bosch MH, Blom AB, van de Loo FA, Koenders MI, Lafeber FP, van den Berg WB, van der Kraan PM, van Lent PL.

Arthritis Rheumatol. 2017 Oct;69(10):1978-1983. doi: 10.1002/art.40206. Epub 2017 Aug 29.

29.

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis.

Rogier R, Ederveen THA, Boekhorst J, Wopereis H, Scher JU, Manasson J, Frambach SJCM, Knol J, Garssen J, van der Kraan PM, Koenders MI, van den Berg WB, van Hijum SAFT, Abdollahi-Roodsaz S.

Microbiome. 2017 Jun 23;5(1):63. doi: 10.1186/s40168-017-0278-2.

30.

Transcriptional profiling distinguishes inner and outer annulus fibrosus from nucleus pulposus in the bovine intervertebral disc.

van den Akker GGH, Koenders MI, van de Loo FAJ, van Lent PLEM, Blaney Davidson E, van der Kraan PM.

Eur Spine J. 2017 Aug;26(8):2053-2062. doi: 10.1007/s00586-017-5150-3. Epub 2017 May 31.

PMID:
28567592
31.

SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.

de Kroon LM, Narcisi R, van den Akker GG, Vitters EL, Blaney Davidson EN, van Osch GJ, van der Kraan PM.

Sci Rep. 2017 Feb 27;7:43164. doi: 10.1038/srep43164.

32.

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis.

Roeleveld DM, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar L, van de Loo FA, van Lent PL, van der Kraan PM, van den Berg WB, Koenders MI.

PLoS One. 2017 Feb 3;12(2):e0171757. doi: 10.1371/journal.pone.0171757. eCollection 2017.

33.

The changing role of TGFβ in healthy, ageing and osteoarthritic joints.

van der Kraan PM.

Nat Rev Rheumatol. 2017 Mar;13(3):155-163. doi: 10.1038/nrrheum.2016.219. Epub 2017 Feb 2. Review.

PMID:
28148919
34.

Osteoarthritis year in review 2016: biology.

Blaney Davidson EN, van Caam AP, van der Kraan PM.

Osteoarthritis Cartilage. 2017 Feb;25(2):175-180. doi: 10.1016/j.joca.2016.09.024. Epub 2017 Jan 16. Review.

35.

IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes.

van Geffen EW, van Caam AP, van Beuningen HM, Vitters EL, Schreurs W, van de Loo FA, van Lent PL, Koenders MI, Blaney Davidson EN, van der Kraan PM.

Rheumatology (Oxford). 2017 Mar 1;56(3):351-361. doi: 10.1093/rheumatology/kew411.

PMID:
27940589
36.

Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology.

Di Ceglie I, van den Akker GG, Ascone G, Ten Harkel B, Häcker H, van de Loo FA, Koenders MI, van der Kraan PM, de Vries TJ, Vogl T, Roth J, van Lent PL.

J Leukoc Biol. 2017 Apr;101(4):957-966. doi: 10.1189/jlb.1AB0416-180RR. Epub 2016 Dec 5.

PMID:
27920208
37.

Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium.

Broeren MG, de Vries M, Bennink MB, van Lent PL, van der Kraan PM, Koenders MI, Thurlings RM, van de Loo FA.

PLoS One. 2016 Nov 21;11(11):e0167076. doi: 10.1371/journal.pone.0167076. eCollection 2016.

38.

S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis.

Geven EJ, van den Bosch MH, Di Ceglie I, Ascone G, Abdollahi-Roodsaz S, Sloetjes AW, Hermann S, Schäfers M, van de Loo FA, van der Kraan PM, Koenders MI, Foell D, Roth J, Vogl T, van Lent PL.

Arthritis Res Ther. 2016 Oct 24;18(1):247.

39.

Expression of TGF-β Signaling Regulator RBPMS (RNA-Binding Protein With Multiple Splicing) Is Regulated by IL-1β and TGF-β Superfamily Members, and Decreased in Aged and Osteoarthritic Cartilage.

Shanmugaapriya S, van Caam A, de Kroon L, Vitters EL, Walgreen B, van Beuningen H, Davidson EB, van der Kraan PM.

Cartilage. 2016 Oct;7(4):333-45. doi: 10.1177/1947603515623991. Epub 2016 Feb 24.

40.

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis.

van Dalen SC, Blom AB, Slöetjes AW, Helsen MM, Roth J, Vogl T, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, van den Bosch MH, van Lent PL.

Osteoarthritis Cartilage. 2017 Mar;25(3):385-396. doi: 10.1016/j.joca.2016.09.009. Epub 2016 Sep 18.

41.

Factors that influence outcome in experimental osteoarthritis.

van der Kraan PM.

Osteoarthritis Cartilage. 2017 Mar;25(3):369-375. doi: 10.1016/j.joca.2016.09.005. Epub 2016 Sep 9. Review.

42.

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, van Lent PL, van der Kraan PM, van den Berg WB, van den Hoogen FH, Koenders MI, van de Loo FA.

Arthritis Res Ther. 2016 Aug 12;18:186. doi: 10.1186/s13075-016-1083-1.

43.

Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins.

de Munter W, Geven EJ, Blom AB, Walgreen B, Helsen MM, Joosten LA, Roth J, Vogl T, van de Loo FA, Koenders MI, van den Berg WB, van der Kraan PM, van Lent PL.

Osteoarthritis Cartilage. 2017 Jan;25(1):118-127. doi: 10.1016/j.joca.2016.07.020. Epub 2016 Aug 8.

44.

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.

van den Bosch MH, Blom AB, Schelbergen RF, Koenders MI, van de Loo FA, van den Berg WB, Vogl T, Roth J, van der Kraan PM, van Lent PL.

J Rheumatol. 2016 Oct;43(10):1874-1884. Epub 2016 Aug 1.

PMID:
27481901
45.

Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?

Madej W, van Caam A, Blaney Davidson E, Buma P, van der Kraan PM.

Osteoarthritis Cartilage. 2016 Oct;24(10):1807-1815. doi: 10.1016/j.joca.2016.05.018. Epub 2016 Jun 4.

46.

Translation of clinical problems in osteoarthritis into pathophysiological research goals.

van der Kraan PM, Berenbaum F, Blanco FJ, Cosimo de B, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; EULAR Study group in OA (http://www.eular.org/investigative_rheumatology_study_groups.cfm).

RMD Open. 2016 May 26;2(1):e000224. doi: 10.1136/rmdopen-2015-000224. eCollection 2016. Erratum in: RMD Open. 2016 Oct 7;2(2):e000224corr1.

47.

Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation.

Oliveira MC, Arntz OJ, Blaney Davidson EN, van Lent PL, Koenders MI, van der Kraan PM, van den Berg WB, Ferreira AV, van de Loo FA.

J Nutr Biochem. 2016 Apr;30:74-84. doi: 10.1016/j.jnutbio.2015.11.017. Epub 2015 Dec 28.

PMID:
27012623
48.

Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors.

van Caam A, Madej W, Thijssen E, Garcia de Vinuesa A, van den Berg W, Goumans MJ, Ten Dijke P, Blaney Davidson E, van der Kraan PM.

Osteoarthritis Cartilage. 2016 Jul;24(7):1235-45. doi: 10.1016/j.joca.2016.02.008. Epub 2016 Mar 12.

49.

Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

de Kroon LM, Narcisi R, Blaney Davidson EN, Cleary MA, van Beuningen HM, Koevoet WJ, van Osch GJ, van der Kraan PM.

PLoS One. 2015 Dec 31;10(12):e0146124. doi: 10.1371/journal.pone.0146124. eCollection 2015.

50.

Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, Blom AB, Koenders MI, van Lent PL, van der Kraan PM, van den Berg WB, van de Loo FA.

Hum Gene Ther. 2016 Mar;27(3):244-54. doi: 10.1089/hum.2015.127. Epub 2016 Feb 16.

PMID:
26711533

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