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Items: 1 to 50 of 101


An effector from the Huanglongbing-associated pathogen targets citrus proteases.

Clark K, Franco JY, Schwizer S, Pang Z, Hawara E, Liebrand TWH, Pagliaccia D, Zeng L, Gurung FB, Wang P, Shi J, Wang Y, Ancona V, van der Hoorn RAL, Wang N, Coaker G, Ma W.

Nat Commun. 2018 Apr 30;9(1):1718. doi: 10.1038/s41467-018-04140-9.


Unravelling the mode of action of plant proteases.

van der Hoorn RAL, Rivas S.

New Phytol. 2018 May;218(3):879-881. doi: 10.1111/nph.15156. No abstract available.


Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants.

Husaini AM, Morimoto K, Chandrasekar B, Kelly S, Kaschani F, Palmero D, Jiang J, Kaiser M, Ahrazem O, Overkleeft HS, van der Hoorn RAL.

Plant Physiol. 2018 May;177(1):24-37. doi: 10.1104/pp.18.00250. Epub 2018 Mar 19.


Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production.

Santos RB, Chandrasekar B, Mandal MK, Kaschani F, Kaiser M, Both L, van der Hoorn RAL, Schiermeyer A, Abranches R.

Biotechnol J. 2018 Jul;13(7):e1800050. doi: 10.1002/biot.201800050. Epub 2018 Mar 26.


Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato Lines.

Planas-Marquès M, Bernardo-Faura M, Paulus J, Kaschani F, Kaiser M, Valls M, van der Hoorn RAL, Coll NS.

Mol Cell Proteomics. 2018 Jun;17(6):1112-1125. doi: 10.1074/mcp.RA117.000052. Epub 2018 Mar 9.


Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana.

Grosse-Holz F, Madeira L, Zahid MA, Songer M, Kourelis J, Fesenko M, Ninck S, Kaschani F, Kaiser M, van der Hoorn RAL.

Plant Biotechnol J. 2018 Oct;16(10):1797-1810. doi: 10.1111/pbi.12916. Epub 2018 May 24.


Ten Prominent Host Proteases in Plant-Pathogen Interactions.

Thomas EL, van der Hoorn RAL.

Int J Mol Sci. 2018 Feb 24;19(2). pii: E639. doi: 10.3390/ijms19020639. Review.


Tricked or trapped-Two decoy mechanisms in host-pathogen interactions.

Paulus JK, van der Hoorn RAL.

PLoS Pathog. 2018 Feb 15;14(2):e1006761. doi: 10.1371/journal.ppat.1006761. eCollection 2018 Feb. No abstract available.


Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function.

Kourelis J, van der Hoorn RAL.

Plant Cell. 2018 Feb;30(2):285-299. doi: 10.1105/tpc.17.00579. Epub 2018 Jan 30. Review.


N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.

Zhang H, Gannon L, Hassall KL, Deery MJ, Gibbs DJ, Holdsworth MJ, van der Hoorn RAL, Lilley KS, Theodoulou FL.

New Phytol. 2018 May;218(3):1106-1126. doi: 10.1111/nph.14909. Epub 2017 Nov 23.


The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire.

Grosse-Holz F, Kelly S, Blaskowski S, Kaschani F, Kaiser M, van der Hoorn RAL.

Plant Biotechnol J. 2018 May;16(5):1068-1084. doi: 10.1111/pbi.12852. Epub 2017 Dec 17.


Vacuolar processing enzyme activates programmed cell death in the apical meristem inducing loss of apical dominance.

Teper-Bamnolker P, Buskila Y, Belausov E, Wolf D, Doron-Faigenboim A, Ben-Dor S, Van der Hoorn RAL, Lers A, Eshel D.

Plant Cell Environ. 2017 Oct;40(10):2381-2392. doi: 10.1111/pce.13044. Epub 2017 Aug 25.


From structure to function - a family portrait of plant subtilases.

Schaller A, Stintzi A, Rivas S, Serrano I, Chichkova NV, Vartapetian AB, Martínez D, Guiamét JJ, Sueldo DJ, van der Hoorn RAL, Ramírez V, Vera P.

New Phytol. 2018 May;218(3):901-915. doi: 10.1111/nph.14582. Epub 2017 May 3. Review.


Bodyguards: Pathogen-Derived Decoys That Protect Virulence Factors.

Paulus JK, Kourelis J, van der Hoorn RAL.

Trends Plant Sci. 2017 May;22(5):355-357. doi: 10.1016/j.tplants.2017.03.004. Epub 2017 Mar 27. Review.


Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.

Kovács J, Poór P, Kaschani F, Chandrasekar B, Hong TN, Misas-Villamil JC, Xin BT, Kaiser M, Overkleeft HS, Tari I, van der Hoorn RA.

Front Plant Sci. 2017 Feb 3;8:107. doi: 10.3389/fpls.2017.00107. eCollection 2017.


Plant life needs cell death, but does plant cell death need Cys proteases?

Sueldo DJ, van der Hoorn RAL.

FEBS J. 2017 May;284(10):1577-1585. doi: 10.1111/febs.14034. Epub 2017 Feb 26. Review.


Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections.

Misas-Villamil JC, van der Burgh AM, Grosse-Holz F, Bach-Pages M, Kovács J, Kaschani F, Schilasky S, Emon AE, Ruben M, Kaiser M, Overkleeft HS, van der Hoorn RA.

Plant J. 2017 Apr;90(2):418-430. doi: 10.1111/tpj.13494. Epub 2017 Mar 14.


Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves.

Pružinská A, Shindo T, Niessen S, Kaschani F, Tóth R, Millar AH, van der Hoorn RA.

BMC Plant Biol. 2017 Jan 6;17(1):4. doi: 10.1186/s12870-016-0955-5.


Inhibitor Discovery by Convolution ABPP.

Chandrasekar B, Hong TN, van der Hoorn RA.

Methods Mol Biol. 2017;1491:47-56.


Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases.

Shindo T, Kaschani F, Yang F, Kovács J, Tian F, Kourelis J, Hong TN, Colby T, Shabab M, Chawla R, Kumari S, Ilyas M, Hörger AC, Alfano JR, van der Hoorn RA.

PLoS Pathog. 2016 Sep 7;12(9):e1005874. doi: 10.1371/journal.ppat.1005874. eCollection 2016 Sep.


Papain-like cysteine proteases as hubs in plant immunity.

Misas-Villamil JC, van der Hoorn RA, Doehlemann G.

New Phytol. 2016 Dec;212(4):902-907. doi: 10.1111/nph.14117. Epub 2016 Aug 4. Review.


Activity-based protein profiling of hydrolytic enzymes induced by gibberellic acid in isolated aleurone layers of malting barley.

Daneri-Castro SN, Chandrasekar B, Grosse-Holz FM, van der Hoorn RA, Roberts TH.

FEBS Lett. 2016 Sep;590(17):2956-62. doi: 10.1002/1873-3468.12320. Epub 2016 Aug 4.


Twelve ways to confirm targets of activity-based probes in plants.

Kovács J, van der Hoorn RA.

Bioorg Med Chem. 2016 Aug 1;24(15):3304-11. doi: 10.1016/j.bmc.2016.05.036. Epub 2016 May 20. Review.


The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity.

Paireder M, Mehofer U, Tholen S, Porodko A, Schähs P, Maresch D, Biniossek ML, van der Hoorn RA, Lenarcic B, Novinec M, Schilling O, Mach L.

Arch Biochem Biophys. 2016 Aug 1;603:110-7. doi: 10.1016/ Epub 2016 May 28.


Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutrition.

Kaschani F, Wei Q, Dingemans J, van der Hoorn RA, Cornelis P, Kaiser M.

Bioorg Med Chem. 2016 Aug 1;24(15):3330-5. doi: 10.1016/j.bmc.2016.04.051. Epub 2016 Apr 26.


Decoy Engineering: The Next Step in Resistance Breeding.

Kourelis J, van der Hoorn RAL, Sueldo DJ.

Trends Plant Sci. 2016 May;21(5):371-373. doi: 10.1016/j.tplants.2016.04.001. Epub 2016 Apr 12. Review.


Inspirational decoys: a new hunt for effector targets.

Malik S, Van der Hoorn RA.

New Phytol. 2016 Apr;210(2):371-3. doi: 10.1111/nph.13917. No abstract available.


Characterization of senescence-associated protease activities involved in the efficient protein remobilization during leaf senescence of winter oilseed rape.

Poret M, Chandrasekar B, van der Hoorn RAL, Avice JC.

Plant Sci. 2016 May;246:139-153. doi: 10.1016/j.plantsci.2016.02.011. Epub 2016 Feb 16.


Nicotinamide Cofactors Suppress Active-Site Labeling of Aldehyde Dehydrogenases.

Stiti N, Chandrasekar B, Strubl L, Mohammed S, Bartels D, van der Hoorn RA.

ACS Chem Biol. 2016 Jun 17;11(6):1578-86. doi: 10.1021/acschembio.5b00784. Epub 2016 Mar 25.


The Increasing Impact of Activity-Based Protein Profiling in Plant Science.

Morimoto K, van der Hoorn RA.

Plant Cell Physiol. 2016 Mar;57(3):446-61. doi: 10.1093/pcp/pcw003. Epub 2016 Feb 12. Review.


Beta galactosidases in Arabidopsis and tomato - a mini review.

Chandrasekar B, van der Hoorn RA.

Biochem Soc Trans. 2016 Feb;44(1):150-8. doi: 10.1042/BST20150217. Review.


Juggling jobs: roles and mechanisms of multifunctional protease inhibitors in plants.

Grosse-Holz FM, van der Hoorn RA.

New Phytol. 2016 May;210(3):794-807. doi: 10.1111/nph.13839. Epub 2016 Jan 22. Review.


Activity profiling reveals changes in the diversity and activity of proteins in Arabidopsis roots in response to nematode infection.

Hütten M, Geukes M, Misas-Villamil JC, van der Hoorn RA, Grundler FM, Siddique S.

Plant Physiol Biochem. 2015 Dec;97:36-43. doi: 10.1016/j.plaphy.2015.09.008. Epub 2015 Sep 14.


Functional Divergence of Two Secreted Immune Proteases of Tomato.

Ilyas M, Hörger AC, Bozkurt TO, van den Burg HA, Kaschani F, Kaiser M, Belhaj K, Smoker M, Joosten MH, Kamoun S, van der Hoorn RA.

Curr Biol. 2015 Aug 31;25(17):2300-6. doi: 10.1016/j.cub.2015.07.030. Epub 2015 Aug 20.


Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.

Lu H, Chandrasekar B, Oeljeklaus J, Misas-Villamil JC, Wang Z, Shindo T, Bogyo M, Kaiser M, van der Hoorn RA.

Plant Physiol. 2015 Aug;168(4):1462-75. doi: 10.1104/pp.114.254466. Epub 2015 Jun 5. Erratum in: Plant Physiol. 2017 May;174(1):465-466.


SNARE-RNAi results in higher terpene emission from ectopically expressed caryophyllene synthase in Nicotiana benthamiana.

Ting HM, Delatte TL, Kolkman P, Misas-Villamil JC, van der Hoorn RA, Bouwmeester HJ, van der Krol AR.

Mol Plant. 2015 Mar;8(3):454-66. doi: 10.1016/j.molp.2015.01.006. Epub 2015 Jan 15.


Broad-range glycosidase activity profiling.

Chandrasekar B, Colby T, Emran Khan Emon A, Jiang J, Hong TN, Villamor JG, Harzen A, Overkleeft HS, van der Hoorn RA.

Mol Cell Proteomics. 2014 Oct;13(10):2787-800. doi: 10.1074/mcp.O114.041616. Epub 2014 Jul 23.


PIRIN2 stabilizes cysteine protease XCP2 and increases susceptibility to the vascular pathogen Ralstonia solanacearum in Arabidopsis.

Zhang B, Tremousaygue D, Denancé N, van Esse HP, Hörger AC, Dabos P, Goffner D, Thomma BP, van der Hoorn RA, Tuominen H.

Plant J. 2014 Sep;79(6):1009-19. doi: 10.1111/tpj.12602. Epub 2014 Aug 7.


Dynamic hydrolase activities precede hypersensitive tissue collapse in tomato seedlings.

Sueldo D, Ahmed A, Misas-Villamil J, Colby T, Tameling W, Joosten MH, van der Hoorn RA.

New Phytol. 2014 Aug;203(3):913-25. doi: 10.1111/nph.12870. Epub 2014 May 29.


DIGE-ABPP by click chemistry: pairwise comparison of serine hydrolase activities from the apoplast of infected plants.

Hong TN, van der Hoorn RA.

Methods Mol Biol. 2014;1127:183-94. doi: 10.1007/978-1-62703-986-4_15.


Effector specialization in a lineage of the Irish potato famine pathogen.

Dong S, Stam R, Cano LM, Song J, Sklenar J, Yoshida K, Bozkurt TO, Oliva R, Liu Z, Tian M, Win J, Banfield MJ, Jones AM, van der Hoorn RA, Kamoun S.

Science. 2014 Jan 31;343(6170):552-5. doi: 10.1126/science.1246300.


Selective conjugation of proteins by mining active proteomes through click-functionalized magnetic nanoparticles.

Ilyas S, Ilyas M, van der Hoorn RA, Mathur S.

ACS Nano. 2013 Nov 26;7(11):9655-63. doi: 10.1021/nn402382g. Epub 2013 Oct 24.


Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis.

Zulet A, Gil-Monreal M, Villamor JG, Zabalza A, van der Hoorn RA, Royuela M.

PLoS One. 2013 Sep 6;8(9):e73847. doi: 10.1371/journal.pone.0073847. eCollection 2013.


The structural basis of specific protease-inhibitor interactions at the plant-pathogen interface.

Hörger AC, van der Hoorn RA.

Curr Opin Struct Biol. 2013 Dec;23(6):842-50. doi: 10.1016/ Epub 2013 Aug 9. Review.


Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes.

Villamor JG, Kaschani F, Colby T, Oeljeklaus J, Zhao D, Kaiser M, Patricelli MP, van der Hoorn RA.

Mol Cell Proteomics. 2013 Sep;12(9):2481-96. doi: 10.1074/mcp.M112.026278. Epub 2013 May 29.


Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases.

Gu C, Shannon DA, Colby T, Wang Z, Shabab M, Kumari S, Villamor JG, McLaughlin CJ, Weerapana E, Kaiser M, Cravatt BF, van der Hoorn RA.

Chem Biol. 2013 Apr 18;20(4):541-8. doi: 10.1016/j.chembiol.2013.01.016.


Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sites.

Misas-Villamil JC, Kolodziejek I, Crabill E, Kaschani F, Niessen S, Shindo T, Kaiser M, Alfano JR, van der Hoorn RA.

PLoS Pathog. 2013 Mar;9(3):e1003281. doi: 10.1371/journal.ppat.1003281. Epub 2013 Mar 28.


A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB.

Lu H, Wang Z, Shabab M, Oeljeklaus J, Verhelst SH, Kaschani F, Kaiser M, Bogyo M, van der Hoorn RA.

Chem Biol. 2013 Feb 21;20(2):168-76. doi: 10.1016/j.chembiol.2012.11.007.


The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.

Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M.

Chem Biol. 2012 Dec 21;19(12):1546-55. doi: 10.1016/j.chembiol.2012.09.020.

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