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Items: 18

1.

Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function.

Kattan WE, Chen W, Ma X, Lan TH, van der Hoeven D, van der Hoeven R, Hancock JF.

Life Sci Alliance. 2019 Aug 26;2(5). pii: e201900431. doi: 10.26508/lsa.201900431. Print 2019 Oct.

2.

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding.

McCarthy MJ, Pagba CV, Prakash P, Naji AK, van der Hoeven D, Liang H, Gupta AK, Zhou Y, Cho KJ, Hancock JF, Gorfe AA.

ACS Omega. 2019 Feb 28;4(2):2921-2930. doi: 10.1021/acsomega.8b03308. Epub 2019 Feb 8.

3.

HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.

Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K.

EMBO Rep. 2019 Apr;20(4). pii: e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20.

PMID:
30787043
4.

Integration of Basic and Clinical Sciences: Faculty Perspectives at a U.S. Dental School.

van der Hoeven D, van der Hoeven R, Zhu L, Busaidy K, Quock RL.

J Dent Educ. 2018 Apr;82(4):349-355. doi: 10.21815/JDE.018.038.

5.

Sphingomyelin Metabolism Is a Regulator of K-Ras Function.

van der Hoeven D, Cho KJ, Zhou Y, Ma X, Chen W, Naji A, Montufar-Solis D, Zuo Y, Kovar SE, Levental KR, Frost JA, van der Hoeven R, Hancock JF.

Mol Cell Biol. 2018 Jan 16;38(3). pii: e00373-17. doi: 10.1128/MCB.00373-17. Print 2018 Feb 1.

6.

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.

Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF.

Mol Cell Biol. 2016 Nov 28;36(24):3086-3099. Print 2016 Dec 15.

7.

Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.

Cho KJ, van der Hoeven D, Zhou Y, Maekawa M, Ma X, Chen W, Fairn GD, Hancock JF.

Mol Cell Biol. 2015 Nov 16;36(2):363-74. doi: 10.1128/MCB.00719-15. Print 2016 Jan 15.

8.

SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K, Hancock JF.

Science. 2015 Aug 21;349(6250):873-6. doi: 10.1126/science.aaa5619.

9.

Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy.

Iglesias DA, Yates MS, van der Hoeven D, Rodkey TL, Zhang Q, Co NN, Burzawa J, Chigurupati S, Celestino J, Bowser J, Broaddus R, Hancock JF, Schmandt R, Lu KH.

Mol Cancer Ther. 2013 Dec;12(12):2847-56. doi: 10.1158/1535-7163.MCT-13-0439. Epub 2013 Sep 27.

10.

Inhibitors of K-Ras plasma membrane localization.

Cho KJ, van der Hoeven D, Hancock JF.

Enzymes. 2013;33 Pt A:249-65. doi: 10.1016/B978-0-12-416749-0.00011-7. Epub 2013 Aug 8. Review.

PMID:
25033808
11.

Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.

van der Hoeven D, Cho KJ, Ma X, Chigurupati S, Parton RG, Hancock JF.

Mol Cell Biol. 2013 Jan;33(2):237-51. doi: 10.1128/MCB.00884-12. Epub 2012 Nov 5.

12.

Raf inhibitors target ras spatiotemporal dynamics.

Cho KJ, Kasai RS, Park JH, Chigurupati S, Heidorn SJ, van der Hoeven D, Plowman SJ, Kusumi A, Marais R, Hancock JF.

Curr Biol. 2012 Jun 5;22(11):945-55. doi: 10.1016/j.cub.2012.03.067. Epub 2012 May 3.

13.

A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils.

van der Hoeven D, Wan TC, Gizewski ET, Kreckler LM, Maas JE, Van Orman J, Ravid K, Auchampach JA.

J Pharmacol Exp Ther. 2011 Sep;338(3):1004-12. doi: 10.1124/jpet.111.181792. Epub 2011 Jun 21.

14.

Activation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils.

van der Hoeven D, Gizewski ET, Auchampach JA.

Biochem Pharmacol. 2010 Jun 1;79(11):1667-73. doi: 10.1016/j.bcp.2010.02.002. Epub 2010 Feb 10.

15.

A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells.

Ge ZD, van der Hoeven D, Maas JE, Wan TC, Auchampach JA.

J Mol Cell Cardiol. 2010 Aug;49(2):280-6. doi: 10.1016/j.yjmcc.2010.01.018. Epub 2010 Feb 2.

16.

Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction.

Inder KL, Lau C, Loo D, Chaudhary N, Goodall A, Martin S, Jones A, van der Hoeven D, Parton RG, Hill MM, Hancock JF.

J Biol Chem. 2009 Oct 9;284(41):28410-9. doi: 10.1074/jbc.M109.001537. Epub 2009 Aug 6.

17.

Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.

Auchampach JA, Kreckler LM, Wan TC, Maas JE, van der Hoeven D, Gizewski E, Narayanan J, Maas GE.

J Pharmacol Exp Ther. 2009 Apr;329(1):2-13. doi: 10.1124/jpet.108.148270. Epub 2009 Jan 13.

18.

Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils.

van der Hoeven D, Wan TC, Auchampach JA.

Mol Pharmacol. 2008 Sep;74(3):685-96. doi: 10.1124/mol.108.048066. Epub 2008 Jun 26.

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