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Commentary: Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the Trans-Golgi Network in COS-7 Cells.

Zangerl-Plessl EM, van der Heyden MAG.

Front Physiol. 2018 Oct 5;9:1401. doi: 10.3389/fphys.2018.01401. eCollection 2018. No abstract available.


Editorial: Ion Channel Trafficking and Cardiac Arrhythmias.

van der Heyden MAG, Delisle BP, Abriel H.

Front Physiol. 2018 Sep 25;9:1254. doi: 10.3389/fphys.2018.01254. eCollection 2018. No abstract available.


Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation.

Szatmári V, Ji Y, Herwijnen BV, Feng M, Wang MZ, Bossu A, van der Heyden MAG.

J Vet Intern Med. 2018 Sep;32(5):1549-1554. doi: 10.1111/jvim.15242. Epub 2018 Aug 5.


Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry.

Vandersickel N, Bossu A, De Neve J, Dunnink A, Meijborg VMF, van der Heyden MAG, Beekman JDM, De Bakker JMT, Vos MA, Panfilov AV.

JACC Clin Electrophysiol. 2017 Dec 26;3(13):1565-1576. doi: 10.1016/j.jacep.2017.06.016. Epub 2017 Dec 18.


Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs.

Bossu A, Kostense A, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA.

Pharmacol Res. 2018 Jul;133:132-140. doi: 10.1016/j.phrs.2018.05.001. Epub 2018 May 16.


Review of case reports on hyperkalemia induced by dietary intake: not restricted to chronic kidney disease patients.

Te Dorsthorst RPM, Hendrikse J, Vervoorn MT, van Weperen VYH, van der Heyden MAG.

Eur J Clin Nutr. 2019 Jan;73(1):38-45. doi: 10.1038/s41430-018-0154-6. Epub 2018 Mar 27. Review.


Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA.

Br J Pharmacol. 2018 Jun;175(12):2470-2482. doi: 10.1111/bph.14217. Epub 2018 May 6.


Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective.

van Bavel JJA, Vos MA, van der Heyden MAG.

Front Physiol. 2018 Feb 23;9:127. doi: 10.3389/fphys.2018.00127. eCollection 2018.


Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.

Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S.

Pharmacol Res. 2018 May;131:150-163. doi: 10.1016/j.phrs.2018.02.024. Epub 2018 Mar 15.


Gold open access: the best of both worlds.

van der Heyden MAG, van Veen TAB.

Neth Heart J. 2018 Jan;26(1):3-4. doi: 10.1007/s12471-017-1064-2. Review.


Response to the letter from Warren et al.

Takanari H, Fontes MSC, van der Heyden MAG, Vos MA, van Veen TAB.

Cardiovasc Res. 2017 Dec 1;113(14):1799-1800. doi: 10.1093/cvr/cvx200. No abstract available.


High-potency block of Kir4.1 channels by pentamidine: Molecular basis.

Aréchiga-Figueroa IA, Marmolejo-Murillo LG, Cui M, Delgado-Ramírez M, van der Heyden MAG, Sánchez-Chapula JA, Rodríguez-Menchaca AA.

Eur J Pharmacol. 2017 Nov 15;815:56-63. doi: 10.1016/j.ejphar.2017.10.009. Epub 2017 Oct 6.


The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on IK1.

Goversen B, van der Heyden MAG, van Veen TAB, de Boer TP.

Pharmacol Ther. 2018 Mar;183:127-136. doi: 10.1016/j.pharmthera.2017.10.001. Epub 2017 Oct 3. Review.


Commentary: Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration.

Van Weperen VYH, Vos MA, Van der Heyden MAG.

Front Physiol. 2017 Jun 30;8:459. doi: 10.3389/fphys.2017.00459. eCollection 2017. No abstract available.


PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.

Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K, van Haaften G, Zangerl-Plessl EM, Takanari H, Stary-Weinzinger A, van der Heyden MAG.

J Biomed Sci. 2017 Jul 15;24(1):44. doi: 10.1186/s12929-017-0352-x.


Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog.

Bossu A, Varkevisser R, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA.

J Cardiovasc Pharmacol. 2017 Jun;69(6):398-407. doi: 10.1097/FJC.0000000000000488. Review.


The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.

Ji Y, Varkevisser R, Opacic D, Bossu A, Kuiper M, Beekman JDM, Yang S, Khan AP, Dobrev D, Voigt N, Wang MZ, Verheule S, Vos MA, van der Heyden MAG.

Br J Pharmacol. 2017 Aug;174(15):2576-2590. doi: 10.1111/bph.13869. Epub 2017 Jun 28.


Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking.

Ji Y, Takanari H, Qile M, Nalos L, Houtman MJC, Romunde FL, Heukers R, van Bergen En Henegouwen PMP, Vos MA, van der Heyden MAG.

J Cell Mol Med. 2017 Oct;21(10):2514-2523. doi: 10.1111/jcmm.13172. Epub 2017 Apr 19.


The toxicology of zinc chloride smoke producing bombs and screens.

El Idrissi A, van Berkel L, Bonekamp NE, Dalemans DJ, van der Heyden MA.

Clin Toxicol (Phila). 2017 Mar;55(3):167-174. doi: 10.1080/15563650.2016.1271125. Epub 2017 Jan 11. Review.


Commentary: Reciprocal Modulation of IK1-INa Extends Excitability in Cardiac Ventricular Cells.

Goversen B, de Boer TP, van der Heyden MA.

Front Physiol. 2016 Dec 23;7:647. doi: 10.3389/fphys.2016.00647. eCollection 2016. No abstract available.


Preventing Publication of Falsified and Fabricated Data: Roles of Scientists, Editors, Reviewers, and Readers.

Korte SM, van der Heyden MA.

J Cardiovasc Pharmacol. 2017 Feb;69(2):65-70. doi: 10.1097/FJC.0000000000000443. No abstract available.


Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent.

Takanari H, Bourgonje VJ, Fontes MS, Raaijmakers AJ, Driessen H, Jansen JA, van der Nagel R, Kok B, van Stuijvenberg L, Boulaksil M, Takemoto Y, Yamazaki M, Tsuji Y, Honjo H, Kamiya K, Kodama I, Anderson ME, van der Heyden MA, van Rijen HV, van Veen TA, Vos MA.

Cardiovasc Res. 2016 Sep;111(4):410-21. doi: 10.1093/cvr/cvw173. Epub 2016 Jun 29. Erratum in: Cardiovasc Res. 2017 Dec 1;113(14):1797.


Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.

Stams TR, Oosterhoff P, Heijdel A, Dunnink A, Beekman JD, van der Nagel R, van Rijen HV, van der Heyden MA, Vos MA.

Circ J. 2016 May 25;80(6):1336-45. doi: 10.1253/circj.CJ-15-1335. Epub 2016 May 6.


A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.

van Stigt AH, Overduin RJ, Staats LC, Loen V, van der Heyden MA.

Chin J Physiol. 2016 Feb 29;59(1):1-8. doi: 10.4077/CJP.2016.BAE364. Review.


A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology.

Takanari H, Miwa K, Fu X, Nakai J, Ito A, Ino K, Honda H, Tonomura W, Konishi S, Opthof T, van der Heyden MA, Kodama I, Lee JK.

J Cell Physiol. 2016 Oct;231(10):2249-56. doi: 10.1002/jcp.25342. Epub 2016 Mar 16.


Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation.

van der Heyden MA, Jespersen T.

Eur J Pharmacol. 2016 Jan 15;771:56-64. doi: 10.1016/j.ejphar.2015.11.026. Epub 2015 Nov 18. Review.


A 2015 focus on preventing drug-induced arrhythmias.

Bossu A, van der Heyden MA, de Boer TP, Vos MA.

Expert Rev Cardiovasc Ther. 2016;14(2):245-53. doi: 10.1586/14779072.2016.1116940. Epub 2015 Nov 26. Review.


Structure-Affinity Relationships (SARs) and Structure-Kinetics Relationships (SKRs) of Kv11.1 Blockers.

Yu Z, van Veldhoven JP, Louvel J, 't Hart IM, Rook MB, van der Heyden MA, Heitman LH, IJzerman AP.

J Med Chem. 2015 Aug 13;58(15):5916-29. doi: 10.1021/acs.jmedchem.5b00518. Epub 2015 Jul 17.


Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

Houtman MJ, Korte SM, Ji Y, Kok B, Vos MA, Stary-Weinzinger A, van der Heyden MA.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):992-7. doi: 10.1016/j.bbrc.2014.09.031. Epub 2014 Sep 16.


AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.

Varkevisser R, Vos MA, Beekman JD, Tieland RG, Van Der Heyden MA.

J Cardiovasc Electrophysiol. 2015 Jan;26(1):82-9. doi: 10.1111/jce.12533. Epub 2014 Sep 19.


A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.

Burgers PP, van der Heyden MA, Kok B, Heck AJ, Scholten A.

Biochemistry. 2015 Jan 13;54(1):11-21. doi: 10.1021/bi500721a. Epub 2014 Sep 10.


Barium toxicity and the role of the potassium inward rectifier current.

Bhoelan BS, Stevering CH, van der Boog AT, van der Heyden MA.

Clin Toxicol (Phila). 2014 Jul;52(6):584-93. doi: 10.3109/15563650.2014.923903. Epub 2014 Jun 6.


Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model.

Varkevisser R, van der Heyden MA, Tieland RG, Beekman JD, Vos MA.

Eur J Pharmacol. 2013 Nov 15;720(1-3):49-54. doi: 10.1016/j.ejphar.2013.10.054. Epub 2013 Nov 5.


Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TA.

Cardiovasc Pathol. 2013 Sep-Oct;22(5):314-8. doi: 10.1016/j.carpath.2013.04.002. Epub 2013 May 17.


Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.

Takanari H, Nalos L, Stary-Weinzinger A, de Git KC, Varkevisser R, Linder T, Houtman MJ, Peschar M, de Boer TP, Tidwell RR, Rook MB, Vos MA, van der Heyden MA.

Cardiovasc Res. 2013 Jul 1;99(1):203-14. doi: 10.1093/cvr/cvt103. Epub 2013 Apr 25.


Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.

Varkevisser R, Houtman MJ, Linder T, de Git KC, Beekman HD, Tidwell RR, Ijzerman AP, Stary-Weinzinger A, Vos MA, van der Heyden MA.

Br J Pharmacol. 2013 Jul;169(6):1322-34. doi: 10.1111/bph.12208.


Cardiac ion channel trafficking defects and drugs.

de Git KC, de Boer TP, Vos MA, van der Heyden MA.

Pharmacol Ther. 2013 Jul;139(1):24-31. doi: 10.1016/j.pharmthera.2013.03.008. Epub 2013 Apr 2. Review.


Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

van der Heyden MA, Stary-Weinzinger A, Sanchez-Chapula JA.

Curr Mol Med. 2013 Sep;13(8):1284-98. Review.


Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.

Varkevisser R, Houtman MJ, Waasdorp M, Man JC, Heukers R, Takanari H, Tieland RG, van Bergen En Henegouwen PM, Vos MA, van der Heyden MA.

Pflugers Arch. 2013 Feb;465(2):247-59. doi: 10.1007/s00424-012-1189-5. Epub 2012 Nov 29.


Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.

Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA.

Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23.


A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ.

J Biol Chem. 2012 Dec 21;287(52):43789-97. doi: 10.1074/jbc.M112.395970. Epub 2012 Oct 31.


Personalized medicine and the role of induced pluripotent stem cells.

van der Heyden MA, Jonsson MK.

Cardiovasc Res. 2012 Sep 1;95(4):395-6. doi: 10.1093/cvr/cvs242. Epub 2012 Jul 20. No abstract available.


Deciphering hERG channels: molecular basis of the rapid component of the delayed rectifier potassium current.

Jonsson MK, van der Heyden MA, van Veen TA.

J Mol Cell Cardiol. 2012 Sep;53(3):369-74. doi: 10.1016/j.yjmcc.2012.06.011. Epub 2012 Jun 26. Review.


Dominant missense mutations in ABCC9 cause Cantú syndrome.

Harakalova M, van Harssel JJ, Terhal PA, van Lieshout S, Duran K, Renkens I, Amor DJ, Wilson LC, Kirk EP, Turner CL, Shears D, Garcia-Minaur S, Lees MM, Ross A, Venselaar H, Vriend G, Takanari H, Rook MB, van der Heyden MA, Asselbergs FW, Breur HM, Swinkels ME, Scurr IJ, Smithson SF, Knoers NV, van der Smagt JJ, Nijman IJ, Kloosterman WP, van Haelst MM, van Haaften G, Cuppen E.

Nat Genet. 2012 May 18;44(7):793-6. doi: 10.1038/ng.2324.


Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.

Varkevisser R, Wijers SC, van der Heyden MA, Beekman JD, Meine M, Vos MA.

Heart Rhythm. 2012 Oct;9(10):1718-26. doi: 10.1016/j.hrthm.2012.05.016. Epub 2012 May 15. Review.


Grayanotoxin poisoning: 'mad honey disease' and beyond.

Jansen SA, Kleerekooper I, Hofman ZL, Kappen IF, Stary-Weinzinger A, van der Heyden MA.

Cardiovasc Toxicol. 2012 Sep;12(3):208-15. doi: 10.1007/s12012-012-9162-2. Review.


Geographical distribution of plakophilin-2 mutation prevalence in patients with arrhythmogenic cardiomyopathy.

Jacob KA, Noorman M, Cox MG, Groeneweg JA, Hauer RN, van der Heyden MA.

Neth Heart J. 2012 May;20(5):234-9. doi: 10.1007/s12471-012-0274-x.


Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel.

Houtman MJ, Takanari H, Kok BG, van Eck M, Montagne DR, Vos MA, de Boer TP, van der Heyden MA.

Front Physiol. 2012 Jan 30;3:9. doi: 10.3389/fphys.2012.00009. eCollection 2012.


Finding inward rectifier channel inhibitors: why and how?

van der Heyden MA.

Front Pharmacol. 2012 Jan 9;2:95. doi: 10.3389/fphar.2011.00095. eCollection 2011. No abstract available.


Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human?

Stams TR, Bourgonje VJ, Vos MA, van der Heyden MA.

Br J Pharmacol. 2012 May;166(2):554-6. doi: 10.1111/j.1476-5381.2011.01818.x.

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