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Items: 1 to 50 of 69

1.

Recellularization of auricular cartilage via elastase-generated channels.

Lehmann J, Nürnberger S, Narcisi R, Stok KS, van der Eerden BCJ, Koevoet WJLM, Kops N, Ten Berge D, van Osch GJ.

Biofabrication. 2019 Apr 26;11(3):035012. doi: 10.1088/1758-5090/ab1436.

PMID:
30921774
2.

Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo.

Fahmy-Garcia S, Farrell E, Witte-Bouma J, Robbesom-van den Berge I, Suarez M, Mumcuoglu D, Walles H, Kluijtmans SGJM, van der Eerden BCJ, van Osch GJVM, van Leeuwen JPTM, van Driel M.

Front Bioeng Biotechnol. 2019 Mar 1;7:38. doi: 10.3389/fbioe.2019.00038. eCollection 2019.

3.

A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice.

Lodberg A, van der Eerden BCJ, Boers-Sijmons B, Thomsen JS, Brüel A, van Leeuwen JPTM, Eijken M.

FASEB J. 2019 May;33(5):6001-6010. doi: 10.1096/fj.201801969RR. Epub 2019 Feb 13.

PMID:
30759349
4.

Osteocalcin-A Versatile Bone-Derived Hormone.

Moser SC, van der Eerden BCJ.

Front Endocrinol (Lausanne). 2019 Jan 10;9:794. doi: 10.3389/fendo.2018.00794. eCollection 2018. Review.

5.

Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow-Release System Induce Ectopic Bone Formation.

Fahmy-Garcia S, Mumcuoglu D, de Miguel L, Dieleman V, Witte-Bouma J, van der Eerden BCJ, van Driel M, Eglin D, Verhaar JAN, Kluijtmans SGJM, van Osch GJVM, Farrell E.

Adv Healthc Mater. 2018 Dec;7(24):e1801496. doi: 10.1002/adhm.201801496. No abstract available.

PMID:
30565901
6.

Mucin 1 (Muc1) Deficiency in Female Mice Leads to Temporal Skeletal Changes During Aging.

Brum AM, van der Leije CS, Schreuders-Koedam M, Chaibi S, van Leeuwen JP, van der Eerden BC.

JBMR Plus. 2018 Jul 14;2(6):341-350. doi: 10.1002/jbm4.10061. eCollection 2018 Nov.

7.

Zika virus infection perturbs osteoblast function.

Mumtaz N, Koedam M, van den Doel PB, van Leeuwen JPTM, Koopmans MPG, van der Eerden BCJ, Rockx B.

Sci Rep. 2018 Nov 19;8(1):16975. doi: 10.1038/s41598-018-35422-3.

8.

Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

Andreasen CM, Delaisse JM, van der Eerden BCJ, van Leeuwen JPTM, Ding M, Andersen TL.

Bone. 2018 Dec;117:70-82. doi: 10.1016/j.bone.2018.09.011. Epub 2018 Sep 18.

9.

Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow-Release System Induce Ectopic Bone Formation.

Fahmy-Garcia S, Mumcuoglu D, de Miguel L, Dieleman V, Witte-Bouma J, van der Eerden BCJ, van Driel M, Eglin D, Verhaar JAN, Kluijtmans SGJM, van Osch GJVM, Farrell E.

Adv Healthc Mater. 2018 Nov;7(21):e1800507. doi: 10.1002/adhm.201800507. Epub 2018 Sep 19. Erratum in: Adv Healthc Mater. 2018 Dec;7(24):e1801496.

PMID:
30230271
10.

Human mesenchymal stromal cells in adhesion to cell-derived extracellular matrix and titanium: Comparative kinome profile analysis.

Baroncelli M, Fuhler GM, van de Peppel J, Zambuzzi WF, van Leeuwen JP, van der Eerden BCJ, Peppelenbosch MP.

J Cell Physiol. 2019 Mar;234(3):2984-2996. doi: 10.1002/jcp.27116. Epub 2018 Jul 30.

11.

Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive.

Baroncelli M, van der Eerden BCJ, Chatterji S, Rull Trinidad E, Kan YY, Koedam M, van Hengel IAJ, Alves RDAM, Fratila-Apachitei LE, Demmers JAA, van de Peppel J, van Leeuwen JPTM.

Tissue Eng Part A. 2018 Sep;24(17-18):1377-1389. doi: 10.1089/ten.TEA.2017.0448. Epub 2018 May 21.

PMID:
29667532
12.

A soluble activin type IIA receptor mitigates the loss of femoral neck bone strength and cancellous bone mass in a mouse model of disuse osteopenia.

Lodberg A, Eijken M, van der Eerden BCJ, Okkels MW, Thomsen JS, Brüel A.

Bone. 2018 May;110:326-334. doi: 10.1016/j.bone.2018.02.026. Epub 2018 Feb 28.

PMID:
29499419
13.

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F.

Am J Hum Genet. 2018 Jan 4;102(1):88-102. doi: 10.1016/j.ajhg.2017.12.005.

14.

Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.

Brum AM, van de Peppel J, Nguyen L, Aliev A, Schreuders-Koedam M, Gajadien T, van der Leije CS, van Kerkwijk A, Eijken M, van Leeuwen JPTM, van der Eerden BCJ.

J Cell Physiol. 2018 Jun;233(6):4895-4906. doi: 10.1002/jcp.26298. Epub 2018 Jan 15.

PMID:
29194609
15.

Understanding Age-Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor.

Andreasen CM, Delaisse JM, van der Eerden BC, van Leeuwen JP, Ding M, Andersen TL.

J Bone Miner Res. 2018 Apr;33(4):606-620. doi: 10.1002/jbmr.3354. Epub 2018 Jan 4.

16.

Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro.

Both T, van de Peppel HJ, Zillikens MC, Koedam M, van Leeuwen JPTM, van Hagen PM, van Daele PLA, van der Eerden BCJ.

J Cell Mol Med. 2018 Feb;22(2):873-882. doi: 10.1111/jcmm.13373. Epub 2017 Oct 3.

17.

Hydroxychloroquine affects bone resorption both in vitro and in vivo.

Both T, Zillikens MC, Schreuders-Koedam M, Vis M, Lam WK, Weel AEAM, van Leeuwen JPTM, van Hagen PM, van der Eerden BCJ, van Daele PLA.

J Cell Physiol. 2018 Feb;233(2):1424-1433. doi: 10.1002/jcp.26028. Epub 2017 Aug 3.

PMID:
28556961
18.

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation.

Brum AM, van der Leije CS, Schreuders-Koedam M, Verhoeven J, Janssen M, Dekkers DH, Demmers JA, Eijken M, van de Peppel J, van Leeuwen JP, van der Eerden BC.

JBMR Plus. 2017 Apr 28;1(1):16-26. doi: 10.1002/jbm4.10003. eCollection 2017 Aug.

19.

Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization.

Baroncelli M, van der Eerden BC, Kan YY, Alves RD, Demmers JA, van de Peppel J, van Leeuwen JP.

J Cell Physiol. 2018 Jan;233(1):387-395. doi: 10.1002/jcp.25898. Epub 2017 May 19.

PMID:
28272740
20.

Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS.

Campos-Obando N, Koek WNH, Hooker ER, van der Eerden BC, Pols HA, Hofman A, van Leeuwen JP, Uitterlinden AG, Nielson CM, Zillikens MC.

J Bone Miner Res. 2017 Jun;32(6):1182-1193. doi: 10.1002/jbmr.3094. Epub 2017 Mar 27.

21.

Effects of Chronic Estrogen Administration in the Ventromedial Nucleus of the Hypothalamus (VMH) on Fat and Bone Metabolism in Ovariectomized Rats.

Zhang Z, Liu J, Veldhuis-Vlug AG, Su Y, Foppen E, van der Eerden BC, Koedam M, Bravenboer N, Kalsbeek A, Boelen A, Fliers E, Bisschop PH.

Endocrinology. 2016 Dec;157(12):4930-4942. Epub 2016 Oct 24.

PMID:
27911148
22.

Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis.

Koek WNH, van der Eerden BCJ, Alves RDAM, van Driel M, Schreuders-Koedam M, Zillikens MC, van Leeuwen JPTM.

Bone. 2017 Feb;95:108-114. doi: 10.1016/j.bone.2016.11.010. Epub 2016 Nov 12.

PMID:
27845263
23.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

Zambetti NA, Ping Z, Chen S, Kenswil KJG, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EMJ, Adisty MN, Van Strien PMH, van der Leije CS, Westers TM, Cremers EMP, Milanese C, Mastroberardino PG, van Leeuwen JPTM, van der Eerden BCJ, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MHGP.

Cell Stem Cell. 2016 Nov 3;19(5):613-627. doi: 10.1016/j.stem.2016.08.021. Epub 2016 Sep 22.

24.

Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis.

Mourik BC, Leenen PJ, de Knegt GJ, Huizinga R, van der Eerden BC, Wang J, Krois CR, Napoli JL, Bakker-Woudenberg IA, de Steenwinkel JE.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):233-241. doi: 10.1165/rcmb.2016-0185OC.

PMID:
27654457
25.

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells.

Morhayim J, van de Peppel J, Braakman E, Rombouts EW, Ter Borg MN, Dudakovic A, Chiba H, van der Eerden BC, Raaijmakers MH, van Wijnen AJ, Cornelissen JJ, van Leeuwen JP.

Sci Rep. 2016 Sep 2;6:32034. doi: 10.1038/srep32034.

26.

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH.

Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24.

27.

Novel Compound Heterozygous Mutations in the CYP27B1 Gene Lead to Pseudovitamin D-Deficient Rickets.

Koek WN, Zillikens MC, van der Eerden BC, van Leeuwen JP.

Calcif Tissue Int. 2016 Sep;99(3):326-31. doi: 10.1007/s00223-016-0165-z. Epub 2016 Jul 1.

PMID:
27364341
28.

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.

van der Eerden BC, Koek WN, Roschger P, Zillikens MC, Waarsing JH, van der Kemp A, Schreuders-Koedam M, Fratzl-Zelman N, Leenen PJ, Hoenderop JG, Klaushofer K, Bindels RJ, van Leeuwen JP.

Oncotarget. 2016 May 3;7(18):24928-41. doi: 10.18632/oncotarget.8779.

29.

Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway.

Brum AM, van de Peppel J, van der Leije CS, Schreuders-Koedam M, Eijken M, van der Eerden BC, van Leeuwen JP.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12711-6. doi: 10.1073/pnas.1501597112. Epub 2015 Sep 29.

30.

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

Tudpor K, van der Eerden BC, Jongwattanapisan P, Roelofs JJ, van Leeuwen JP, Bindels RJ, Hoenderop JG.

Bone. 2015 Mar;72:14-22. doi: 10.1016/j.bone.2014.11.004. Epub 2014 Nov 18.

PMID:
25460576
31.

Identification of microRNAs in human plasma.

van der Eerden BC, Alves RD, Kockx CE, Ozgur Z, Schreuders-Koedam M, van de Peppel J, van Ijcken WF, van Leeuwen JP.

Methods Mol Biol. 2015;1226:71-85. doi: 10.1007/978-1-4939-1619-1_7.

PMID:
25331044
32.

A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses.

van der Eerden BC, van der Heyden JC, van Hamburg JP, Schreuders-Koedam M, Asmawidjaja PS, de Muinck Keizer-Schrama SM, Boot AM, Lubberts E, Drop SL, van Leeuwen JP.

Bone. 2014 Dec;69:6-11. doi: 10.1016/j.bone.2014.08.005. Epub 2014 Sep 6.

PMID:
25201466
33.

Bone, a dynamic and integrating tissue.

van der Eerden BC, Teti A, Zambuzzi WF.

Arch Biochem Biophys. 2014 Nov 1;561:1-2. doi: 10.1016/j.abb.2014.08.012. Epub 2014 Aug 23. No abstract available.

PMID:
25157441
34.

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

Delhanty PJ, van der Velde M, van der Eerden BC, Sun Y, Geminn JM, van der Lely AJ, Smith RG, van Leeuwen JP.

Endocrinology. 2014 Nov;155(11):4287-95. doi: 10.1210/en.2013-2055. Epub 2014 Jul 25.

PMID:
25060361
35.

MicroRNAs in the skeleton: cell-restricted or potent intercellular communicators?

van der Eerden BC.

Arch Biochem Biophys. 2014 Nov 1;561:46-55. doi: 10.1016/j.abb.2014.04.016. Epub 2014 May 14. Review.

PMID:
24832391
36.

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.

van der Eerden BC, Oei L, Roschger P, Fratzl-Zelman N, Hoenderop JG, van Schoor NM, Pettersson-Kymmer U, Schreuders-Koedam M, Uitterlinden AG, Hofman A, Suzuki M, Klaushofer K, Ohlsson C, Lips PJ, Rivadeneira F, Bindels RJ, van Leeuwen JP.

Bone. 2013 Dec;57(2):443-54. doi: 10.1016/j.bone.2013.09.017. Epub 2013 Sep 29.

PMID:
24084385
37.

Ghrelin and bone.

Delhanty PJ, van der Eerden BC, van Leeuwen JP.

Biofactors. 2014 Jan-Feb;40(1):41-8. doi: 10.1002/biof.1120. Epub 2013 Jun 27. Review.

PMID:
23804549
38.

1α,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization.

Woeckel VJ, van der Eerden BC, Schreuders-Koedam M, Eijken M, Van Leeuwen JP.

J Cell Physiol. 2013 Nov;228(11):2167-74. doi: 10.1002/jcp.24388.

PMID:
23589129
39.

1α,25-dihydroxyvitamin D3 and rosiglitazone synergistically enhance osteoblast-mediated mineralization.

Woeckel VJ, Bruedigam C, Koedam M, Chiba H, van der Eerden BC, van Leeuwen JP.

Gene. 2013 Jan 10;512(2):438-43. doi: 10.1016/j.gene.2012.07.051. Epub 2012 Aug 8.

PMID:
22967709
40.

Characterization of vitamin D-deficient klotho(-/-) mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho(-/-) mice?

Woudenberg-Vrenken TE, van der Eerden BC, van der Kemp AW, van Leeuwen JP, Bindels RJ, Hoenderop JG.

Nephrol Dial Transplant. 2012 Nov;27(11):4061-8. doi: 10.1093/ndt/gfs177. Epub 2012 Jul 9.

PMID:
22778178
41.

The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.

van der Eerden BC, Fratzl-Zelman N, Nijenhuis T, Roschger P, Zügel U, Steinmeyer A, Hoenderop JG, Bindels RJ, Klaushofer K, van Leeuwen JP.

J Cell Physiol. 2013 Feb;228(2):402-7. doi: 10.1002/jcp.24144.

PMID:
22740316
42.

An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.

van der Velde M, van der Eerden BC, Sun Y, Almering JM, van der Lely AJ, Delhanty PJ, Smith RG, van Leeuwen JP.

Endocrinology. 2012 Aug;153(8):3593-602. doi: 10.1210/en.2012-1277. Epub 2012 Jun 14. Erratum in: Endocrinology. 2013 Oct;154(10):3951.

43.

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice.

Nicolaije C, Diderich KE, Botter SM, Priemel M, Waarsing JH, Day JS, Brandt RM, Schilling AF, Weinans H, Van der Eerden BC, van der Horst GT, Hoeijmakers JH, van Leeuwen JP.

PLoS One. 2012;7(4):e35246. doi: 10.1371/journal.pone.0035246. Epub 2012 Apr 10.

44.

Evidence of vitamin D and interferon-β cross-talk in human osteoblasts with 1α,25-dihydroxyvitamin D3 being dominant over interferon-β in stimulating mineralization.

Woeckel VJ, Koedam M, van de Peppel J, Chiba H, van der Eerden BC, van Leeuwen JP.

J Cell Physiol. 2012 Sep;227(9):3258-66. doi: 10.1002/jcp.24020.

PMID:
22105341
45.

IFNβ impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation.

Woeckel VJ, Eijken M, van de Peppel J, Chiba H, van der Eerden BC, van Leeuwen JP.

J Cell Physiol. 2012 Jun;227(6):2668-76. doi: 10.1002/jcp.23009.

PMID:
21898404
46.

Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins: a human bone protein library.

Alves RD, Demmers JA, Bezstarosti K, van der Eerden BC, Verhaar JA, Eijken M, van Leeuwen JP.

J Proteome Res. 2011 Oct 7;10(10):4725-33. doi: 10.1021/pr200522n. Epub 2011 Sep 21. Erratum in: J Proteome Res. 2011 Dec 2;10(2):5576.

PMID:
21892838
47.

The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice.

van der Eerden BC, Weissgerber P, Fratzl-Zelman N, Olausson J, Hoenderop JG, Schreuders-Koedam M, Eijken M, Roschger P, de Vries TJ, Chiba H, Klaushofer K, Flockerzi V, Bindels RJ, Freichel M, van Leeuwen JP.

J Cell Physiol. 2012 May;227(5):1951-9. doi: 10.1002/jcp.22923.

PMID:
21732366
48.

Basic techniques in human mesenchymal stem cell cultures: differentiation into osteogenic and adipogenic lineages, genetic perturbations, and phenotypic analyses.

Bruedigam C, Driel Mv, Koedam M, Peppel Jv, van der Eerden BC, Eijken M, van Leeuwen JP.

Curr Protoc Stem Cell Biol. 2011 Jun;Chapter 1:Unit1H.3. doi: 10.1002/9780470151808.sc01h03s17.

PMID:
21633940
49.

1Alpha,25-(OH)2D3 acts in the early phase of osteoblast differentiation to enhance mineralization via accelerated production of mature matrix vesicles.

Woeckel VJ, Alves RD, Swagemakers SM, Eijken M, Chiba H, van der Eerden BC, van Leeuwen JP.

J Cell Physiol. 2010 Nov;225(2):593-600. doi: 10.1002/jcp.22244.

PMID:
20506116
50.

The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake.

Koek WN, van Meurs JB, van der Eerden BC, Rivadeneira F, Zillikens MC, Hofman A, Obermayer-Pietsch B, Lips P, Pols HA, Uitterlinden AG, van Leeuwen JP.

J Bone Miner Res. 2010 Sep;25(9):1980-7. doi: 10.1002/jbmr.83.

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