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Items: 1 to 50 of 254

1.

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.

Bobeica SC, Dong SH, Huo L, Mazo N, McLaughlin MI, Jiménez-Osés G, Nair SK, van der Donk WA.

Elife. 2019 Jan 14;8. pii: e42305. doi: 10.7554/eLife.42305.

2.

Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin.

Bougioukou DJ, Ting CP, Peck SC, Mukherjee S, van der Donk WA.

Org Biomol Chem. 2019 Jan 23;17(4):822-829. doi: 10.1039/c8ob02860e.

PMID:
30608108
3.

Investigations into the mechanism of action of sublancin.

Wu C, Biswas S, Garcia De Gonzalo CV, van der Donk WA.

ACS Infect Dis. 2018 Dec 24. doi: 10.1021/acsinfecdis.8b00320. [Epub ahead of print]

PMID:
30582697
4.

18O Kinetic Isotope Effects Reveal an Associative Transition State for Phosphite Dehydrogenase Catalyzed Phosphoryl Transfer.

Howe G, van der Donk WA.

J Am Chem Soc. 2018 Dec 7. doi: 10.1021/jacs.8b06301. [Epub ahead of print]

PMID:
30525552
5.

CylA is a sequence-specific protease involved in toxin biosynthesis.

Tang W, Bobeica SC, Wang L, van der Donk WA.

J Ind Microbiol Biotechnol. 2018 Nov 27. doi: 10.1007/s10295-018-2110-9. [Epub ahead of print]

PMID:
30484123
6.

Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin.

Wang KA, Ng TL, Wang P, Huang Z, Balskus EP, van der Donk WA.

Nat Commun. 2018 Sep 11;9(1):3687. doi: 10.1038/s41467-018-06083-7.

7.

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli.

Si T, Tian Q, Min Y, Zhang L, Sweedler JV, van der Donk WA, Zhao H.

J Am Chem Soc. 2018 Sep 26;140(38):11884-11888. doi: 10.1021/jacs.8b05544. Epub 2018 Sep 12.

PMID:
30183279
8.

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli.

Ren H, Biswas S, Ho S, van der Donk WA, Zhao H.

ACS Chem Biol. 2018 Oct 19;13(10):2966-2972. doi: 10.1021/acschembio.8b00599. Epub 2018 Sep 18.

PMID:
30183259
9.

Substrate-assisted enzymatic formation of lysinoalanine in duramycin.

An L, Cogan DP, Navo CD, Jiménez-Osés G, Nair SK, van der Donk WA.

Nat Chem Biol. 2018 Oct;14(10):928-933. doi: 10.1038/s41589-018-0122-4. Epub 2018 Sep 3.

PMID:
30177849
10.

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin.

Hegemann JD, Schwalen CJ, Mitchell DA, van der Donk WA.

Chem Commun (Camb). 2018 Aug 21;54(65):9007-9010. doi: 10.1039/c8cc04411b. Epub 2018 Jul 26.

PMID:
30046789
11.

Synthesis of Antibiotics and Related Molecules.

Movassaghi M, van der Donk WA.

J Org Chem. 2018 Jul 6;83(13):6826-6828. doi: 10.1021/acs.joc.8b01330. No abstract available.

PMID:
29976072
12.

Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3.

McLaughlin MI, van der Donk WA.

Biochemistry. 2018 Aug 21;57(33):4967-4971. doi: 10.1021/acs.biochem.8b00616. Epub 2018 Jul 10.

PMID:
29969250
13.

Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation.

Dutta D, Lai KY, Reyes-Ordoñez A, Chen J, van der Donk WA.

J Lipid Res. 2018 Aug;59(8):1433-1445. doi: 10.1194/jlr.M085274. Epub 2018 Jun 7.

PMID:
29880530
14.

The Enzymology of Prochlorosin Biosynthesis.

Bobeica SC, van der Donk WA.

Methods Enzymol. 2018;604:165-203. doi: 10.1016/bs.mie.2018.01.038. Epub 2018 Mar 12.

PMID:
29779652
15.

Development and Application of Yeast and Phage Display of Diverse Lanthipeptides.

Hetrick KJ, Walker MC, van der Donk WA.

ACS Cent Sci. 2018 Apr 25;4(4):458-467. doi: 10.1021/acscentsci.7b00581. Epub 2018 Mar 28.

16.

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems.

Hegemann JD, van der Donk WA.

J Am Chem Soc. 2018 May 2;140(17):5743-5754. doi: 10.1021/jacs.8b01323. Epub 2018 Apr 19.

PMID:
29633842
17.

Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB.

Repka LM, Hetrick KJ, Chee SH, van der Donk WA.

J Am Chem Soc. 2018 Mar 28;140(12):4200-4203. doi: 10.1021/jacs.7b13506. Epub 2018 Mar 20.

PMID:
29537838
18.

A lanthipeptide library used to identify a protein-protein interaction inhibitor.

Yang X, Lennard KR, He C, Walker MC, Ball AT, Doigneaux C, Tavassoli A, van der Donk WA.

Nat Chem Biol. 2018 Apr;14(4):375-380. doi: 10.1038/s41589-018-0008-5. Epub 2018 Mar 5.

19.

Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.

Kakkar N, Perez JG, Liu WR, Jewett MC, van der Donk WA.

ACS Chem Biol. 2018 Apr 20;13(4):951-957. doi: 10.1021/acschembio.7b01024. Epub 2018 Feb 21.

PMID:
29439566
20.

Investigation of Amide Bond Formation during Dehydrophos Biosynthesis.

Ulrich EC, Bougioukou DJ, van der Donk WA.

ACS Chem Biol. 2018 Mar 16;13(3):537-541. doi: 10.1021/acschembio.7b00949. Epub 2018 Jan 12.

PMID:
29303545
21.

Structural basis for methylphosphonate biosynthesis.

Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL.

Science. 2017 Dec 8;358(6368):1336-1339. doi: 10.1126/science.aao3435.

22.

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.

Zhang Z, Mahanta N, Hudson GA, Mitchell DA, van der Donk WA.

J Am Chem Soc. 2017 Dec 27;139(51):18623-18631. doi: 10.1021/jacs.7b10203. Epub 2017 Dec 15.

23.

Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.

Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12928-12933. doi: 10.1073/pnas.1716035114. Epub 2017 Nov 20.

24.

Structure-Activity Relationships of the S-Linked Glycocin Sublancin.

Biswas S, Garcia De Gonzalo CV, Repka LM, van der Donk WA.

ACS Chem Biol. 2017 Dec 15;12(12):2965-2969. doi: 10.1021/acschembio.7b00819. Epub 2017 Nov 10.

25.

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products.

Burkhart BJ, Kakkar N, Hudson GA, van der Donk WA, Mitchell DA.

ACS Cent Sci. 2017 Jun 28;3(6):629-638. doi: 10.1021/acscentsci.7b00141. Epub 2017 Jun 6.

26.

Ribosomal Natural Products, Tailored To Fit.

Funk MA, van der Donk WA.

Acc Chem Res. 2017 Jul 18;50(7):1577-1586. doi: 10.1021/acs.accounts.7b00175. Epub 2017 Jul 6.

27.

Evolutionary radiation of lanthipeptides in marine cyanobacteria.

Cubillos-Ruiz A, Berta-Thompson JW, Becker JW, van der Donk WA, Chisholm SW.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5424-E5433. doi: 10.1073/pnas.1700990114. Epub 2017 Jun 19.

28.

Introduction: Unusual Enzymology in Natural Product Synthesis.

van der Donk WA.

Chem Rev. 2017 Apr 26;117(8):5223-5225. doi: 10.1021/acs.chemrev.7b00124. No abstract available.

PMID:
28441875
29.

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis.

Mahanta N, Zhang Z, Hudson GA, van der Donk WA, Mitchell DA.

J Am Chem Soc. 2017 Mar 29;139(12):4310-4313. doi: 10.1021/jacs.7b00693. Epub 2017 Mar 21.

30.

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era.

Hetrick KJ, van der Donk WA.

Curr Opin Chem Biol. 2017 Jun;38:36-44. doi: 10.1016/j.cbpa.2017.02.005. Epub 2017 Mar 2. Review.

31.

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.

Repka LM, Chekan JR, Nair SK, van der Donk WA.

Chem Rev. 2017 Apr 26;117(8):5457-5520. doi: 10.1021/acs.chemrev.6b00591. Epub 2017 Jan 30. Review.

32.

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.

He C, Zeng M, Dutta D, Koh TH, Chen J, van der Donk WA.

Sci Rep. 2017 Jan 20;7:40980. doi: 10.1038/srep40980.

33.

O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase.

Peck SC, Wang C, Dassama LM, Zhang B, Guo Y, Rajakovich LJ, Bollinger JM Jr, Krebs C, van der Donk WA.

J Am Chem Soc. 2017 Feb 8;139(5):2045-2052. doi: 10.1021/jacs.6b12147. Epub 2017 Jan 31.

34.

New Insights into the Biosynthesis of Fosfazinomycin.

Huang Z, Wang KA, van der Donk WA.

Chem Sci. 2016;7(8):5219-5223. doi: 10.1039/C6SC01389A. Epub 2016 May 6.

35.

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli SI, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA.

ACS Chem Biol. 2017 Feb 17;12(2):548-557. doi: 10.1021/acschembio.6b01031. Epub 2017 Jan 13.

36.

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

Olivares P, Ulrich EC, Chekan JR, van der Donk WA, Nair SK.

ACS Chem Biol. 2017 Feb 17;12(2):456-463. doi: 10.1021/acschembio.6b00939. Epub 2016 Dec 27.

37.

Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin.

Mukherjee S, Huo L, Thibodeaux GN, van der Donk WA.

Org Lett. 2016 Dec 2;18(23):6188-6191. Epub 2016 Nov 18.

38.
39.

Insights into the Biosynthesis of Duramycin.

Huo L, Ökesli A, Zhao M, van der Donk WA.

Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02698-16. doi: 10.1128/AEM.02698-16. Print 2017 Feb 1.

40.

Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes.

Peck SC, van der Donk WA.

J Biol Inorg Chem. 2017 Apr;22(2-3):381-394. doi: 10.1007/s00775-016-1399-y. Epub 2016 Oct 25. Review.

41.

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.

Zhang Z, Hudson GA, Mahanta N, Tietz JI, van der Donk WA, Mitchell DA.

J Am Chem Soc. 2016 Dec 7;138(48):15511-15514. doi: 10.1021/jacs.6b08987. Epub 2016 Oct 13.

42.

Cameo appearances of aminoacyl-tRNA in natural product biosynthesis.

Ulrich EC, van der Donk WA.

Curr Opin Chem Biol. 2016 Dec;35:29-36. doi: 10.1016/j.cbpa.2016.08.018. Epub 2016 Sep 4. Review.

43.

The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis.

Tang W, Thibodeaux GN, van der Donk WA.

ACS Chem Biol. 2016 Sep 16;11(9):2438-46. doi: 10.1021/acschembio.6b00397. Epub 2016 Jul 11.

44.

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM.

Garg N, Goto Y, Chen T, van der Donk WA.

Biopolymers. 2016 Nov;106(6):834-842. doi: 10.1002/bip.22876.

45.

Bacteria Do It Differently: An Alternative Path to Squalene.

van der Donk WA.

ACS Cent Sci. 2015 May 27;1(2):64-5. doi: 10.1021/acscentsci.5b00142. Epub 2015 May 8. No abstract available.

46.

Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.

Thibodeaux CJ, Wagoner J, Yu Y, van der Donk WA.

J Am Chem Soc. 2016 May 25;138(20):6436-44. doi: 10.1021/jacs.6b00163. Epub 2016 May 10.

47.

Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic.

Huo L, van der Donk WA.

J Am Chem Soc. 2016 Apr 27;138(16):5254-7. doi: 10.1021/jacs.6b02513. Epub 2016 Apr 18.

48.

Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium.

Zhao X, van der Donk WA.

Cell Chem Biol. 2016 Feb 18;23(2):246-256. doi: 10.1016/j.chembiol.2015.11.014. Epub 2016 Jan 28.

49.

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes.

Ding W, Liu WQ, Jia Y, Li Y, van der Donk WA, Zhang Q.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3521-6. doi: 10.1073/pnas.1522907113. Epub 2016 Mar 15.

50.

Editorial overview: Biocatalysis and Biotransformation: Esoteric, Niche Enzymology.

Tawfik DS, van der Donk WA.

Curr Opin Chem Biol. 2016 Apr;31:v-vii. doi: 10.1016/j.cbpa.2016.03.002. Epub 2016 Mar 10. No abstract available.

PMID:
26972779

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