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Cofactor binding protects flavodoxin against oxidative stress.

Lindhoud S, van den Berg WA, van den Heuvel RH, Heck AJ, van Mierlo CP, van Berkel WJ.

PLoS One. 2012;7(7):e41363. doi: 10.1371/journal.pone.0041363. Epub 2012 Jul 19.


Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.

Monti MC, Cohen SX, Fish A, Winterwerp HH, Barendregt A, Friedhoff P, Perrakis A, Heck AJ, Sixma TK, van den Heuvel RH, Lebbink JH.

Nucleic Acids Res. 2011 Oct;39(18):8052-64. doi: 10.1093/nar/gkr498. Epub 2011 Jul 6.


Structure of the ribosome associating GTPase HflX.

Wu H, Sun L, Blombach F, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J.

Proteins. 2010 Feb 15;78(3):705-13. doi: 10.1002/prot.22599.


A mutagenic analysis of the RNase mechanism of the bacterial Kid toxin by mass spectrometry.

Diago-Navarro E, Kamphuis MB, Boelens R, Barendregt A, Heck AJ, van den Heuvel RH, Díaz-Orejas R.

FEBS J. 2009 Sep;276(17):4973-86. doi: 10.1111/j.1742-4658.2009.07199.x. Epub 2009 Aug 4.


Crystal structure and biochemical properties of a novel thermostable esterase containing an immunoglobulin-like domain.

Levisson M, Sun L, Hendriks S, Swinkels P, Akveld T, Bultema JB, Barendregt A, van den Heuvel RH, Dijkstra BW, van der Oost J, Kengen SW.

J Mol Biol. 2009 Jan 23;385(3):949-62. doi: 10.1016/j.jmb.2008.10.075. Epub 2008 Nov 5.


Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process.

Jin J, Mazon H, van den Heuvel RH, Heck AJ, Janssen DB, Fraaije MW.

FEBS J. 2008 Oct;275(20):5191-200. doi: 10.1111/j.1742-4658.2008.06649.x. Epub 2008 Sep 11.


ADP competes with FAD binding in putrescine oxidase.

van Hellemond EW, Mazon H, Heck AJ, van den Heuvel RH, Heuts DP, Janssen DB, Fraaije MW.

J Biol Chem. 2008 Oct 17;283(42):28259-64. doi: 10.1074/jbc.M803255200. Epub 2008 Aug 4.


Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases.

Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ.

J Bacteriol. 2008 Aug;190(15):5199-209. doi: 10.1128/JB.01945-07. Epub 2008 May 23.


Discovery of a eugenol oxidase from Rhodococcus sp. strain RHA1.

Jin J, Mazon H, van den Heuvel RH, Janssen DB, Fraaije MW.

FEBS J. 2007 May;274(9):2311-21. Epub 2007 Apr 5.


Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers.

Monti MC, Hernández-Arriaga AM, Kamphuis MB, López-Villarejo J, Heck AJ, Boelens R, Díaz-Orejas R, van den Heuvel RH.

Nucleic Acids Res. 2007;35(5):1737-49. Epub 2007 Feb 21.


Structure and function of bacterial kid-kis and related toxin-antitoxin systems.

Kamphuis MB, Monti MC, van den Heuvel RH, López-Villarejo J, Díaz-Orejas R, Boelens R.

Protein Pept Lett. 2007;14(2):113-24. Review.


Transcriptional activation by CprK1 is regulated by protein structural changes induced by effector binding and redox state.

Mazon H, Gábor K, Leys D, Heck AJ, van der Oost J, van den Heuvel RH.

J Biol Chem. 2007 Apr 13;282(15):11281-90. Epub 2007 Feb 15.


Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE.

Kamphuis MB, Monti MC, van den Heuvel RH, Santos-Sierra S, Folkers GE, Lemonnier M, Díaz-Orejas R, Heck AJ, Boelens R.

Proteins. 2007 Apr 1;67(1):219-31.


Improving the performance of a quadrupole time-of-flight instrument for macromolecular mass spectrometry.

van den Heuvel RH, van Duijn E, Mazon H, Synowsky SA, Lorenzen K, Versluis C, Brouns SJ, Langridge D, van der Oost J, Hoyes J, Heck AJ.

Anal Chem. 2006 Nov 1;78(21):7473-83.


Resolving stoichiometries and oligomeric states of glutamate synthase protein complexes with curve fitting and simulation of electrospray mass spectra.

van Breukelen B, Barendregt A, Heck AJ, van den Heuvel RH.

Rapid Commun Mass Spectrom. 2006;20(16):2490-6.


Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.

Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J.

J Biol Chem. 2006 Sep 15;281(37):27378-88. Epub 2006 Jul 17.


Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex.

Synowsky SA, van den Heuvel RH, Mohammed S, Pijnappel PW, Heck AJ.

Mol Cell Proteomics. 2006 Sep;5(9):1581-92. Epub 2006 Jul 7.


CprK crystal structures reveal mechanism for transcriptional control of halorespiration.

Joyce MG, Levy C, Gábor K, Pop SM, Biehl BD, Doukov TI, Ryter JM, Mazon H, Smidt H, van den Heuvel RH, Ragsdale SW, van der Oost J, Leys D.

J Biol Chem. 2006 Sep 22;281(38):28318-25. Epub 2006 Jun 27.


Analysis of protein-protein interaction surfaces using a combination of efficient lysine acetylation and nanoLC-MALDI-MS/MS applied to the E9:Im9 bacteriotoxin--immunity protein complex.

Scholten A, Visser NFC, van den Heuvel RHH, Heck AJR.

J Am Soc Mass Spectrom. 2006 Jul;17(7):983-994. doi: 10.1016/j.jasms.2006.03.005. Epub 2006 May 19.


Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring.

van Duijn E, Simmons DA, van den Heuvel RH, Bakkes PJ, van Heerikhuizen H, Heeren RM, Robinson CV, van der Vies SM, Heck AJ.

J Am Chem Soc. 2006 Apr 12;128(14):4694-702.


Model for RNA binding and the catalytic site of the RNase Kid of the bacterial parD toxin-antitoxin system.

Kamphuis MB, Bonvin AM, Monti MC, Lemonnier M, Muñoz-Gómez A, van den Heuvel RH, Díaz-Orejas R, Boelens R.

J Mol Biol. 2006 Mar 17;357(1):115-26. Epub 2005 Dec 27.


Structure-function studies on the complex iron-sulfur flavoprotein glutamate synthase: the key enzyme of ammonia assimilation.

Vanoni MA, Dossena L, van den Heuvel RH, Curti B.

Photosynth Res. 2005;83(2):219-38. Review.


Coenzyme binding during catalysis is beneficial for the stability of 4-hydroxyacetophenone monooxygenase.

van den Heuvel RH, Tahallah N, Kamerbeek NM, Fraaije MW, van Berkel WJ, Janssen DB, Heck AJ.

J Biol Chem. 2005 Sep 16;280(37):32115-21. Epub 2005 Jul 27.


Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry.

van den Heuvel RH, Gato S, Versluis C, Gerbaux P, Kleanthous C, Heck AJ.

Nucleic Acids Res. 2005 Jun 13;33(10):e96.


Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry.

van Duijn E, Bakkes PJ, Heeren RM, van den Heuvel RH, van Heerikhuizen H, van der Vies SM, Heck AJ.

Nat Methods. 2005 May;2(5):371-6. Epub 2005 Apr 21.


Decharging of globular proteins and protein complexes in electrospray.

Catalina MI, van den Heuvel RH, van Duijn E, Heck AJ.

Chemistry. 2005 Jan 21;11(3):960-8.


Native protein mass spectrometry: from intact oligomers to functional machineries.

van den Heuvel RH, Heck AJ.

Curr Opin Chem Biol. 2004 Oct;8(5):519-26. Review.


Crystal structure of E.coli alcohol dehydrogenase YqhD: evidence of a covalently modified NADP coenzyme.

Sulzenbacher G, Alvarez K, Van Den Heuvel RH, Versluis C, Spinelli S, Campanacci V, Valencia C, Cambillau C, Eklund H, Tegoni M.

J Mol Biol. 2004 Sep 10;342(2):489-502.


Investigation of intact protein complexes by mass spectrometry.

Heck AJ, Van Den Heuvel RH.

Mass Spectrom Rev. 2004 Sep-Oct;23(5):368-89. Review.


Laboratory-evolved vanillyl-alcohol oxidase produces natural vanillin.

van den Heuvel RH, van den Berg WA, Rovida S, van Berkel WJ.

J Biol Chem. 2004 Aug 6;279(32):33492-500. Epub 2004 May 28.


Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate.

van den Heuvel RH, Curti B, Vanoni MA, Mattevi A.

Cell Mol Life Sci. 2004 Mar;61(6):669-81. Review.


Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action.

van den Heuvel RH, Westphal AH, Heck AJ, Walsh MA, Rovida S, van Berkel WJ, Mattevi A.

J Biol Chem. 2004 Mar 26;279(13):12860-7. Epub 2003 Dec 31.


The active conformation of glutamate synthase and its binding to ferredoxin.

van den Heuvel RH, Svergun DI, Petoukhov MV, Coda A, Curti B, Ravasio S, Vanoni MA, Mattevi A.

J Mol Biol. 2003 Jun 27;330(1):113-28.


Quaternary structure of Azospirillum brasilense NADPH-dependent glutamate synthase in solution as revealed by synchrotron radiation x-ray scattering.

Petoukhov MV, Svergun DI, Konarev PV, Ravasio S, van den Heuvel RH, Curti B, Vanoni MA.

J Biol Chem. 2003 Aug 8;278(32):29933-9. Epub 2003 May 30.


Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase.

Tahallah N, Van Den Heuvel RH, Van Den Berg WA, Maier CS, Van Berkel WJ, Heck AJ.

J Biol Chem. 2002 Sep 27;277(39):36425-32. Epub 2002 Jul 9.


Redox properties of vanillyl-alcohol oxidase.

van den Heuvel RH, Fraaije MW, van Berkel WJ.

Methods Enzymol. 2002;353:177-86. No abstract available.


Structural studies on the synchronization of catalytic centers in glutamate synthase.

van den Heuvel RH, Ferrari D, Bossi RT, Ravasio S, Curti B, Vanoni MA, Florencio FJ, Mattevi A.

J Biol Chem. 2002 Jul 5;277(27):24579-83. Epub 2002 Apr 19.


Tuning of the product spectrum of vanillyl-alcohol oxidase by medium engineering.

van den Heuvel RH, Partridge J, Laane C, Halling PJ, van Berkel WJ.

FEBS Lett. 2001 Aug 17;503(2-3):213-6.


Enzymatic synthesis of vanillin.

van den Heuvel RH, Fraaije MW, Laane C, van Berkel WJ.

J Agric Food Chem. 2001 Jun;49(6):2954-8.


Direction of the reactivity of vanillyl-alcohol oxidase with 4-alkylphenols.

van den Heuvel RH, Fraaije MW, van Berkel WJ.

FEBS Lett. 2000 Sep 15;481(2):109-12.


Structural analysis of flavinylation in vanillyl-alcohol oxidase.

Fraaije MW, van Den Heuvel RH, van Berkel WJ, Mattevi A.

J Biol Chem. 2000 Dec 8;275(49):38654-8.


Inversion of stereospecificity of vanillyl-alcohol oxidase.

van Den Heuvel RH, Fraaije MW, Ferrer M, Mattevi A, van Berkel WJ.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9455-60.


Asp-170 is crucial for the redox properties of vanillyl-alcohol oxidase.

van den Heuvel RH, Fraaije MW, Mattevi A, van Berkel WJ.

J Biol Chem. 2000 May 19;275(20):14799-808.


Detection of intact megaDalton protein assemblies of vanillyl-alcohol oxidase by mass spectrometry.

van Berkel WJ, van den Heuvel RH, Versluis C, Heck AJ.

Protein Sci. 2000 Mar;9(3):435-9.


Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase.

Fraaije MW, van den Heuvel RH, van Berkel WJ, Mattevi A.

J Biol Chem. 1999 Dec 10;274(50):35514-20.


Enhanced (+)-catechin transglucosylating activity of Streptococcus mutans GS-5 glucosyltransferase-D due to fructose removal.

Meulenbeld GH, Zuilhof H, van Veldhuizen A, van den Heuvel RH, Hartmans S.

Appl Environ Microbiol. 1999 Sep;65(9):4141-7.


Regio- and stereospecific conversion of 4-alkylphenols by the covalent flavoprotein vanillyl-alcohol oxidase.

van den Heuvel RH, Fraaije MW, Laane C, van Berkel WJ.

J Bacteriol. 1998 Nov;180(21):5646-51.


Kinetic mechanism of vanillyl-alcohol oxidase with short-chain 4-alkylphenols.

Fraaije MW, van den Heuvel RH, Roelofs JC, van Berkel WJ.

Eur J Biochem. 1998 May 1;253(3):712-9.

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