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Items: 14


Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization.

van Vuuren RJ, Botes M, Jurgens T, Joubert AM, van den Bout I.

Cancer Cell Int. 2019 Jan 3;19:1. doi: 10.1186/s12935-018-0719-4. eCollection 2019.


A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions.

Botes M, Jurgens T, Riahi Z, Visagie M, Janse van Vuuren R, Joubert AM, van den Bout I.

Cancer Cell Int. 2018 Nov 19;18:188. doi: 10.1186/s12935-018-0688-7. eCollection 2018.


A Novel 2-Methoxyestradiol Analogue Is Responsible for Vesicle Disruption and Lysosome Aggregation in Breast Cancer Cells.

Nkandeu SD, van den Bout I, Cronjé MJ, van Papendorp DH, Joubert AM.

Pharmacology. 2018;102(1-2):9-16. doi: 10.1159/000487443. Epub 2018 Apr 19.


A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis.

Visagie MH, van den Bout I, Joubert AM.

PLoS One. 2017 Apr 14;12(4):e0176006. doi: 10.1371/journal.pone.0176006. eCollection 2017.


Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT.

Visuttijai K, Pettersson J, Mehrbani Azar Y, van den Bout I, Örndal C, Marcickiewicz J, Nilsson S, Hörnquist M, Olsson B, Ejeskär K, Behboudi A.

PLoS One. 2016 Oct 7;11(10):e0164063. doi: 10.1371/journal.pone.0164063. eCollection 2016.


Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations.

Theron A, Prudent R, Nolte E, van den Bout I, Punchoo R, Marais S, du Toit P, Hlophe Y, van Papendorp D, Lafanechère L, Joubert A.

Cancer Chemother Pharmacol. 2015 Feb;75(2):431-7. doi: 10.1007/s00280-014-2653-z. Epub 2014 Dec 30.


Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.

van den Bout I, Jones DR, Shah ZH, Halstead JR, Keune WJ, Mohammed S, D'Santos CS, Divecha N.

Biochem J. 2013 Nov 1;455(3):347-58. doi: 10.1042/BJ20130259.


Epigenetic regulation of galectin-3 expression by β1 integrins promotes cell adhesion and migration.

Margadant C, van den Bout I, van Boxtel AL, Thijssen VL, Sonnenberg A.

J Biol Chem. 2012 Dec 28;287(53):44684-93. doi: 10.1074/jbc.M112.426445. Epub 2012 Nov 1.


Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

Halstead JR, Savaskan NE, van den Bout I, Van Horck F, Hajdo-Milasinovic A, Snell M, Keune WJ, Ten Klooster JP, Hordijk PL, Divecha N.

J Cell Sci. 2010 Oct 15;123(Pt 20):3535-46. doi: 10.1242/jcs.062679. Epub 2010 Sep 14.


PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.

van den Bout I, Divecha N.

J Cell Sci. 2009 Nov 1;122(Pt 21):3837-50. doi: 10.1242/jcs.056127. Review.


Investigation into the mechanism regulating MRP localization.

van den Bout I, van Rheenen J, van Angelen AA, de Rooij J, Wilhelmsen K, Jalink K, Divecha N, Sonnenberg A.

Exp Cell Res. 2008 Jan 15;314(2):330-41. Epub 2007 Aug 29.


Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src.

Huveneers S, van den Bout I, Sonneveld P, Sancho A, Sonnenberg A, Danen EH.

Cancer Res. 2007 Mar 15;67(6):2693-700.


The regulation of MacMARCKS expression by integrin beta3.

van den Bout I, Truong HH, Huveneers S, Kuikman I, Danen EH, Sonnenberg A.

Exp Cell Res. 2007 Apr 1;313(6):1260-9. Epub 2007 Jan 12.


Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin.

Wilhelmsen K, Litjens SH, Kuikman I, Tshimbalanga N, Janssen H, van den Bout I, Raymond K, Sonnenberg A.

J Cell Biol. 2005 Dec 5;171(5):799-810.

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