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Items: 43

1.

Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy.

Verhagen JMA, van den Born M, van der Linde HC, G J Nikkels P, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, Verheijen FW, Hassel D, Hofstra RMW, Hegde RS, van Hasselt PM, van Ham TJ, van de Laar IMBH.

Circ Genom Precis Med. 2019 Sep;12(9):397-406. doi: 10.1161/CIRCGEN.119.002507. Epub 2019 Aug 28.

PMID:
31461301
2.

Correction: The phenotypic spectrum of WWOX-related disorders: 20 additional cases of WOREE syndrome and review of the literature.

Piard J, Hawkes L, Milh M, Villard L, Borgatti R, Romaniello R, Fradin M, Capri Y, Héron D, Nougues MC, Nava C, Arsene OT, Shears D, Taylor J, Pagnamenta A, Taylor JC, Sogawa Y, Johnson D, Firth H, Vasudevan P, Jones G, Nguyen-Morel MA, Busa T, Roubertie A, van den Born M, Brischoux-Boucher E, Koenig M, Mignot C; DDD Study, Kini U, Philippe C.

Genet Med. 2019 Jul;21(7):1667-1671. doi: 10.1038/s41436-019-0460-y.

PMID:
30783266
3.

Homozygous Truncating Variant in PKP2 Causes Hypoplastic Left Heart Syndrome.

Verhagen JMA, van den Born M, Kurul S, Asimaki A, van de Laar IMBH, Frohn-Mulder IME, Kammeraad JAE, Yap SC, Bartelings MM, van Slegtenhorst MA, von der Thüsen JH, Wessels MW.

Circ Genom Precis Med. 2018 Dec;11(12):e002397. doi: 10.1161/CIRCGEN.118.002397. No abstract available.

PMID:
30562116
4.

Profiling proliferative cells and their progeny in damaged murine hearts.

Kretzschmar K, Post Y, Bannier-Hélaouët M, Mattiotti A, Drost J, Basak O, Li VSW, van den Born M, Gunst QD, Versteeg D, Kooijman L, van der Elst S, van Es JH, van Rooij E, van den Hoff MJB, Clevers H.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12245-E12254. doi: 10.1073/pnas.1805829115. Epub 2018 Dec 7.

5.

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Hu H, Gehart H, Artegiani B, LÖpez-Iglesias C, Dekkers F, Basak O, van Es J, Chuva de Sousa Lopes SM, Begthel H, Korving J, van den Born M, Zou C, Quirk C, Chiriboga L, Rice CM, Ma S, Rios A, Peters PJ, de Jong YP, Clevers H.

Cell. 2018 Nov 29;175(6):1591-1606.e19. doi: 10.1016/j.cell.2018.11.013.

PMID:
30500538
6.

The phenotypic spectrum of WWOX-related disorders: 20 additional cases of WOREE syndrome and review of the literature.

Piard J, Hawkes L, Milh M, Villard L, Borgatti R, Romaniello R, Fradin M, Capri Y, Héron D, Nougues MC, Nava C, Arsene OT, Shears D, Taylor J, Pagnamenta A, Taylor JC, Sogawa Y, Johnson D, Firth H, Vasudevan P, Jones G, Nguyen-Morel MA, Busa T, Roubertie A, van den Born M, Brischoux-Boucher E, Koenig M, Mignot C; DDD Study, Kini U, Philippe C.

Genet Med. 2019 Jun;21(6):1308-1318. doi: 10.1038/s41436-018-0339-3. Epub 2018 Oct 25. Erratum in: Genet Med. 2019 Feb 20;:.

7.

N-Acetylglutamate Synthase Deficiency Due to a Recurrent Sequence Variant in the N-acetylglutamate Synthase Enhancer Region.

Williams M, Burlina A, Rubert L, Polo G, Ruijter GJG, van den Born M, Rüfenacht V, Haskins N, van Zutven LJCM, Tuchman M, Saris JJ, Häberle J, Caldovic L.

Sci Rep. 2018 Oct 18;8(1):15436. doi: 10.1038/s41598-018-33457-0.

8.

Insight into the sulfur metabolism of Desulfurella amilsii by differential proteomics.

Florentino AP, Pereira IAC, Boeren S, van den Born M, Stams AJM, Sánchez-Andrea I.

Environ Microbiol. 2019 Jan;21(1):209-225. doi: 10.1111/1462-2920.14442. Epub 2018 Nov 15.

9.

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.

Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H.

Nat Cell Biol. 2018 Aug;20(8):909-916. doi: 10.1038/s41556-018-0143-y. Epub 2018 Jul 23.

10.

Characterization of glycosylphosphatidylinositol biosynthesis defects by clinical features, flow cytometry, and automated image analysis.

Knaus A, Pantel JT, Pendziwiat M, Hajjir N, Zhao M, Hsieh TC, Schubach M, Gurovich Y, Fleischer N, Jäger M, Köhler S, Muhle H, Korff C, Møller RS, Bayat A, Calvas P, Chassaing N, Warren H, Skinner S, Louie R, Evers C, Bohn M, Christen HJ, van den Born M, Obersztyn E, Charzewska A, Endziniene M, Kortüm F, Brown N, Robinson PN, Schelhaas HJ, Weber Y, Helbig I, Mundlos S, Horn D, Krawitz PM.

Genome Med. 2018 Jan 9;10(1):3. doi: 10.1186/s13073-017-0510-5.

11.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin H, van Es JH, Offerhaus GJ, Clevers H.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11859-11864. Epub 2016 Oct 5.

12.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29.

13.

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data.

Grün D, Muraro MJ, Boisset JC, Wiebrands K, Lyubimova A, Dharmadhikari G, van den Born M, van Es J, Jansen E, Clevers H, de Koning EJP, van Oudenaarden A.

Cell Stem Cell. 2016 Aug 4;19(2):266-277. doi: 10.1016/j.stem.2016.05.010. Epub 2016 Jun 23.

14.

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.

Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2016 Feb 4;18(2):203-13. doi: 10.1016/j.stem.2016.01.001. Epub 2016 Jan 28.

15.

Dysregulated cytokine expression in lesional and nonlesional skin in hidradenitis suppurativa.

Kelly G, Hughes R, McGarry T, van den Born M, Adamzik K, Fitzgerald R, Lawlor C, Tobin AM, Sweeney CM, Kirby B.

Br J Dermatol. 2015 Dec;173(6):1431-9. doi: 10.1111/bjd.14075. Epub 2015 Nov 17.

PMID:
26282467
16.

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.

Koo BK, van Es JH, van den Born M, Clevers H.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7548-50. doi: 10.1073/pnas.1508113112. Epub 2015 May 28.

17.

A20 controls intestinal homeostasis through cell-specific activities.

Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G.

Nat Commun. 2014 Sep 30;5:5103. doi: 10.1038/ncomms6103.

PMID:
25267258
18.

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

Boj SF, van Es JH, Huch M, Li VS, José A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H.

Cell. 2012 Dec 21;151(7):1595-607. doi: 10.1016/j.cell.2012.10.053.

19.

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

van Es JH, Sato T, van de Wetering M, Lyubimova A, Yee Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens ACM, Barker N, van Oudenaarden A, Clevers H.

Nat Cell Biol. 2012 Oct;14(10):1099-1104. doi: 10.1038/ncb2581. Epub 2012 Sep 23.

20.

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H.

Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. Epub 2012 Aug 1.

21.

Idiopathic noncirrhotic portal hypertension is associated with poor survival: results of a long-term cohort study.

Schouten JN, Nevens F, Hansen B, Laleman W, van den Born M, Komuta M, Roskams T, Verheij J, Janssen HL.

Aliment Pharmacol Ther. 2012 Jun;35(12):1424-33. doi: 10.1111/j.1365-2036.2012.05112.x. Epub 2012 Apr 27.

22.

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

van Es JH, Haegebarth A, Kujala P, Itzkovitz S, Koo BK, Boj SF, Korving J, van den Born M, van Oudenaarden A, Robine S, Clevers H.

Mol Cell Biol. 2012 May;32(10):1918-27. doi: 10.1128/MCB.06288-11. Epub 2012 Mar 5.

23.

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.

Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ.

PLoS One. 2011;6(8):e22616. doi: 10.1371/journal.pone.0022616. Epub 2011 Aug 3.

24.

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.

Schepers AG, Vries R, van den Born M, van de Wetering M, Clevers H.

EMBO J. 2011 Mar 16;30(6):1104-9. doi: 10.1038/emboj.2011.26. Epub 2011 Feb 4.

25.

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H.

Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28.

26.

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H.

Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016/j.cell.2010.09.016.

27.

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.

Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.

28.

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H.

Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013.

29.

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.

Menke V, van Es JH, de Lau W, van den Born M, Kuipers EJ, Siersema PD, de Bruin RW, Kusters JG, Clevers H.

Dis Model Mech. 2010 Jan-Feb;3(1-2):104-10. doi: 10.1242/dmm.003012.

30.

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H.

Gastroenterology. 2009 Oct;137(4):1333-45.e1-3. doi: 10.1053/j.gastro.2009.06.044. Epub 2009 Jun 21.

PMID:
19549527
31.

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H.

Gastroenterology. 2009 Jun;136(7):2187-2194.e1. doi: 10.1053/j.gastro.2009.03.002. Epub 2009 Mar 24.

PMID:
19324043
32.

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H.

Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031.

33.

Detection of beta-catenin localization by immunohistochemistry.

Barker N, van den Born M.

Methods Mol Biol. 2008;468:91-8. doi: 10.1007/978-1-59745-249-6_7.

PMID:
19099248
34.

Crypt stem cells as the cells-of-origin of intestinal cancer.

Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H.

Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17.

PMID:
19092804
35.

Identification of stem cells in small intestine and colon by marker gene Lgr5.

Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H.

Nature. 2007 Oct 25;449(7165):1003-7. Epub 2007 Oct 14.

PMID:
17934449
36.

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B.

Gastroenterology. 2007 Aug;133(2):539-46. Epub 2007 May 21.

PMID:
17681175
37.

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.

Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R.

Development. 2007 Feb;134(3):535-44.

38.

Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.

Haramis AP, Hurlstone A, van der Velden Y, Begthel H, van den Born M, Offerhaus GJ, Clevers HC.

EMBO Rep. 2006 Apr;7(4):444-9. Epub 2006 Jan 27.

39.

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H.

Nature. 2005 Jun 16;435(7044):959-63.

PMID:
15959515
40.

Wnt signalling induces maturation of Paneth cells in intestinal crypts.

van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H.

Nat Cell Biol. 2005 Apr;7(4):381-6. Epub 2005 Mar 20.

PMID:
15778706
41.

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

Haramis AP, Begthel H, van den Born M, van Es J, Jonkheer S, Offerhaus GJ, Clevers H.

Science. 2004 Mar 12;303(5664):1684-6.

42.

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.

Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T, Clevers H.

Cell. 2002 Oct 18;111(2):251-63.

43.

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H.

Cell. 2002 Oct 18;111(2):241-50.

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