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Items: 12


Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson IR, McNeish I, Ennis D, Ali H, Kugeratski FG, Al Khamici H, van den Biggelaar M, van den Berghe PV, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC, Zanivan S.

Nat Commun. 2017 Feb 15;8:14206. doi: 10.1038/ncomms14206.


CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.

Macpherson IR, Rainero E, Mitchell LE, van den Berghe PV, Speirs C, Dozynkiewicz MA, Chaudhary S, Kalna G, Edwards J, Timpson P, Norman JC.

J Cell Sci. 2014 Sep 15;127(Pt 18):3893-901. doi: 10.1242/jcs.135947. Epub 2014 Jul 11.


Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.

Muller PA, Trinidad AG, Timpson P, Morton JP, Zanivan S, van den Berghe PV, Nixon C, Karim SA, Caswell PT, Noll JE, Coffill CR, Lane DP, Sansom OJ, Neilsen PM, Norman JC, Vousden KH.

Oncogene. 2013 Mar 7;32(10):1252-65. doi: 10.1038/onc.2012.148. Epub 2012 May 14.


Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

Dozynkiewicz MA, Jamieson NB, Macpherson I, Grindlay J, van den Berghe PV, von Thun A, Morton JP, Gourley C, Timpson P, Nixon C, McKay CJ, Carter R, Strachan D, Anderson K, Sansom OJ, Caswell PT, Norman JC.

Dev Cell. 2012 Jan 17;22(1):131-45. doi: 10.1016/j.devcel.2011.11.008. Epub 2011 Dec 22.


The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.

Vonk WI, de Bie P, Wichers CG, van den Berghe PV, van der Plaats R, Berger R, Wijmenga C, Klomp LW, van de Sluis B.

Cell Mol Life Sci. 2012 Jan;69(1):149-63. doi: 10.1007/s00018-011-0743-1. Epub 2011 Jun 11.


Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin.

van den Berghe PV, Stapelbroek JM, Krieger E, de Bie P, van de Graaf SF, de Groot RE, van Beurden E, Spijker E, Houwen RH, Berger R, Klomp LW.

Hepatology. 2009 Dec;50(6):1783-95. doi: 10.1002/hep.23209.


Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate.

van der Velden LM, Stapelbroek JM, Krieger E, van den Berghe PV, Berger R, Verhulst PM, Holthuis JC, Houwen RH, Klomp LW, van de Graaf SF.

Hepatology. 2010 Jan;51(1):286-96. doi: 10.1002/hep.23268.


New developments in the regulation of intestinal copper absorption.

van den Berghe PV, Klomp LW.

Nutr Rev. 2009 Nov;67(11):658-72. doi: 10.1111/j.1753-4887.2009.00250.x. Review.


Posttranslational regulation of copper transporters.

van den Berghe PV, Klomp LW.

J Biol Inorg Chem. 2010 Jan;15(1):37-46. doi: 10.1007/s00775-009-0592-7. Epub 2009 Oct 8. Review.


Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing.

Beekman JM, van der Poel CE, van der Linden JA, van den Berg DL, van den Berghe PV, van de Winkel JG, Leusen JH.

J Immunol. 2008 Mar 15;180(6):3938-45.


Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake.

van den Berghe PV, Folmer DE, Malingré HE, van Beurden E, Klomp AE, van de Sluis B, Merkx M, Berger R, Klomp LW.

Biochem J. 2007 Oct 1;407(1):49-59.


Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.

Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH.

PLoS Biol. 2003 Oct;1(1):E12. Epub 2003 Oct 13.

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