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Items: 1 to 50 of 521

1.

Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production.

van den Bosch MHJ, Ramos YFM, den Hollander W, Bomer N, Nelissen RGHH, Bovée JVMG, van den Berg WB, van Lent PLEM, Blom AB, van der Kraan PM, Meulenbelt I.

Rheumatology (Oxford). 2019 Jun 1;58(6):1065-1074. doi: 10.1093/rheumatology/key426.

PMID:
30649473
2.

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Waterborg CEJ, Broeren MGA, Blaney Davidson EN, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ.

Rheumatology (Oxford). 2019 Mar 1;58(3):536-546. doi: 10.1093/rheumatology/key337.

PMID:
30508140
3.

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation.

Broeren MGA, Di Ceglie I, Bennink MB, van Lent PLEM, van den Berg WB, Koenders MI, Blaney Davidson EN, van der Kraan PM, van de Loo FAJ.

PeerJ. 2018 May 30;6:e4771. doi: 10.7717/peerj.4771. eCollection 2018.

4.

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models.

Waterborg CEJ, Beermann S, Broeren MGA, Bennink MB, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ.

Front Immunol. 2018 Apr 13;9:742. doi: 10.3389/fimmu.2018.00742. eCollection 2018.

5.

Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis.

van der Geest T, Roeleveld DM, Walgreen B, Helsen MM, Nayak TK, Klein C, Hegen M, Storm G, Metselaar JM, van den Berg WB, van der Kraan PM, Laverman P, Boerman OC, Koenders MI.

Rheumatology (Oxford). 2018 Apr 1;57(4):737-747. doi: 10.1093/rheumatology/kex456.

PMID:
29361119
6.

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis.

Rogier R, Evans-Marin H, Manasson J, van der Kraan PM, Walgreen B, Helsen MM, van den Bersselaar LA, van de Loo FA, van Lent PL, Abramson SB, van den Berg WB, Koenders MI, Scher JU, Abdollahi-Roodsaz S.

Sci Rep. 2017 Nov 15;7(1):15613. doi: 10.1038/s41598-017-15802-x.

7.

WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis.

van den Bosch MH, Blom AB, Kram V, Maeda A, Sikka S, Gabet Y, Kilts TM, van den Berg WB, van Lent PL, van der Kraan PM, Young MF.

Osteoarthritis Cartilage. 2017 Nov;25(11):1900-1911. doi: 10.1016/j.joca.2017.07.012. Epub 2017 Jul 19.

8.

Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis.

van den Bosch MH, Blom AB, van de Loo FA, Koenders MI, Lafeber FP, van den Berg WB, van der Kraan PM, van Lent PL.

Arthritis Rheumatol. 2017 Oct;69(10):1978-1983. doi: 10.1002/art.40206. Epub 2017 Aug 29.

9.

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis.

Rogier R, Ederveen THA, Boekhorst J, Wopereis H, Scher JU, Manasson J, Frambach SJCM, Knol J, Garssen J, van der Kraan PM, Koenders MI, van den Berg WB, van Hijum SAFT, Abdollahi-Roodsaz S.

Microbiome. 2017 Jun 23;5(1):63. doi: 10.1186/s40168-017-0278-2.

10.

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis.

Roeleveld DM, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar L, van de Loo FA, van Lent PL, van der Kraan PM, van den Berg WB, Koenders MI.

PLoS One. 2017 Feb 3;12(2):e0171757. doi: 10.1371/journal.pone.0171757. eCollection 2017.

11.

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis.

van Dalen SC, Blom AB, Slöetjes AW, Helsen MM, Roth J, Vogl T, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, van den Bosch MH, van Lent PL.

Osteoarthritis Cartilage. 2017 Mar;25(3):385-396. doi: 10.1016/j.joca.2016.09.009. Epub 2016 Sep 18.

12.

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, van Lent PL, van der Kraan PM, van den Berg WB, van den Hoogen FH, Koenders MI, van de Loo FA.

Arthritis Res Ther. 2016 Aug 12;18:186. doi: 10.1186/s13075-016-1083-1.

13.

Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins.

de Munter W, Geven EJ, Blom AB, Walgreen B, Helsen MM, Joosten LA, Roth J, Vogl T, van de Loo FA, Koenders MI, van den Berg WB, van der Kraan PM, van Lent PL.

Osteoarthritis Cartilage. 2017 Jan;25(1):118-127. doi: 10.1016/j.joca.2016.07.020. Epub 2016 Aug 8.

14.

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.

van den Bosch MH, Blom AB, Schelbergen RF, Koenders MI, van de Loo FA, van den Berg WB, Vogl T, Roth J, van der Kraan PM, van Lent PL.

J Rheumatol. 2016 Oct;43(10):1874-1884. Epub 2016 Aug 1.

PMID:
27481901
15.

Secukinumab for rheumatology: development and its potential place in therapy.

Koenders MI, van den Berg WB.

Drug Des Devel Ther. 2016 Jun 24;10:2069-80. doi: 10.2147/DDDT.S105263. eCollection 2016. Review.

16.

Milk-Derived Nanoparticle Fraction Promotes the Formation of Small Osteoclasts But Reduces Bone Resorption.

Oliveira MC, Di Ceglie I, Arntz OJ, van den Berg WB, van den Hoogen FH, Ferreira AV, van Lent PL, van de Loo FA.

J Cell Physiol. 2017 Jan;232(1):225-33. doi: 10.1002/jcp.25414. Epub 2016 Jun 2.

PMID:
27138291
17.

Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation.

Oliveira MC, Arntz OJ, Blaney Davidson EN, van Lent PL, Koenders MI, van der Kraan PM, van den Berg WB, Ferreira AV, van de Loo FA.

J Nutr Biochem. 2016 Apr;30:74-84. doi: 10.1016/j.jnutbio.2015.11.017. Epub 2015 Dec 28.

PMID:
27012623
18.

Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, Blom AB, Koenders MI, van Lent PL, van der Kraan PM, van den Berg WB, van de Loo FA.

Hum Gene Ther. 2016 Mar;27(3):244-54. doi: 10.1089/hum.2015.127. Epub 2016 Feb 16.

PMID:
26711533
19.

High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis.

de Munter W, van den Bosch MH, Slöetjes AW, Croce KJ, Vogl T, Roth J, Koenders MI, van de Loo FA, van den Berg WB, van der Kraan PM, van Lent PL.

Osteoarthritis Cartilage. 2016 May;24(5):844-55. doi: 10.1016/j.joca.2015.11.016. Epub 2015 Dec 12.

20.

Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis.

van den Bosch MH, Gleissl TA, Blom AB, van den Berg WB, van Lent PL, van der Kraan PM.

Rheumatology (Oxford). 2016 Sep;55(9):1536-47. doi: 10.1093/rheumatology/kev402. Epub 2015 Dec 14. Review.

PMID:
26667213
21.

Impaired Porphyromonas gingivalis-Induced Tumor Necrosis Factor Production by Dendritic Cells Typifies Patients With Rheumatoid Arthritis.

Santegoets KC, Wenink MH, Braga FA, Cossu M, Lamers-Karnebeek FB, van Riel PL, Sturm PD, van den Berg WB, Radstake TR.

Arthritis Rheumatol. 2016 Apr;68(4):795-804. doi: 10.1002/art.39514.

22.

Inflammation in osteoarthritis: changing views.

Berenbaum F, van den Berg WB.

Osteoarthritis Cartilage. 2015 Nov;23(11):1823-4. doi: 10.1016/j.joca.2015.09.012. No abstract available.

23.

Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis.

van den Bosch MH, Blom AB, Schelbergen RF, Vogl T, Roth JP, Slöetjes AW, van den Berg WB, van der Kraan PM, van Lent PL.

Arthritis Rheumatol. 2016 Jan;68(1):152-63. doi: 10.1002/art.39420.

24.

Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis.

Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K.

Arthritis Res Ther. 2015 Aug 26;17:230. doi: 10.1186/s13075-015-0742-y.

25.

High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis?

de Munter W, van der Kraan PM, van den Berg WB, van Lent PL.

Rheumatology (Oxford). 2016 Jan;55(1):16-24. doi: 10.1093/rheumatology/kev270. Epub 2015 Jul 31. Review.

PMID:
26231344
26.
27.

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models.

Arntz OJ, Pieters BC, Oliveira MC, Broeren MG, Bennink MB, de Vries M, van Lent PL, Koenders MI, van den Berg WB, van der Kraan PM, van de Loo FA.

Mol Nutr Food Res. 2015 Sep;59(9):1701-12. doi: 10.1002/mnfr.201500222. Epub 2015 Jul 1.

PMID:
26047123
28.

Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage.

van den Bosch MH, Blom AB, Sloetjes AW, Koenders MI, van de Loo FA, van den Berg WB, van Lent PL, van der Kraan PM.

Am J Pathol. 2015 Jul;185(7):1970-80. doi: 10.1016/j.ajpath.2015.03.013. Epub 2015 May 12.

PMID:
25976248
29.

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL.

Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12.

PMID:
25969431
30.

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis.

Vermeij EA, Koenders MI, Bennink MB, Crowe LA, Maurizi L, Vallée JP, Hofmann H, van den Berg WB, van Lent PL, van de Loo FA.

PLoS One. 2015 May 8;10(5):e0126687. doi: 10.1371/journal.pone.0126687. eCollection 2015.

31.

Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β.

Pieters BC, Arntz OJ, Bennink MB, Broeren MG, van Caam AP, Koenders MI, van Lent PL, van den Berg WB, de Vries M, van der Kraan PM, van de Loo FA.

PLoS One. 2015 Mar 30;10(3):e0121123. doi: 10.1371/journal.pone.0121123. eCollection 2015.

32.

Novel therapeutic targets in rheumatoid arthritis.

Koenders MI, van den Berg WB.

Trends Pharmacol Sci. 2015 Apr;36(4):189-95. doi: 10.1016/j.tips.2015.02.001. Epub 2015 Feb 27. Review.

PMID:
25732812
33.

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

Blaney Davidson EN, van Caam AP, Vitters EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent PL, van de Loo FA, van der Kraan PM.

Osteoarthritis Cartilage. 2015 Mar;23(3):478-86. doi: 10.1016/j.joca.2014.12.005. Epub 2014 Dec 18.

34.

Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals.

Santegoets KC, Wenink MH, van den Berg WB, Radstake TR.

PLoS One. 2014 Oct 23;9(10):e110966. doi: 10.1371/journal.pone.0110966. eCollection 2014.

35.

Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.

Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL.

Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480. Epub 2014 Sep 1.

PMID:
25180294
36.

Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis.

Mahler EA, Zweers MC, van Lent PL, Blom AB, van den Hoogen FH, van den Berg WB, Roth J, Vogl T, Bijlsma JW, van den Ende CH, den Broeder AA.

Scand J Rheumatol. 2015;44(1):56-60. doi: 10.3109/03009742.2014.918176. Epub 2014 Sep 2.

PMID:
25179566
37.

How to build an inducible cartilage-specific transgenic mouse.

Blaney Davidson EN, van de Loo FA, van den Berg WB, van der Kraan PM.

Arthritis Res Ther. 2014;16(3):210. Review.

38.

Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis.

Vermeij EA, Broeren MG, Bennink MB, Arntz OJ, Gjertsson I, van Lent PL, van den Berg WB, Koenders MI, van de Loo FA.

Ann Rheum Dis. 2015 Nov;74(11):2084-91. doi: 10.1136/annrheumdis-2014-205223. Epub 2014 Jul 15.

PMID:
25028707
39.

Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages.

Gramoun A, Crowe LA, Maurizi L, Wirth W, Tobalem F, Grosdemange K, Coullerez G, Eckstein F, Koenders MI, Van den Berg WB, Hofmann H, Vallée JP.

Arthritis Res Ther. 2014 Jun 23;16(3):R131. doi: 10.1186/ar4588.

40.

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels.

Schelbergen RF, van Dalen S, ter Huurne M, Roth J, Vogl T, Noël D, Jorgensen C, van den Berg WB, van de Loo FA, Blom AB, van Lent PL.

Osteoarthritis Cartilage. 2014 Aug;22(8):1158-66. doi: 10.1016/j.joca.2014.05.022. Epub 2014 Jun 10.

41.

In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice.

Vermeij EA, Koenders MI, Blom AB, Arntz OJ, Bennink MB, van den Berg WB, van Lent PL, van de Loo FA.

Mol Imaging. 2014;13:1-10.

PMID:
24881106
42.

Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis.

Marijnissen RJ, Roeleveld DM, Young D, Nickerson-Nutter C, Abdollahi-Roodsaz S, Garcia de Aquino S, van de Loo FA, van Spriel AB, Boots AM, van den Berg WB, Koenders MI.

Arthritis Rheumatol. 2014 Apr;66(4):886-95. doi: 10.1002/art.38312.

43.

Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response.

de Aquino SG, Abdollahi-Roodsaz S, Koenders MI, van de Loo FA, Pruijn GJ, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar LA, de Molon RS, Avila Campos MJ, Cunha FQ, Cirelli JA, van den Berg WB.

J Immunol. 2014 May 1;192(9):4103-11. doi: 10.4049/jimmunol.1301970. Epub 2014 Mar 28.

44.

Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis.

Remst DF, Blom AB, Vitters EL, Bank RA, van den Berg WB, Blaney Davidson EN, van der Kraan PM.

Arthritis Rheumatol. 2014 Mar;66(3):647-56. doi: 10.1002/art.38266.

45.

Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions.

van Beuningen HM, de Vries-van Melle ML, Vitters EL, Schreurs W, van den Berg WB, van Osch GJ, van der Kraan PM.

Tissue Eng Part A. 2014 Aug;20(15-16):2243-52. doi: 10.1089/ten.TEA.2013.0553. Epub 2014 Mar 25.

46.

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8.

van den Bosch MH, Blom AB, van Lent PL, van Beuningen HM, Blaney Davidson EN, van der Kraan PM, van den Berg WB.

Cell Signal. 2014 May;26(5):951-8. doi: 10.1016/j.cellsig.2014.01.021. Epub 2014 Jan 23.

PMID:
24463008
47.

Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.

Blaney Davidson EN, Vitters EL, Bennink MB, van Lent PL, van Caam AP, Blom AB, van den Berg WB, van de Loo FA, van der Kraan PM.

Ann Rheum Dis. 2015 Jun;74(6):1257-64. doi: 10.1136/annrheumdis-2013-204528. Epub 2014 Jan 21.

PMID:
24448347
48.

Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.

van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR.

N Engl J Med. 2014 Jan 30;370(5):433-43. doi: 10.1056/NEJMoa1114576. Epub 2013 Dec 18.

49.

Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis.

de Munter W, Blom AB, Helsen MM, Walgreen B, van der Kraan PM, Joosten LA, van den Berg WB, van Lent PL.

Arthritis Res Ther. 2013 Nov 4;15(6):R178. doi: 10.1186/ar4367.

50.

TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling.

Remst DF, Blaney Davidson EN, Vitters EL, Bank RA, van den Berg WB, van der Kraan PM.

Cell Tissue Res. 2014 Jan;355(1):163-71. doi: 10.1007/s00441-013-1740-5. Epub 2013 Nov 6.

PMID:
24192939

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